Effect of Pulse Frequency and Current Density on Steel Sheet Cleanliness and Hydrogen Permeation

AbstractThe effect of pulse frequency and current density on the effectiveness of biphasic pulse electrocleaning is discussed. Moderate frequency (5Hz) is found to be more effective than lower or higher frequency on steel surface cleanliness. A novel interpretation of cyclic voltammagrams is used to estimate the surface cleanliness. This correlates very well with XPS determination of surface carbon levels. This result is discussed in terms of mechanisms of electrocleaning. Moderate frequency (5–10Hz) is more effective than lower frequency for inhibiting hydrogen permeation. This method can prevent hydrogen brittleness on the electrocleaning high-strength steel

Critical size of ego communication networks

With the help of information and communication technologies, studies on the overall social networks have been extensively reported recently. However, investigations on the directed Ego Communication Networks (ECNs) remain insufficient, where an ECN stands for a sub network composed of a centralized individual and his/her direct contacts. In this paper, the directed ECNs are built on the Call Detail Records (CDRs), which cover more than 7 million people of a provincial capital city in China for half a year. Results show that there is a critical size for ECN at about 150, above which the average emotional closeness between ego and alters drops, the balanced relationship between ego and network collapses, and the proportion of strong ties decreases. This paper not only demonstrate the significance of ECN size in affecting its properties, but also shows accordance with the "Dunbar's Number". These results can be viewed as a cross-culture supportive evidence to the well-known Social Brain Hypothesis (SBH).Comment: 6 pages, 4 figures, 1 tabl

A broken "α\alpha-intensity" relation caused by the evolving photosphere emission and the nature of the extraordinarily bright GRB~230307A

GRB~230307A is one of the brightest gamma-ray bursts detected so far. With the excellent observation of GRB~230307A by Fermi-GBM, we can reveal the details of the prompt emission evolution. As found in high-time-resolution spectral analysis, the early low-energy spectral indices ($\alpha$) of this burst exceed the limit of synchrotron radiation ($\alpha=-2/3$), and gradually decreases with the energy flux ($F$). A tight $E_{\rm p}\propto F^{0.54}$ correlation anyhow holds within the whole duration of the burst, where $E_{\rm p}$ is the spectral peak energy. Such evolution pattern of $\alpha$ and $E_{\rm p}$ with intensity is called ``double tracking". For the $\alpha-F$ relation, we find a log Bayes factor $\sim$ 210 in favor of a smoothly broken power-law function over a linear function in log-linear space. We call this particular $\alpha-F$ relation as broken ``$\alpha$-intensity", and interpret it as the evolution of the ratio of thermal and non-thermal components, which is also the evolution of the photosphere. We also show that GRB 230307A with a duration of $\sim 35~\rm s$, if indeed at a redshift of $z=0.065$, is likely a neutron star merger event (i.e., it is intrinsically ``short"). Intriguingly, different from GRB 060614 and GRB 211211A, this long event is not composed of a hard spike followed by a soft tail, suggesting that the properties of the prompt emission light curves are not a good tracer of the astrophysical origins of the bursts. The other possibility of $z=3.87$ would point toward very peculiar nature of both GRB 230307A and its late time thermal-like emission.Comment: 14 pages, 6 figures, 1 table. We have excluded the GBM instrument pile-up time interval in the data analysis and also discussed the nature of this even

Experimentally realized mechanochemistry distinct from force-accelerated scission of loaded bonds

Stretching polymer chains accelerates dissociation of a variety of internal covalent bonds, to an extent that correlates well with the force experienced by the scissile bond. Recent theory has also predicted scenarios in which applied force accelerates dissociation of unloaded bonds and kinetically strengthens strained bonds. We report here unambiguous experimental validation of this hypothesis: Detailed kinetic measurements demonstrate that stretching phosphotriesters accelerates dissociation of the unloaded phosphorus-oxygen bond orthogonal to the pulling axis, whereas stretching organosiloxanes inhibits dissociation of the aligned loaded silicon-oxygen bonds. Qualitatively, the outcome is determined by phosphoester elongation and siloxane contraction along the pulling axis in the respective rate-determining transition states. Quantitatively, the results agree with a simple mechanochemical kinetics model

Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol

Abstract5-Aminolevulinic acid synthase-1 (ALAS1) and heme oxygenase-1 (HO-1) are the rate-controlling enzymes for heme biosynthesis and degradation, respectively. Expression of these two genes showed tissue-specific expression pattern at both mRNA and protein levels in selected non-treated rat tissues. In the livers of rats receiving oral ethanol for 10 weeks, ALAS1 mRNA levels were increased by 65%, and the precursor and mature ALAS1 protein levels were increased by 1.8- and 2.3-fold, respectively, while no changes were observed in HO-1 mRNA and protein levels, compared with pair-fed controls. These results provide novel insights into the effects of chronic ethanol consumption on hepatic heme biosynthesis and porphyrias

Zinc Mesoporphyrin Induces Rapid Proteasomal Degradation of Hepatitis C Nonstructural 5A Protein in Human Hepatoma Cells

The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV), plays a critical role in HCV replication and is an attractive target for the therapy of HCV infection. So far, little is known about the post-translational regulation of NS5A protein and its precise role in HCV RNA replication. Our objectives were to elucidate the down-regulation of NS5A protein and HCV RNA replication by zinc mesoporphyrin (ZnMP), and the mechanism by which this process occurs

MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins

Hepatitis C virus (HCV) directly induces oxidative stress and liver injury. Bach1, a zipper (bZip) mammalian transcriptional repressor, negatively regulates heme oxygenase 1 (HMOX1), a key cytoprotective enzyme that has anti-oxidant and anti-inflammatory activities. microRNAs are small non-coding RNAs (~22 nt) that are important regulators of gene expression. Whether and how microRNAs regulate Bach1 or HCV are largely unknown. The aims of this study were to determine whether miR-196 regulates Bach1, HMOX1, and/or HCV gene expression. HCV replicon cell lines (Con1 and 9-13) of the Con1 isolate and J6/JFH1-based HCV cell culture system were used in this study. The effects of miR-196 mimic on Bach1, HMOX1 and HCV RNA and protein levels were measured by qRT-PCR and Western blots, respectively. The Dual Glo™ Luciferase Assay System was used to determine reporter activities. miR-196 mimic significantly down-regulated Bach1 and up-regulated HMOX1 gene expression, and inhibited HCV expression. Dual luciferase reporter assays demonstrated that transfection of miR-196 mimic resulted in a significant decrease in Bach1 3′-UTR-dependent luciferase activity but not in mutant Bach1 3′-UTR-dependent luciferase activity. Moreover, there was no detectable effect of mutant miR-196 on Bach1 3′-UTR-dependent luciferase activity

Activated IL-23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients

<p>Abstract</p> <p>Background</p> <p>Foxp3 protein plays a critical role in mediating the inflammatory response and can inhibit the proinflammatory IL-23/IL-17 pathway. However, the molecular interplay of Foxp3 and the IL-23/IL-17 pathway in patients with chronic hepatitis B (CHB) remains unclear. To this end, we analyzed the expression patterns of Foxp3- and IL-23/IL-17 pathway-related proinflammatory cytokines in 39 patients with acute-on-chronic liver failure, 71 patients with CHB and 32 healthy controls.</p> <p>Results</p> <p>Foxp3 expression was found to be elevated in and mainly expressed by the CD4⁺T cell sub-population of peripheral blood mononuclear cells and liver tissues of patients with hepatitis B. The intrahepatic expression of Foxp3 strongly correlated with the copies of HBV DNA and the concentration of surface antigen, HBsAg. IL-23/IL-17 pathway-related proinflammatory cytokines were also found to be significantly increased in patients' liver tissues, as compared to healthy controls. Moreover, Foxp3 expression was strikingly correlated with the production of these cytokines in liver tissues of CHB patients.</p> <p>Conclusions</p> <p>The closely-correlated increase of Foxp3 and IL-23/IL-17 pathway activity in HBV-infected livers suggests that the proinflammatory IL-23/IL-17 pathway had not been effectively suppressed by the host immune machinery, such as Treg (Foxp3) cells. Constitutive activation of the IL-23/17 pathway, thus, may support the chronic hepatitis B state.</p

Preparing a novel gradient porous metal fiber sintered felt with better manufacturability for hydrogen production via methanol steam reforming

Abstract(#br)The porous copper fiber sintered felts with gradient porosity structure (gradient PCFSFs) as catalyst supports is beneficial for heat and mass transfer for methanol steam reforming (MSR). However, the previously developed gradient PCFSF based on the velocity distribution introduces curved interface between different porosity portions, making the mold pressing method for its preparation more sensitive to tiny process changes. To improve its manufacturability, a novel gradient PCFSF with planar interface (PCFSF-SLR) is proposed in this paper by fabrication with multi-step mold pressing and solid phase sintering method using cutting copper fibers. Furthermore, MSR experiments under different gas hourly space velocities and reaction temperatures are conducted to verify the characteristics of PCFSF-SLR loaded with Cu/Zn/Al/Zr catalyst. The results have shown that the reaction characteristics of the PCFSF-SLR were similar to those with curved interfaces, and PCFSF-SLRs with a middle portion porosity of 0.9 have better hydrogen production performance and lower carbon monoxide concentration. More importantly, the results indicated that the methanol conversion and hydrogen flow rate of the gradient PCFSF with planar interface and porosity of 0.7-0.9-0.8 were close or even almost the same with that of the best gradient PCFSFs with curved interface and porosities of 0.7-0.9-0.8 and 0.8-0.9-0.7. Therefore, the proposed PCFSF-SLR provides a superior alternative to gradient PCFSFs with better manufacturability