Essais d’introduction de sucro-glycérides dans les aliments d’allaitement pour veaux de boucherie. 1. — Effets du sucro-glycéride de palme, utilisé seul ou en association avec des antibiotiques.

Joussellin Wilfrid, Ladrat J., Craplet Camille, Barre P., Thoret J. P. Essais d’introduction de sucro-glycérides dans les aliments d’allaitement pour veaux de boucherie. I. Effets du sucro-glycéride de palme, utilisé seul ou en association avec des antibiotiques. In: Bulletin de l'Académie Vétérinaire de France tome 117 n°6, 1964. pp. 277-281

Including osteoprotegerin and collagen IV in a score-based blood test for liver fibrosis increases diagnostic accuracy

BACKGROUND: Noninvasive methods for liver fibrosis evaluation in chronic liver diseases have been recently developed, i.e. transient elastography (Fibroscan™) and blood tests (Fibrometer®, Fibrotest®, and Hepascore®). In this study, we aimed to design a new score in chronic hepatitis C (CHC) by selecting blood markers in a large panel and we compared its diagnostic performance with those of other noninvasive methods. METHODS: Sixteen blood tests were performed in 306 untreated CHC patients included in a multicenter prospective study (ANRS HC EP 23 Fibrostar) using METAVIR histological fibrosis stage as reference. The new score was constructed by non linear regression using the most accurate biomarkers. RESULTS: Five markers (alpha-2-macroglobulin, apolipoprotein-A1, AST, collagen IV and osteoprotegerin) were included in the new function called Coopscore©. Using the Obuchowski Index, Coopscore© shows higher diagnostic performances than for Fibrometer®, Fibrotest®, Hepascore® and Fibroscan™ in CHC. Association between Fibroscan™ and Coopscore© might avoid 68% of liver biopsies for the diagnosis of significant fibrosis. CONCLUSION: Coopscore© provides higher accuracy than other noninvasive methods for the diagnosis of liver fibrosis in CHC. The association of Coopscore© with Fibroscan™ increases its predictive value

Intuitive control of rolling sound synthesis

International audienceThis paper presents a rolling sound synthesis model which can be intuitively controlled. To propose this model, different aspects of the rolling phenomenon are explored : physical modeling, perceptual attributes and signal morphology. A source-filter model for rolling sounds synthesis is presented with associated intuitive controls

Timbre from Sound Synthesis and High-level Control Perspectives

International audienceExploring the many surprising facets of timbre through sound manipulations has been a common practice among composers and instrument makers of all times. The digital era radically changed the approach to sounds thanks to the unlimited possibilities offered by computers that made it possible to investigate sounds without physical constraints. In this chapter we describe investigations on timbre based on the analysis by synthesis approach that consists in using digital synthesis algorithms to reproduce sounds and further modify the parameters of the algorithms to investigate their perceptual relevance. In the first part of the chapter timbre is investigated in a musical context. An examination of the sound quality of different wood species for xylophone making is first presented. Then the influence of instrumental control on timbre is described in the case of clarinet and cello performances. In the second part of the chapter, we mainly focus on the identification of sound morphologies, so called invariant sound structures responsible for the evocations induced by environmental sounds by relating basic signal descriptors and timbre descriptors to evocations in the case of car door noises, motor noises, solid objects, and their interactions

Essai de supplémentation d’un aliment d’allaitement pour veaux avec une association d’antibiotiques (Terramycine et Oléandomycine)

Joussellin Wilfrid, Ladrat J., Craplet Camille, Thoret J. P. Essai de supplémentation d’un aliment d’allaitement pour veaux avec une association d’antibiotiques (Terramycine et Oléandomycine). In: Bulletin de l'Académie Vétérinaire de France tome 117 n°5, 1964. pp. 225-228

Study of NH

A series of zeolites dealuminated with ammonium hexafluorosilicafe (AHF) is prepared using NH4-Y as the starting material. The modification of the framework composition is checked by X-ray diffraction, 29Si and 27Al MAS NMR, and infrared spectroscopy. Linear correlation is found between the number of framework Al atoms per unit cell (AlF) and the unit cell parameter. Relationships between the framework Si/Al ratio or AlF and the concentration of AHF are given

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.

International audienceSome hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction and shown to inhibit microtubule assembly. These compounds have been elaborated in order to interact with both the "vinca site" and the "peptide site" of the vinca domain in tubulin. Two out of three hybrids are potent inhibitors of microtubules assembly and they present good cytotoxicity against different cell lines. Molecular modelling studies show that they could bind, within the vinca domain, in similar spatial regions as those of vinca and phomopsin thanks to the flexibility provided by the glycine linker used to elaborate these hybrids

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.

International audienceSome hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction and shown to inhibit microtubule assembly. These compounds have been elaborated in order to interact with both the "vinca site" and the "peptide site" of the vinca domain in tubulin. Two out of three hybrids are potent inhibitors of microtubules assembly and they present good cytotoxicity against different cell lines. Molecular modelling studies show that they could bind, within the vinca domain, in similar spatial regions as those of vinca and phomopsin thanks to the flexibility provided by the glycine linker used to elaborate these hybrids

An Intuitive Synthesizer of Continuous Interaction Sounds: Rubbing, Scratching and Rolling

International audienceIn this paper, we propose a control strategy for synthesized continuous interaction sounds. The framework of our research is based on the \emph{action-object} paradigm that describes the sound as the result of an action on an object and that presumes the existence of sound invariants, i.e. perceptually relevant signal morphologies that carry information about the action's or the object's attributes. Auditory cues are here investigated for the evocations of rubbing, scratching and rolling interactions. A generic sound synthesis model that simulates these interactions is detailed. Then, we propose an intuitive control strategy that enables users to navigate continuously from one interaction to another in an ''action space'', hereby offering the possibility to simulate morphed interactions, for instance between rubbing and rolling