3,353 research outputs found
Identifying coherent spatiotemporal modes in time-uncertain proxy paleoclimate records
Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Climate Dynamics 41 (2013): 1291-1306, doi:10.1007/s00382-012-1483-0.High-resolution sedimentary paleoclimate proxy records offer the potential to expand the detection and analysis of decadal- to centennial-scale climate variability during
recent millennia, particularly within regions where traditional high-resolution proxies may
be short, sparse, or absent. However, time uncertainty in these records potentially limits a
straightforward objective identification of broad-scale patterns of climate variability. Here,
we describe a procedure for identifying common patterns of spatiotemporal variability from
time uncertain sedimentary records. This approach, which we term Monte Carlo Empirical
Orthogonal Function (MCEOF) analysis, uses iterative age modeling and eigendecomposition of proxy time series to isolate common regional patterns and estimate uncertainties.
As a test case, we apply this procedure to a diverse set of time-uncertain lacustrine proxy
records from East Africa. We also perform a pseudoproxy experiment using climate model
output to examine the ability of the method to extract shared anomalies given known signals.
We discuss the advantages and disadvantages of our approach, including possible extensions
of the technique.JET acknowledges the UCAR Climate
and Global Change Postdoctoral Fellowship for support.2014-08-2
Big Data and Analysis of Data Transfers for International Research Networks Using NetSage
Modern science is increasingly data-driven and collaborative in nature. Many scientific disciplines, including genomics, high-energy physics, astronomy, and atmospheric science, produce petabytes of data that must be shared with collaborators all over the world. The National Science Foundation-supported International Research Network Connection (IRNC) links have been essential to enabling this collaboration, but as data sharing has increased, so has the amount of information being collected to understand network performance. New capabilities to measure and analyze the performance of international wide-area networks are essential to ensure end-users are able to take full advantage of such infrastructure for their big data applications. NetSage is a project to develop a unified, open, privacy-aware network measurement, and visualization service to address the needs of monitoring today's high-speed international research networks. NetSage collects data on both backbone links and exchange points, which can be as much as 1Tb per month. This puts a significant strain on hardware, not only in terms storage needs to hold multi-year historical data, but also in terms of processor and memory needs to analyze the data to understand network behaviors. This paper addresses the basic NetSage architecture, its current data collection and archiving approach, and details the constraints of dealing with this big data problem of handling vast amounts of monitoring data, while providing useful, extensible visualization to end users
High concentrations of flavor chemicals are present in electronic cigarette refill fluids.
We characterized the flavor chemicals in a broad sample of commercially available electronic cigarette (EC) refill fluids that were purchased in four different countries. Flavor chemicals in 277 refill fluids were identified and quantified by gas chromatography-mass spectrometry, and two commonly used flavor chemicals were tested for cytotoxicity with the MTT assay using human lung fibroblasts and epithelial cells. About 85% of the refill fluids had total flavor concentrations >1 mg/ml, and 37% were >10 mg/ml (1% by weight). Of the 155 flavor chemicals identified in the 277 refill fluids, 50 were present at ≥1 mg/ml in at least one sample and 11 were ≥10 mg/ml in 54 of the refill fluids. Sixty-one% (170 out of 277) of the samples contained nicotine, and of these, 56% had a total flavor chemical/nicotine ratio >2. Four chemicals were present in 50% (menthol, triacetin, and cinnamaldehyde) to 80% (ethyl maltol) of the samples. Some products had concentrations of menthol ("Menthol Arctic") and ethyl maltol ("No. 64") that were 30 times (menthol) and 100 times (ethyl maltol) their cytotoxic concentration. One refill fluid contained cinnamaldehyde at ~34% (343 mg/ml), more than 100,000 times its cytotoxic level. High concentrations of some flavor chemicals in EC refill fluids are potentially harmful to users, and continued absence of any regulations regarding flavor chemicals in EC fluids will likely be detrimental to human health
High school music classes enhance the neural processing of speech
Should music be a priority in public education? One argument for teaching music in school is that private music instruction relates to enhanced language abilities and neural function. However, the directionality of this relationship is unclear and it is unknown whether school-based music training can produce these enhancements. Here we show that 2 years of group music classes in high school enhance the neural encoding of speech. To tease apart the relationships between music and neural function, we tested high school students participating in either music or fitness-based training. These groups were matched at the onset of training on neural timing, reading ability, and IQ. Auditory brainstem responses were collected to a synthesized speech sound presented in background noise. After 2 years of training, the neural responses of the music training group were earlier than at pre-training, while the neural timing of students in the fitness training group was unchanged. These results represent the strongest evidence to date that in-school music education can cause enhanced speech encoding. The neural benefits of musical training are, therefore, not limited to expensive private instruction early in childhood but can be elicited by cost-effective group instruction during adolescence
Modulation of Mid‐Holocene African Rainfall by Dust Aerosol Direct and Indirect Effects
Climate model simulations of the mid‐Holocene (MH) consistently underestimate northern African rainfall for reasons not fully understood. While most models incorporate orbital forcing and vegetation feedbacks, they neglect dust reductions associated with greater vegetation cover. Here we simulate the MH climate response to reduced Saharan dust using CESM CAM5‐chem, which resolves direct and indirect dust aerosol effects. Direct aerosol effects increase Saharan and Sahel convective rainfall by ~16% and 8%. In contrast, indirect aerosol effects decrease stratiform rainfall, damping the dust‐induced total rainfall increase by ~13% in the Sahara and ~59% in the Sahel. Sensitivity experiments indicate the dust‐induced precipitation anomaly in the Sahara and Sahel (0.27 and 0.18 mm/day) is smaller than the anomaly from MH vegetation cover (1.19 and 1.08 mm/day). Although sensitive to dust radiative properties, sea surface temperatures, and indirect aerosol effect parameterization, our results suggest that dust reductions had competing effects on MH African rainfall.Plain Language SummarySix thousand years ago, changes in Earth’s orbit led to greater summer season solar radiation over northern Africa. The increase in energy resulted in higher rainfall amounts, widespread vegetation, and reduced dust aerosols over regions that today are desert. In this study we use a climate model, CESM CAM5‐chem, that accounts for the ways dust aerosols interact with sunlight and cloud droplets to examine how the reduction in Saharan dust during this past humid time affected rainfall. When dust aerosols are reduced in the model, more sunlight reaches the surface, the Sahara warms, and convective rainfall from the West African Monsoon increases. However, through dust‐cloud droplet interactions, the same reduction in dust decreases nonconvective rainfall, which is less prevalent during the monsoon season but still important, and thus dampens the total rainfall increase. Overall, dust reduction leads to a rainfall response that is dependent on rainfall type. Lastly, we compare the rainfall response of reducing dust to that of increasing vegetation cover and find that while important, the response from dust is considerably weaker.Key PointsChanges in direct dust aerosol effects from reduced mid‐Holocene Saharan dust loading increase convective rainfall in northern AfricaChanges in indirect dust aerosol effects weaken total precipitation increases by limiting stratiform rainfall, particularly in the SahelThe African rainfall response to total dust aerosol effects is lower than a previous study and substantially less than vegetation forcingPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149324/1/grl58759-sup-0001-2018GL081225-SI.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149324/2/grl58759_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149324/3/grl58759.pd
Creating New Knowledge with Undergraduate Students: Institutional Incentives and Faculty Agency
Undergraduate students today face a more demanding and competitive labor market than their parents’ generation. In response, some pursue double majors to signal breadth to potential employers and to improve their job prospects. Some students also realize that a strong signal of workplace readiness is acquiring in-demand skills through independent and collaborative research. In this article, four professors at an undergraduate-focused public university in the United States share their experiences working with undergraduate students on research, focusing on the “supply side” of student research training and mentoring. We discuss how institutions can support differently situated faculty members, who face different career incentives and constraints, to integrate undergraduates in their research. We also address the limits of what is possible for faculty‐student research and suggest ways to overcome them
Differential Binding of Co(II) and Zn(II) to Metallo-β-Lactamase Bla2 from \u3cem\u3eBacillus anthracis\u3c/em\u3e
In an effort to probe the structure, mechanism, and biochemical properties of metallo-β-lactamase Bla2 from Bacillus anthracis, the enzyme was overexpressed, purified, and characterized. Metal analyses demonstrated that recombinant Bla2 tightly binds 1 equiv of Zn(II). Steady-state kinetic studies showed that mono-Zn(II) Bla2 (1Zn-Bla2) is active, while di-Zn(II) Bla2 (ZnZn-Bla2) was unstable. Catalytically, 1Zn-Bla2 behaves like the related enzymes CcrA and L1. In contrast, di-Co(II) Bla2 (CoCo-Bla2) is substantially more active than the mono-Co(II) analogue. Rapid kinetics and UV−vis, 1H NMR, EPR, and EXAFS spectroscopic studies show that Co(II) binding to Bla2 is distributed, while EXAFS shows that Zn(II) binding is sequential. To our knowledge, this is the first documented example of a Zn enzyme that binds Co(II) and Zn(II) via distinct mechanisms, underscoring the need to demonstrate transferability when extrapolating results on Co(II)-substituted proteins to the native Zn(II)-containing forms
Lesson Plans for Teaching Economics with The Big Bang Theory
Using examples in the classroom from current and past television shows and movies is becoming increasingly common. Being able to relate ideas back to a popular clip or episode allows the instructor to reach students in ways the traditional lecture cannot. Building on the work of Tierney, Mateer, Smith, Wooten, and Geerling (2016), this paper introduces five lesson plans tied to clips from The Big Bang Theory that can be used in high school (9-12) economics courses
Comparison of three methods for the methylation of aliphatic and aromatic compounds
Rationale: Methylation protocols commonly call for acidic, hot conditions that are known to promote organic ^1H/^2H exchange in aromatic and aliphatic C—H bonds. Here we tested two such commonly-used methods and compared a third that avoids these acidic conditions, to quantify isotope effects with each method and to directly determine acidic-exchange rates relevant to experimental conditions.
Methods: We compared acidic and non-acidic methylation approaches catalyzed by hydrochloric acid, acetyl chloride and EDCI (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) / DMAP (4-dimethylaminopyridine) respectively. These were applied to two analytes: phthalic acid (an aromatic) and octacosanoic acid (an aliphatic). We analyzed yield by gas chromatography flame ionization (GC/FID) and hydrogen and carbon isotopic composition by isotope ratio mass spectrometry (GC/IRMS). We quantified the ^1H/^2H exchange rate on dimethyl phthalate under acidic conditions with proton nuclear magnetic resonance (^1H-NMR) measurements.
Results: The δ^2H and δ^(13)C values and yield were equivalent among the three methods for methyl octacosanoate. The two acidic methods resulted in comparable yield and isotopic composition of dimethyl phthalate; however, the non-acidic method resulted in lower δ^2H and δ^(13)C values perhaps due to low yields. Concerns over acid-catalyzed ^1H/^2H exchange are unwarranted as the effect was trivial over a 12-hour reaction time.
Conclusions: We find product isolation yield and evaporation to be the main concerns in the accurate determination of isotopic composition. ^1H/^2H exchange reactions are too slow to cause measurable isotope fractionation over the typical duration and reaction conditions used in methylation. Thus, we are able to recommend continued use of acidic catalysts in such methylation reactions for both aliphatic and aromatic compounds
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