3,055 research outputs found
U.S. congressional district cancer death rates
BACKGROUND: Geographic patterns of cancer death rates in the U.S. have customarily been presented by county or aggregated into state economic or health service areas. Herein, we present the geographic patterns of cancer death rates in the U.S. by congressional district. Many congressional districts do not follow state or county boundaries. However, counties are the smallest geographical units for which death rates are available. Thus, a method based on the hierarchical relationship of census geographic units was developed to estimate age-adjusted death rates for congressional districts using data obtained at county level. These rates may be useful in communicating to legislators and policy makers about the cancer burden and potential impact of cancer control in their jurisdictions. RESULTS: Mortality data were obtained from the National Center for Health Statistics (NCHS) for 1990â2001 for 50 states, the District of Columbia, and all counties. We computed annual average age-adjusted death rates for all cancer sites combined, the four major cancers (lung and bronchus, prostate, female breast, and colorectal cancer) and cervical cancer. Cancer death rates varied widely across congressional districts for all cancer sites combined, for the four major cancers, and for cervical cancer. When examined at the national level, broad patterns of mortality by sex, race and region were generally similar with those previously observed based on county and state economic area. CONCLUSION: We developed a method to generate cancer death rates by congressional district using county-level mortality data. Characterizing the cancer burden by congressional district may be useful in promoting cancer control and prevention programs, and persuading legislators to enact new cancer control programs and/or strengthening existing ones. The method can be applied to state legislative districts and other analyses that involve data aggregation from different geographic units
Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer
Background
Selective cyclooxygenase inhibitors may retard the progression of cancer, but they
have enhanced thrombotic potential. We report on cardiovascular adverse events in
patients receiving rofecoxib to reduce rates of recurrence of colorectal cancer.
Methods
All serious adverse events that were cardiovascular thrombotic events were reviewed
in 2434 patients with stage II or III colorectal cancer participating in a randomized,
placebo-controlled trial of rofecoxib, 25 mg daily, started after potentially curative
tumor resection and chemotherapy or radiotherapy as indicated. The trial was terminated
prematurely owing to worldwide withdrawal of rofecoxib. To examine possible
persistent risks, we examined cardiovascular thrombotic events reported up to 24
months after the trial was closed.
Results
The median duration of active treatment was 7.4 months. The 1167 patients receiving
rofecoxib and the 1160 patients receiving placebo were well matched, with a median
follow-up period of 33.0 months (interquartile range, 27.6 to 40.1) and 33.4 months
(27.7 to 40.4), respectively. Of the 23 confirmed cardiovascular thrombotic events,
16 occurred in the rofecoxib group during or within 14 days after the treatment
period, with an estimated relative risk of 2.66 (from the Cox proportional-hazards
model; 95% confidence interval [CI], 1.03 to 6.86; P = 0.04). Analysis of the Antiplatelet
Trialistsâ Collaboration end point (the combined incidence of death from
cardiovascular, hemorrhagic, and unknown causes; of nonfatal myocardial infarction;
and of nonfatal ischemic and hemorrhagic stroke) gave an unadjusted relative
risk of 1.60 (95% CI, 0.57 to 4.51; P = 0.37). Fourteen more cardiovascular thrombotic
events, six in the rofecoxib group, were reported within the 2 years after trial
closure, with an overall unadjusted relative risk of 1.50 (95% CI, 0.76 to 2.94;
P = 0.24). Four patients in the rofecoxib group and two in the placebo group died
from thrombotic causes during or within 14 days after the treatment period, and
during the follow-up period, one patient in the rofecoxib group and five patients in
the placebo group died from cardiovascular causes.
Conclusions
Rofecoxib therapy was associated with an increased frequency of adverse cardiovascular
events among patients with a median study treatment of 7.4 monthsâ duration.
(Current Controlled Trials number, ISRCTN98278138.
Spallation Neutron Production by 0.8, 1.2 and 1.6 GeV Protons on various Targets
Spallation neutron production in proton induced reactions on Al, Fe, Zr, W,
Pb and Th targets at 1.2 GeV and on Fe and Pb at 0.8, and 1.6 GeV measured at
the SATURNE accelerator in Saclay is reported. The experimental
double-differential cross-sections are compared with calculations performed
with different intra-nuclear cascade models implemented in high energy
transport codes. The broad angular coverage also allowed the determination of
average neutron multiplicities above 2 MeV. Deficiencies in some of the models
commonly used for applications are pointed out.Comment: 20 pages, 32 figures, revised version, accepted fpr publication in
Phys. Rev.
Detecting the (Quasi-)Two-Body Decays of Leptons in Short-Baseline Neutrino Oscillation Experiments
Novel detector schemes are proposed for the short-baseline neutrino
experiments of next generation, aimed at exploring the large-
domain of \omutau oscillations in the appearance mode. These schemes emphasize
good spectrometry for charged particles and for electromagnetic showers and
efficient reconstruction of \ypi_gg decays. The basic elements are a sequence
of relatively thin emulsion targets, immersed in magnetic field and
interspersed with electronic trackers, and a fine-grained electromagnetic
calorimeter built of lead glass. These elements act as an integral whole in
reconstructing the electromagnetic showers. This conceptual scheme shows good
performance in identifying the (quasi-)two-body decays by their
characteristic kinematics and in selecting the electronic decays of the .Comment: 34 pages, 8 figure
Experimental limits on massive neutrinos from e(+)e(-) annihilations at 29 GeV
This is the publisher's version, also available electronically from http://journals.aps.org/prd/abstract/10.1103/PhysRevD.37.577.A search was made in 29-GeV e(+)e(-) annihilations for massive neutrinos decaying to e(±)X(â)(Îœ) where X is a muon or meson. A 300-pb(-1) data sample yielded just one candidate event with a mass m(e)X>1.8 GeV. Significant limits are found for new neutrinos with masses from 1.8 to 6.7 GeV and with mixing parameters in the range 3Ă10(-6)<âUâ(2)<1. .A
Zeno dynamics yields ordinary constraints
The dynamics of a quantum system undergoing frequent measurements (quantum
Zeno effect) is investigated. Using asymptotic analysis, the system is found to
evolve unitarily in a proper subspace of the total Hilbert space. For spatial
projections, the generator of the "Zeno dynamics" is the Hamiltonian with
Dirichlet boundary conditions.Comment: 6 page
Quantum criticalities in a two-leg antiferromagnetic S=1/2 ladder induced by a staggered magnetic field
We study a two-leg antiferromagnetic spin-1/2 ladder in the presence of a
staggered magnetic field. We consider two parameter regimes: strong (weak)
coupling along the legs and weak (strong) coupling along the rungs. In both
cases, the staggered field drives the Haldane spin-liquid phase of the ladder
towards a Gaussian quantum criticality. In a generalized spin ladder with a
non-Haldane, spontaneously dimerized phase, the staggered magnetic field
induces an Ising quantum critical regime. In the vicinity of the critical
lines, we derive low-energy effective field theories and use these descriptions
to determine the dynamical response functions, the staggered spin
susceptibility and the string order parameter.Comment: 29 pages of revtex, 10 figure
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