8,501 research outputs found

    Does Practice-Based Teacher Preparation Increase Student Achievement? Early Evidence from the Boston Teacher Residency

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    The Boston Teacher Residency is an innovative practice-based preparation program in which candidates work alongside a mentor teacher for a year before becoming a teacher of record in Boston Public Schools. We find that BTR graduates are more racially diverse than other BPS novices, more likely to teach math and science, and more likely to remain teaching in the district through year five. Initially, BTR graduates for whom value-added performance data are available are no more effective at raising student test scores than other novice teachers in English language arts and less effective in math. The effectiveness of BTR graduates in math improves rapidly over time, however, such that by their fourth and fifth years they out-perform veteran teachers. Simulations of the program’s overall impact through retention and effectiveness suggest that it is likely to improve student achievement in the district only modestly over the long run.

    Summer Dormancy and Survival of Tall Fescue in Relation to Endophyte Presence

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    True summer dormancy in temperate perennial grasses is the ability to survive summer stresses by ceasing growth and senescing vegetative tissues independently of water supply, as opposed to summer-active grasses, which respond to rains by continuing growth, but senesce during droughts (Volaire and Norton 2006). Summer dormancy is a common drought-escape mechanism for Mediterranean-origin perennial grasses, but is also being considered as a potentially useful trait in semiarid to humid zones whose climates are not strictly Mediterranean, but where temperate grass survival is threatened by summer heat and water deficits (Malinowski et al. 2005). Moreover, summer dormancy may provide a mechanism for adapting to climate change patterns that exacerbate summer stresses (West et al. 2009). Tall fescue [Lolium arundinaceum (Schreb.) S.J. Darbyshire] populations exhibit a range of summer dormancy potentials from nondormant (summer active) to varying levels of incomplete dormancy, but not complete dormancy (Norton et al. 2006). Summer drought survival of tall fescue is generally aided by symbiosis with a fungal endophyte [Neotyphodium coenophialum (Morgan-Jones & Gams) Glenn, Bacon & Hanlin comb.], and this endophyte is endemic in nearly all native populations of tall fescue (West 1994). Little is known of the influence of the endophyte on the expression of summer dormancy in their grass hosts or of the role of endophytes in host drought survival. We investigated the influence of environment and endophyte presence on expression of summer dormancy and survival in tall fescue in relation to expression of biochemical protectants

    On the Inconsistency of Fayet-Iliopoulos Terms in Supergravity Theories

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    Motivated by recent discussions, we revisit the issue of whether globally supersymmetric theories with non-zero Fayet-Iliopoulos terms may be consistently coupled to supergravity. In particular, we examine claims that a fundamental inconsistency arises due to the conflicting requirements which are imposed on the RR-symmetry properties of the theory by the supergravity framework. We also prove that certain kinds of Fayet-Iliopoulos contributions to the supercurrent supermultiplets of theories with non-zero Fayet-Iliopoulos terms fail to exist. A key feature of our discussion is an explicit comparison between results from the chiral (or ``old minimal'') and linear (or ``new minimal'') formulations of supergravity, and the effects within each of these formalisms that are induced by the presence of non-zero Fayet-Iliopoulos terms.Comment: Comments: 69 pages, LaTeX, 2 figures, 7 tables. Significant new material on conformal-compensator formalisms added, previous results clarified and extended, references adde

    Characterizing Distances of Networks on the Tensor Manifold

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    At the core of understanding dynamical systems is the ability to maintain and control the systems behavior that includes notions of robustness, heterogeneity, or regime-shift detection. Recently, to explore such functional properties, a convenient representation has been to model such dynamical systems as a weighted graph consisting of a finite, but very large number of interacting agents. This said, there exists very limited relevant statistical theory that is able cope with real-life data, i.e., how does perform analysis and/or statistics over a family of networks as opposed to a specific network or network-to-network variation. Here, we are interested in the analysis of network families whereby each network represents a point on an underlying statistical manifold. To do so, we explore the Riemannian structure of the tensor manifold developed by Pennec previously applied to Diffusion Tensor Imaging (DTI) towards the problem of network analysis. In particular, while this note focuses on Pennec definition of geodesics amongst a family of networks, we show how it lays the foundation for future work for developing measures of network robustness for regime-shift detection. We conclude with experiments highlighting the proposed distance on synthetic networks and an application towards biological (stem-cell) systems.Comment: This paper is accepted at 8th International Conference on Complex Networks 201

    Love, rights and solidarity: studying children's participation using Honneth's theory of recognition

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    Recent attempts to theorize children’s participation have drawn on a wide range of ideas, concepts and models from political and social theory. The aim of this article is to explore the specific usefulness of Honneth’s theory of a ‘struggle for recognition’ in thinking about this area of practice. The article identifies what is distinctive about Honneth’s theory of recognition, and how it differs from other theories of recognition. It then considers the relevance of Honneth’s conceptual framework to the social position of children, including those who may be involved in a variety of ‘participatory’ activities. It looks at how useful Honneth’s ideas are in direct engagement with young people’s praxis, drawing on ethnographic research with members of a children and young people’s forum. The article concludes by reflecting on the implications of this theoretical approach and the further questions which it opens up for theories of participation and of adult–child relations more generally

    A Gemini/GMOS Study of Intermediate Luminosity Early-Type Virgo Cluster Galaxies. I. Globular Cluster and Stellar Kinematics

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    We present a kinematic analysis of the globular cluster systems and diffuse stellar light of four intermediate luminosity (sub-LL^{\ast}) early-type galaxies in the Virgo cluster based on Gemini/GMOS data. Our galaxy sample is fainter (23.8<MK<22.7-23.8<M_K<-22.7) than most previous studies, nearly doubling the number of galaxies in this magnitude range that now have GC kinematics. The data for the diffuse light extends to 4Re4R_e, and the data for the globular clusters reaches 8--12Re12R_e. We find that the kinematics in these outer regions are all different despite the fact that these four galaxies have similar photometric properties, and are uniformly classified as "fast rotators" from their stellar kinematics within 1Re1R_e. The globular cluster systems exhibit a wide range of kinematic morphology. The rotation axis and amplitude can change between the inner and outer regions, including a case of counter-rotation. This difference shows the importance of wide-field kinematic studies, and shows that stellar and GC kinematics can change significantly as one moves beyond the inner regions of galaxies. Moreover, the kinematics of the globular cluster systems can differ from that of the stars, suggesting that the formation of the two populations are also distinct.Comment: 24 pages, 21 figures, 9 table, ApJ in pres

    Crystal structure of LIR-2 (ILT4) at 1.8 Å: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18

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    BACKGROUND: Leukocyte Immunoglobulin-like Receptor-1 (LIR-1) and LIR-2 (also known as ILT2 and ILT4 respectively) are highly related cell surface receptors that bind a broad range of class I MHC molecules with low (μM) affinities. Expressed on monocytic cells and macrophages, both molecules transmit inhibitory signals after binding ligands. In addition to binding host class I MHC, the LIR-1 molecule, which is also expressed on lymphoid tissues, binds with a high (nM) affinity to UL18, a class I MHC homolog encoded by Human Cytomegalovirus (HCMV). In comparison, LIR-2 binds UL18 only weakly (μM K(D)). To understand how HCMV preferentially targets the more broadly expressed LIR-1 molecule, we determined the crystal structure of a ligand-binding fragment of LIR-2, and compared this to the existing high-resolution crystal structure of LIR-1. RESULTS: Recombinant LIR-2 (domains 1 and 2) was produced in E. coli and crystallized using streak seeding to optimize the crystal morphology. A data set complete to 1.8 Å was collected at 100 K from a single crystal in the P4(1)2(1)2 spacegroup. The structure was solved by molecular replacement, using a search model based on the LIR-1 structure. CONCLUSIONS: The overall structure of LIR-2 D1D2 resembles both LIR-1, and Killer Inhibitory Receptors, in that the A strand in each domain forms hydrogen bonds to both β sheets, and there is a sharp angle between the two immunoglobulin-like domains. However, differences from LIR-1 are observed in each domain, with two key changes apparent in the ligand-binding domain, D1. The region corresponding to the residue 44–57 helix of LIR-1 adopts a topology distinct from that of both LIR-1 and the KIR structures, involving a shortened 3(10) helix. Secondly, the predicted UL18 binding region of LIR-1 is altered substantially in LIR-2: the 76–84 loop mainchain is displaced 11 Å with respect to LIR-1, and Tyrosine 38 adopts an alternative rotamer conformation. In summary, the structure of LIR-2 has revealed significant differences to LIR-1, including ones that may help to explain the >1000-fold lower affinity of LIR-2 for UL18

    The effectiveness, safety and cost-effectiveness of cytisine versus varenicline for smoking cessation in an Australian population: a study protocol for a randomized controlled non-inferiority trial

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    Smoking cessation medications are effective but often underutilised because of costs and side effects. Cytisine is a plant-based smoking cessation medication with over 50 years of use in Central and Eastern Europe. While cytisine has been found to be well-tolerated and more effective than nicotine replacement therapy, direct comparison with varenicline have not been conducted. This study evaluates the effectiveness, safety and cost-effectiveness of cytisine compared with varenicline.Two arm, parallel group, randomised, non-inferiority trial, with allocation concealment and blinded outcome assessment.Australian population-based study.Adult daily smokers (N=1266) interested in quitting will be recruited through advertisements and Quitline telephone-based cessation support services.Eligible participants will be randomised (1:1 ratio) to receive either cytisine capsules (25-day supply) or varenicline tablets (12-week supply), prescribed in accordance with the manufacturer's recommended dosing regimen. The medication will be mailed to each participant's nominated residential address. All participants will also be offered standard Quitline behavioural support (up to six 10-12 minute sessions).Assessments will be undertaken by telephone at baseline, 4- and 7-months post-randomisation. Participants will also be contacted twice (two and four weeks post-randomisation) to ascertain adverse events, treatment adherence and smoking status. The primary outcome will be self-reported 6-month continuous abstinence from smoking, verified by carbon monoxide at 7-month follow-up. We will also evaluate the relative safety and cost-effectiveness of cytisine compared with varenicline. Secondary outcomes will include self-reported continuous and 7-day point prevalence abstinence and cigarette consumption at each follow-up interview.If cytisine is as effective as varenicline, its lower cost and natural plant-based composition may make it an acceptable and affordable smoking cessation medication that could save millions of lives worldwide

    On the Nature of the X-ray Emission from the Ultraluminous X-ray Source, M33 X-8: New Constraints from NuSTAR and XMM-Newton

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    We present nearly simultaneous NuSTAR and XMM-Newton observations of the nearby (832 kpc) ultraluminous X-ray source (ULX) M33 X-8. M33 X-8 has a 0.3-10 keV luminosity of LX ~ 1.4 x 10^39 erg/s, near the boundary of the "ultraluminous" classification, making it an important source for understanding the link between typical Galactic X-ray binaries and ULXs. Past studies have shown that the 0.3-10 keV spectrum of X-8 can be characterized using an advection-dominated accretion disk model. We find that when fitting to our NuSTAR and XMM-Newton observations, an additional high-energy (>10 keV) Comptonization component is required, which allows us to rule out single advection-dominated disk and classical sub-Eddington models. With our new constraints, we analyze XMM-Newton data taken over the last 17 years to show that small (~30%) variations in the 0.3-10 keV flux of M33 X-8 result in spectral changes similar to those observed for other ULXs. The two most likely phenomenological scenarios suggested by the data are degenerate in terms of constraining the nature of the accreting compact object (i.e., black hole versus neutron star). We further present a search for pulsations using our suite of data; however, no clear pulsations are detected. Future observations designed to observe M33 X-8 at different flux levels across the full 0.3-30 keV range would significantly improve our constraints on the nature of this important source.Comment: Accepted for publication in ApJ (15 pages, 4 tables, 6 figures
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