Die Euromed-MemoriaCarte

L’Euromed-MemoriaCarte, un projet initié dans le cadre de la Fondation Espace des savoirs Europe-Méditerranée (Stiftung Wissensraum Europa-Mittelmeer e.V., WEM), est une carte virtuelle des lieux de mémoire « euro-méditerranéens», tant en Méditerranée au sens strict que dans ses extensions en Europe et en Afrique subsaharienne. L’objectif de la carte, correspondant aux objectifs de la Fondation WEM, est de contribuer au développement d’une conscience « euro-méditerranéenne» par l’échange et l’intégration des savoirs dans un espace partagé euro-méditerranéen. En ce qui concerne particulièrement l’élaboration de la carte, il s’agit de contribuer à la simplification et à la lisibilité de la masse et de la complexité des informations en faisant appel à un système de codage et de symboles qui se réfèrent à des lieux de mémoire. À travers ces lieux, chargés d’une superposition des savoirs des cultures des deux rives de la Méditerranée, la carte ne visualise pas seulement un héritage partagé mais aussi les enchevêtrements et le dynamisme culturels de l’espace euro-méditerranéen. Parce que les lieux sont vus à la fois de façon géographique et topographique, se pose alors la question de savoir si la carte est vraiment partie prenante du « tournant topographique» ou plutôt d’un tournant « post-topographique» qui prend en compte à nouveau les faits géographiques et historiques. Ce thème, ainsi que les concepts d’espace, de lieu et de mémoire sont discutés à la fin de la contribution.The Euromed-MemoriaCarte, a project created in the framework of the Euro-Mediterranean Knowledge Space Foundation (Stiftung Wissensraum Europa-Mittelmeer e.V., WEM) is a virtual map of “Euro-Mediterranean” places of remembrance both in the Mediterranean region in the strictest sense and in its extensions in Europe and in Sub-Saharan Africa. The objective of the map and indeed the WEM Foundation’s objectives are to contribute to the development of an “Euro-Mediterranean” consciousness through the exchange and integration of knowledge in a shared Euro-Mediterranean space. More specifically, the development of the map was intended to contribute to the simplification and greater legibility of the mass of complex information by using a coding system and symbols which refer to places of remembrance. These places are loaded with overlapping layers of knowledge of the cultures on both sides of the Mediterranean and through that knowledge the map displays both shared heritage and also the cultural dynamism of the Euro-Mediterranean area. These places are shown both geographically and topographically and therefore we may ask whether the map is really part of a “topographical turn” or rather “post-topographical turn” which once more geographical and historical facts takes into account. This theme is discussed at the end of the paper along with the concepts of space, place and remembrance

Introduction

La Méditerranée sépare l’Europe de l’Afrique du Nord et du Proche-Orient mais dans le même temps établit un espace d’échanges particulier. La spécificité de cet espace partagé, lié par une histoire mêlée, constitue un défi constant pour les circulations, voire les migrations circulatoires de part en part de la Méditerranée. Aujourd’hui, il est clairement établi que la circulation des hommes, des idées, des savoirs, des corpus scientifiques et des formes artistiques et esthétiques autour de l..

Deutsche Hochschulen im Dialog mit der arabischen Welt

Dieses Buch soll eine Öffentlichkeit ansprechen, die wissenschaftlich, kulturell und politisch an einem Dialog mit islamischen Ländern interessiert ist. Sein Ziel ist es, diese Öffentlichkeit mit Ergebnissen der Hochschulzusammenarbeit zwischen Deutschland und der islamisch geprägten Arabischen Welt sowie mit entsprechenden Planungen vertraut zu machen. Im Vordergrund stehen dabei kulturwissenschaftlich geprägte Projekte. Der Band stützt sich in größeren Teilen auf eine Tagung, des Wissenschaftlichen Initiativkreises Kultur und Außenpolitik (WIKA) und der Fakultät für Geistes- und Sozialwissenschaften der Universität Karlsruhe (TH), die in Karlsruhe veranstaltet wurde. Der Initiativkreis wurde 2004 vom Institut für Auslandsbeziehungen (ifa) Stuttgart gegründet

MicroRNA Profiling during Cardiomyocyte-Specific Differentiation of Murine Embryonic Stem Cells Based on Two Different miRNA Array Platforms

MicroRNA (miRNA) plays a critical role in a wide variety of biological processes. Profiling miRNA expression during differentiation of embryonic stem cells will help to understand the regulation pathway of differentiation, which in turn may elucidate disease mechanisms. The identified miRNAs could then serve as a new group of possible therapeutic targets. In the present paper, miRNA expression profiles were determined during cardiomyocyte-specific differentiation and maturation of murine embryonic stem (ES) cells. For this purpose a homogeneous cardiomyocyte population was generated from a transgenic murine ES cell line. Two high throughput array platforms (Affymetrix and Febit) were used for miRNA profiling in order to compare the effect of the platforms on miRNA profiling as well as to increase the validity of target miRNA identification. Four time points (i.e. day 0, day 12, day 19 and day 26) were chosen for the miRNA profiling study, which corresponded to different stages during cardiomyocyte-specific differentiation and maturation. Fifty platform and pre-processing method-independent miRNAs were identified as being regulated during the differentiation and maturation processes. The identification of these miRNAs is an important step for characterizing and understanding the events involved in cardiomyocyte-specific differentiation of ES cells and may also highlight candidate target molecules for therapeutic purposes

Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma

Background: MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC. Methodology/Principal Findings: 62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P<0.001); there was no difference between serum miR-21 in patients with CHC and CHC-associated HCC. Serum miR-21 levels correlated with histological activity index (HAI) in the liver (r = −0.494, P = 0.00002), alanine aminotransferase (ALT) (r = −0.309, P = 0.007), aspartate aminotransferase (r = −0.495, P = 0.000007), bilirubin (r = −0.362, P = 0.002), international normalized ratio (r = −0.338, P = 0.034) and γ-glutamyltransferase (r = −0.244, P = 0.034). Multivariate analysis revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21 discriminated between minimal and mild-severe necroinflammation (AUC = 0.758) with a sensitivity of 53.3% and a specificity of 95.2%. Conclusions/Significance: The serum miR-21 level is a marker for necroinflammatory activity, but does not differ between patients with HCV and HCV-induced HCC

Türkisch-deutsche Bildungszusammenarbeit : Zur Planung einer deutschsprachigen Universität in der Türkei

Donated by Klaus Kreise

Türken als "Fremde" : Die Ordnung des Diskurses als Faktor internationaler Verständigung. Beispiel Frühe Neuzei

Donated by Klaus Kreise

Die Notebook-Universität Karlsruhe (TH) NUKATH

Neue Wege in der Lehre und Forschung an deutschen Hochschulen: Die Universität Karlsruhe (TH) entwickelte, erprobte und evaluierte Wege und Instrumente zur Verbesserung der Qualität mobilen und multimediagestützten Lebens, Lehrens und Lernens. An dem 18-monatigen Projekt "Notebook-Universität Karlsruhe (TH) NUKATH" waren Institute unterschiedlicher Fakultäten interdisziplinär beteiligt. Der Band enthält Einblicke in die einzelnen Projekte, die sich der Anwendungs-, Dienste- und Infrastrukturebene einer zukunftsgerichteten Universität widmen