5 research outputs found
Mathematical modelling of clostridial acetone-butanol-ethanol fermentation
- Author
- A Harder
- A Poehlein
- A Poehlein
- A Ravagnani
- A Varma
- AF Emery
- AK Srivastava
- AM Junelles
- BH Kim
- BP Tracy
- C Croux
- C Grimmler
- C Wagner
- C Xue
- CB Milne
- CH Park
- CK Chen
- CK Chen
- CL Meyer
- CL Meyer
- CM Cooksley
- D Amador-Noguez
- D Herbert
- D Hönicke
- D Lehmann
- D Segrè
- DA Fell
- DP Wiesenborn
- DT Jones
- E Biegel
- EH Wintermute
- EM Green
- ET Papoutsakis
- F Monot
- F Napoli
- F Raganati
- F Schlögl
- G Wu
- GC Robinson
- GH Schoutens
- GJ Thorn
- GJ Thorn
- H Bahl
- H Bahl
- H Bahl
- H González-Peñas
- H Grupe
- H Janssen
- H Janssen
- H Shinto
- H Shinto
- HA George
- HB Hartman
- HG Wood
- HR Badr
- I Dolejš
- I Thiele
- IC Chou
- IM Brockman
- J Au
- J Ballongue
- J Chiao
- J Kim
- J Lee
- J Nölling
- J Votruba
- JC Gottschal
- JD Orth
- JR Banga
- JW Roos
- JW Veening
- KC Schuster
- KC Schuster
- KG Clarke
- KJ Kauffman
- Klaus Winzer
- KV Alsaker
- KV Alsaker
- KV Alsaker
- L Girbal
- L Huang
- L Yerushalmi
- L Yerushalmi
- L Yu
- LD Mermelstein
- LM Harris
- M Ackermann
- M Ashyraliyev
- M Dobrijevic
- M Durot
- M Ehsaan
- M Gao
- M Gottwald
- M Gottwald
- M Kumar
- M Kumar
- M McAnulty
- M Wietzke
- M Yoo
- MA Al-Hinai
- MC Ho
- MGN Hartmanis
- MHW Hüsemann
- MJ Johnson
- MP Gerstl
- NG Kampen van
- O Fond
- P Dürre
- P Patakova
- P Rogers
- PA Hoskisson
- PW Atkins
- Q Li
- Q Wang
- R Datta
- R Diestel
- R Gheshlaghi
- R Heinrich
- R Heinrich
- R Mayank
- R Shaheen
- R Vichuviwat
- RA Holt
- RC Woolley
- RD Li
- RJ Fischer
- RK Bajpai
- RP Desai
- RP Desai
- RS Senger
- RS Senger
- RW Hutkins
- RW Welch
- S Audoly
- S Dash
- S Dash
- S Haus
- S Keis
- S Klamt
- S Long
- S Peguin
- S Schuster
- S Schuster
- S Schuster
- SA Kuehne
- SB Crown
- SJ Mason
- SY Li
- T Fiedler
- T Lütke-Eversloh
- T Millat
- T Millat
- T Millat
- T Millat
- TF Weiss
- Thomas Millat
- TS Kim
- VV Zverlov
- W Andersch
- W Buckel
- W Ebeling
- X Yang
- Y Wang
- Y Wang
- Y Wang
- Y Zhao
- YS Jang
- Z Li
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Clostridial acetone-butanol-ethanol (ABE) fermentation features a remarkable shift in the cellular metabolic activity from acid formation, acidogenesis, to the production of industrial-relevant solvents, solventogensis. In recent decades, mathematical models have been employed to elucidate the complex interlinked regulation and conditions that determine these two distinct metabolic states and govern the transition between them. In this review, we discuss these models with a focus on the mechanisms controlling intra- and extracellular changes between acidogenesis and solventogenesis. In particular, we critically evaluate underlying model assumptions and predictions in the light of current experimental knowledge. Towards this end, we briefly introduce key ideas and assumptions applied in the discussed modelling approaches, but waive a comprehensive mathematical presentation. We distinguish between structural and dynamical models, which will be discussed in their chronological order to illustrate how new biological information facilitates the ‘evolution’ of mathematical models. Mathematical models and their analysis have significantly contributed to our knowledge of ABE fermentation and the underlying regulatory network which spans all levels of biological organization. However, the ties between the different levels of cellular regulation are not well understood. Furthermore, contradictory experimental and theoretical results challenge our current notion of ABE metabolic network structure. Thus, clostridial ABE fermentation still poses theoretical as well as experimental challenges which are best approached in close collaboration between modellers and experimentalists
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
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- Beattie G
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- Chandramoorthy L
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- Chang A
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- Chang M
- Chappelow I
- Chapple K
- Charnley R
- Chaudhry A
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
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- Publication date
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Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Evaluating the efficacy of three sanitizing agents for extending the shelf life of fresh-cut baby spinach: food safety and quality aspects
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Biochemical Effects of Drugs Acting on the Central Nervous System
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- W Schaumann
- W Schaumann
- W Schaumann
- W Schiure
- W Sharples
- W Singer
- W Taterka-Seiler
- W Thorn
- W Traczyk
- W Wilbrandt
- W Wirth
- WA Himwich
- WA Krivoy
- WC Starbock
- WC Ullrich
- WD Gray
- WD Gray
- WD Gray
- WD Mcelroy
- WD Mcelroy
- WD Wosilait
- WDM Paton
- WE Glover
- WE Stern
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Stone
- WE Wilson
- WG Schafer
- WG Schäfer
- WH Macmillan
- WJ Johnson
- WJ Johnson
- WK Jordan
- WL Magee
- WL Nelson
- WM Govier
- WM Mcisaac
- WN Aldridge
- WN Aldridge
- WN Alridge
- WP Burkard
- WR Drucker
- WR Soroka
- WR Williams
- WT Jenkins
- Y Hatefi
- Y Hatefi
- Y Hatefi
- Y Takahashi
- Y Tsukada
- Z Suzuki
- ZA Raiko
- ZC Bronowizkaya
- ZS Gerschenovitsch
- ZS Gersenovic
- ZS Gershenovich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1965
- Field of study
Animal’s Functional Role in the Landscape
- Author
- A Bakke
- A Bernhart
- A Drodz
- A Fischer
- A Gigon
- A Gigon
- A Gigon
- A Järvinen
- A Kirchhefer
- A Meyer
- A Murie
- A Myrcha
- A Myrcha
- A Nilssen
- A Tatur
- A Tatur
- A Vaarama
- A Vogel
- A Yair
- AA Berryman
- AA Fineran
- AB Carey
- AB Chrisman
- AC Holcroft
- AC Imeson
- AD Delella-Benedict
- AD Slavik
- AE Burger
- AG Tansley
- AI Malizia
- AJ Ash
- AJ Belsky
- AJ Belsky
- AJ Belsky
- AJ Rebertus
- AL Shigo
- AM Schultz
- AN Andersen
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- ARE Sinclair
- AS Watt
- AT Bergerud
- AV Andreev
- B Frenzel
- B Gerken
- B Heinrich
- B Hespeler
- B Hiller
- B Lovegrove
- B Mitchell
- B Osborn
- B Voslamber
- BA Ross
- BB Aston
- BB Lamont
- BD Abaturov
- BE McLaren
- BH Baker
- BJ Graae
- BJ Wilks
- BM Doube
- BM Fitzgerald
- C Auer
- C Auer
- C Auer
- C Carcalliet
- C Crocq
- C Dulamsuren
- C Maser
- C Maser
- C Nellemann
- C Rolland
- C Watts
- C Wüthrich
- C Wüthrich
- CA Burga
- CA Burga
- CA Edwards
- CA Tisdell
- CA White
- CC Delwiche
- CE Thorn
- CGT Morrison
- CH Fry
- CJ Krebs
- CL Jensen
- CL Teipner
- CM French
- CN Challies
- CT Robbins
- CW Fowler
- D Allen
- D Bezzola
- D Blumenberg
- D Burckhart
- D Choquenot
- D Eisfeld
- D Fortin
- D Gomez-Garcia
- D Klimetzek
- D Simberloff
- D Thannheiser
- D Tscherko
- D Wagner
- D-Y Alexandre
- DA Frank
- DA Levin
- DA MacLean
- DA Perry
- DB Botkin
- DB Houston
- DC Andersen
- DC Andersen
- DC Andersen
- DC Andersen
- DF Doak
- DF Lott
- DF Owen
- DF Owen
- DF Owen
- DF Rhoades
- DF Rhoades
- DF Tomback
- DF Tomback
- DF Tomback
- DF Tomback
- DF Tomback
- DF Tomback
- DF Vesey-Fitzgerald
- DF Waterhouse
- DG Fellin
- DH Ashton
- DH Boucher
- DH Cumming
- DHM Cumming
- DI Rasmussen
- DJ Augustine
- DJ Eldridge
- DJ Gibson
- DJ Haberd
- DJ Haberd
- DJ Mattson
- DJ Mattson
- DJ Mattson
- DJ Mattson
- DJ Schimpf
- DL Coppock
- DL Moorhead
- DP Reinhart
- DR Bazeley
- DR Butler
- DR Butler
- DR Butler
- DR Klein
- DR Klein
- DR Klein
- DS Madge
- DV Weseloh
- DW Malloch
- E Campell
- E Christiansen
- E Haukioja
- E Haukioja
- E Haukioja
- E Haukioja
- E Haukioja
- E Haukioja
- E Jonca
- E Löffler
- E Munroe
- E Odum
- E Odum
- E Sutter
- EA Carl
- ED Mould
- EE Berg
- EF Hooven
- EJ Thacker
- ET Thorne
- EV Wehncke
- F Darling
- F Feer
- F Frank
- F Hole
- F Klötzli
- F Kurt
- F Lamparski
- F Messier
- F Reimoser
- F Reimoser
- F Richardson
- F Russow
- F Turcek
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- F-K Holtmeier
- FB Christiansen
- FC Benedict
- FF Reijmers
- FH Schweingruber
- FJ Singer
- FL Sicuro
- FM Mörschel
- FN Robinson
- FS Chapin III
- G Alschner
- G Area
- G Benz
- G Bott
- G Caughley
- G Heth
- G Meister
- G Miehe
- G Miehe
- G Peterken
- G Spatz
- G Trolldenier
- G Wendelberger
- GA Sickle Van
- GB Schaller
- GF Bornemissza
- GF Midgley
- GH Martin
- GO Batzli
- GO Batzli
- GR Evans
- GT Pitchard
- GT Turner
- GTZ
- GV Hilderbrand
- GW Cox
- GW Cox
- GW Cox
- H Andrén
- H Aulitzky
- H Aulitzky
- H Bylund
- H Bylund
- H Drummond
- H Ellenberg
- H Fritz
- H Gruttke
- H Hartmann
- H Henttonen
- H Herbold
- H Ida
- H Korn
- H Kühnlein
- H Leirs
- H Mattes
- H Mielke
- H Müri
- H Müri
- H Nather
- H Remmert
- H Remmert
- H Remmert
- H Remmert
- H Remmert
- H Schmutterer
- H Schütz
- H Walter
- H Walter
- H Walter
- H-U Schütz
- HF Lamprey
- HF Lamprey
- HG Abbot
- HG Reynolds
- HJ Zeevalking
- HK Buechner
- HK Buechner
- HL Hansen
- HM Braun
- HT Dublin
- HT Mun
- HW Polley
- I Bossema
- I Everson
- I Hjorth
- IB Campbell
- IJ Strange
- ISC Parker
- J Blüthgen
- J Castro
- J Dighton
- J Graf
- J Grinell
- J Honkavaara
- J Hoogesteger
- J Jacob
- J Lehtonen
- J Lehtonen
- J Pastor
- J Rudolph
- J Schultz
- J Schultz
- J Tast
- J Thorp
- J Tricart
- J Vitala
- J Welander
- J-C Dionne
- JA Chapman
- JA Estes
- JA Gessaman
- JA Lee
- JA Logan
- JA MacMahon
- JA Nicholson
- JA Sánchez-Zapata
- JA Wallwork
- JB Bryant
- JB Kirkpatrick
- JC Hatton
- JC Schultz
- JD McKendrick
- JE Dewey
- JE Malo
- JG Wiener
- JH Brown
- JJ Craighead
- JK Detling
- JL Pease
- JM Anderson
- JM Constible
- JM Lock
- JM Schmid
- JM Schmid
- JMN Smith
- JO Elliott
- JO Wolf
- JP Bakker
- JP Bryant
- JP Bryant
- JP Bryant
- JP Hayes
- JPEC Darlington
- JS Gashwiler
- JU Jepsen
- JUM Jarvis
- JW Laundre
- JW Maher
- K Campbell
- K Faegri
- K Hall
- K Johannesson-Gross
- K Kielland
- K Krueger
- K Laine
- K Onderscheka
- K Ruohomäki
- K-F Schreiber
- K-F Schreiber
- KC Kendall
- KE Hodges
- KE Lee
- KG McCullagh
- KH Voous
- KJ Dahlstedt
- KJ Hall
- KL Kausrud
- KM Clancy
- KR Ashby
- KS Hadley
- L Beck
- L Ellison
- L Ellison
- L Hawkins
- L Kärenlampi
- L Maddock
- L Oksanen
- L Pennycuick
- L Pijl Van der
- L Tevis
- LA Fiedler
- LA Lobry de Bryn
- LB Keith
- LB Keith
- LC Blakemore
- LC Contreras
- LD Mech
- LD Wing
- LE Rogers
- LE Stipe
- LF Cantor
- LJ Chapman
- LJ Verme
- LM Talbot
- LW Price
- M Andersson
- M Ben-David
- M Grzimek
- M Grzimek
- M Lieberman
- M Llewellyn
- M Petelle
- M Petelle
- M Petrak
- M Schütz
- M Seppäla
- M Sonesson
- MB Davis
- MDL Brooke
- MF Allen
- MF Allen
- MF Allen
- MF Miller
- MF Schneider
- MG Jones
- MG Murray
- MG Turner
- MI Dyer
- MI Litaor
- MJ Coe
- MJ Coe
- ML Leamy
- MM Kotter
- MM Kotter
- MM Kotter
- MR Cortinas
- MR Raupach
- MS Ghilarov
- MS Gould
- MV Price
- MW Shaw
- MW Shaw
- N Bax
- N Dunstone
- N Fan
- N Huntly
- N Malajczuk
- N Owen-Smith
- NA Huston
- National Audubon Society
- NE West
- NM Collins
- NM Wace
- O Graff
- O Hogstad
- O Holzgang
- O Julander
- O Julander
- O Tenow
- O Tenow
- O Tenow
- O Tenow
- O Tenow
- O Tenow
- O Tenow
- OA Reig
- OE Sala
- OJ Reichman
- OR Vignolio
- P Bachmann
- P Blumer
- P Boye
- P Dostál
- P Fabian
- P Feinsinger
- P Ferrar
- P Ferreras
- P Kallio
- P Kallio
- P Kaltenrieder
- P Mikola
- P Mitchell
- P Müller-Schneider
- P Niemelä
- P Nola
- P Nuorteva
- P Ryser
- P Ward
- P Ward
- P Westrich
- P Wormell
- PA Khomentovsky
- PC Johnson
- PD Coley
- PF Hickie
- PJ Jarman
- PJ Soest Van
- PM Kotanen
- PO Reardon
- PO Reardon
- PR Zimmermann
- PY Sweanor
- R Ben-Shahar
- R East
- R Feldmann
- R Fogel
- R Geiger
- R Gerell
- R Harmer
- R Hofmann
- R Hofmann
- R Hofmann
- R Kuoch
- R Lanner
- R Moral Del
- R Mrotzek
- R Peveling
- R Treiber
- R-M Canals
- RA Rasmussen
- RA Werner
- RA Werner
- RAP Pellew
- RB Livingston
- RE Crocker
- RE Farmer
- RE Ingham
- RE Kenward
- RF Costantino
- RG Sheets
- RG Woodmansee
- RH McBee
- RI Alfaro
- RI Yeaton
- RJ Berg
- RJ Verweij
- RJ Whittaker
- RK Herman
- RL Burton
- RL Senft
- RM Chew
- RM Hansen
- RM Hansen
- RM Lanner
- RM Lanner
- RM Laws
- RM Laws
- RM Laws
- RM Laws
- RO Peterson
- RR Hofmann
- RR Mason
- RS Inouye
- RT Bowyer
- RT Hoffmann
- RT Palo
- RTT Forman
- RTT Forman
- RW Dingle
- RW Furness
- RW Reid
- S Begall
- S Bjerke
- S Darley-Hill
- S Eurola
- S Klaus
- S Lange
- S Marchant
- S Mellmann-Brown
- S Myrberget
- S Myrberget
- S Neuvonen
- S Neuvonen
- S Newey
- S Schrader
- S Skoczen
- S Stender
- S Strandgaard
- SB Vander Wall
- SB Vander Wall
- SC Torbit
- SD Albon
- SD Albon
- SE Aldous
- SE Allen
- SE McGregor
- SF Burns
- SF Burns
- SF Chapin III
- SF Fischer
- SF Fischer
- SF MacLean
- SG Nilsson
- SJ McNaughton
- SJ McNaughton
- SJ Milton
- SJ Seybold
- SK Eltringham
- SK Sherrod
- SM Alcorn
- SM Alcorn
- SM Alcorn
- SM Cargill
- SP French
- SRJ Woodell
- SW Brewer
- SW Taylor
- SW Wambugu
- SY Zhang
- T Edland
- T Heinken
- T Kajimoto
- T Klemola
- T Mosimann
- T Palm
- T Santos
- T Tammaru
- T Virtanen
- TA Brandner
- TA Rabotnov
- TA Scheunert
- TA Vaughan
- TH Clutton-Brock
- TH Clutton-Brock
- TI Storer
- TJ Kingston
- TP Sullivan
- TW Swetnam
- U Emanuelsson
- U Hohmann
- U Krüger
- U Schickhoff
- U Schickhoff
- U Tadzhiyev
- UM Weber
- V Ballenberghe Van
- V Ballenberghe Van
- VB Richens
- VR Smith
- VS Summerhayes
- W Baltensweiler
- W Baltensweiler
- W Baltensweiler
- W Bäumler
- W Goszynska
- W Herre
- W Hinz
- W Jezierski
- W Leuthold
- W Leuthold
- W Schröder
- W Swank
- W Tinner
- W Zhong
- WA Laycock
- WC Johnson
- WC Mahaney
- WD Bowman
- WD Boyer
- WE Howard
- WEJ Milton
- WEJ Milton
- WJ Bancroft
- WJ Maher
- WJ Platt
- WJ Ripple
- WJ Ripple
- WM Schaffer
- WM Tomas
- WN Bonner
- WR Howard
- WRJ Dean
- WT McDonough
- Y Cambefort
- Y Joly
- Y Semenov
- Y Tardy
- YB Linhart
- Z Maser
- Z Maser
- Z Naveh
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study