A Highly Selective 8th Order Band-Pass Filter for Lightning Remote Sensing Applications

Recently, it has been discovered there was an emission of microwave radiation in advance of the lightning process. Therefore, a lot of researches focus on designing alarm systems that can detect and analyze these radiated signals. The previous designs based on commercial band-pass filters which have low accuracy factor and quite expensive as well as the detected signal were tiny in amplitude, thus higher efficiency filters are needed with a flat frequency response for passed band frequencies between 950 MHz to 1050 MHz in order to avoid the GSM band which generates a high interference to the mentioned detection system. In this research, a band-pass filter has been designed and tested for measurement with a center frequency of 1 GHz and by using Advance Design System (ADS) to be simulated and then fabricated on FR-4 substrate. The measurement came with good compatibility to the simulation results at return loss of -34.747 dB and also the insertion loss of -3.83 dB. This design also works perfectly for the Lightning detection sensor of Narrow Bipolar Event (NBE)

Effects of Mesenchymal Stem Cell Derivatives on Hematopoiesis and Hematopoietic Stem Cells

Hematopoiesis is a balance among quiescence, self-renewal, proliferation, and differentiation, which is believed to be firmly adjusted through interactions between hematopoietic stem and progenitor cells (HSPCs) with the microenvironment. This microenvironment is derived from a common progenitor of mesenchymal origin and its signals should be capable of regulating the cellular memory of transcriptional situation and lead to an exchange of stem cell genes expression. Mesenchymal stem cells (MSCs) have self-renewal and differentiation capacity into tissues of mesodermal origin, and these cells can support hematopoiesis through release various molecules that play a crucial role in migration, homing, self-renewal, proliferation, and differentiation of HSPCs. Studies on the effects of MSCs on HSPC differentiation can develop modern solutions in the treatment of patients with hematologic disorders for more effective Bone Marrow (BM) transplantation in the near future. However, considerable challenges remain on realization of how paracrine mechanisms of MSCs act on the target tissues, and how to design a therapeutic regimen with various paracrine factors in order to achieve optimal results for tissue conservation and regeneration. The aim of this review is to characterize and consider the related aspects of the ability of MSCs secretome in protection of hematopoiesis

The Effect of Mesenchymal Stem Cell-Derived Microvesicles on Erythroid Differentiation of Umbilical Cord Blood-Derived CD34+ Cells

Purpose: Mesenchymal stem cells (MSCs) play an important role in the proliferation and differentiation of hematopoietic stem cells (HSCs) in the bone marrow via cell-to-cell contact, as well as secretion of cytokines and microvesicles (MVs). In this study, we investigated the effect of mesenchymal stem cell-derived microvesicles (MSC-MVs) on erythroid differentiation of umbilical cord blood-derived CD34+ cells. Methods: In this descriptive study, CD34+ cells were cultured with mixture of SCF (10 ng/ml) and rhEPO (5 U/ml) cytokines in complete IMDM medium as positive control group. Then, in MV1- and MV2-groups, microvesicles at 10 and 20 µg/ml concentration were added. After 72 hours, erythroid specific markers (CD71 and CD235a) and genes (HBG1, GATA1, FOG1 and NFE2) were assessed by flow cytometry and qRT-PCR, respectively. Results: The expression of specific markers of the erythroid lineages (CD71 and GPA) in the presence of different concentration of microvesicles were lower than that of the control group (P<0.001). Also, the expression of specific genes of the erythroid lineages (NFE2, FOG1, GATA1, and HBG1) was investigated in comparison to the internal control (GAPDH). Among all of them, HBG1 and FOG1 genes were significantly decreased to the control group (P<0.0001) but GATA1 and NFE2 gene expressions was not significant. Conclusion: The results of this study showed that MSC-MVs decrease the erythroid differentiation of umbilical cord blood-derived CD34+ cells. Therefore, MSC-MVs play a key role in the regulation of normal erythropoiesis

Correlation between Neutrophil Gelatinase Associated with Lipocaline and Beta-2 Microglobulin with Other Renal Markers in Iraqi Patients with Multiple Myeloma

Multiple myeloma, often known as myeloma, is a kind of bone marrow cancer. The bone marrow is a spongy tissue in the middle of some bones that creates the body's blood cells. The current study is designed to find the correlation between Neutrophil gelatinase-associated lipocalin and ß2-Microglobulin with other renal markers among patients with multiple myeloma and healthy people. One hundred twenty patients with multiple myeloma and sixty healthy control were attending the National Center for Teaching Laboratories (NCFTL), Baghdad Hospital Advisory (BHA), and Baghdad Teaching Hospital. For the period from November 2021 to March 2022. Information taken from patients involved age, genus, drugs used, and other medical details. Multiple myeloma disease was diagnosed using symptoms, biochemical testing, x-ray, and clinical examination by specialists. Then serum urea, creatinine, total protein, globulin, and albumin are done by Autoanalyzer. Furthermore, Neutrophil gelatinase-associated lipocalin and ß2-Microglobulin were done by ELISA technique. The present study found that the male patients in the age range (60-69) and (50-59) years had a higher percentage (30%, 20% and 36%,16.7%) than female patients in both studied groups. The multiple myeloma disease patients with urea and creatinine above normal had a highly significant increase (p= 0.000) in the mean ± SD of urea, creatinine, total protein, globulin, Beta 2 microglobulin, and Neutrophil gelatinase-associated lipocalin (57.83±30.92 mg/dl, 2.09±1.38 mg/dl, 77.95±13.08 g/l, 42.52±11.16 g/l, 39.14±16.20, 452.50±188.83) respectively. In addition, patients with urea and creatinine normal had a highly significant increase (p= 0.000) in the mean ± SD of creatinine, total protein, Globulin, Beta 2 microglobulin, and Neutrophil gelatinase-associated lipocalin (0.80±0.20 mg/dl, 73.07±11.75 g/l, 40.34±10.67 g/l, 43.28±18.78, 432.77±198.45) respectively compared with the healthy controls

Peakon Employee Voice esihenkilötyössä : henkilöstökyselyt aktiivisena osana johtamista

Tässä opinnäytetyössä kuvataan Workdayn Peakon Employee Voice -henkilöstökyselyalustan käyttöä toimeksiantajayrityksessä esihenkilöiden näkökulmasta. Toimeksiantajan nimeä ei mainita opinnäytetyössä yrityksen omasta tahdosta. Tarve työn toteutukselle on noussut suoraan työelämästä, ja se on toteutettu tiiviissä yhteistyössä toimeksiantajan henkilöstöhallinnon kanssa. Opinnäytetyön tavoitteena on selvittää, kuinka toimeksiantajayrityksen esihenkilöt hyödyntävät Peakonia työssään. Työn tarkoitus on auttaa toimeksiantajaa kehittämään ja yhtenäistämään Peakonin käyttöä Suomen yksiköissään. Opinnäytetyöhön sisältyneen tutkimuksen tulokset antavat pohjan Peakonin käytön kehittämiselle ja kokoavat yhteen esihenkilöiden tavat käyttää Peakonia. Työn teoreettinen viitekehys on esihenkilötyössä ja johtamisessa. Työssä perehdytään erityisesti henkilöstökyselyihin johtamisen tukena, työhyvinvoinnin johtamiseen ja tiedolla johtamiseen. Työssä käsitellään myös johtamisen kehittämistä. Työssä selvitettiin esihenkilöiden kokemuksia Peakonin käytöstä ja heidän tapojaan hyödyntää sitä työssään. Työssä yhdistetään kvalitatiivista ja kvantitatiivista tutkimusta ja aineistonkeruu on toteutettu kyselylomakkeen sekä teemahaastattelujen avulla. Tuloksista selviää, että käytännöt Peakonin käytön osalta vaihtelevat esihenkilöstä riippuen. Vaihtelua on esimerkiksi tavoissa reagoida Peakonin kautta saatuun palautteeseen ja kyselytulosten hyödyntämisessä osana toiminnan kehittämistä. Syitä vaihtelun taustalla on paljon. Selittäviä tekijöitä ovat esimerkiksi kiire, palautteen sisältö sekä esihenkilön oma Peakon-osaaminen. Myös yhtäläisyyksiä löytyy. Suurin osa esihenkilöistä luottaa Peakonista saamaansa hyötyyn ja vastaa negatiivisiin kommentteihin toimeksiantajan ohjeistuksen mukaisesti. Suurin osa kokee Peakonin soveltuvan hyvin työtyytyväisyyden mittaamiseen. Raportissa toimeksiantajalle esitellään kuusi kehitysehdotusta opinnäytetyöhön sisältyneen tutkimustyön pohjalta. Kehitysehdotusten on tarkoitus luoda pohjaa Peakonin käytön kehittämiselle ja yhtenäistämiselle toimeksiantajayrityksessä.This thesis described how Workday’s Peakon Employee Voice platform is used by the commissioner company’s managers. The objective of this thesis was to examine how the managers utilize Peakon. The aim was to help the commissioner develop and standardize the utilization of Peakon in their departments in Finland. The theoretical framework discussed management and leadership. The study addressed the different aspects of leadership and the ways surveys support leadership. The research showed how the managers use Peakon and their experiences using it. The study combined the qualitative and quantitative elements. The results showed that there are differences in the ways the managers react to feedback from Peakon and how they use the results to guide development. Some of the explaining factors are lack of time, the substance of the feedback and the manager’s Peakon knowledge. The similarities include the trust in the benefits of using Peakon and its suitability for measuring job satisfaction as well as responding to negative feedback according to the directions from the commissioner. Based on the results this report introduces six propositions on how to improve the company’s work with Peakon. They are meant to create a basis for the future development and standardizing the ways commissioner utilizes Peakon