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Seventy four Reference Sites of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) have been recognised by the European Commission in 2016 for their commitment to excellence in investing and scaling up innovative solutions for active and healthy ageing. The Reference Site Collaborative Network (RSCN) brings together the EIP on AHA Reference Sites awarded by the European Commission, and Candidate Reference Sites into a single forum. The overarching goals are to promote cooperation, share and transfer good practice and solutions in the development and scaling up of health and care strategies, policies and service delivery models, while at the same time supporting the action groups in their work. The RSCN aspires to be recognized by the EU Commission as the principal forum and authority representing all EIP on AHA Reference Sites. The RSCN will contribute to achieve the goals of the EIP on AHA by improving health and care outcomes for citizens across Europe, and the development of sustainable economic growth and the creation of jobs

Physical activity and cognitive function in adults born very preterm or with very low birth weight–an individual participant data meta-analysis

Objective Individuals born very preterm (<32 weeks of gestation) or with very low birthweight (<1500g) have lower cognitive function compared with term-born peers. Furthermore, some studies suggest that they are less physically active as young adults than controls, but the relationship between physical activity and cognitive function remains unclear. We performed an individual participant data meta-analysis to examine whether being born preterm/with very low birth weight is associated with physical activity in adulthood and examined if cognitive function mediates this association. Study design Cohorts with data on physical activity and cognitive function in adults born very preterm/very low birth weight and term-born controls were recruited from the Research on European Children and Adults Born Preterm, and the Adults Born Preterm International Collaboration Consortia. A systematic literature search was performed in PubMed and Embase. Results Five cohorts with 1644 participants aged 22–28 years (595 very preterm/very low birth weight and 1049 controls) were included. Adults born very preterm/very low birth weight reported 1.11 (95% CI: 0.68 to 1.54) hours less moderate to vigorous physical activity per week than controls, adjusted for cohort, age and sex. The difference between individuals born very preterm/very low birth weight and controls was larger among women than among men. Neither intelligence quotient nor self-reported executive function mediated the association between very preterm/very low birth weight and moderate to vigorous physical activity. Results were essentially the same when we excluded individuals with neurosensory impairments. Conclusion Adults born very preterm/very low birth weight, especially women, reported less moderate to vigorous physical activity than their term-born peers. Cognitive function did not mediate this association. Considering the risk of adverse health outcomes among individuals born preterm, physical activity could be a target for intervention.Peer reviewe

Overview of questions used to assess moderate to vigorous physical activity.

AYLS = Arvo Ylppö Longitudinal Study; ESTER = ESTER Preterm Birth Study; HeSVA = Helsinki Study of Very Low Birth Weight Adults; NTNU LBW Life = Norwegian University of Science and Technology Low Birth Weight in a Lifetime Perspective study; NZ VLBW = New Zealand Very Low Birth Weight Follow-up Study; Q = question. (DOCX)</p

Summary of the cohorts included in individual participant data meta-analysis.

Summary of the cohorts included in individual participant data meta-analysis.</p

Direct, indirect and total effect of very preterm/very low birth weight on moderate to vigorous physical activity with cognitive function as mediator.

Direct, indirect and total effect of very preterm/very low birth weight on moderate to vigorous physical activity with cognitive function as mediator.</p

Direct, indirect and total effect of very preterm/very low birth weight on moderate to vigorous physical activity with cognitive function as mediator.

Participants with neurosensory impairment excluded. Analyses adjusted for cohort, age and sex. BRIEF-A GEC = Behavior Rating Inventory of Executive Function–Adult Version, Global Executive Composite (overall summary score); CI = confidence interval; IQ = intelligence quotient; VP/VLBW = very preterm (aVP/VLBW, Control. (DOCX)</p

Moderate to vigorous physical activity, full scale intelligence quotient and Behavior Rating Inventory of Executive Function–Adult Version, Global Executive Composite in the extremely preterm/extremely low birth weight and the control group.

BRIEF-A GEC = Behavior Rating Inventory of Executive Function–Adult Version, Global Executive Composite (overall summary score); CI = confidence interval; EP/ELBW = extremely preterm (aEP/ELBW, Control. bBased on bootstrapped regression analysis with group and cohort as fixed factor, and age and sex as covariates. (DOCX)</p

Direct, indirect and total effect of extremely preterm/extremely low birth weight on moderate to vigorous physical activity with cognitive function as mediator.

Analyses adjusted for cohort, age and sex. BRIEF-A GEC = Behavior Rating Inventory of Executive Function–Adult Version, Global Executive Composite (overall summary score); CI = confidence interval; EP/ELBW = extremely preterm (aEP/ELBW, Control. (DOCX)</p

Newcastle-Ottawa criteria and quality score for each cohort.

AYLS = Arvo Ylppö Longitudinal Study; ESTER = ESTER Preterm Birth Study; HeSVA = Helsinki Study of Very Low Birth Weight Adults; NTNU LBW Life = Norwegian University of Science and Technology Low Birth Weight in a Lifetime Perspective study; NZ VLBW = New Zealand Very Low Birth Weight Follow-up Study. (DOCX)</p