MARKET DRIVEN MOBILE GAMING TAXONOMY

This discourse describes a mobile game taxonomy that classifies mobile games into various main genres (e.g., action games, arcade games, role-playing games, music games, etc.) and further classifies the mobile games into various subgenres. For example, mobile games that are categorized as adventure games may be further classified into text adventure games, graphic adventure games, visual novel games, interactive movie games, etc. The main genre and/or the subgenre of a mobile game may be identified based on one or more game elements (e.g., game themes, game art styles, etc.) contained in the mobile game. Based on the identified main genre and/or the subgenre of the mobile game, a market analysis for the mobile game may be generated. For example, a market analysis for a particular mobile game may include a subgenre rank for the mobile game, suggested game elements for the mobile game, and a potential player profile for the mobile game

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.

Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cofactor Apoc2 results in significantly reduced HSPC expansion during definitive hematopoiesis in zebrafish. A human APOC2 mimetic peptide or the human very low-density lipoprotein, which carries APOC2, rescues the phenotype in apoc2 but not in lpl mutant zebrafish. Creating parabiotic apoc2 and lpl mutant zebrafish rescues the hematopoietic defect in both. Docosahexaenoic acid (DHA) is identified as an important factor in HSPC expansion. FFA-DHA, but not TG-DHA, rescues the HSPC defects in apoc2 and lpl mutant zebrafish. Reduced blood cell counts are also observed in Apoc2 mutant mice at the time of weaning. These results indicate that LPL-mediated release of the essential fatty acid DHA regulates HSPC expansion and definitive hematopoiesis

Toxicity Mechanisms and Potential Uses of Extracted Mushroom Toxins - Amatoxin, Antamanide, Muscurine

Mushroom, as a popular kind of wild edible fungi, has raised the attention of many scientists around the globe, due to the fact that increasing numbers of fatal mushroom poisoning cases worldwide have been reported each year. Therefore, to overcome the issue of fatality of mushrooms with an attempt to help people prevent mushroom poisoning, studying mushroom toxicology has become a significant topic to many biochemists; a growing number of researches are conducted focusing on mushroom toxins as well as their chemical properties and toxicity mechanism. In this review, properties and mechanisms of three major toxins (amatoxin, antamanide, muscarine) are chosen as the research focus. The three major toxins, which are extracted from wild mushrooms, will be summarized and studied based on past research findings. Our goals are trying to find possible treatments of each toxin as well as their potential usage in the pharmaceutical industry, which can be especially beneficial towards research of mushroom-extracted drug and food-poisoning toxicity treatment for further investigation and academic references

ANN Model-Based Simulation of the Runoff Variation in Response to Climate Change on the Qinghai-Tibet Plateau, China

Precisely quantitative assessments of stream flow response to climatic change and permafrost thawing are highly challenging and urgent in cold regions. However, due to the notably harsh environmental conditions, there is little field monitoring data of runoff in permafrost regions, which has limited the development of physically based models in these regions. To identify the impacts of climate change in the runoff process in the Three-River Headwater Region (TRHR) on the Qinghai-Tibet Plateau, two artificial neural network (ANN) models, one with three input variables (previous runoff, air temperature, and precipitation) and another with two input variables (air temperature and precipitation only), were developed to simulate and predict the runoff variation in the TRHR. The results show that the three-input variable ANN model has a superior real-time prediction capability and performs well in the simulation and forecasting of the runoff variation in the TRHR. Under the different scenarios conditions, the forecasting results of ANN model indicated that climate change has a great effect on the runoff processes in the TRHR. The results of this study are of practical significance for water resources management and the evaluation of the impacts of climatic change on the hydrological regime in long-term considerations

Wear monitoring of diamond saw wire based on YOLOv5 and DeepSORT

In order to improve the efficiency and quality of diamond wire saw cutting and meet the demand of real-time monitoring of saw wire wear, a detection algorithm based on improved YOLOv5 was proposed. The algorithm combined coordinate attention mechanism and BiFPN module on the basis of YOLOv5. The detection accuracy, recall rate and average accuracy were increased by 1.7%, 3.7% and 3.2% respectively. Abrasive particles with different wear degrees can be effectively detected. Besides, the DeepSORT multi-target tracking algorithm was connected to set up a virtual detection line, count the number of abrasive particles with different wear degrees, and monitor the wear of diamond saw wire

Flow State at Impeller Inlet: Optimization of Conical Frustum Section of Elbow Inlet Conduit in Large Low-Lift Pump Station

In large low-lift pump stations, the pump assembly comprises an inlet conduit, a pump, and an outlet conduit. A short conical frustum section that connects the elbow section with the impeller inlet directly affects the impeller inflow state, thereby influencing the overall performance. Therefore, investigating the conical frustum section contributes to studying the effect of inflow states on the performances of pump assemblies and similar pumping systems. To improve the pump assembly efficiency, three parameters of the conical frustum section, i.e., the contraction angle, height, and centerline inclination angle, are investigated and optimized via univariate and multivariate analyses. The flow field and external characteristics of the pump assembly are investigated via computational fluid dynamics simulation with a constant head. Furthermore, a comprehensive analysis and discussion of the performance improvement mechanisms are presented. The results indicate that the axial velocity distribution at the impeller inlet conforming to the cascade high-efficiency characteristics will achieve a better pump performance compared with a uniform distribution. The pump efficiency distribution can be predicted and visualized based on the cascade efficiency characteristics and the flow state at the impeller inlet using a machine learning method. In addition, the directions and distribution of the lateral and axial components of the inflow velocities have great impacts on the circulation distribution. A sensible circulation distribution at the guide vane outlet can suppress the entropy production and reduce hydraulic loss of the outlet conduit. In this case, a significant increase in the pump assembly efficiency is obtaine

Simulation and Optimization of a Multistage Interconnected Fluidized Bed Reactor for Coal Chemical Looping Combustion

This work established a three-dimensional model of a chemical looping system with multistage reactors coupled with hydrodynamics and chemical reactions. The thermal characteristics in the chemical looping combustion (CLC) system were simulated using coal as fuel and hematite as an oxygen carrier (OC). Some significant aspects, including gas composition, particle residence time, backmixing rate, wall erosion, carbon capture rate, etc., were investigated in the simulation. Owing to the optimization by adding baffles in the fuel reactor (FR), the gas conversion capacity of the multistage FR was high, where the outlet CO2 concentration was as high as 93.8% and the oxygen demand was as low as 3.8%. Through tracing and analyzing the path of char particles, we found that the residence time of most char particles was too short to be fully gasified. The residual char will be entrained into the air reactor (AR), reducing the CO2 capture rate, which is only 80.3%. In the simulation, the wall erosion on the cyclone could be relieved by increasing the height of the horizontal pipe. In addition, improving the structure of the AR loop seal could control the residual char entrained by OC particles to the AR, and the CO2 capture rate was increased up to 90% in the multistage CLC reactor