8,083 research outputs found
Adhesion of surfaces via particle adsorption: Exact results for a lattice of fluid columns
We present here exact results for a one-dimensional gas, or fluid, of
hard-sphere particles with attractive boundaries. The particles, which can
exchange with a bulk reservoir, mediate an interaction between the boundaries.
A two-dimensional lattice of such one-dimensional gas `columns' represents a
discrete approximation of a three-dimensional gas of particles between two
surfaces. The effective particle-mediated interaction potential of the
boundaries, or surfaces, is calculated from the grand-canonical partition
function of the one-dimensional gas of particles, which is an extension of the
well-studied Tonks gas. The effective interaction potential exhibits two
minima. The first minimum at boundary contact reflects depletion interactions,
while the second minimum at separations close to the particle diameter results
from a single adsorbed particle that crosslinks the two boundaries. The second
minimum is the global minimum for sufficiently large binding energies of the
particles. Interestingly, the effective adhesion energy corresponding to this
minimum is maximal at intermediate concentrations of the particles.Comment: to appear in Journal of Statistical Mechanics: Theory and Experimen
Variational Thomas-Fermi Theory of a Nonuniform Bose Condensate at Zero Temperature
We derive a description of the spatially inhomogeneous Bose-Einstein
condensate which treats the system locally as a homogeneous system. This
approach, similar to the Thomas-Fermi model for the inhomogeneous many-particle
fermion system, is well-suited to describe the atomic Bose-Einstein condensates
that have recently been obtained experimentally through atomic trapping and
cooling. In this paper, we confine our attention to the zero temperature case,
although the treatment can be generalized to finite temperatures, as we shall
discuss elsewhere.Comment: 24 pages, latex, 6 ps figures, BoxedEPS include
Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.
Mitochondrial complex I, the primary entry point for electrons into the mitochondrial respiratory chain, is both critical for aerobic respiration and a major source of reactive oxygen species. In the heart, chronic dysfunction driving cardiomyopathy is frequently associated with decreased complex I activity, from both genetic and environmental causes. To examine the functional relationship between complex I disruption and cardiac dysfunction we used an established mouse model of mild and chronic complex I inhibition through heart-specific Ndufs4 gene ablation. Heart-specific Ndufs4-null mice had a decrease of ∼ 50% in complex I activity within the heart, and developed severe hypertrophic cardiomyopathy as assessed by magnetic resonance imaging. The decrease in complex I activity, and associated cardiac dysfunction, occurred absent an increase in mitochondrial hydrogen peroxide levels in vivo, accumulation of markers of oxidative damage, induction of apoptosis, or tissue fibrosis. Taken together, these results indicate that diminished complex I activity in the heart alone is sufficient to drive hypertrophic cardiomyopathy independently of alterations in levels of mitochondrial hydrogen peroxide or oxidative damage
Intrinsic response time of graphene photodetectors
Graphene-based photodetectors are promising new devices for high-speed
optoelectronic applications. However, despite recent efforts, it is not clear
what determines the ultimate speed limit of these devices. Here, we present
measurements of the intrinsic response time of metal-graphene-metal
photodetectors with monolayer graphene using an optical correlation technique
with ultrashort laser pulses. We obtain a response time of 2.1 ps that is
mainly given by the short lifetime of the photogenerated carriers. This time
translates into a bandwidth of ~262 GHz. Moreover, we investigate the
dependence of the response time on gate voltage and illumination laser power
Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network
One of the most important and challenging problems in biomedicine and genomics is how to identify the disease genes. In this study, we developed a computational method to identify colorectal cancer-related genes based on (i) the gene expression profiles, and (ii) the shortest path analysis of functional protein association networks. The former has been used to select differentially expressed genes as disease genes for quite a long time, while the latter has been widely used to study the mechanism of diseases. With the existing protein-protein interaction data from STRING (Search Tool for the Retrieval of Interacting Genes), a weighted functional protein association network was constructed. By means of the mRMR (Maximum Relevance Minimum Redundancy) approach, six genes were identified that can distinguish the colorectal tumors and normal adjacent colonic tissues from their gene expression profiles. Meanwhile, according to the shortest path approach, we further found an additional 35 genes, of which some have been reported to be relevant to colorectal cancer and some are very likely to be relevant to it. Interestingly, the genes we identified from both the gene expression profiles and the functional protein association network have more cancer genes than the genes identified from the gene expression profiles alone. Besides, these genes also had greater functional similarity with the reported colorectal cancer genes than the genes identified from the gene expression profiles alone. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying colorectal cancer genes. It has not escaped our notice that the method can be applied to identify the genes of other diseases as well
Neutrino Mass, Sneutrino Dark Matter and Signals of Lepton Flavor Violation in the MRSSM
We study the phenomenology of mixed-sneutrino dark matter in the Minimal
R-Symmetric Supersymmetric Standard Model (MRSSM). Mixed sneutrinos fit
naturally within the MRSSM, as the smallness (or absence) of neutrino Yukawa
couplings singles out sneutrino A-terms as the only ones not automatically
forbidden by R-symmetry. We perform a study of randomly generated sneutrino
mass matrices and find that (i) the measured value of is well
within the range of typical values obtained for the relic abundance of the
lightest sneutrino, (ii) with small lepton-number-violating mass terms
for the right-handed sneutrinos, random
matrices satisfying the constraint have a decent probability of
satisfying direct detection constraints, and much of the remaining parameter
space will be probed by upcoming experiments, (iii) the terms radiatively generate appropriately small Majorana neutrino
masses, with neutrino oscillation data favoring a mostly sterile lightest
sneutrino with a dominantly mu/tau-flavored active component, and (iv) a
sneutrino LSP with a significant mu component can lead to striking signals of
e-mu flavor violation in dilepton invariant-mass distributions at the LHC.Comment: Revised collider analysis in Sec. 5 after fixing error in particle
spectrum, References adde
Magnetic properties of the S=1/2 quasi-one-dimensional antiferromagnet CaCu2O3
We report single crystal growth and magnetic susceptibility and neutron
diffraction studies of the S=1/2 quasi-1D antiferromagnet CaCu2O3. The
structure of this material is similar to that of the prototype two-leg
spin-ladder compound SrCu2O3. However, the Cu-O-Cu bond angle in the ladder
rungs in CaCu2O3 is equal to 123 deg, and therefore the magnetic interaction
along the rungs is expected to be much weaker in this material. At high
temperatures, the magnetic susceptibility of CaCu2O3 can be decomposed into a
contribution from 1D antiferromagnetic chains of finite-size chain segments
together with a weak Curie contribution. The intrachain magnetic exchange
constant, determined from the magnetic susceptibility measurements, is 2000 K.
CaCu2O3 undergoes a Neel transition at T_N=25 K with ordering wavevector of
(0.429(5), 0.5, 0.5). The magnetic structure is incommensurate in the direction
of the frustrated interchain interaction. Weak commensurate (0.5, 0.5, 0.5)
magnetic peaks are also observed below T_N. Application of a magnetic field
induces a metamagnetic transition at which the incommensurability of the
magnetic structure is substantially reduced. The material possesses only
short-range magnetic order above the transition field.Comment: 12 pages, 10 embedded figure
Therapeutic targeting of integrin αvβ6 in breast cancer
BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of ?6 in breast cell lines, the role of ?v?6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, invasion, growth in vivo) was assessed by flow cytometry, MTT, Transwell invasion, proximity ligation assay, and xenografts (n ? 3), respectively. A student's t-test was used for two variables; three-plus variables used one-way analysis of variance with Bonferroni's Multiple Comparison Test. Xenograft growth was analyzed using linear mixed model analysis, followed by Wald testing and survival, analyzed using the Log-Rank test. All statistical tests were two sided.RESULTS: High expression of either the mRNA or protein for the integrin subunit ?6 was associated with very poor survival (HR = 1.60, 95% CI = 1.19 to 2.15, P = .002) and increased metastases to distant sites. Co-expression of ?6 and HER2 was associated with worse prognosis (HR = 1.97, 95% CI = 1.16 to 3.35, P = .01). Monotherapy with 264RAD or trastuzumab slowed growth of MCF-7/HER2-18 and BT-474 xenografts similarly (P < .001), but combining 264RAD with trastuzumab effectively stopped tumor growth, even in trastuzumab-resistant MCF-7/HER2-18 xenografts.CONCLUSIONS: Targeting ?v?6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.<br/
Enhancement of long-range magnetic order by magnetic field in superconducting La2CuO(4+y)
We report a detailed study, using neutron scattering, transport and
magnetization measurements, of the interplay between superconducting (SC) and
spin density wave (SDW) order in La2CuO(4+y). Both kinds of order set in below
the same critical temperature. However, the SDW order grows with applied
magnetic field, whereas SC order is suppressed. Most importantly, the field
dependence of the SDW Bragg peak intensity has a cusp at zero field, as
predicted by a recent theory of competing SDW and SC order. This leads us to
conclude that there is a repulsive coupling between the two order parameters.
The question of whether the two kinds of order coexist or microscopically phase
separate is discussed.Comment: Version accepted for publication in Phys. Rev. B. Improved discussion
in connection with the muSR result
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