Displacement Profile of Charge Density Waves and Domain Walls at Critical Depinning

The influence of a strong surface potential on the critical depinning of an elastic system driven in a random medium is considered. If the surface potential prevents depinning completely the elastic system shows a parabolic displacement profile. Its curvature $\mathcal{C}$ exhibits at zero temperature a pronounced rhombic hysteresis curve of width $2f_c$ with the bulk depinning threshold $f_c$. The hysteresis disappears at non-zero temperatures if the driving force is changed adiabatically. If the surface depins by the applied force or thermal creep, $\mathcal{C}$ is reduced with increasing velocity. The results apply, e.g., to driven magnetic domain walls, flux-line lattices and charge-density waves.Comment: 4 pages, 2 figure

Macroscopic Black Holes, Microscopic Black Holes and Noncommutative Membrane

We study the stretched membrane of a black hole as consisting of a perfect fluid. We find that the pressure of this fluid is negative and the specific heat is negative too. A surprising result is that if we are to assume the fluid be composed of some quanta, then the dispersion relation of the fundamental quantum is $E=m^2/k$, with $m$ at the scale of the Planck mass. There are two possible interpretation of this dispersion relation, one is the noncommutative spacetime on the stretched membrane, another is that the fundamental quantum is microscopic black holes.Comment: 10 pages, harvmac; v2: refs. adde

The Hoop Conjecture in Spherically Symmetric Spacetimes

We give general sufficient conditions for the existence of trapped surfaces due to concentration of matter in spherically symmetric initial data sets satisfying the dominant energy condition. These results are novel in that they apply and are meaningful for arbitrary spacelike slices, that is they do not require any auxiliary assumptions such as maximality, time-symmetry, or special extrinsic foliations, and most importantly they can easily be generalized to the nonspherical case once an existence theory for a modified version of the Jang equation is developed. Moreover, our methods also yield positivity and monotonicity properties of the Misner-Sharp energy

Gravity: A New Holographic Perspective

A general paradigm for describing classical (and semiclassical) gravity is presented. This approach brings to the centre-stage a holographic relationship between the bulk and surface terms in a general class of action functionals and provides a deeper insight into several aspects of classical gravity which have no explanation in the conventional approach. After highlighting a series of unresolved issues in the conventional approach to gravity, I show that (i) principle of equivalence, (ii) general covariance and (iii)a reasonable condition on the variation of the action functional, suggest a generic Lagrangian for semiclassical gravity of the form $L=Q_a^{bcd}R^a_{bcd}$ with $\nabla_b Q_a^{bcd}=0$. The expansion of $Q_a^{bcd}$ in terms of the derivatives of the metric tensor determines the structure of the theory uniquely. The zeroth order term gives the Einstein-Hilbert action and the first order correction is given by the Gauss-Bonnet action. Any such Lagrangian can be decomposed into a surface and bulk terms which are related holographically. The equations of motion can be obtained purely from a surface term in the gravity sector. Hence the field equations are invariant under the transformation $T_{ab} \to T_{ab} + \lambda g_{ab}$ and gravity does not respond to the changes in the bulk vacuum energy density. The cosmological constant arises as an integration constant in this approach. The implications are discussed.Comment: Plenary talk at the International Conference on Einstein's Legacy in the New Millennium, December 15 - 22, 2005, Puri, India; to appear in the Proceedings to be published in IJMPD; 16 pages; no figure

Domain Wall Depinning in Random Media by AC Fields

The viscous motion of an interface driven by an ac external field of frequency omega_0 in a random medium is considered here for the first time. The velocity exhibits a smeared depinning transition showing a double hysteresis which is absent in the adiabatic case omega_0 --> 0. Using scaling arguments and an approximate renormalization group calculation we explain the main characteristics of the hysteresis loop. In the low frequency limit these can be expressed in terms of the depinning threshold and the critical exponents of the adiabatic case.Comment: 4 pages, 3 figure

Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver.

We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015

Commercial air transport hazard warning and avoidance system. Volume 3 - Radar performance studies Final report

Technology and system analysis of radar performance for hazard warning and avoidance syste

High Resolution Ionization of Ultracold Neutral Plasmas

Collective effects, such as waves and instabilities, are integral to our understanding of most plasma phenomena. We have been able to study these in ultracold neutral plasmas by shaping the initial density distribution through spatial modulation of the ionizing laser intensity. We describe a relay imaging system for the photoionization beam that allows us to create higher resolution features and its application to extend the observation of ion acoustic waves to shorter wavelengths. We also describe the formation of sculpted density profiles to create fast expansion of plasma into vacuum and streaming plasmas

R-mode Instability of Slowly Rotating Non-isentropic Relativistic Stars

We investigate properties of $r$-mode instability in slowly rotating relativistic polytropes. Inside the star slow rotation and low frequency formalism that was mainly developed by Kojima is employed to study axial oscillations restored by Coriolis force. At the stellar surface, in order to take account of gravitational radiation reaction effect, we use a near-zone boundary condition instead of the usually imposed boundary condition for asymptotically flat spacetime. Due to the boundary condition, complex frequencies whose imaginary part represents secular instability are obtained for discrete $r$-mode oscillations in some polytropic models. It is found that such discrete $r$-mode solutions can be obtained only for some restricted polytropic models. Basic properties of the solutions are similar to those obtained by imposing the boundary condition for asymptotically flat spacetime. Our results suggest that existence of a continuous part of spectrum cannot be avoided even when its frequency becomes complex due to the emission of gravitational radiation.Comment: 10 pages, 4 figures, accepted for publlication in PR

Progress in prevention of mother-to-child transmission of HIV infection in Ukraine: results from a birth cohort study

Background: Ukraine was the epicentre of the HIV epidemic in Eastern Europe, which has the most rapidly accelerating HIV epidemic world-wide today; national HIV prevalence is currently estimated at 1.6%. Our objective was to evaluate the uptake and effectiveness of interventions for prevention of mother-to-child transmission (PMTCT) over an eight year period within operational settings in Ukraine, within the context of an ongoing birth cohort study.Methods: The European Collaborative Study (ECS) is an ongoing birth cohort study in which HIV-infected pregnant women identified before or during pregnancy or at delivery were enrolled and their infants prospectively followed. Three centres in Ukraine started enrolling in 2000, with a further three joining in September 2006.Results: Of the 3356 women enrolled, 21% (689) reported current or past injecting drug use (IDU). Most women were diagnosed antenatally and of those, the proportion diagnosed in the first/second trimester increased from 47% in 2000/01 (83/178) to 73% (776/1060) in 2006/07 (p < 0.001); intrapartum diagnosis was associated with IDU (Adjusted odds ratio 4.38; 95% CI 3.19-6.02). The percentage of women not receiving any antiretroviral prophylaxis declined from 18% (36/205) in 2001 to 7% in 2007 (61/843) p < 0.001). Use of sdNVP alone substantially declined after 2003, with a concomitant increase in zidovudine prophylaxis. Median antenatal zidovudine prophylaxis duration increased from 24 to 72 days between 2000 and 2007. Elective caesarean section (CS) rates were relatively stable over time and 34% overall. Mother-to-child transmission (MTCT) rates decreased from 15.2% in 2001 (95% CI 10.2-21.4) to 7.0% in 2006 (95% CI 2.6-14.6). In adjusted analysis, MTCT risk was reduced by 43% with elective CS versus vaginal delivery and by 75% with zidovudine versus no prophylaxis.Conclusion: There have been substantial improvements in use of PMTCT interventions in Ukraine, including earlier diagnosis of HIV-infected pregnant women and increasing coverage with antiretroviral prophylaxis and the initial MTCT rate has more than halved. Future research should focus on hard-to-reach populations such as IDU and on missed opportunities for further reducing the MTCT rate