Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

An Evaluation of the Teaching Effectiveness of Two Library Instructional Videotapes

published or submitted for publicatio

Long-Range Effectiveness of Library Use Instruction

published or submitted for publicatio

Prophylaxis against Pneumocystis carinii Pneumonia among Children with Perinatally Acquired Human Immunodeficiency Virus Infection in the United States

Most cases of Pneumocystis carinii pneumonia (PCP) in children infected perinatally with the human immunodeficiency virus (HIV) occur in infants between three and six months of age. 1 Because PCP is the most common opportunistic infection classified as indicating the presence of the acquired immunodeficiency syndrome (AIDS) in children, 1 because it is often rapidly fatal, 2 and because it can be prevented by chemoprophylaxis, 3 clinicians and public health officials emphasize its prevention as part of the care of children exposed to HIV and in setting priorities for public health policy. In 1991, a panel of experts in pediatric HIV infection issued guidelines . . 

Evaluating a problem-based empowerment program for African Americans with diabetes: results of a randomized controlled trial.

We believe that results of this study can be attributed to volunteer bias, study effects (ie, providing study data on several occasions to patients and their physicians during the one-year study period), and impact of the interventions. However, the study design does not allow us to examine the relative impact of these three factors on the patient improvements seen over the one-year study period

Melissa Jimenez

Palo Alto, California. The Center for Special Education Finance (CSEF) is supported through a cooperative agreement with the U.S. Department of Education, Office of Special Education Programs (H159G20002). Points of view or opinions expressed in this paper do not necessarily represent the official agency positions of the U.S. Department of Education or our network of advisors and professional organizations. The Center for Special Education Finance (CSEF) was established in October 1992 to address a comprehensive set of fiscal issues related to the delivery and support of special education services to children throughout the U.S. The Center’s mission is to provide information needed by policymakers to make informed decisions regarding the provision of services to children with disabilities, and to provide opportunities for information sharing regarding critical fiscal policy issues