5,962 research outputs found
Preliminary ultraviolet reflectance of some rocks and minerals from 2000 angstrom to 3000 angstrom
Ultraviolet reflectance measurements of rocks and minerals from 2000 A to 3000
Extremely Anisotropic Scintillations
A small number of quasars exhibit interstellar scintillation on time-scales
less than an hour; their scintillation patterns are all known to be
anisotropic. Here we consider a totally anisotropic model in which the
scintillation pattern is effectively one-dimensional. For the persistent rapid
scintillators J1819+3845 and PKS1257-326 we show that this model offers a good
description of the two-station time-delay measurements and the annual cycle in
the scintillation time-scale. Generalising the model to finite anisotropy
yields a better match to the data but the improvement is not significant and
the two additional parameters which are required to describe this model are not
justified by the existing data. The extreme anisotropy we infer for the
scintillation patterns must be attributed to the scattering medium rather than
a highly elongated source. For J1819+3845 the totally anisotropic model
predicts that the particular radio flux variations seen between mid July and
late August should repeat between late August and mid November, and then again
between mid November and late December as the Earth twice changes its direction
of motion across the scintillation pattern. If this effect can be observed then
the minor-axis velocity component of the screen and the orientation of that
axis can both be precisely determined. In reality the axis ratio is finite,
albeit large, and spatial decorrelation of the flux pattern along the major
axis may be observable via differences in the pairwise fluxes within this
overlap region; in this case we can also constrain both the major-axis velocity
component of the screen and the magnitude of the anisotropy.Comment: 5 pages, 4 figures, MNRAS submitte
Protective Effect of Anti-Phosphatidylserine Antibody in a Guinea Pig Model of Advanced Hemorrhagic Arenavirus Infection
Objective: Host derived markers on virally infected cells or virions may provide targets for the generation of antiviral agents. Recently, we identified phosphatidylserine (PS) as a host marker of virions and virally-infected cells.
Methods and Materials: Under normal physiological conditions, PS is maintained on the inner leaflet of the plasma membrane facing the cytosol. Following viral infection, activation or pre-apoptotic changes cause PS to become externalized. We have previously shown that bavituximab, a chimeric human-mouse antibody that binds PS complexed with β2-glycoprotein I (β2GP1), protected rodents against lethal Pichinde virus and cytomegalovirus infections.
Results: Here, we determined the antiviral activity of a fully human monoclonal antibody, PGN632, that directly binds to PS. Treatment with PGN632 protected 20% of guinea pigs with advanced infections of the hemorrhagic arenavirus, Pichinde, from death. Combining PGN632 with ribavirin improved the antiviral activity of both agents, such that the combination rescued 50% of animals from death.
Conclusion: The major mechanisms of action of PGN632 appear to be opsonization of virus and antibody-dependent cellular cytotoxicity of virally-infected cells. PS-targeting agents may have utility in the treatment of viral diseases
Floppy modes and the free energy: Rigidity and connectivity percolation on Bethe Lattices
We show that negative of the number of floppy modes behaves as a free energy
for both connectivity and rigidity percolation, and we illustrate this result
using Bethe lattices. The rigidity transition on Bethe lattices is found to be
first order at a bond concentration close to that predicted by Maxwell
constraint counting. We calculate the probability of a bond being on the
infinite cluster and also on the overconstrained part of the infinite cluster,
and show how a specific heat can be defined as the second derivative of the
free energy. We demonstrate that the Bethe lattice solution is equivalent to
that of the random bond model, where points are joined randomly (with equal
probability at all length scales) to have a given coordination, and then
subsequently bonds are randomly removed.Comment: RevTeX 11 pages + epsfig embedded figures. Submitted to Phys. Rev.
Charge-Focusing Readout of Time Projection Chambers
Time projection chambers (TPCs) have found a wide range of applications in
particle physics, nuclear physics, and homeland security. For TPCs with
high-resolution readout, the readout electronics often dominate the price of
the final detector. We have developed a novel method which could be used to
build large-scale detectors while limiting the necessary readout area. By
focusing the drift charge with static electric fields, we would allow a small
area of electronics to be sensitive to particle detection for a much larger
detector volume. The resulting cost reduction could be important in areas of
research which demand large-scale detectors, including dark matter searches and
detection of special nuclear material. We present simulations made using the
software package Garfield of a focusing structure to be used with a prototype
TPC with pixel readout. This design should enable significant focusing while
retaining directional sensitivity to incoming particles. We also present first
experimental results and compare them with simulation.Comment: 5 pages, 17 figures, Presented at IEEE Nuclear Science Symposium 201
Decorrelation Stretches (DCS) of Visible Images as a Tool for Sedimentary Provenance Investigations on Earth and Mars
The surface of Mars exhibits vast expanses of mafic sediments and ancient sedimentary rocks that record signals of climate and environment. To decipher the paleoenvironments, the sediment sources and transport histories must be con-strained, but it is not well known how physical fractionation and aqueous alteration affect mafic sediments during glacial, eolian, and fluvial processes. Semi-Autonomous Navigation for Detrital Environments (SAND-E), a NASA Planetary Science and Technology through Analog Research (PSTAR) project, bridges this gap through studies of sediment-grain properties and mineralogy in the glacio-XRD)-derived mineralogies
Stressed backbone and elasticity of random central-force systems
We use a new algorithm to find the stress-carrying backbone of ``generic''
site-diluted triangular lattices of up to 10^6 sites. Generic lattices can be
made by randomly displacing the sites of a regular lattice. The percolation
threshold is Pc=0.6975 +/- 0.0003, the correlation length exponent \nu =1.16
+/- 0.03 and the fractal dimension of the backbone Db=1.78 +/- 0.02. The number
of ``critical bonds'' (if you remove them rigidity is lost) on the backbone
scales as L^{x}, with x=0.85 +/- 0.05. The Young's modulus is also calculated.Comment: 5 pages, 5 figures, uses epsfi
Gas permeation through a polymer network
We study the diffusion of gas molecules through a two-dimensional network of
polymers with the help of Monte Carlo simulations. The polymers are modeled as
non-interacting random walks on the bonds of a two-dimensional square lattice,
while the gas particles occupy the lattice cells. When a particle attempts to
jump to a nearest-neighbor empty cell, it has to overcome an energy barrier
which is determined by the number of polymer segments on the bond separating
the two cells. We investigate the gas current as a function of the mean
segment density , the polymer length and the probability
for hopping across segments. Whereas decreases monotonically with
for fixed , its behavior for fixed and increasing
depends strongly on . For small, non-zero , appears to increase
slowly with . In contrast, for , it is dominated by the underlying
percolation problem and can be non-monotonic. We provide heuristic arguments to
put these interesting phenomena into context.Comment: Dedicated to Lothar Schaefer on the occasion of his 60th birthday. 11
pages, 3 figure
Sediment Sorting and Rounding in a Basaltic Glacio-Fluvio-Aeolian Environment: hrisjkull Glacier, Iceland
Sediments and sedimentary rocks preserve a rich history of environment and climate. Identifying these signals requires an understanding of the physical and chemical processes that have affected sedimentary deposits [1]. Such processes include sorting and rounding during transport and chemical alteration through weathering and diagenesis. Although these processes have long been studied in quartz-dominated sedimentary systems [2], a lack of studies of basaltic sedimentary systems limits our interpretations of the environment and climate where mafic source rocks dominate, such as on Mars [3,4]. As part of the SAND-E: Semi-Autonomous Navigation for Detrital Environments project [5], which uses robotic operations to examine physical and chemical changes to sediments in basaltic glacio-fluvialaeolian environments, this research studies changes in sorting and rounding of fluvial-aeolian sediments along a glacier-proximal-to-glacier-distal transect in the outwash-plain of the risjkull glacier in SW Iceland (Fig. 1
- …