The role of tenascin-C in tissue injury and tumorigenesis

The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer

Biomass burning aerosols in most climate models are too absorbing

Uncertainty in the representation of biomass burning (BB) aerosol composition and optical properties in climate models contributes to a range in modeled aerosol effects on incoming solar radiation. Depending on the model, the top-of-the-atmosphere BB aerosol effect can range from cooling to warming. By relating aerosol absorption relative to extinction and carbonaceous aerosol composition from observational datasets to nine state-of-the-art Earth System Models/Chemical Transport Models,we identify varying degrees of overestimation in BB aerosol absorptivity by these models. Modifications to BB aerosol refractive index, size, and mixing state improve the Community Atmosphere Model version 5 (CAM5) agreement with observations, leading to a global change in BB direct radiative effect of -0.07 W m-2,and regional changes of -2 W m-2(Africa) and -0.5 W m-2(South America/Temperate). Our findings suggest that current modeled BB contributes less to warming than previously thought, largely due to treatments of aerosol mixing state

Time-resolved analysis of primary volatile emissions and secondary aerosol formation potential from a small-scale pellet boiler.

Small-scale pellet boilers and stoves became popular as a wood combustion appliance for domestic heating in Europe, North America and Asia due to economic and environmental aspects. Therefore, an increasing contribution of pellet boilers to air pollution is expected despite their general high combustion efficiency. As emissions of primary organic aerosol (POA) and permanent gases of pellet boilers are well investigated, the scope of this study was to investigate the volatile organic emissions and the formation potential of secondary aerosols for this type of appliance. Fresh and aged emissions were analysed by a soot-particle aerosol time-of-flight mass spectrometry (SP-AMS) and the molecular composition of the volatile precursors with single-photon ionisation time-of-flight mass spectrometry (SPI-TOFMS) at different pellet boiler operation conditions. Organic emissions in the gas phase were dominated by unsaturated hydrocarbons while wood-specific VOCs, e.g. phenolic species or substituted furans, were only detected during the starting phase. Furthermore, organic emissions in the gas phase were found to correlate with fuel grade and combustion technology in terms of secondary air supply. Secondary organic aerosols of optimised pellet boiler conditions (OPT, state-of-the-art combustion appliance) and reduced secondary air supply (RSA, used as a proxy for pellet boilers of older type) were studied by simulating atmospheric ageing in a Potential Aerosol Mass (PAM) flow reactor. Different increases in OA mass (55% for OPT, 102% for RSA), associated with higher average carbon oxidation state and O:C, could be observed in a PAM chamber experiment. Finally, it was found that derived SOA yields and emission factors were distinctly lower than reported for log wood stoves

Intercomparison of holographic imaging and single-particle forward light scattering in situ measurements of liquid clouds in changing atmospheric conditions

Upon a new measurement technique, it is possible to sharpen the determination of microphysical properties of cloud droplets using high resolving power imaging. The shape, size, and position of each particle inside a welldefined, three-dimensional sample volume can be measured with holographic methods without assumptions of particle properties. In situ cloud measurements were carried out at the Puijo station in Kuopio, Finland, focusing on intercomparisons between cloud droplet analyzers over 2 months in September–November 2020. The novel holographic imaging instrument (ICEMET) was adapted to measure microphysical properties of liquid clouds, and these values were compared with parallel measurements of a cloud droplet spectrometer (FM-120) and particle measurements using a twininlet system. When the intercomparison was carried out during isoaxial sampling, our results showed good agreement in terms of variability between the instruments, with the averaged ratios between ICEMET and FM-120 being 0.6 ± 0.2, 1.0 ± 0.5, and 1.2 ± 0.2 for the total number concentration (Nd) of droplets, liquid water content (LWC), and median volume diameter (MVD), respectively. This agreement during isoaxial sampling was also confirmed by mutual correlation and Pearson correlation coefficients. The ICEMETobserved LWC was more reliable than FM-120 (without a swivel-head mount), which was verified by comparing the estimated LWC to measured values, whereas the twin-inlet DMPS system and FM-120 observations of Nd showed good agreement both in variability and amplitude. Field data revealed that ICEMET can detect small cloud droplets down to5 µm via geometric magnification

Volatile organic compounds from logwood combustion: Emissions and transformation under dark and photochemical aging conditions in a smog chamber.

Residential wood combustion (RWC) emits high amounts of volatile organic compounds (VOCs) into ambient air, leading to formation of secondary organic aerosol (SOA), and various health and climate effects. In this study, the emission factors of VOCs from a logwood-fired modern masonry heater were measured using a Proton-Transfer Reactor Time-of-Flight Mass Spectrometer. Next, the VOCs were aged in a 29 m(3) Teflon chamber equipped with UV black lights, where dark and photochemical atmospheric conditions were simulated. The main constituents of the VOC emissions were carbonyls and aromatic compounds, which accounted for 50%-52% and 30%-46% of the detected VOC emission, respectively. Emissions were highly susceptible to different combustion conditions, which caused a 2.4-fold variation in emission factors. The overall VOC concentrations declined considerably during both dark and photochemical aging, with simultaneous increase in particulate organic aerosol mass. Especially furanoic and phenolic compounds decreased, and they are suggested to be the major precursors of RWC-originated SOA in all aging conditions. On the other hand, dark aging produced relatively high amounts of nitrogen-containing organic compounds in both gas and particulate phase, while photochemical aging increased especially the concentrations of certain gaseous carbonyls, particularly acid anhydrides

Intercomparison of holographic imaging and single-particle forward light scattering in situ measurements of liquid clouds in changing atmospheric conditions

Abstract Upon a new measurement technique, it is possible to sharpen the determination of microphysical properties of cloud droplets using high resolving power imaging. The shape, size, and position of each particle inside a well-defined, three-dimensional sample volume can be measured with holographic methods without assumptions of particle properties. In situ cloud measurements were carried out at the Puijo station in Kuopio, Finland, focusing on intercomparisons between cloud droplet analyzers over 2 months in September–November 2020. The novel holographic imaging instrument (ICEMET) was adapted to measure microphysical properties of liquid clouds, and these values were compared with parallel measurements of a cloud droplet spectrometer (FM-120) and particle measurements using a twin-inlet system. When the intercomparison was carried out during isoaxial sampling, our results showed good agreement in terms of variability between the instruments, with the averaged ratios between ICEMET and FM-120 being 0.6 ± 0.2, 1.0 ± 0.5, and 1.2 ± 0.2 for the total number concentration (Nd) of droplets, liquid water content (LWC), and median volume diameter (MVD), respectively. This agreement during isoaxial sampling was also confirmed by mutual correlation and Pearson correlation coefficients. The ICEMET-observed LWC was more reliable than FM-120 (without a swivel-head mount), which was verified by comparing the estimated LWC to measured values, whereas the twin-inlet DMPS system and FM-120 observations of Nd showed good agreement both in variability and amplitude. Field data revealed that ICEMET can detect small cloud droplets down to 5 µm via geometric magnification