Genome characterization and population genetic structure of the zoonotic pathogen, streptococcus canis

Background - Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen. Results - Here we provide characterization of the first genome sequence for this species, strain FSL S3-227 (milk isolate from a cow with an intra-mammary infection). A diverse array of putative virulence factors was encoded by the S. canis FSL S3-227 genome. Approximately 75% of these gene sequences were homologous to known Streptococcal virulence factors involved in invasion, evasion, and colonization. Present in the genome are multiple potentially mobile genetic elements (MGEs) [plasmid, phage, integrative conjugative element (ICE)] and comparison to other species provided convincing evidence for lateral gene transfer (LGT) between S. canis and two additional bovine mastitis causing pathogens (Streptococcus agalactiae, and Streptococcus dysgalactiae subsp. dysgalactiae), with this transfer possibly contributing to host adaptation. Population structure among isolates obtained from Europe and USA [bovine = 56, canine = 26, and feline = 1] was explored. Ribotyping of all isolates and multi locus sequence typing (MLST) of a subset of the isolates (n = 45) detected significant differentiation between bovine and canine isolates (Fisher exact test: P = 0.0000 [ribotypes], P = 0.0030 [sequence types]), suggesting possible host adaptation of some genotypes. Concurrently, the ancestral clonal complex (54% of isolates) occurred in many tissue types, all hosts, and all geographic locations suggesting the possibility of a wide and diverse niche. Conclusion - This study provides evidence highlighting the importance of LGT in the evolution of the bacteria S. canis, specifically, its possible role in host adaptation and acquisition of virulence factors. Furthermore, recent LGT detected between S. canis and human bacteria (Streptococcus urinalis) is cause for concern, as it highlights the possibility for continued acquisition of human virulence factors for this emerging zoonotic pathogen

Three-dimensional flux states as a model for the pseudogap phase of transition metal oxides

We propose that the pseudogap state observed in the transition metal oxides can be explained by a three-dimensional flux state, which exhibits spontaneously generated currents in its ground state due to electron-electron correlations. We compare the energy of the flux state to other classes of mean field states, and find that it is stabilized over a wide range of $t$ and $\delta$. The signature of the state will be peaks in the neutron diffraction spectra, the location and intensity of which are presented. The dependence of the pseudogap in the optical conductivity is calculated based on the parameters in the model.Comment: submitted to Phys. Rev. B on January 8, 200

Spin Susceptibility and Gap Structure of the Fractional-Statistics Gas

This paper establishes and tests procedures which can determine the electron energy gap of the high-temperature superconductors using the $t\!-\!J$ model with spinon and holon quasiparticles obeying fractional statistics. A simpler problem with similar physics, the spin susceptibility spectrum of the spin 1/2 fractional-statistics gas, is studied. Interactions with the density oscillations of the system substantially decrease the spin gap to a value of $(0.2 \pm 0.2)$ $\hbar \omega_c$, much less than the mean-field value of $\hbar\omega_c$. The lower few Landau levels remain visible, though broadened and shifted, in the spin susceptibility. As a check of the methods, the single-particle Green's function of the non-interacting Bose gas viewed in the fermionic representation, as computed by the same approximation scheme, agrees well with the exact results. The same mechanism would reduce the gap of the $t\!-\!J$ model without eliminating it.Comment: 35 pages, written in REVTeX, 16 figures available upon request from [email protected]

Paired States in the Even Integer Quantum Hall Effect

We argue that a new type of quantum Hall state requiring non-perturbative Landau level mixing arises at low electron density. In these states, up and down spin electrons pair to form spinless bosons that condense into a bosonic quantum Hall state. We describe a wavefunction for a paired quantum Hall state at $\nu=2$ and argue that it is stabilized by a BCS instability arising in flux attachment calculations. Based on this state, we derive a new global phase diagram for the integral quantum Hall effect with spin. Additional experimental implications are discussed.Comment: uufile, includes 4 page revtex file and 1 figure fil

Confinement of Slave-Particles in U(1) Gauge Theories of Strongly-Interacting Electrons

We show that slave particles are always confined in U(1) gauge theories of interacting electron systems. Consequently, the low-lying degrees of freedom are different from the slave particles. This is done by constructing a dual formulation of the slave-particle representation in which the no-double occupany constraint becomes linear and, hence, soluble. Spin-charge separation, if it occurs, is due to the existence of solitons with fractional quantum numbers

Effective Field Theory and Integrability in Two-Dimensional Mott Transition

We study the Mott transition in a two-dimensional lattice spinless fermion model with nearest neighbors density-density interactions. By means of a two-dimensional Jordan-Wigner transformation, the model is mapped onto the lattice XXZ spin model, which is shown to possess a Quantum Group symmetry as a consequence of a recently found solution of the Zamolodchikov Tetrahedron Equation. A projection (from three to two space-time dimensions) property of the solution is used to identify the symmetry of the model at the Mott critical point as U_q(sl(2))xU_q(sl(2)), with deformation parameter q=-1. Based on this result, the low-energy Effective Field theory for the model is obtained and shown to be a lattice double Chern-Simons theory with coupling constant k=1 (with the standard normalization). By further employing the Effective Filed Theory methods, we show that the Mott transition that arises is of topological nature, with vortices in an antiferromagnetic array and matter currents characterized by a d-density wave order parameter. We also analyze the behavior of the system upon weak coupling, and conclude that it undergoes a quantum gas-liquid transition which belongs to the Ising universality class.Comment: 36 page

On the Current Carried by `Neutral' Quasiparticles

The current should be proportional to the momentum in a Galilean-invariant system of particles of fixed charge-to-mass ratio, such as an electron liquid in jellium. However, strongly-interacting electron systems can have phases characterized by broken symmetry or fractionalization. Such phases can have neutral excitations which can presumably carry momentum but not current. In this paper, we show that there is no contradiction: `neutral' excitations {\em do} carry current in a Galilean-invariant system of particles of fixed charge-to-mass ratio. This is explicitly demonstrated in the context of spin waves, the Bogoliubov-de Gennes quasiparticles of a superconductor, the one-dimensional electron gas, and spin-charge separated systems in 2+1 dimensions. We discuss the implications for more realistic systems, which are not Galilean-invariant

Berezinskii-Kosterlitz-Thouless Transition in Spin-Charge Separated Superconductor

A model for spin-charge separated superconductivity in two dimensions is introduced where the phases of the spinon and holon order parameters couple gauge-invariantly to a statistical gauge-field representing chiral spin-fluctuations. The model is analyzed in the continuum limit and in the low-temperature limit. In both cases we find that physical electronic phase correlations show a superconducting-normal phase transition of the Berezinskii-Kosterlitz-Thouless type, while statistical gauge-field excitations are found to be strictly gapless. The normal-to-superconductor phase boundary for this model is also obtained as a function of carrier density, where we find that its shape compares favorably with that of the experimentally observed phase diagram for the oxide superconductors.Comment: 35 pages, TeX, CSLA-P-93-

Topological Phase Diagram of a Two-Subband Electron System

We present a phase diagram for a two-dimensional electron system with two populated subbands. Using a gated GaAs/AlGaAs single quantum well, we have mapped out the phases of various quantum Hall states in the density-magnetic filed plane. The experimental phase diagram shows a very different topology from the conventional Landau fan diagram. We find regions of negative differential Hall resistance which are interpreted as preliminary evidence of the long sought reentrant quantum Hall transitions. We discuss the origins of the anomalous topology and the negative differential Hall resistance in terms of the Landau level and subband mixing.Comment: 4 pages, 4 figure

Quasiholes and fermionic zero modes of paired fractional quantum Hall states: the mechanism for nonabelian statistics

The quasihole states of several paired states, the Pfaffian, Haldane-Rezayi, and 331 states, which under certain conditions may describe electrons at filling factor $\nu=1/2$ or 5/2, are studied, analytically and numerically, in the spherical geometry, for the Hamiltonians for which the ground states are known exactly. We also find all the ground states (without quasiparticles) of these systems in the toroidal geometry. In each case, a complete set of linearly-independent functions that are energy eigenstates of zero energy is found explicitly. For fixed positions of the quasiholes, the number of linearly-independent states is $2^{n-1}$ for the Pfaffian, $2^{2n-3}$ for the Haldane-Rezayi state; these degeneracies are needed if these systems are to possess nonabelian statistics, and they agree with predictions based on conformal field theory. The dimensions of the spaces of states for each number of quasiholes agree with numerical results for moderate system sizes. The effects of tunneling and of the Zeeman term are discussed for the 331 and Haldane-Rezayi states, as well as the relation to Laughlin states of electron pairs. A model introduced by Ho, which was supposed to connect the 331 and Pfaffian states, is found to have the same degeneracies of zero-energy states as the 331 state, except at its Pfaffian point where it is much more highly degenerate than either the 331 or the Pfaffian. We introduce a modification of the model which has the degeneracies of the 331 state everywhere including the Pfaffian point; at the latter point, tunneling reduces the degeneracies to those of the Pfaffian state. An experimental difference is pointed out between the Laughlin states of electron pairs and the other paired states, in the current-voltage response when electrons tunnel into the edge. And there's more.Comment: 43 pages, requires RevTeX. The 14 figures and 2 tables are available on request at [email protected] (include mailing address