Male Weight Control: Crowdsourcing and an Intervention to Discover More

Men and women have similar rates of obesity but the combined prevalence of overweight and obesity is higher among men. Men who are overweight are a high-risk group for many obesity-related chronic diseases, as they are more likely to carry excess weight in the abdomen, which is generally more harmful than weight stored in the lower body. Men are also less likely than women to perceive themselves as overweight, and thus are less likely to initiate weight loss through organized weight loss programs. On average, less than 27% of weight loss trial participants have been men. Internet-based research is a low-cost, efficient way to produce novel hypotheses related to weight loss that may have previously escaped weight loss professionals. Additionally, incentives are an effective tool to motivate behavior change, and there is ample evidence to support the use of incentives to encourage many health-promoting behaviors, such as weight loss. The purpose our initial study was to facilitate intervention development by using crowdsourcing to detect unexpected beliefs and unpredicted barriers to male weight loss. The aim of our main study was to evaluate the impact of financial incentives to facilitate weight loss in men, delivered as part of a weight loss intervention. Two separate studies were conducted. In the first project, participants were recruited to a crowdsourcing survey website which was used to generate hypotheses for behaviors related to overweight and obesity in men. Participants provided 21,846 responses to 193 questions. While several common themes seen in prior research were revealed such as previous health diagnoses and physical activity participation, other potential weight determinants such as dietary habits, sexual behaviors and self-perception were reported. Crowdsourcing in this context provides a mechanism to further investigate perceptions of weight and weight loss interventions in the male population that have not previously been documented. These insights will help guide future intervention design. For the main project, a randomized trial compared the Gutbusters weight loss program (based on the REFIT program) alone with Gutbusters with escalating incentives for successful weight loss. The six-month intervention was conducted online with weekly in-person weight collections for the first 12 weeks. Gutbusters encouraged participants to make six 100-calorie changes to their daily diet, utilizing a variety of online lessons targeting specific eating behaviors. Measures included demographic information, height, weight, waist circumference, and body fat percentage. Participants (N=102, 47. 0± 12. 3 yrs old, 32. 5 kg/m2, 80. 4% with at least two years of college) were randomized in a 1:1 ratio to Gutbusters or Gutbusters+Incentive. Significantly more Gutbusters+Incentive participants lost at least 5% of their baseline weight compared to the Gutbusters group at both 12 and 24 weeks. Similar to the aforementioned REFIT program, Gutbusters participants were able to achieve clinically significant weight loss. The Gutbusters+Incentive achieved greater rates of weight loss than the Gutbusters alone group, further supporting the value of incentives in promoting health behaviors

The Effect of Atorvastatin on Breast Cancer Biomarkers in High-Risk Women

Statins have the potential to reduce breast cancer incidence and recurrence as shown in both epidemiologic and laboratory studies. The purpose of this study was to evaluate the effect of a lipophilic statin, atorvastatin, on breast cancer biomarkers of risk [mammographic density (MD) and insulin growth factor 1 (IGF-1)] in high-risk premenopausal women

Psychometric properties of the Italian versions of the Gambling Urge Scale (GUS) and the Gambling Refusal Self-Efficacy Questionnaire (GRSEQ)

Gambling urges and gambling refusal self-efficacy beliefs play a major role in the development and maintenance of problem gambling. This study aimed to translate the Gambling Urge Scale (GUS) and the Gambling Refusal Self-Efficacy Questionnaire (GRSEQ) from English to Italian (GUS-I, GRSEQ-I) and to test their factor structure, internal consistency, construct validity, concurrent validity, and gender differences in 513 individuals from the Italian community. Factor structure and construct validity were tested through Confirmatory Factor Analysis, internal consistency through Cronbach’s alpha, concurrent validity through correlations with gambling-related cognitions (GRCS-I), probable pathological gambling (SOGS-I), and gambling functioning (GFA-R-I). Results confirmed that the 6 items of the GUS-I load highly on one dimension of Gambling Urge, and each of the 26 items of the GRSEQ-I load highly on their relevant sub-dimension, among the following: situations/thoughts, drugs, positive emotions, negative emotions. Both scales are internally consistent and show concurrent validity with gambling-related cognitions, probable pathological gambling, and gambling functioning. Males score higher than females at the GUS-I; females score higher than males at the GRSEQ-I. The findings from the present study suggest that the GUS-I and the GRSEQ-I are internally consistent and valid scales for the assessment of gambling urges and gambling refusal self-efficacy in Italian individuals from the community, with significant repercussions in terms of assessment, prevention, and intervention

A germline mutation in the BRCA1 3'UTR predicts Stage IV breast cancer.

BackgroundA germline, variant in the BRCA1 3'UTR (rs8176318) was previously shown to predict breast and ovarian cancer risk in women from high-risk families, as well as increased risk of triple negative breast cancer. Here, we tested the hypothesis that this variant predicts tumor biology, like other 3'UTR mutations in cancer.MethodsThe impact of the BRCA1-3'UTR-variant on BRCA1 gene expression, and altered response to external stimuli was tested in vitro using a luciferase reporter assay. Gene expression was further tested in vivo by immunoflourescence staining on breast tumor tissue, comparing triple negative patient samples with the variant (TG or TT) or non-variant (GG) BRCA1 3'UTR. To determine the significance of the variant on clinically relevant endpoints, a comprehensive collection of West-Irish breast cancer patients were tested for the variant. Finally, an association of the variant with breast screening clinical phenotypes was evaluated using a cohort of women from the High Risk Breast Program at the University of Vermont.ResultsLuciferase reporters with the BRCA1-3'UTR-variant (T allele) displayed significantly lower gene expression, as well as altered response to external hormonal stimuli, compared to the non-variant 3'UTR (G allele) in breast cancer cell lines. This was confirmed clinically by the finding of reduced BRCA1 gene expression in triple negative samples from patients carrying the homozygous TT variant, compared to non-variant patients. The BRCA1-3'UTR-variant (TG or TT) also associated with a modest increased risk for developing breast cancer in the West-Irish cohort (OR=1.4, 95% CI 1.1-1.8, p=0.033). More importantly, patients with the BRCA1-3'UTR-variant had a 4-fold increased risk of presenting with Stage IV disease (p=0.018, OR=3.37, 95% CI 1.3-11.0). Supporting that this finding is due to tumor biology, and not difficulty screening, obese women with the BRCA1-3'UTR-variant had significantly less dense breasts (p=0.0398) in the Vermont cohort.ConclusionA variant in the 3'UTR of BRCA1 is functional, leading to decreased BRCA1 expression, modest increased breast cancer risk, and most importantly, presentation with stage IV breast cancer, likely due to aggressive tumor biology