HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation

O2 deprivation (hypoxia) and cellular proliferation engage opposite cellular pathways, yet often coexist during tumor growth. The ability of cells to grow during hypoxia results in part from crosstalk between hypoxia-inducible factors (HIFs) and the proto-oncogene c-Myc. Acting alone, HIF and c-Myc partially regulate complex adaptations undertaken by tumor cells growing in low O2. However, acting in concert these transcription factors reprogram metabolism, protein synthesis, and cell cycle progression, to “fine tune” adaptive responses to hypoxic environments

Cosmological Constraints on a Dynamical Electron Mass

Motivated by recent astrophysical observations of quasar absorption systems, we formulate a simple theory where the electron to proton mass ratio $\mu =m_{e}/m_{p}$ is allowed to vary in space-time. In such a minimal theory only the electron mass varies, with $\alpha$ and $m_{p}$ kept constant. We find that changes in $\mu$ will be driven by the electronic energy density after the electron mass threshold is crossed. Particle production in this scenario is negligible. The cosmological constraints imposed by recent astronomical observations are very weak, due to the low mass density in electrons. Unlike in similar theories for spacetime variation of the fine structure constant, the observational constraints on variations in $\mu$ imposed by the weak equivalence principle are much more stringent constraints than those from quasar spectra. Any time-variation in the electron-proton mass ratio must be less than one part in $10^{9}$since redshifts $z\approx 1.$This is more than one thousand times smaller than current spectroscopic sensitivities can achieve. Astronomically observable variations in the electron-proton must therefore arise directly from effects induced by varying fine structure 'constant' or by processes associated with internal proton structure. We also place a new upper bound of $2\times 10^{-8}$ on any large-scale spatial variation of $\mu$ that is compatible with the isotropy of the microwave background radiation.Comment: New bounds from weak equivalence principle experiments added, conclusions modifie

Evidence for an evolutionarily conserved interaction between cell wall biosynthesis and flowering in maize and sorghum

BACKGROUND: Factors that affect flowering vary among different plant species, and in the grasses in particular the exact mechanism behind this transition is not fully understood. The brown midrib (bm) mutants of maize (Zea mays L.), which have altered cell wall composition, have different flowering dynamics compared to their wild-type counterparts. This is indicative of a link between cell wall biogenesis and flowering. In order to test whether this relationship also exists in other grasses, the flowering dynamics in sorghum (Sorghum bicolor (L.) Moench) were investigated. Sorghum is evolutionarily closely related to maize, and a set of brown midrib (bmr) mutants similar to the maize bm mutants is available, making sorghum a suitable choice for study in this context. RESULTS: We compared the flowering time (time to half-bloom) of several different bmr sorghum lines and their wild-type counterparts. This revealed that the relationship between cell wall composition and flowering was conserved in sorghum. Specifically, the mutant bmr7 flowered significantly earlier than the corresponding wild-type control, whereas the mutants bmr2, bmr4, bmr6, bmr12, and bmr19 flowered later than their wild-type controls. CONCLUSION: The change in flowering dynamics in several of the brown midrib sorghum lines provides evidence for an evolutionarily conserved mechanism that links cell wall biosynthesis to flowering dynamics. The availability of the sorghum bmr mutants expands the germplasm available to investigate this relationship in further detail

GRACE Measurements of Mass Variability in the Earth System

Monthly gravity field estimates made by the twin Gravity Recovery and Climate Experiment (GRACE) satellites have a geoid height accuracy of 2 to 3 millimeters at a spatial resolution as small as 400 kilometers. The annual cycle in the geoid variations, up to 10 millimeters in some regions, peaked predominantly in the spring and fall seasons. Geoid variations observed over South America that can be largely attributed to surface water and groundwater changes show a clear separation between the large Amazon watershed and the smaller watersheds to the north. Such observations will help hydrologists to connect processes at traditional length scales (tens of kilometers or less) to those at regional and global scales

NMFS / Interagency Working Group Evaluation of CITES Criteria and Guidelines.

EXECUTIVE SUMMARY: At present, the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) criteria used to assess whether a population qualifies for inclusion in the CITES Appendices relate to (A) size of the population, (B) area of distribution of the population, and (C) declines in the size of the population. Numeric guidelines are provided as indicators of a small population (less than 5,000 individuals), a small subpopulation (less than 500 individuals), a restricted area of distribution for a population (less than 10,000 km2), a restricted area of distribution for a subpopula-tion (less than 500 km2), a high rate of decline (a decrease of 50% or more in total within 5 years or two generations whichever is longer or, for a small wild population, a decline of 20% or more in total within ten years or three generations whichever is longer), large fluctuations (population size or area of distribution varies widely, rapidly and frequently, with a variation greater than one order of magnitude), and a short-term fluctuation (one of two years or less). The Working Group discussed several broad issues of relevance to the CITES criteria and guidelines. These included the importance of the historical extent of decline versus the recent rate of decline; the utility and validity of incorporating relative population productivity into decline criteria; the utility of absolute numbers for defining small populations or small areas; the appropriateness of generation times as time frames for examining declines; the importance of the magnitude and frequency of fluctuations as factors affecting risk of extinction; and the overall utility of numeric thresh-olds or guidelines

SYSTEM AND METHOD ENABLING SIMULTANEOUS INVESTIGATION OF SAMPLE WITH TWO BEAMS OF ELECTROMAGNETIC RADATION

Disclosed are System and method for characterizing a System consisting of a fluid Sample on a two sided Stage, utilizing data obtained by applying, from both sides thereof, beams of electromagnetic radiation to a fluid coated Surface in a containing cell Volume. The beams can have the same or different wavelength content and/or polarization State, and can be applied at the same or different magnitude angles-of-incidence, and a third typically unpolarized beam can be applied at a normal angle-of-incidence

Development of high shrinkage Polyethylene Terephthalate (PET) shape memory polymer tendons for concrete crack closure

YesThe shrinkage force exerted by restrained shape memory polymers can potentially be used to close cracks in structural concrete. This paper describes the physical processing and experimental work undertaken to develop high shrinkage die-drawn Polyethylene Terephthalate (PET) shape memory polymer tendons for use within a crack closure system. The extrusion and die-drawing procedure used to manufacture a series of PET tendon samples is described. The results from a set of restrained shrinkage tests, undertaken at differing activation temperatures, are also presented along with the mechanical properties of the most promising samples. The stress developed within the tendons is found to be related to the activation temperature, the cross-sectional area and to the draw rate used during manufacture. Comparisons with commercially-available PET strip samples used in previous research are made, demonstrating an increase in restrained shrinkage stress by a factor of two for manufactured PET filament samples.Thanks must go to the EPSRC for their funding of the Materials for Life (M4L) project (EP/K026631/1) and to Costain Group PLC. for their industrial sponsorship of the project and author