Transition from glass to graphite in manufacture of composite aircraft structure

The transition from fiberglass reinforced plastic composites to graphite reinforced plastic composites is described. Structural fiberglass design and manufacturing background are summarized. How this experience provides a technology base for moving into graphite composite secondary structure and then to composite primary structure is considered. The technical requirements that must be fulfilled in the transition from glass to graphite composite structure are also included

Identifying characteristics of frailty in female mice using a phenotype assessment tool

Preclinical studies are important in identifying the underlying mechanisms contributing to frailty. Frailty studies have mainly focused on male rodents with little directed at female rodents. Therefore, the purposes of this study were to identify the onset and prevalence of frailty across the life span in female mice, and to determine if frailty predicts mortality. Female C57BL/6 (n = 27) mice starting at 17 months of age were assessed across the life span using a frailty phenotype, which included body weight, walking speed, strength, endurance, and physical activity. The onset of frailty occurred at approximately 17 months (1/27 mice), with the prevalence of frailty increasing thereafter. At 17 months, 11.1% of the mice were pre-frail and by 26 months peaked at 36.9%. The percentage of frail mice progressively increased up to 66.7% at 32 months. Non-frail mice lived to 29 months whereas frail/pre-frail mice lived only to 26 months (p = .04). In closing, using a mouse frailty phenotype, we are able to identify that the prevalence of frailty in female mice increases across the life span and accurately predicts mortality. Together, this frailty phenotype has the potential to yield information about the underlying mechanisms contributing to frailty.T32 AG029796 - NIA NIH HHSPublished versio

Reactive Molecular Dynamics Simulations of Shock Through a Single Crystal of Pentaerythritol Tetranitrate

Large-scale molecular dynamics simulations and the reactive force field ReaxFF were used to study shock-induced initiation in crystalline pentaerythritol tetranitrate (PETN). In the calculations, a PETN single crystal was impacted against a wall, driving a shockwave back through the crystal in the [100] direction. Two impact speeds (4 and 3 km/s) were used to compare strong and moderate shock behavior. The primary difference between the two shock strengths is the time required to exhibit the same qualitative behaviors with the lower impact speed lagging behind the faster impact speed. For both systems, the shock velocity exhibits an initial deceleration due to onset of endothermic reactions followed by acceleration due to the onset of exothermic reactions. At long times, the shock velocity reaches a steady value. After the initial deceleration period, peaks are observed in the profiles of the density and axial stress with the strongly shocked system having sharp peaks while the weakly shocked system developed broad peaks due to the slower shock velocity acceleration. The dominant initiation reactions in both systems lead to the formation of NO_2 with lesser quantities of NO_3 and formaldehyde also produced

Structural ambiguity of the Chinese version of the hospital anxiety and depression scale in patients with coronary heart disease

Background The Hospital Anxiety and Depression Scale (HADS) is a widely used screening tool designed as a case detector for clinically relevant anxiety and depression. Recent studies of the HADS in coronary heart disease (CHD) patients in European countries suggest it comprises three, rather than two, underlying sub-scale dimensions. The factor structure of the Chinese version of the HADS was evaluated in patients with CHD in mainland China. Methods Confirmatory factor analysis (CFA) was conducted on self-report HADS forms from 154 Chinese CHD patients. Results Little difference was observed in model fit between best performing three-factor and two-factor models. Conclusion The current observations are inconsistent with recent studies highlighting a dominant underlying tri-dimensional structure to the HADS in CHD patients. The Chinese version of the HADS may perform differently to European language versions of the instrument in patients with CHD

Multi-GeV Neutrino Emission from Magnetized Gamma Ray Bursts

We investigate the expected neutrino emissivity from nuclear collisions in magnetically dominated collisional models of gamma-ray bursts, motivated by recent observational and theoretical developments. The results indicate that significant multi-GeV neutrino fluxes are expected for model parameter values which are typical of electromagnetically detected bursts. We show that for detecting at least one muon event in Icecube and its Deep Core sub-array, a single burst must be near the high end of the luminosity function and at a redshift $z\lesssim 0.2$. We also calculate the luminosity and distance ranges that can generate $0.01-1$ muon events per GRB in the same detectors, which may be of interest if simultaneously detected electromagnetically, or if measured with future extensions of Icecube or other neutrino detectors with larger effective volume and better sensitivity.Comment: 12 pages, 7 figures, accepted version for Phys.Rev.

Finite element (MARC) solution technologies for viscoplastic analyses

A need for development of realistic constitutive models for structural components operating at high temperatures, accompanied by appropriate solution technologies for stress/life analyses of these components is studied. Viscoplastic models provide a better description of inelastic behavior of materials, but their mathematical structure is very complex. The highly nonlinear and stiff nature of the constitutive equations makes analytical solutions difficult. Therefore, suitable solution, finite element or other numerical, technologies must be developed to make these models adaptable for better and rational designs of components. NASA-Lewis has developed several solution technologies and successfully applied them to the solution of a number of uniaxial and multiaxial problems. Some of these solution technologies are described along with the models and representative results. The solution technologies developed and presented encompass a wide range of models, such as, isotropic, anisotropic, metal matrix composites, and single crystal models

Sex-specific components of frailty in C57BL/6 mice.

Many age-related biochemical, physiological and behavioral changes are known to be sex-specific. However, how sex influences frailty status and mortality risk in frail rodents has yet to be established. The purpose of this study was therefore to characterize sex differences in frail mice across the lifespan. Male (n=29) and female (n=27) mice starting at 17 months of age were assessed using a frailty phenotype adjusted according to sex, which included body weight, walking speed, strength, endurance and physical activity. Regardless of sex, frail mice were phenotypically dysfunctional compared to age-matched non-frail mice, while non-frail females generally possessed a higher body fat percentage and were more physically active than non-frail males (p≤0.05). The prevalence of frailty was greater in female mice at 26 months of age (p=0.05), but if normalized to mean lifespan, no sex differences remained. No differences were detected in the rate of death or mean lifespan between frail male and female mice (p≥0.12). In closing, these data indicate that sexual differences exist in aging C57BL/6 mice and if the frailty criteria are adjusted according to sex, the prevalence of frailty increases across age with frail mice dying early in life, regardless of sex.T32 AG029796 - NIA NIH HHS; T32 AR007612 - NIAMS NIH HHSPublished versio