DYNAMIC LEARNING AND CONTEXT-DEPENDENCE IN SEQUENTIAL, ATTRIBUTE-BASED CONTINGENT VALUATION

A hybrid stated-preference model is developed that combines the referendum contingent valuation response format with an experimentally designed set of attributes. A sequence of valuation questions is asked to a random sample in a mail-out mail-back format. Econometric analysis shows that willingness to pay for policy attributes is formed dynamically.Research Methods/ Statistical Methods,

Variability of Temperature and Salinity in the Middle Atlantic Bight and Gulf of Maine

Monitoring of the waters of the Middle Atlantic Bight and Gulf of Maine has been conducted by the MARMAP Ships of Opportunity Program since the early 1970's. Presented in this atlas are portrayals of the temporal and spatial patterns of surface and bottom temperature and surface salinity for these areas during the period 1978-1990. These patterns are shown in the form of time-space diagrams for single-year and multiyear (base period) time frames. Each base period figure shows thirteen-year (1978-1990) mean conditions, sample variance in the form of standard deviations of the measured values, and data locations. Each single-year figure displays annual conditions, sampling locations, and departures of annual conditions from the thirteen-year means, expressed as algebraic anomalies and standardized anomalies. (PDF file contains 112 pages.

Transfusion-Related Acute Lung Injury: What the Allied Health Professional Needs to Know about this Life -Threatening Hazard of Blood Transfusion

Transfusion-Related Acute Lung Injury (TRALI) is a rare, life-threatening hazard of blood transfusion. In the intensive care unit, 37% to 44% of admitted patients are transfused with at least one blood component. The opportunity for health professionals and students from nursing, respiratory care, and clinical laboratory science to interact directly with patients receiving a blood transfusion is likely to present itself on a daily basis. It is imperative for those caring for critically ill patients to be fully aware of the clinical signs of TRALI and have knowledge in the prevention and treatment of this clinical syndrome. Common clinical signs of TRALI include cough, fever, and dyspnea. Treatment has been mostly supportive and aimed at reversing acute respiratory distress through oxygen therapy or mechanical ventilation. In 2004, a consensus panel and the U.S. National Heart, Lung, and Blood Institute (NHLBI) working group characterized TRALI as new-onset acute lung injury (ALI) occurring within six hours of transfusion in patients without preexisting ALI. Although the condition is uncommon, knowledge of this clinical syndrome may help identify those patients at risk and may prevent lung injury and possible death due to this rarely encountered hazard of blood transfusion

Chemical Stabilization of Perovskite Solar Cells with Functional Fulleropyrrolidines.

While perovskite solar cells have invigorated the photovoltaic research community due to their excellent power conversion efficiencies (PCEs), these devices notably suffer from poor stability. To address this crucial issue, a solution-processable organic chemical inhibition layer (OCIL) was integrated into perovskite solar cells, resulting in improved device stability and a maximum PCE of 16.3%. Photoenhanced self-doping of the fulleropyrrolidine mixture in the interlayers afforded devices that were advantageously insensitive to OCIL thickness, ranging from 4 to 190 nm. X-ray photoelectron spectroscopy (XPS) indicated that the fulleropyrrolidine mixture improved device stability by stabilizing the metal electrode and trapping ionic defects (i.e., I-) that originate from the perovskite active layer. Moreover, degraded devices were rejuvenated by repeatedly peeling away and replacing the OCIL/Ag electrode, and this repeel and replace process resulted in further improvement to device stability with minimal variation of device efficiency

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8. In the canonical pathway, this triggers the association of these SMADs with SMAD4 and their translocation to the nucleus, where they regulate gene expression. BMPs can also signal independently of SMAD4, but this pathway is poorly understood. Here, we report the discovery and characterization of PAWS1/FAM83G as a novel SMAD1 interactor. PAWS1 forms a complex with SMAD1 in a SMAD4-independent manner, and BMP signalling induces the phosphorylation of PAWS1 through BMPR1A. The phosphorylation of PAWS1 in response to BMP is essential for activation of the SMAD4-independent BMP target genes NEDD9 and ASNS. Our findings identify PAWS1 as the first non-SMAD substrate for type I BMP receptor kinases and as a novel player in the BMP pathway. We also demonstrate that PAWS1 regulates the expression of several non-BMP target genes, suggesting roles for PAWS1 beyond the BMP pathway

Relieving thermal discomfort:effects of sprayed L-Menthol on perception, performance and time trial cycling in the heat

L-menthol stimulates cutaneous thermoreceptors and induces cool sensations improving thermal comfort, but has been linked to heat storage responses; this could increase risk of heat illness during self-paced exercise in the heat. Therefore, L-menthol application could lead to a discrepancy between behavioral and autonomic thermoregulatory drivers. Eight male participants volunteered. They were familiarized and then completed two trials in hot conditions (33.5 °C, 33% relative humidity) where their t-shirt was sprayed with CONTROL-SPRAY or MENTHOL-SPRAY after 10 km (i.e., when they were hot and uncomfortable) of a 16.1-km cycling time trial (TT). Thermal perception [thermal sensation (TS) and comfort (TC)], thermal responses [rectal temperature (Trec), skin temperature (Tskin)], perceived exertion (RPE), heart rate, pacing (power output), and TT completion time were measured. MENTHOL-SPRAY made participants feel cooler and more comfortable and resulted in lower RPE (i.e., less exertion) yet performance was unchanged [TT completion: CONTROL-SPRAY 32.4 (2.9) and MENTHOL-SPRAY 32.7 (3.0) min]. Trec rate of increase was 1.40 (0.60) and 1.45 (0.40) °C/h after CONTROL-SPRAY and MENTHOL-SPRAY application, which were not different. Spraying L-menthol toward the end of self-paced exercise in the heat improved perception, but did not alter performance and did not increase heat illness risk

The Influence of Land Use/Land Cover on Climatological Values of the Diurnal Temperature Range

The diurnal temperature range (DTR) at weather observation stations that make up the U.S. Historical Climatology Network was evaluated with respect to the predominant land use/land cover associated with the stations within three radii intervals (100, 1000, and 10 000 m) of the stations. Those stations that were associated with predominantly rural land use/land cover (LULC) usually displayed the greatest observed DTR, whereas those associated with urban related land use or land cover displayed the least observed DTR. The results of this study suggest that significant differences in the climatological DTR were observed and could be attributed to the predominant LULC associated with the observation stations. The results also suggest that changes in the predominant LULC conditions, within as great as a 10 000 m radius of an observation station, could significantly influence the climatological DTR. Future changes in the predominant LULC associated with observation sites should be monitored similar to the current practice of monitoring changes in instruments or time of observation at the observations sites

Amphotericin B enhances the synthesis and release of the immunosuppressive agent gliotoxin from the pulmonary pathogen Aspergillus fumigatus

Exposure of the pulmonary pathogen Aspergillus fumigatus to amphotericin B alters membrane permeability as indicated by the escape of amino acids and protein from the mycelium. Amphotericin B exposure for periods of 2-4 h also leads to increased release of the immunosuppressive agent gliotoxin into the surrounding culture medium. Examination of the intracellular gliotoxin concentration following exposure to amphotericin B indicated elevated levels within the hyphae as well as in the culture medium - an effect which was also evident upon exposure of A. fumigatus to DMSO. These results indicate that in parallel with the ability of amphotericinBto act as a fungistatic agent it can also induce the synthesis of gliotoxin and facilitate its release by increasing the permeability of the fungal cell membrane. Increased synthesis of gliotoxin may result from the commencement of secondary metabolism in the presence of amphotericin B. The ability of amphotericin B to enhance the synthesis and release of gliotoxin may exacerbate the effects of the toxin and facilitate fungal invasion of pulmonary tissue