Role of IL-33 and ST2 signaling and inflammatory responses in non-small cell lung cancer

Purpose: To investigate the role of the interleukin (IL)-33 and ST2 pathway in  non-small cell lung cancer (NSCLC), and to further explore the critical relationships among inflammation, immunity, and cancer.Methods: From January 2014 to December 2015, paraffin-embedded sections of surgical specimens were obtained from 40 patients definitively diagnosed with NSCLC by pathological examination in Changzhou Wujin People's Hospital and Taicang Hospital of Traditional Chinese Medicine. Sections were further  immunostained with antibodies directed against IL-33 and ST2 cardiac biomarker.Inflammatory reactions were determined by hematoxylin and eosin (H&E) staining. Paracancerous control sample tissues were also collected. In addition, 60 primary NSCLC patients without any complications were enrolled, and 60 healthy volunteers were enrolled at the same institutions. Serum samples of patients were collected, and protein expressions of IL-33, ST2, IL-4, and interferon (IFN)-γ were detected by enzyme-linked immunosorbent assay (ELISA) or western blot assay.Results: The results indicate that IL-33, ST2 and IL-4 expressions in cancer tissues and blood were significantly increased when compared with control groups.Conclusion: IL-33/ST2 in NSCLC microenvironment enhances T helper cell 2 (Th2) response, which may be beneficial for tumor growth.Keywords: Interleukin, IL-33, ST2, IL-4, non-small cell lung cancer (NSCLC

Glass formation and properties of Ge-Ga-Te-ZnI2 far infrared chalcohalide glasses

International audienceIn order to develop novel far infrared window material, a series of Ge-Ga-Te-ZnI2 chalcohalide glasses were prepared by traditional melt-quenching method and their glass-forming region was determined also. Here, some measurements including X-ray diffraction (XRD), differential thermal analysis (DTA), UV-Vis-NIR absorption spectrum, and infrared optical transmission spectra were carried out. The allowed indirect transition optical band gap was calculated according to the classical Tauc equation. The results show that with the addition of ZnI2, the glass-forming ability and thermal stability are improved gradually. With the contents of ZnI2 increased from 5 to 20 at.%, continued blue-shifting occurs in the cutting-off absorption edge of short-wavelength and the values of indirect optical band gaps were observed with ranges from 0.596 to 0.626 eV in these glasses. These GeTe4.3-GaTe3-ZnI2 glasses show wide optical transmission and the infrared cut-off wavelengths are larger than 25 μm, which implies that the Ge-Ga-Te-ZnI2 chalcogenide glasses possess the potential of far-IR optical window applications

Preparation of Low-loss Ge15Ga10Te75 chalcogenide glass for far-IR optics applications

International audienceGe15Ga10Te75 (GGT) glass shows good transparency between 2 and 25 μm wavelengths, good chemical and thermal stability to be drawn into fiber, which appears to be a good candidate for developing far-IR fiber-optics devices, although there are strong absorption peaks caused by impurities in the glass. With the aim of decreasing the content of impurities and micro-crystal particles in prepared \GGT\ glass samples, a rapid heating furnace and the fast distillation method based on vapor evaporation plus deposition under vacuum condition was adopted. Properties measurements including Differential Scanning Calorimeter (DSC), Vis-NIR and \IR\ transmitting spectra were performed on the prepared glass samples. Dependence of optical loss on the types of oxygenic getters and their contents and glass quenching temperature was also studied. All these results show that the average optical losses of distilled glass samples were greatly improved by the designated purification processes. Besides, the quality of the glass samples can be improved with the optimized quenching temperature. In all, the optical loss of the glass can be reduced effectively. Minimum optical losses of 0.042 dB/mm at 9 μm and 0.037 dB/mm at 12 μm are obtained after a right purification process, which are the lowest loss of the \GGT\ chalcogenide glass nowadays

The feasibility of Sn, In, or Al doped ZnSb thin film as candidates for phase change material

The potentials of Sn, In, or Al doped ZnSb thin film as candidates for phase change materials have been studied in this paper. It was found that the Zn-Sb bonds were broken by the addition of the dopants and homopolar Zn-Zn bonds and other heteropolar bonds, such as Sn-Sb, In-Sb, and Al-Sb, were subsequently formed. The existence of homopolar Sn-Sn and In-In bonds in Zn₅₀Sb₃₆Sn₁₄ and Zn₄₁Sb₃₆In₂₃ films, but no any Al-Al bonds in Zn₃₅Sb₃₀Al₃₅ film, was confirmed. All these three amorphous films crystallize with the appearance of crystalline rhombohedral Sb phase, and Zn₃₅Sb₃₅Al₃₅ film even exhibits a second crystallization process where the crystalline AlSb phase is separated out. The Zn₃₅Sb₃₀Al₃₅ film exhibits a reversible phase change behavior with a larger Ea ( 4.7 eV), higher Tc (~ 245ᴼ C), better 10-yr data retention (~ 182ᴼ C), less incubation time (20 ns at 70 mW), and faster complete crystallization speed (45 ns at 70 mW). Moreover, Zn₃₅Sb₃₀Al₃₅ film shows the smaller root-mean-square (1.654 nm) and less change of the thickness between amorphous and crystalline state (7.5%), which are in favor of improving the reliability of phase change memory.This work was financially supported by the Natural Science Foundation of China (Grant Nos. 61306147, 61377061), the Public Project of Zhejiang Province (Grant No.2014C31146), the Young Leaders of academic climbing project of the Education Department of Zhejiang Province (pd2013092), the Natural Science Foundation of Zhejiang Province (Grant No. LQ15F040002), the Scientific Research Foundation of Graduate School of Ningbo University, and sponsored by K. C. Wong Magna Fund in Ningbo University

In situ grown palladium nanoparticles on polyester fabric as easy-separable and recyclable catalyst for Suzuki-Miyaura reaction

Palladium nanoparticles supported on low-melting polyester (Pd/LMPET) fabric were prepared through a microwave irradiation assisted method. In this way, in situ growth of Pd nanoparticles onto an easy to handle material was initiated and proceeded. The results of the characterization revealed that the palladium nanoparticles were well-dispersed on the surfaces of the polyester fibers. The Pd/LMPET fabrics were then employed in the Suzuki-Miyaura coupling. They exhibited excellent catalytic activity in ethanol/water under air atmosphere at 50 °C. Importantly, the Pd/LMPET fabrics could be separated from reaction mixture conveniently and they can still maintain good activity after 8 cycles without Pd leaching. © 2021 The Author

Formation and properties of chalcogenide glasses based on GeS2-​Sb2S3-​AgI system

International audienceNovel glasses in GeS2-​Sb2S3-​AgI system have been prepd. by melt-​quenching method. A large glass-​forming region was found in this novel system, in which almost 60 mol​% AgI has been incorporated. The basic physiochem. properties of glass samples were investigated. With the addn. of AgI, red shift of short-​wavelength absorption edge and distinct drop of the glass transition temp. (Tg) were obsd. In addn., a high Ag+ ion cond. of 6.37×10-​4 S​/cm at room temp. was obtained in 55(0.6GeS2-​0.4Sb2S3)​-​45AgI sample, indicating that these glasses have potential application as amorphous solid electrolytes

Phase change behaviors of Zn-doped Ge2Sb2Te5 films

This work was financially supported by the Program for New Century Excellent Talents in University (Grant No. NCET-10-0976), the International Science & Technology Cooperation Program of China (Grant No. 2011DFA12040), the National Program on Key Basic Research Project (973 Program) (Grant No. 2012CB722703), the Natural Science Foundation of China (Grant Nos. 61008041 and 60978058), the Natural Science Foundation of Zhejiang Province, China (Grant No. Y1090996), the Natural Science Foundation of Ningbo City, China (Grant No. 2011A610092), the Program for Innovative Research Team of Ningbo city (Grant No. 2009B21007), and sponsored by K. C. Wong Magna Fund in Ningbo University

Freely adjusted properties in Ge–S based chalcogenide glasses with iodine incorporation

International audienceIn this study, we examined the function of halogen iodine acting as a glass network modifier in green chalcogenide glasses based on the Ge–S system. We obtained a series of Ge–S–I glasses and determined their glass-forming region. We then recorded the physical, thermal, and optical properties and studied the effect of halogen iodine on Ge–S–I glasses. Results show that these glasses have relatively wide optical transmission window for infrared (IR) applications. The softening temperature of Ge–S–I glasses varies from 210.54 °C to 321.63 °C, this temperature fits well with some kinds of high-temperature polymers, such as PES and PEI, the polymers serve as protective layers with high strength and flexibility, thus simplifying the fabrication processes of IR chalcogenide glass fiber. Finally, we performed a purification process to eliminate impurities and to improve optical spectr