Uncertainties for Pre- and Post-Launch Radiometric Calibration of Imaging Spectrometers for Multi-Sensor Applications

An important aspect to using imaging spectrometer data is the radiometric characterization and calibration of the sensors and validation of their data products and doing so with error budgets with known traceability. The radiometric accuracy of a given sensor is important for demonstrating the expected quality of data from the sensor. Known traceability allows data from multiple sensors to be directly comparable as will become more important in the near future with the expected launches of multiple imaging spectrometers from multiple countries, agencies, and commercial entities. The current work describes the state of pre- and post-launch radiometric absolute and relative uncertainties and their role in harmonising on-orbit data. Examples of prelaunch uncertainties based on the calibration of EnMAP and the calibration planned for the CLARREO Pathfinder Mission are presented highlighting recent work in the area of detector-based approaches using tunable laser sources. Post-launch calibration approaches for Pathfinder, EnMAP, CHIME, and DESIS including traditional vicarious calibration methods and the challenges of working with commercial data are presented. The vicarious calibration discussion relies on the example of the recently-available RadCalNet data to describe typical methods and challenges that will be faced when harmonising data between imaging spectrometers as well as with multispectral sensors

The Theology and Practice of Individual Confession and Absolution and Its Application to Pastoral Care from an Early North American Lutheran Perspective

The two subjects of this study^ namely, pastoral care and Individual confession and absolution, have traditionally been seen as closely connected. Each has also a unique character. In this study both subjects will be focused on from the perspective provided by the historical analysis of their development within the Lutheran context, specifically that of North American Lutheranism in the nineteenth century. Pastoral care has been greatly developed, particularly in the area of pastoral counseling, in the last fifty years. This parallels the increasing development of the behavioral sciences in this century. The causes and consequences of such rapid growth in pastoral care will be analyzed in the present study. This growth has not been free from tensions; on the contrary, in many ways it has brought the ministry, and tile pastor himself, into conflicts and confusion. The solution for this critical situation rests in a correct understanding of the theological principles of pastoral care and of its relationship with basic Christian doctrine. For this reason a solid biblical definition of pastoral care must first be established. It is only on such biblical grounds, and by the guidance of the doctrinal formulations emerging therefrom, that the task of pastoral care and counseling can continue to be accomplished in the faithful use of Word and sacrament (including other Christian resources like confession and absolution, prayer, Chris tian fellowship and pastoral conversation) and in the discriminating application of insists from behavioral sciences. Finally» it is only on this biblical basis and the distinction of law and gospel thus provided that pastoral care will serve to accomplish the church\u27s ultimate purpose to be the servant of God\u27s reconciliation with man

Detection and measurement of paracaspase MALT1 activity.

The paracaspase MALT1 is a Cys-dependent, Arg-specific protease that plays an essential role in the activation and proliferation of lymphocytes during the immune response. Oncogenic activation of MALT1 is associated with the development of specific forms of B-cell lymphomas. Through specific cleavage of its substrates, MALT1 controls various aspects of lymphocyte activation, including the activation of transcriptional pathways, the stabilization of mRNAs, and an increase in cellular adhesion. In lymphocytes, the activity of MALT1 is tightly controlled by its inducible monoubiquitination, which promotes the dimerization of MALT1. Here, we describe both in vitro and in vivo assays that have been developed to assess MALT1 activity

ZNF804A genotype modulates neural activity during working memory for faces

Copyright © 2013 S. Karger AG, Basel.Peer reviewedPublisher PD

Development of interconnected silicon micro-evaporators for the on-detector electronics cooling of the future ITS detector in the ALICE experiment at LHC

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.The design of the future High Energy Physics (HEP) particle detectors for the upgrade of the LHC (Large Hadron Collider) experiments at CERN (European Organization for Nuclear Research) is pushing technological frontiers to the limit trying to reach unprecedented accuracy in particles identification and particle production dynamics in ultra-relativistic hadron collisions. The thermal management of the on-detector electronics and the development of low mass integrated cooling systems have become a crucial task in the design of silicon tracking detectors for HEP applications. In this paper, we present a novel concept of low mass interconnected silicon microchannel devices for the future Inner Tracking System of the ALICE (A Large Ion Collider Experiment) detector at LHC. This innovative design achieves the requirements of the detector while minimizing the total material budget

CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease

Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation

Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death.

The mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex regulating key pathways in cell growth. Hyperactivation of mTORC1 is implicated in numerous cancers, thus making it a potential broad-spectrum chemotherapeutic target. Here, we characterized how mTORC1 responds to cell death induced by various anticancer drugs such rapamycin, etoposide, cisplatin, curcumin, staurosporine and Fas ligand. All treatments induced cleavage in the mTORC1 component, raptor, resulting in decreased raptor-mTOR interaction and subsequent inhibition of the mTORC1-mediated phosphorylation of downstream substrates (S6K and 4E-BP1). The cleavage was primarily mediated by caspase-6 and occurred at two sites. Mutagenesis at one of these sites, conferred resistance to cell death, indicating that raptor cleavage is important in chemotherapeutic apoptosis

Opportunities to Intercalibrate Radiometric Sensors From International Space Station

Highly accurate measurements of Earth's thermal infrared and reflected solar radiation are required for detecting and predicting long-term climate change. We consider the concept of using the International Space Station to test instruments and techniques that would eventually be used on a dedicated mission such as the Climate Absolute Radiance and Refractivity Observatory. In particular, a quantitative investigation is performed to determine whether it is possible to use measurements obtained with a highly accurate reflected solar radiation spectrometer to calibrate similar, less accurate instruments in other low Earth orbits. Estimates of numbers of samples useful for intercalibration are made with the aid of year-long simulations of orbital motion. We conclude that the International Space Station orbit is ideally suited for the purpose of intercalibration