Milieuverliezen Aver Heino binnen de perken

Het project 'Echt Overijssel!' streeft naar een grote rijkdom aan planten- en diersoorten op en rond landbouwgronden, regionaal gesloten grondstofkringlopen en nieuwe economische dragers voor het landelijk gebied. Voor Aver Heino, het proefbedrijf voor biologische melkveehouderij, wordt berekend wat de milieueffecten zijn van het betrekken van meer grondstoffen uit de eigen regio

Лечение артериальной гипертензии в преклонном возрасте: от отрицания до признания необходимости

Представлен анализ результатов клинических исследований антигипертензивной терапии у пожилых пациентов, позволяющий сделать заключение о целесообразности ее проведения даже после достижения 80−летнего возраста.The analysis of the findings of clinical research of antihypertensive therapy in elderly patients, which allowed to conclude about the necessity about the expediency of its administration even in patients over 80, is presented

Relationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration

Uterine and umbilical uptakes of alanine (Ala) were measured in 10 ewes before (control) and during intravenous infusion of Ala, which increased maternal arterial Ala concentration from 115 +/- 14 to 629 +/- 78 microM (P < 0.001). In 8 of these ewes, placental Ala fluxes were traced by constant intravenous infusion of L-[3,3,3-2H3]Ala in the mother and L-[1-13C]Ala in the fetus. Rates are reported as micromoles per minute per kilogram fetus. Ala infusion increased uterine uptake (2.5 +/- 0.6 to 15.6 +/- 3.1, P < 0.001), umbilical uptake (3.1 +/- 0.5 to 6.9 +/- 0.8, P < 0.001), and net uteroplacental utilization (-0.7 +/- 0.8 to 8.6 +/- 2.7, P < 0.01) of Ala. Control Ala flux to fetus from mother (Rf,m) was much less than the Ala flux to fetus from placenta (Rf,p) (0.17 +/- 0.04 vs. 5. 0 +/- 0.6). Two additional studies utilizing L-[U-13C]Ala as the maternal tracer confirmed the small relative contribution of Rf,m to Rf,p. During maternal Ala infusion, Rf,m increased significantly (P < 0.02) but remained a small fraction of Rf,p (0.71 +/- 0.2 vs. 7.3 +/- 1.3). We conclude that maternal Ala entering the placenta is metabolized and exchanged for placental Ala, so that most of the Ala delivered to the fetus is produced within the placenta. An increase in maternal Ala concentration increases placental Ala utilization and the fetal uptake of both maternal and placental Ala

Prospects for Gene lntrogression from Hordeum bulbosum L. into Barley (H. vulgare L.).

Hybridizations between Hordeum vulgare L. (cultivated barley) and H. bulbosum L. have been performed over many years with two aims. First, the production of doubled haploid barley cultivars (Kasha and Kao 1970); second, the transfer of desirable traits such as resistance to fungal and viral pathogens from the wild species into barley. Apart from the report of an occasional recombinant (Xu and Kasha 1992; Pickering et al 1994), successful gene introgression has been hampered by several barriers. In this report we will describe recent progress in overcoming these barriers

Effluentzuivering met eendenkroos = Effluent polishing with duck weed

Duckweed is usable for purifying waste water. At a protein content of 30% in dry matter it has perspective as feed. Fermenting and drying enlarges the usability. Besides duckweed is profitable for protein isolation at large scale production. Duckweed is not profitable for codigestion. Legislation and instructions requires guarantee of food safety. An extensive risk analysis and guarantying the production process are the most important conditions

Effect of dexamethasone on fetal hepatic glutamine-glutamate exchange

Intravenous infusion of dexamethasone (Dex) in the fetal lamb causes a two- to threefold increase in plasma glutamine and other glucogenic amino acids and a decrease of plasma glutamate to approximately one-third of normal. To explore the underlying mechanisms, hepatic amino acid uptake and conversion of L-[1-(13)C]glutamine to L-[1-(13)C]glutamate and (13)CO(2) were measured in six sheep fetuses before and in the last 2 h of a 26-h Dex infusion. Dex decreased hepatic glutamine and alanine uptakes (P < 0.01) and hepatic glutamate output (P < 0.001). Hepatic outputs of the glutamate (R(Glu,Gln)) and CO(2) formed from plasma glutamine decreased to 21 (P < 0.001) and 53% (P = 0.009) of control, respectively. R(Glu,Gln), expressed as a fraction of both outputs, decreased (P < 0.001) from 0.36 +/- 0.02 to 0.18 +/- 0.04. Hepatic glucose output remained virtually zero throughout the experiment. We conclude that Dex decreases fetal hepatic glutamate output by increasing the routing of glutamate carbon into the citric acid cycle and by decreasing the hepatic uptake of glucogenic amino acids

The Use of Animal Models to Study Bacterial Translocation During Acute Pancreatitis

Infection of pancreatic necrosis with intestinal flora is accepted to be a main predictor of outcome during severe acute pancreatitis. Bacterial translocation is the process whereby luminal bacteria migrate to extraintestinal sites. Animal models were proven indispensable in detecting three major aspects of bacterial translocation: small bowel bacterial overgrowth, mucosal barrier failure, and disturbed immune responses. Despite the progress made in the knowledge of bacterial translocation, the exact mechanism, origin and route of bacteria, and the optimal prophylactic and treatment strategies remain unclear. Methodological restrictions of animal models are likely to be the cause of this uncertainty. A literature review of animal models used to study bacterial translocation during acute pancreatitis demonstrates that many experimental techniques per se interfere with intestinal flora, mucosal barrier function, or immune response. Interference with these major aspects of bacterial translocation complicates interpretation of study results. This paper addresses these and other issues of animal models most frequently used to study bacterial translocation during acute pancreatitis

Changes in quantitative sensory testing and patient perspectives following spinal cord stimulation for persistent spinal pain syndrome:an observational study with long-term follow-up

BACKGROUND: Spinal cord stimulation (SCS) can impact sensory, pain and tolerance thresholds in various ways, which can be accessed via quantitative sensory testing (QST). The objectives of this study were to (1) assess the subjective sensory responses using QST in patients following SCS therapy for PSPS and (2) to get a clinical impression of the results of SCS during an interview of these patients with PSPS and SCS during long term follow-up. METHODS: Forty patients with PSPS who received SCS treatment underwent QST via electrical and mechanical pressure stimuli. QST was performed at four different moments (1. pre-implantation SCS, 2. two weeks postoperatively, 3. three months after permanent SCS implantation and 4. six months after permanent SCS implantation. Patients' perspectives on pain, use of drugs and quality of life were assessed via semi-structured interviews during a follow-up between five and eleven years. RESULTS: We found statistical differences in the changes of sensory, pain and tolerance thresholds. A decrease in pain complaints and analgesics use were reported by the patients during follow-up. The quality of life in patients increased from three to eight (NRS 0 (worst QoL imaginable) -10 (best QoL imaginable) after receiving SCS. CONCLUSIONS: The increased thresholds on areas without pain or being covered by the SCS induced paresthesias may indicate that there are central changes contributing to these deviations in thresholds. The overall QoL in patients improved greatly after receiving SCS

The Effect of Smoking and Body Mass Index on The Complication Rate of Alloplastic Breast Reconstruction

Background and Aims: The aim of this study was to evaluate the effect of smoking and body mass index on the occurrence of complications after alloplastic breast reconstruction. Materials and Methods: A consecutive series of 56 patients treated with immediate or delayed alloplastic breast reconstruction, including six cases combined with latissimus dorsi flap, at three hospitals between 2012 and 2018 were included. Complications were scored and defined according to Clavien–Dindo. To evaluate the impact of smoking, body mass index, and other potential risk factors on the occurrence of any and severe complications, univariate and multivariate logistic regression analyses were applied to estimate odds ratios and 95% confidence intervals. Results: In 56 patients, 22 patients had a complication. As much as 46% of smokers had severe complications compared to 18% of non-smokers. Of patients with body mass index ⩾ 25, 40% had severe complications compared to 10% with body mass index < 25. Smokers had eight times more chance of developing severe complications than non-smokers (ORadjusted = 8.0, p = 0.02). Patients with body mass index ⩾ 25 had almost 10 times more severe complications compared to patients with body mass index ⩽ 25 (ORadjusted = 9.9, p = 0.009). No other risk factors were significant. Conclusion: Smoking and body mass index ⩾ 25 both increased the complication rate to such an extent that patients should be informed about their increased risk for complications following alloplastic breast reconstruction and on these grounds surgeons may delay alloplastic breast reconstruction. It is an ethical dilemma whether one should deny overweight and obese patients and those who smoke an immediate alloplastic breast reconstruction. For both life style interventions, adequate guidance should be made available

Mestvergisting op boerderijschaal = Manure digestion on the farm

Door vergisting van mest wordt biogas gevormd waaruit via een warmtekrachtkoppeling duurzame elektriciteit en warmte wordt geproduceerd. Hierdoor vindt een reductie plaats in emissie van methaan uit mest en wordt emissie van broeikasgassen uit niet-duurzame energiebronnen voorkomen. Op Praktijkcentra Sterkel en Nij Bosma Zathe is onderzoek gedaan aan twee installaties voor mestvergisting. Beide installaties dienden ook als demonstratie voor praktijkbedrijven. Dit rapport geeft een overzicht van de resultaten van de installaties gedurende de onderzoeksperiode. In de uitgevoerde TEWI-berekeningen blijkt vergisting van varkens- en rundveedrijfmest een reductie potentieel in broeikasgasemissie te hebben wat boven de 50% ligt. Maar voor een rendabele mestvergistinginstallatie moeten bedrijven een omvang hebben die boven gemiddeld ligt. Hierbij zijn bedrijfsspecifieke kenmerken ook van invloed op de economische evaluatie van een mestvergistinginstallatie