Thermal desorption of ammonia from crystalline forsterite surfaces

The thermal desorption of ammonia (NH$_3$) from single crystal forsterite (010) has been investigated using temperature-programmed desorption. The effect of defects on the desorption process has been probed by the use of a rough cut forsterite surface prepared from the cleaved forsterite sample. Several approaches have been used to extract the desorption energy and pre-exponential factor describing the desorption kinetics. In the sub-monolayer coverage regime, the NH$_3$ desorption shows a broad distribution of desorption energies, indicating the presence of different adsorption sites, which results in an apparent coverage-dependent desorption energy. This distribution is sensitive to the surface roughness with the cut forsterite surface displaying a significantly broader distribution of desorption energies compared to the cleaved forsterite surface. The cut forsterite surface exhibits sites with desorption energies up to 62.5 kJ mol$^{-1}$ in comparison to a desorption energy of up to 58.0 kJ mol$^{-1}$ for the cleaved surface. Multilayer desorption is independent of the nature of the forsterite surface used, with a desorption energy of ($25.8\pm0.9$) kJ mol$^{-1}$. On astrophysically relevant heating time-scales, the presence of a coverage dependent desorption energy distribution results in a lengthening of the NH$_3$ desorption time-scale by $5.9\times 10^4$ yr compared to that expected for a single desorption energy. In addition, the presence of a larger number of high-energy adsorption sites on the rougher cut forsterite surface leads to a further lengthening of ca. 7000 yr.Comment: 12 Pages, 9 Figures. Accepted for publication in MNRA

A study to trial the use of inertial non-optical motion capture for ergonomic analysis of manufacturing work

It is going to be increasingly important for manufacturing system designers to incorporate human activity data and ergonomic analysis with other performance data in digital design modelling and system monitoring. However, traditional methods of capturing human activity data are not sufficiently accurate to meet the needs of digitised data analysis; qualitative data are subject to bias and imprecision, and optically derived data are hindered by occlusions caused by structures or other people in a working environment. Therefore, to meet contemporary needs for more accurate and objective data, inertial non-optical methods of measurement appear to offer a solution. This article describes a case study conducted within the aerospace manufacturing industry, where data on the human activities involved in aircraft wing system installations was first collected via traditional ethnographic methods and found to have limited accuracy and suitability for digital modelling, but similar human activity data subsequently collected using an automatic non-optical motion capture system in a more controlled environment showed better suitability. Results demonstrate the potential benefits of applying not only the inertial non-optical method in future digital modelling and performance monitoring but also the value of continuing to include qualitative analysis for richer interpretation of important explanatory factors

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target

It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes. In breast cancer cells and tumors, SK1 was shown to interact with various pathways involved in cell survival and chemoresistance, such as nuclear factor-kappa B (NFκB), Notch, Ras/MAPK, PKC, and PI3K. SK1 is upregulated by estrogen signaling, which, in turn, confers cancer cells with resistance to tamoxifen. Sphingosine-1-phosphate (S1P) produced by SK1 has been linked to tumor invasion and metastasis. Both SK1 and S1P are closely linked to inflammation and adipokine signaling in breast cancer. In human tumors, high SK1 expression has been linked with poorer survival and prognosis. SK1 is upregulated in triple negative tumors and basal-like subtypes. It is often associated with high phosphorylation levels of ERK1/2, SFK, LYN, AKT, and NFκB. Higher tumor SK1 mRNA levels were correlated with poor response to chemotherapy. This review summarizes the up-to-date evidence and discusses the therapeutic potential for the SK1 inhibition in breast cancer, with emphasis on the mechanisms of chemoresistance and combination with other therapies such as gefitinib or docetaxel. We have outlined four key areas for future development, including tumor microenvironment, combination therapies, and nanomedicine. We conclude that SK1 may have a potential as a target for precision medicine, its high expression being a negative prognostic marker in ER-negative breast cancer, as well as a target for chemosensitization therapy

Formation and Stability of Cellular Carbon Foam Structures:An {\em Ab Initio} Study

We use ab initio density functional calculations to study the formation and structural as well as thermal stability of cellular foam-like carbon nanostructures. These systems with a mixed $sp^2/sp^3$ bonding character may be viewed as bundles of carbon nanotubes fused to a rigid contiguous 3D honeycomb structure that can be compressed more easily by reducing the symmetry of the honeycombs. The foam may accommodate the same type of defects as graphene, and its surface may be be stabilized by terminating caps. We postulate that the foam may form under non-equilibrium conditions near grain boundaries of a carbon-saturated metal surface

Digitisation of a moving assembly operation using multiple depth imaging sensors

Several manufacturing operations continue to be manual even in today’s highly automated industry because the complexity of such operations makes them heavily reliant on human skills, intellect and experience. This work aims to aid the automation of one such operation, the wheel loading operation on the trim and final moving assembly line in automotive production. It proposes a new method that uses multiple low-cost depth imaging sensors, commonly used in gaming, to acquire and digitise key shopfloor data associated with the operation, such as motion characteristics of the vehicle body on the moving conveyor line and the angular positions of alignment features of the parts to be assembled, in order to inform an intelligent automation solution. Experiments are conducted to test the performance of the proposed method across various assembly conditions, and the results are validated against an industry standard method using laser tracking. Some disadvantages of the method are discussed, and suggestions for improvements are suggested. The proposed method has the potential to be adopted to enable the automation of a wide range of moving assembly operations in multiple sectors of the manufacturing industry

Utilization of the resources of the sea

In a hungry world, we are looking to the sea to provide much of the animal protein needed to feed our ever-increasing population. Fishing has developed in many parts of the Northern Hemisphere to such an extent that further increases in the catch are not possible. In the Southern Hemisphere appreciable increases are still possible but if they are not to be wasted, post-catch utilization must be efficient and effective. Seafoods are highly perishable products, and it is necessary to process them to extend the shelf life. This paper describes traditional methods of preserving fish, such as freezing, curing, smoking, canning and fermenting; it also considers new methods which make more efficient use of resources and reduce wastage. The advantages of producing fish meal and comminuted fish are also discussed. The paper looks at the prospects for future growth in the fishing indus try and stresses the importance of introducing modern handling and processing techniques. The relevance of these future developments to the Australian industry and their implications for future product development are considered

Despite Obama’s actions on gun control, there is little he is able to do to change the status quo.

In the two weeks since President Obama announced his latest tranche of executive orders on guns, many Republicans have accused him of making a dramatic power grab over the legislature. Alex Bolton and Sharece Thrower disagree, writing that there is little guarantee that any of Obama’s instructions will actually be executed, and those that are may be overturned by the courts. They argue that Obama’s actions actually exemplify the constraints faced by presidents who try to make policy without Congress