Coming Together: Successful Press, Library, Vendor Content Collaboration: A Case Study

University presses (UP\u27s) are essential to the advancement of our culture and the understanding of our world, and, are just as much at the forefront of publishing innovation as anyone. UP\u27s publish and engage in some of the most essential research across the humanities, sciences and arts, and, also dive in to top-of-mind trending topics. Academic libraries are prized hubs of information, supporting a school\u27s curriculum and the research of its university faculty and students - the foundation of content. In an effort to strengthen its relationship with its host institution library and help promote scholarship, the University Press of Kentucky (UPK) launched an initiative with Ingram to revive its out-of-print library. In addition to providing both physical and e-book editions of these titles globally for the first time since going out of print, UPK also has made all the titles freely available in the library\u27s repository to the worldwide University of Kentucky community. This panel will look at how this successful scholarly-driven project helped resurrect valuable content for students and educators worldwide and fostered a closer relationship between the institution and its university press. Panelists will drill down to the basics about the initiative and discuss program development, lessons learned and recommended best-practices

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant