8 research outputs found
Front end for GPS receivers
- Author
- Publication venue
- Publication date
- 30/11/1999
- Field of study
The front end in GPS receivers has the functions of amplifying, down-converting, filtering and sampling the received signals. In the preferred embodiment, only two operations, A/D conversion and a sum, bring the signal from RF to filtered quadrature baseband samples. After amplification and filtering at RF, the L1 and L2 signals are each sampled at RF at a high selected subharmonic rate. The subharmonic sample rates are approximately 900 MHz for L1 and 982 MHz for L2. With the selected subharmonic sampling, the A/D conversion effectively down-converts the signal from RF to quadrature components at baseband. The resulting sample streams for L1 and L2 are each reduced to a lower rate with a digital filter, which becomes a straight sum in the simplest embodiment. The frequency subsystem can be very simple, only requiring the generation of a single reference frequency (e.g. 20.46 MHz minus a small offset) and the simple multiplication of this reference up to the subharmonic sample rates for L1 and L2. The small offset in the reference frequency serves the dual purpose of providing an advantageous offset in the down-converted carrier frequency and in the final baseband sample rate
P-code enhanced method for processing encrypted GPS signals without knowledge of the encryption code
- Publication venue
- Publication date
- 09/05/2000
- Field of study
In the preferred embodiment, an encrypted GPS signal is down-converted from RF to baseband to generate two quadrature components for each RF signal (L1 and L2). Separately and independently for each RF signal and each quadrature component, the four down-converted signals are counter-rotated with a respective model phase, correlated with a respective model P code, and then successively summed and dumped over presum intervals substantially coincident with chips of the respective encryption code. Without knowledge of the encryption-code signs, the effect of encryption-code sign flips is then substantially reduced by selected combinations of the resulting presums between associated quadrature components for each RF signal, separately and independently for the L1 and L2 signals. The resulting combined presums are then summed and dumped over longer intervals and further processed to extract amplitude, phase and delay for each RF signal. Precision of the resulting phase and delay values is approximately four times better than that obtained from straight cross-correlation of L1 and L2. This improved method provides the following options: separate and independent tracking of the L1-Y and L2-Y channels; separate and independent measurement of amplitude, phase and delay L1-Y channel; and removal of the half-cycle ambiguity in L1-Y and L2-Y carrier phase
Method of implementing digital phase-locked loops
- Publication venue
- Publication date
- Field of study
In a new formulation for digital phase-locked loops, loop-filter constants are determined from loop roots that can each be selectively placed in the s-plane on the basis of a new set of parameters, each with simple and direct physical meaning in terms of loop noise bandwidth, root-specific decay rate, or root-specific damping. Loops of first to fourth order are treated in the continuous-update approximation (BLT yields 0) and in a discrete-update formulation with arbitrary BLT. Deficiencies of the continuous-update approximation in large-BLT applications are avoided in the new discrete-update formulation. A new method for direct, transient-free acquisition with third- and fourth-order loops can improve the versatility and reliability of acquisition with such loops
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
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- Breda David
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- de Chambure Daniel
- de Jong Pauline
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- Deschenes Jeremy
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- Douglas Jr. Robert E.
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- Espinoza NĂ©stor
- Etienne Odessa
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- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
- Benyon Sarah
- Benzekri Dalila
- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bharaj Kiranjit
- Bhattarai Bina
- Bhattarai Binita
- Bhonagiri Deepak
- Biddie Simon
- Bigas Judit
- Bihari Shailesh
- Bin Hasan Mohd Shahnaz
- Bindels Manon
- Binnie Alexandra
- Biradar Vishwanath
- Birch Catherine
- Birch Janine
- Birch Sophie
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
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- Blanck Wendy
- Bland Yvonne
- Blank Elisabeth
- Bleasdale John
- Bloomfield Jack
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- Board Jasmin
- Boardman Melanie
- Boari Gianluca
- Bocher Simon
- Bociek Aneta
- Boivin Anne-Helene
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bomken Charlotte
- Bonaccorso Allesandra
- Bongaerts Katherine
- Bonner Stephen
- Bonten Marc J. M.
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Bothma Pieter
- Boudineau Michel
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Boutin Mireille
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte A.
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- Brakké Karen
- Brant Emily
- Brasselet Aurélie
- Breen Patrick
- Bremmer Pamela
- Brend Morwenna
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Bridges Sarah
- Brieger Klaus-Gerd
- Brightling Chris
- Brimfield Lutece
- Brittain Michael
- Britton Kate
- Brochard Laurent
- Brodbeck Andreas
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Julia
- Brown Louise
- Brown Nerissa
- Brown Zarah
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank M.
- Brunskill Nigel
- Bryan-Morris Kayla
- Bryden Emma
- Budd Joanna
- Buehner Ulrike
- Buhay Megan
- Buhr Heidi
- Burbee Dylan
- Burda Dorota
- Burgess Richard
- Burke David
- Burke Tara
- Burkey Jason
- Burnish Rachel
- Burns Dean
- Burns Karen
- Burrell Aidan
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- Butler Amelia
- Butler Magdalena
- Butler Susan
- Buxton Meredith
- Buzgau Adrian
- Byrne Kathleen
- Byrne Rahim
- Cabrelli Louise
- Cabreros Leilani
- Cairns Tom
- Calfee Carolyn
- Callahan Jean-Christophe
- Cambalova Lenka
- Campbell Andrew
- Campbell Bridget
- Campbell Debbie
- Campbell Hilary
- Campbell Lewis
- Campbell Marion
- Campbell Ryan
- Campion Alexandra
- Campisi Josie
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmichael Samantha
- Carmona Rosario
- Carn Vanessa
- Carpio Lillian
- Carr Zoe
- Carr-Wilkinson Joanne
- Carrier François
- Carrier Marc
- Carter Angus
- Carter Brittney
- Carter David
- Carter Jay
- Carter Michael
- Casali Sherry
- Casey Ruth
- Casey Siobhan
- Castelain Vincent
- Castle James
- Cathcart Susanne
- Catorze Nuno José Teodoro Amaro dos Santos
- Cattelan Jessy
- Cavayas Alexandros
- Cawley Kathryn
- Cecconi Maurizio
- Centofanti John
- Chambers Emma
- Champanerkar Shreekant
- Chan Carmen
- Chan Charles
- Chan Peter
- Chapman Rachel
- Chapman Susan
- Charles Bethan
- Charles Walton
- Charlewood Richard
- Charlton Sam
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Jonathan
- Chen Lixian
- Chen Yan
- Cheng Allen C.
- Cherian Shiney
- Chhablani Manish
- Chin Teri
- Chudeau Nicolas
- Chukkambotla Sri
- Ciccarelli Michele
- Cirstea Emanuel
- Clair Bernard
- Clark Amy
- Clark Michele
- Clark Richard
- Clark Sarah
- Clarke Frances
- Clarke Jennifer
- Claxton Andrew
- Cleary Joanne
- Clement Ian
- Clere-Jehl Raphael
- Clermont Giles
- Clermont Gilles
- Clinton Alison
- Cloutier Ăve
- Cockrell Maeve
- Codreanu Daniel
- Coetzee Samantha
- Coghlan Phoebe
- Cole Jade
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Amy
- Collins Daniel
- Collins Emma
- Collins Joanne
- Collins Ărin
- Collis Matthew
- Combaux Daniele
- Commons Robert
- Comp Susan
- Concha Pablo
- Connolly Karen
- Constantini Elena
- Constantino-Occhipinti Claudia
- Contou Damien
- Convery Karen
- Conway Robert
- Conzelmann Nadine
- Cook Deborah
- Cook Tim
- Cooke Jill
- Cooke Justin
- Cooper Jamie
- Cooper Josh
- Cooper Lauren
- Cooper Melanie
- Cooper Nichola
- Corbett Sarah
- Corcoran Ele
- Corcoran Kathleen
- Cornell Sarah
- Cornell Thomas
- Cort Jon
- Costerousse Olivier
- Couillard-ChĂ©nard Ămilie
- Courtin Laura
- Coutts Amanda
- Couture Lourie
- Cove Matthew
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craddock Richard
- Craner Michelle
- Craven Thomas
- Crawshaw Sarah
- Creagh-Brown Ben
- Creange Vanessa
- Cremer Olaf
- Crisp Nikki
- Croft Maria
- Csabi Peter
- Cudlipp Joanna
- Cuesta Jeronimo
- Cuffaro Raffaele
- Curley Gerard
- Currie Andrew
- Cusack Rebecca
- Cuthbertson Brian
- Cutler Sean
- CĂĄrcel Sheila
- CĂŽtĂ© Ămilie
- D?Amato Fabiola
- D?Aragon Frédérick
- Daebis Admad
- Daher Rana
- Dale Katie
- Daley Jessica
- Dalton James
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darnell Robert
- Darreau Cedric
- Daugherty Jason
- Davey Miriam
- Davidson Neil
- Davies Ellie
- Davies Gwyneth
- Davies Jennifer
- Davies Louisa
- Davies Michelle
- Davies Rhys
- Dawson Laura Ann
- Dawvda Ashlish
- Day Christopher
- Da Rocha Joana
- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
- de Jonge Evert
- De Keulenaer Bart
- de la Torre Cisneros Julian
- de Man Angelique
- De Neef Mark
- De Smeytere Anouska
- Deacon Bethan
- Dean Steven
- Dean Tessa
- Dearden Joy
- Dechert William
- Declercq Pierre-Louis
- Degracia Anna
- del Sorbo Lorenzo
- Dela Rosa Arnold
- Delaney Kirsha
- Dell Abbie
- del Prado Michael
- Demetriou Carrie
- Dempster Debra
- Denham Lynn
- Denmade Craig
- Dent Martin
- Depante Maria
- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
- De Waele Jan
- Dheke Krishan
- Di Lucca Giuseppe
- Dias Priya
- Dice Julie
- Digby Stephen
- Diridis Kristina
- Distler Michael
- Dobell-Brown Kelsey
- Doble Patricia
- Dobson Jade
- Doherty Kaleigh
- Doherty Ronan
- Doi Yohei
- Dolman Rozzie
- Domingo-Marco Joana
- Donadee Chenell
- Donaldson Kate
- Dondrop Arjen
- Donegan Clare
- Donlon Sinead
- Donnelly Adrian
- Donnelly Kieran
- Donnison Phil
- Doonan Reece
- Doran Peter
- Dore Rachael
- Dormand Natalie
- Dos Santos Filipa
- Douillard Thomas
- Drake Chelsea
- Drapola Debra
- Drayss Maria
- Drummond Andrew
- Drury Kay
- Duan Erick
- Duberley Stephen
- Duffy Eamon
- Duffy Oscar
- Duke Graeme
- Duke Zoe
- Duncan Tracy
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- Duplaix Mathilde
- Duric Natalie
- Duroux Maree
- Dushianthan Ahilanandan
- Dyas Sarah
- Eapen Beena
- Eastgate Christine
- Ebenezer R
- Edmunds Natasha
- Edwards Alexandra
- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
- Eichenauer Dennis
- Eisenbeis Simone
- Ekhérian Jean-Michel
- El-Khawas Khaled
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- Eroglu Ege
- Estcourt Lise J.
- Estensen Kristen
- Evans Amy
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- Ewalds Esther
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- Fagan Laura
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- Ford Megan
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- Foulds Angela
- Fowler Rob
- Fowler Robert
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- Fujitani Shigeki
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- Haider Nafeesah
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- Hall Alistair S
- Hall Amelia
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- HC Ooi
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- Holland Nicky
- Holland Susan
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- Honda Hitoshi
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- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
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- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
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- Keeler Sheryl
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- Khanal Sushil
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- Kilner Mari
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- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Adrian F. Nagle IV
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bernier Antoine-Darveau
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
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- Bluth Marcel
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- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wetering Inge van de
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit
\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution
- Author
- Abdelnabi Mai
- Abrams Marita K
- Abusheikh Tariq
- Ackerman Cheri M
- Adams Andrew
- Adams Stephanie J
- Agarwalla Anant
- Agbley Kwabea
- Aldrup Megan E
- Alldredge Justin
- Allen Alicia B
- Alvarez Consuelo J
- Alvendia Erica L
- Ament Caitlin
- Anderson John E
- Archambault Alexi
- Armistead Isaac O
- Armstrong Andrew R
- Armstrong William
- Aronhalt Todd
- Ashrawi Yara
- Asinof Sam
- Aso Soham
- Augustine LaJerald
- Baatenberg Lara
- Bahr Thomas J
- Bailey Robert J
- Baker Atlee
- Baker Morgan
- Baldassari Shane M
- Banker Roxanne
- Barberi Chelsea R
- Barnett Jason M
- Bartling Justina R
- Baumgardner Jordan S
- Beck Christopher
- Beck Lauren R
- Beckett Alissa
- Bedard James E J
- Bednarski April E
- Beken Levent H
- Belella Carissa
- Bellush James M
- Benitez Pedro
- Benson Jonathon M
- Bertolet Anne
- Bhalla Satish C
- Bhatiya Chinmoy I
- Blaker Amanda L
- Blunden Christopher E
- Bodenberg Jessica M
- Boham Sampson K
- Bor Matthew J
- Botsford Bobbi
- Boudoures Anna L
- Boudreaux Lauren R
- Bourland Megan
- Brand Jordan P
- Braverman John M
- Brinkley Briana
- Brock Ethan J
- Brooks Dana W
- Broomfield Daniel
- Brouwer Lindsay K
- Brown Adam D
- Brown Ashley S
- Brown Carter
- Brown Marie
- Bryant Ashley
- Bryant Julie
- Burg Martin G
- Burke Christa
- Burkhart Brandon J
- Bushhouse Kelsey T
- Butzler Sarah C
- Caesar Nicole M
- Campana Christopher
- Carney Jordan E
- Caronna Jason
- Carranza David
- Cassidy Daniel W
- Cesko Lejla
- Chamma Norma
- Chandrasekaran Vidya
- Chapman Julia
- Chapman Kayla
- Chase Ian O
- Chau Kim M
- Chavez Miranda
- Chavez Ramiro A
- Chen Maida
- Chiang Scott
- Chlebina Ben
- Choeying Tenzin
- Choi Tiffany Y Y
- Chong Insun
- Christgen Shelbi L
- Christiansen Lena
- Christie Jordan S
- Cifelli Alyssa
- Clark Eric M
- Clark Nicole B
- Clarke-Medley Nicole
- Clary Andrea N
- Cognetti Peter A
- Cohen Heather
- Cole Mara G
- Collins Ashley A
- Conn Michael A
- Conrad Turner
- Conturso Alaina C
- Cooper Kristen M
- Corrielus Maureen
- Cotteleer Rebecca J
- Coulson Kevin
- Cristostomo Michael C
- Cromwell Avery B
- Crowley Matt J
- Crowley Samuel T
- Cruz Samantha
- Cullimore Peterson R
- Custer Ashley F
- Cyranowski Olivia
- Damsteegt Amanda M
- Danner Benjamin L
- Darusz Jess M
- DaSilva Paolo A
- Dauphin Cory M
- Davis Kristen C
- Davis Yelena P
- Davis-Reyes Brionna
- Dawson Seth G
- Debow Calise
- DeFazio Steve
- DeJong Randall J
- Delacruz Noelle
- DeMichele Gabriella A
- Deranek Kelly M
- DeShetler Megan
- Deuschle Frederic J
- DiAngelo Justin R
- Diekema Emily J
- DiLorenzo Lauren A
- Dirkes William
- DiTommaso Tia M
- Dobbe Ali
- Dobbe Ian
- Docking Carter T
- Does Benjamin R
- Dorsett Sasha L
- dos Santos Vieira Carolina Marques
- Dothager Matthew
- Doty Jennifer S
- Dougherty Grace A
- Dow Brian A
- Dowd Rose M
- Downey Kaitlyn A
- Drake Andrew P
- Drewry Melissa
- Drumm Kelly
- Du Chunguang
- Dunbar David A
- Dunham Carrie A
- Earl Erica K
- Echendu Vivienne
- Eckardt Alexandra K
- Eckdahl Todd T
- Edwards Curtis R
- Ehret Sharon C
- Eisen Michelle E M
- Eisler Heather L
- El-Adaimi Jad
- Elder Darcie D
- Elliott GiNell
- Emerson Charlene
- Emerson Julia A
- Emiah Shadie
- English Johnathan D
- Enoch Erica
- Faber Hayley M
- Faber Katherine J
- Fadus Matthew C
- Falk I N
- Fanning John P
- Farek Jesse R
- Farrar Cassandra
- Fearnow Adam
- Feenstra Elizabeth
- Fefelova Nadezhda
- Felzer-Kim Isabella T
- Fese Jessica
- Fick Cameron N
- Fitzgibbons John D
- Flohr Sarah
- Flores Amanda H
- Floyd Trevor G
- Foret Don
- Forsyth Joshua D
- Fosselman Daniel S
- Foust Jonathan D
- Franchi Spencer L
- Freda Philip J
- Freeburg Trip
- French Kristin M
- Friedman Harrison
- Friedrichs Chelsey
- Fusco Zach
- Garibay Edgar
- Garrett Amanda D
- Gaur Shailly
- Geary James F
- Gier Chad
- Gill Ishwar S
- Gilman Hannah
- Glenn Omolara
- Goeller Katie L
- Gomez Carolina
- Gonzales Justin A
- Gooch John
- Goodman Anya L
- Goodwin Zane
- Goscinski Nora C
- Gosser Yuying
- Govind Shubha
- Grantham Alaina J
- Greenwell Alyson
- Grove Ryan A
- Guadron Leslie
- Gutierrez Nestor
- Haberman Adam
- Hales Jasmine
- Hammett Deborah
- Hammond Brandy L
- Hammond Maureen S
- Hanson Cynthia K
- Harding Taylor S
- Hare Amber N
- Hark Amy T
- Harker Katherine S
- Harnoto Raechel S
- Harrington William
- Harris Cameron B
- Hatfield Kristen R
- Hauke Jeanette
- Hauser Charles R
- Havill Jessen T
- Heckman Jonathan M
- Hedeen Heather
- Helmreich Eric
- Hendricksma Jesse
- Hennessy Bryan M
- Henry Tyneshia C P
- Herbstsomer Robert A
- Herrick Douglas A
- Herrold Milton R
- Heslop Michelle
- Hilbrands Julia A
- Hirsch Sarah
- Hockenberger Kelsey
- Holderness Heather L
- Hong Emily L
- Hoogenboom Lindsay
- Hoogewerf Arlene J
- Hoopes Laura L M
- Hoover Betsy
- Hopkins Barbara L
- Howell Emily J
- Howey Nicole A
- Huerta Vilma F
- Ibarra Sharon
- Ibrahem Marwan
- Ighile Osagie
- Intriago Stephanie
- Jacobs Dontae A
- Janssen Bridget M
- Jarrell Jenifer N
- Jelgerhuis Sarah A
- Jelsema Timothy R
- Jewell Elizabeth S
- Jimenez Luis A
- Jipp Jacob
- Johnson Ashlee G
- Johnson Benjamin K
- Johnson Cristen
- Johnson Diana E
- Johnson Jaelyn L
- Johnson Lauriaun
- Johnson Todd D
- Jones Christopher J
- Jones Jennifer K
- Jones Kelly K
- Jones Melissa
- Kabaso Rita
- Kaehler Marian M
- Kaisler Maria
- Kammrath Anna
- Kandahari Adrese
- Kappes Michelle L
- Karaska Elizabeth A
- Katz Brandon M
- Kaur Sukhjit
- Kehoe James L
- Kelley Colleen V
- Kelly Elisabeth A
- Kennedy Andre
- Kennedy William R
- Keny Lauren J
- Kerber John M
- Keysock Nicholas
- Khan Ambreen
- Khayrullina Guzal
- Khoshabian Colin
- Khoury Christopher B
- Kiernan Elizabeth
- Kiley John
- Kim Andrew J
- Kim Anna
- Kim Van
- King Jessica E
- Klett Bethany M
- Knepper John Mark
- Knob Christopher R
- Knouse Kristin A
- Knudsen Nelson H
- Koaches Hannah C
- Koehler Jessica
- Koenig Dana
- Kokan Nighat P
- Kolibas Kimberly S
- Kooienga Ross D
- Koplinsky Chad A
- Kraftmann Karen J
- Kubricky Cassandra
- Kufel Christina N
- Kujawski Alexander J
- Kuleck Gary A
- Kulich Danielle
- Kung Faith
- Kus Jordan E
- Kuschner Cyrus E
- Kusner Matt
- Kwan Wa Shum Yuki
- Ladzekpo Danielle
- LaForge Kristin M
- Lamb Travis
- Lambright Anthony K
- Lammers Jennifer A
- Lane Curtiss E
- Langner Christine
- Lau Dawn
- Lea Charlotte
- Leads Rachel R
- Leatherman Emily C
- LeBlanc Mark T
- Lee Cassidy T
- Lee Paul
- Lemmon Eric
- Leung Wilson
- Lewis Benjamin M
- Li Linghui
- Light Morgan R
- Limle Austin B
- Lin Devry
- Lindbeck Peter
- Lippert Rachel N
- Lopez Lenin
- Lopilato Jane E
- Louie Christopher A
- Lowell Shannon M
- Lu Alvin
- Lucas Gabi
- Luippold Erin K
- Lupey Lena N
- Lydon Anniken M
- Macchi Christopher R
- Machone Joshua F
- Macias Elizabeth
- Macias Jason S
- Maffa Amanda
- Mageeney Catherine M
- Malkowitz Lorraine
- Mammo Danny
- Maniaci Brian J
- Marra Jonathan
- Martinez Megan
- Martiniuc Daniela
- Martinov Tijana
- Mason Portia
- Matthews Jordan E
- May Francis J
- Mayorga Lissett
- Mazur Tammy
- Mazzeo Cheryl
- McCabe Nikie L
- McCartha Shannon R
- McCracken Marly R
- McDonald Mitchell
- McDonough Alexa M
- McFarland Darryl
- McLaughlin Christopher
- Mecoli Jonathan P
- Medina Joseph
- Meghdari Mariam
- Meier Anne C
- Melton Amy D
- Membreno Nelson
- Mendoza Carlos
- Menillo Daniella
- Menyes Erika E
- Mercer Amanda
- Merry Callie R
- Messenger Gregory S
- Messiah Shady
- Messler James
- Meyer Lauren R
- Miller Emily G
- Minnick Phillip J
- Minniti Carl J
- Minton Thomas F
- Misch Jonathan
- Mitchell Ryan D
- Monsma Nicholaus
- Moran Joseph V
- Morgan Abbie
- Morlock Elaine V
- Morris William M
- Morrow Adam T
- Mudumbi Krishna
- Mullen Gregory J
- Muller Sarah E
- Musick Adam E
- Musokotwane Sepo
- Myirski Kevin
- Naik Monal
- Naik Priyanka
- Neufeld Lacey
- Neutzling William
- Newcomb Victoria
- Newhart William H
- Newman Alyssa M
- Ng Chun Leung
- Ng Simon
- Nguyen San Francisco
- Nguyen Trung T
- Nichols Zachary
- Nicolas Daniel S
- Nietmann Jana
- Nikam Vinyak S
- Nollet Eric A
- Nordman Elizabeth C
- Norton Diana
- Noynaert Joseph W
- Nyabeta Onsarigo Eric
- O\u27Rouke Allison
- Obiorah Ifeanyi
- Ochoa Andrea
- Odisho George
- Ogden Bradley J
- Olson Nicole C
- Ortiz Carlos
- Ostby Kristine
- Osterloh Jeanette M
- Overvoorde Paul J
- Ovu Steven
- Paetkau Don W
- Palozola Katherine C
- Paluskievicz Christina
- Pamnani Brad
- Parrish Susan
- Parry Kesley
- Pasierb Brittany D
- Patao Melissa D
- Patao Shane M
- Patterson Seantay D
- Pattison Claire
- Penn Jessica
- Peoples Emily
- Perella Mallory
- Perez Marcos A
- Peterson Daymon
- Pfeil Jacob J
- Pham Philip
- Plante Olivia
- Plasman Haley J
- Plescher Brittany E
- Poet Jeffrey L
- Polk Jessica W
- Potocny Stephanie J
- Powers Michelle K
- Pozmanter Caitlin
- Prasad Shreya
- Presley Jonathan D
- Price Amber L
- Primus Shekerah
- Puetz William J
- Quach Michael
- Ragland Nicolas
- Raimey England
- Ramic Alen
- Ramirez Roman E, Jr.
- Ramsey Kimberley
- Ramthun Jennifer R
- Randazzo Matt J
- Rankin Helen
- Rathore Sunil
- Ratliff Camille D
- Rauf Sabya A
- Reed Emily
- Reem Rachel M
- Regan Melanie K
- Regisford E Gloria C
- Reilly Mary T
- Rekai Jade Lea
- Rempe Ryan Michael
- Rennhack Jonathan P
- Revie Dennis
- Reynolds Katherine R
- Reynolds Lyndsey A
- Reynolds Thomas J
- Reza Evangelina
- Rhee Dong K
- Rigby Nichole
- Rios Lindsay
- Rivard Allyson B
- Robertson Gregory M
- Robic Srebenka
- Robinett Deirdre
- Robinson Lauren M
- Rodela Laura
- Rodriguez Priscilla
- Rodriguez Vanessa
- Roecklein-Canfield Jennifer A
- Ronk Adam J
- Rooney Meghan B
- Rose Jenny L
- Rose Thomas J
- Rosenwald Anne G
- Rossi Franca G
- Rossi Nadine L
- Rubin Lainey S
- Ruiz Jorge
- Rupley Bryan J
- Sable Joseph E
- Sadovsky Griffin
- Safa Nadia
- Salbert Luke R
- Salgado Michael S
- Saluja Rasleen K
- Salzman Garrett
- Sandusky Michael W
- Sanusi Fareed
- Sassu Eric D
- Saville Kenneth
- Scala Victoria
- Schauder Taylor
- Schepers Allison J
- Schibler Jeanine
- Schiedermeyer Holly
- Schmidt Lasse
- Schmuecker Samantha M
- Schneiter Allison R
- Schottler Jennifer
- Schueler Mary Grace
- Schultz Darrin
- Schulz Robert W
- Schwartz Nicholas U
- Scoma Alexandra H
- Scott Geoff
- Scott Zachary W
- Sessions Bridget J
- Seydoux Marie-Isabelle B
- Shallman Devon
- Shantzer Lindsey
- Sharif Karim A
- Shaw Mary E
- Shelton Micah
- Sherrill Will
- Shevin Yakov
- Shipman Anna L
- Shoemaker Emma
- Shoop Elizabeth
- Shuen Jessica A
- Shuford Rebecca
- Silva Valeria
- Silver Key S Catherine
- Simon Matthew
- Simone Bisogno Laura
- Smith Anna L
- Smith Christopher D
- Smith Jonathan E
- Smith Joshua R
- Smith Karl E
- Smith Mary A
- Smith Melanie A
- Smith Samuel I
- Smith-Gee Maxwell T
- Snavely Michael
- Soliterman Eugenia A
- Song Roy
- Soos Mahdi
- Spaeder Lindsay A
- Spana Eric P
- Sparks Ciani J
- Sparks Jeri
- Spencer Eric
- Spencer Sarah
- Sreenivasan Aparna
- Stagaard Erica
- Starcher Justin R
- Starkey Kristin M
- Statton Geeta
- Sterling Allison M
- Svoronos Petros
- Swanson Bryant R
- Sweeney Edward P
- Tache Melissa A
- Tare Archana
- Tenney Jenna C
- Tewilliager Ashley A
- Thistle Katrina
- Thomas Jessica G
- Thompson Jeffrey S
- Thomsen Kristen M
- Tilot Amanda K
- Timko Ashley S
- Tirasawasdichai Tiara
- Tomkins Trisha
- Torchon Karvyn
- Townsend Ashley
- Tran Danny L
- Trieu Melissa
- Tuberty Sarah
- Tucci Jessica M
- Tumminello Richard A
- Turner Bryce A
- Tynon Marykathryn
- Uitvlugt Chris
- Undem Blair
- Unruh Anna K
- Unzicker Matthew R
- Urick Damian
- Valdez Isabel
- VanderVennen Marielle
- VanDyken Rachel E
- VanEck Eve
- Velasquez Vicente
- Verbofsky Evan M
- Vernon William B
- Vetor Ashley
- Villerot Matthew M
- Vondy Kayla
- Vrable Abby
- Vue Samantha
- Vuong Tam
- Vylonis Megan B
- Waggoner Andrew W
- Walji Tezin A
- Walker Chelsea A
- Wan Tiffany
- Wande Lucia
- Ward Alyssa
- Waters Mary
- Watson David T
- Wawersik Matthew
- Weaver Jennifer A
- Welker Anne A
- Wellinghoff Jules
- Wendland Pete
- Westphal Kyle
- White Jackie X
- Williams Charlotte
- Winkler Stacey
- Winn Wesley W
- Winters Jenifer
- Woehlke Sarah
- Wolski Matthew W
- Wolyniak Michael J
- Wong Jeanette
- Wong Jeremy N
- Woyski Dustin S
- Wurzler Juliana A
- Wylie Anna
- Wysocki Lauren M
- Xiong David
- Xu Amy
- Xu Thomas Q
- Yalamanchili Monica
- Yang Bib
- Yarrington Bryan
- Yemelyanova Anastasia K
- Youngblom Jim
- Yu Nicole S
- Yuan Han
- Zaborowicz Matthew A
- Zarrasola Stephanie
- Zhang Yi
- Zhu Xiao
- Zidan Ameer
- Zumkehr Joannee
- Publication venue
- ScholarWorks@GVSU
- Publication date
- 01/05/2015
- Field of study
The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25â50%) than euchromatic reference regions (3â11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11â27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4â3.6 vs. 8.4â8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu
Effect of Antiplatelet Therapy on Survival and Organ SupportâFree Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel JakĆĄa
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastola Sirjana
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bean Sarah
- Beane Abi
- Beard Gregory
- Beasley Richard
- Beavis Sarah
- Bedford Caroline
- Beer Deborah
- Begin Phillipe
- Begum Salma
- Bell Gillian
- Bellemare David
- Beltran Mercedes
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Benyon Sarah
- Benzekri Dalila
- Berdaguer Fernando
- Bergin Colin
- Berry Lindsay
- Berry Scott
- Berryman Emily
- Bertel Melanie
- Best-Lane Janis
- Besten Henny
- Bevan Emily
- Bewley Jeremy
- Beyerl Ashley
- Bhagani Sanjay
- Bhandal Khushpreet
- Bhattarai Binita
- Bhimani Zahra
- Bhonagiri Deepak
- Biddie Simon
- Bihari Shailesh
- Binnie Alexandra
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Kathrine
- Birkinshaw Isobel
- Black Ethel
- Blackledge Bethany
- Blakemore Hayley
- Bland Yvonne
- Blank Elisabeth
- Bloos Frank
- Board Jasmin
- Bocher Simon
- Bociek Aneta
- Boivin Anne-HĂ©lĂšne
- Bojunga Jörg
- Bone Allison
- Bonner Stephen
- Bonten Marc
- Borgatta Barbara
- Borislavova Borislava
- Borrill Zoe
- Boschert Catherine
- Bossard Isabelle
- Boulanger Marie-Claude
- Boumahni Dounia
- Bouman Angela
- Bounab Rania
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouvier Elodie
- Bouw-Ruiter Marianne
- Boué Yvonnick
- Bowen James
- Bowler Helen
- Boyd Craig
- Boyles Rebecca
- Bracke Stephanie
- Bradbury Charlotte
- Bradley Paul
- Brady Kara
- Brailsford Jane
- Brain Matthew
- BrajkoviÄ Ana
- Brakké Karen
- Brant Emily
- Breen Patrick
- Bremmer Pamela
- Brennan Aoife
- Bretagnol Anne
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brieger Klaus-Gerd
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Brooks Nicole
- Brown Cynthia
- Brown Louise
- Browne Troy
- Brugman Curt
- Brunetta Enrico
- Brunkhorst Frank
- Brunskill Nigel
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- Roynon-Reed Anna
- RueĂ-Paterno Giusi
- Ruiz Winningtom
- Runge Isabelle
- Ryalls Kim
- Ryan Donal
- Ryan Emily
- Ryan Lucy
- Sabaretnam Suganya
- Sabelhaus Timo
- Sackrowitz Rachel
- Sadera Girendra
- Sagnier Anne
- Saha Sian
- Saito Hiroki
- Saiyed Salim
- Salahuddin Nawal
- Salberg Armorel
- Saleem Malik
- Salerno Tania
- Salhi Sara
- Sall Jas
- Salmon Charlotte
- Salmon Karen
- Saluzzio Romina
- Sanders Arnate
- Sanderson Amanda
- Sandhu Gyan
- Sanghavi Ritesh
- Sanil Ashish
- Santamaria John
- Santos Filipa
- Santos Marlene
- Saran Anita
- Sathe Sonia
- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina
- Saunderson Paula
- Saxena Manoj
- Sayehli Cyrus
- Scanlan Jeremy
- Scano Riccardo
- Schaaf Bernhard
- Scheepstra-Beukers Irma
- Schmidhofer Mark
- Schneider Francis
- Schoenling Andrew
- Scholl Denise
- Schotsman Joost
- Schouten Jeroen
- Schreuder Gerwin
- Schueler Robert
- Schuster-Bruce Martin
- Schutgens Roger
- Schweikert Sacha
- SchĂŒtze Bianka
- Scott Kathryn
- Scott Paula
- Scott Zoe
- Scully Michael
- Seaman Rebecca
- Seidu Fatima
- Sekiwala Rose
- Sellers Katharine
- Selmi Carlo
- Sement Arnaud
- Senya Ho
- Seppelt Ian
- Serpa-Neto Ary
- Serri Karim
- Sever Helena
- Sevilla Chanthou
- Seymour Christopher
- Shah Asim
- Shah Faraaz
- Shahid Tasnin
- Shaikh Mohiuddin
- Shankar-Hari Manu
- Shaw David
- Shaw Deborah
- Shaw Joanne
- Shearer Audrey
- Sheath Ben
- Shehabi Yahya
- Shekar Kiran
- Shelton Sarah
- Shetty Varun
- Shimabukuro-Vornhagen Alexander
- Shovelton Charmaine
- Shree Madhu
- Shrestha Tapaswi
- Shuker Karen
- Shyamsundar Murali
- Siami Shidasp
- Sibin Sindhu
- Sicat Christine
- Siddiqui Atif
- Siddiqui Ayesha
- Sidéris Georgios
- Sikondari Nyma
- Silversides Jon
- Sim Malcolm
- Simmonds Catherine
- Simons Koen
- Simpson Benjamin
- Simpson Joanna
- Simpson Scott
- Simpson Tom
- Sinclair Julie-Ann
- Singh Jayaprakash
- Singh Rajeev
- Singh Vanessa
- Singleton Jo
- Sinha Pratik
- Skinner Denise
- Skorko Agnieszka
- Skrtich Aimee
- Slaughter Melanie
- Slieker Kitty
- Sligl Wendy
- Sloots-Cuppen Sonja
- Small Charlotte
- Smallwood Andrew
- Smee Joanna
- Smit Albertine
- Smith Alex
- Smith Catherine
- Smith Emma
- Smith John
- Smith Judith
- Smith Julie
- Smith Lucie
- Smith Matthew
- Smith Paul
- Smith Roger
- Smith Simon
- Smith Tim
- Smuts Sara
- Smyth Kirsty
- Smyth Michelle
- Smyth Naoise
- Soar Natalie
- Solesbury Amanda
- Somerville Alastair
- Song Rima
- Soukup Jens
- Southern David
- Southin Sara
- Spain Sandra
- Spencer Stephen
- Spencer Thomas
- Speyer Rebecca
- Spittle Nick
- Spivey Michael
- Spong Adam
- Sprinckmoller Stefan
- Squires Rebecca
- Stambaugh Martha
- Stammers Katie
- Stanciu Delia
- Stanworth Simon
- Starke Lisa
- Stavor Dara
- Stedman Roger
- Steffen Melanie
- Stephanie Gelinotte
- Sterba Martin
- Stevenson Lesley
- Stewart Richard
- Stone Sarah
- Stratton Emma
- Stronach Lucy
- Subbanna Umesh
- Suber Tomeka
- Sukuraman Anila
- Summerfield Anna
- Summers Charlotte
- Sundaram Radha
- Sundaran Dhinesh
- Surti Zuhra
- Sutherland Helen
- Sutherland Sara-Beth
- Sutterlin Laetitia
- Sutton Joanne
- SvitĆĄkar Nikolai
- Swabe Jacqueline
- Sweet Katie
- Sy Eric
- Szakmany Tamas
- Szigligeti GĂĄbor
- SzĆke ViktĂłria
- Tai Charlotte
- Talia Nadine
- Tallott Mandy
- Tamme Kadri
- Taqdees Huda
- Tarr Esther
- Tate Margaret
- Tatham Kate
- Taylor Holly
- Taylor Melanie
- Templeton Maie
- Thomas Amy
- Thomas Emma
- Thomas Helen
- Thomas Matt
- Thomas Vicky
- Thompson Patricia
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Thurairatnam Saranya
- Tierney Carey
- Tinmouth Alan
- Tlayjeh Haytham
- Toffalo Sue
- Tolppa Timo
- Tomlinson Helen
- Tong Steve
- Tong Steven
- Tony Kiran
- Totzke Juliane
- Touma Omar
- Towns Miriam
- Trapani Tony
- Trask Kara
- Traverse Eleanor
- Tridente Ascanio
- Trim Fiona
- Trimmer Ken
- Triulzi Darrell
- Troeman Darren
- Trues Estefania
- Truman Nicholas
- Tsakiridou Kyriaki
- Tsang Jennifer
- Tsinaslanidis Georgios
- Tuckwell Caroline
- Tully Redmond
- Tully Riona
- Tung Raymond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Keri
- Turner-Bone Ian
- Turns Margaret
- Tv Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Umrani Zulfiqar
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van Bree Sjoerd
- van de Veerdonk Frank
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- van der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Oosten Nienke
- van Opdorp Marjolein
- van Vonderen Marit
- van Zanten Arthur
- van Zuylen Tamara
- Vanjak Christian
- Vanmali Piyush
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
- Vazquez-Grande Gloria
- Veenith Tonny
- Venkatesh Bala
- Venz Ellen
- Verlander Mark
- Vermassen Joris
- Vermeiren Daisy
- Verrier Nathalie
- Vertue Mark
- Verula Jerik
- Victor Saji
- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Vincent Rachel
- Virdee Satwinder
- Visser Yorik
- Vita Tina
- Vodovar Dominique
- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Voza Antonio
- Vrolijk Loes
- Vuylsteke Alain
- Wagh Atul
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Wang Shu
- Ward Geraldine
- Ward Kathryn
- Ward Luke
- Warnapura Loku
- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watts Angela
- Waugh Victoria
- Webb Steve
- Weber Lisa
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Karen
- Williams Patricia
- Williams Tony
- Williams Virginie
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wiseman Sophie
- Wisniewski Mary
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Helen
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Äimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc