1,012 research outputs found

    The Immediate Effects of Deep Pressure on Young People with Autism and Severe Intellectual Difficulties: Demonstrating Individual Differences

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    Background. Deep pressure is widely used by occupational therapists for people with autism spectrum disorders. There is limited research evaluating deep pressure. Objective. To evaluate the immediate effects of deep pressure on young people with autism and severe intellectual disabilities. Methods. Mood and behaviour were rated for 13 pupils with ASD and severe ID before and after deep pressure sessions. Results. Sufficient data was available from 8 participants to be analysed using Tau-U, a nonparametric technique that allows for serial dependence in data. Six showed benefits statistically. Five of these showed benefits across all domains, and one showed benefits on three out of five domains. Relevance to Clinical Practice. Deep pressure appears to be of immediate benefit to this population with autism and severe ID, but the heterogeneity of response suggests that careful monitoring of response should be used and deep pressure discontinued when it is no longer of benefit. Limitations. This is an open label evaluation study using rating scales. Recommendations for Future Research. Future studies of the use of deep pressure should use physiological response measures, in addition to blinded raters for aspects of behaviours such as attitude to learning psychological health not captured physiologically

    A Solidarity Machine? Hong Kong Labour NGOs in Guangdong

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    Although the literature on labour NGOs (LNGOs) in China has significantly expanded, few scholars have attempted to subject the work of these organizations to a Marxist perspective. This article draws on a recently developed Marxian theoretical framework on social movements to analyse the pioneering work of Hong Kong LNGOs and their partners in the province of Guangdong, China. Over the past 15 years, the Hong Kong groups, as they are known collectively, have been ideally placed to develop specific interventions in response to migrant workers’ pursuance of wage claims and improved working conditions during a time of increased rights awareness and widespread labour shortages. While consistently careful to remain the right side of China’s restrictive laws on freedom of association and demonstrations, the Hong Kong LNGOs were able to contribute to a narrative of class-based collective solidarity that has yielded significant gains for workers

    A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior

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    Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a approximately 475 kb tandem duplication on chromosome 17 that includes Glo1 (30,174,390-30,651,226 Mb; mouse genome build 36). We developed a PCR-based strategy and used it to detect this duplication in 23 of 71 inbred strains tested, and in various outbred and wild-caught mice. Presence of the duplication is associated with a cis-acting expression QTL for Glo1 (LOD>30) in BXD recombinant inbred strains. However, evidence for an eQTL for Glo1 was not obtained when we analyzed single SNPs or 3-SNP haplotypes in a panel of 27 inbred strains. We conclude that association analysis in the inbred strain panel failed to detect an eQTL because the duplication was present on multiple highly divergent haplotypes. Furthermore, we suggest that non-allelic homologous recombination has led to multiple reversions to the non-duplicated state among inbred strains. We show associations between multiple duplication-containing haplotypes, Glo1 expression and anxiety-like behavior in both inbred strain panels and outbred CD-1 mice. Our findings provide a molecular basis for differential expression of Glo1 and further implicate Glo1 in anxiety-like behavior. More broadly, these results identify problems with commonly employed tests for association in inbred strains when CNVs are present. Finally, these data provide an example of biologically significant phenotypic variability in model organisms that can be attributed to CNVs.These studies were funded by MH070933, MH79103 and MH020065
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