Wearable Hearing Accessory Technology

We set out in August 2017 to develop an active noise suppressing device that would be usable both in military and civilian activities. Due to constraints in knowledge and time, we decided our best course of action was to divide the project into two equal projects with the hope to be able to combine them into a single project at the end of the allotted time. This consisted of an active noise suppression device and a passive noise suppression device. The passive device would have no electronic components and the active device would be pure circuitry with no housing. This approach meant that if one of the two devices were to fail we would still have a working deliverable. Over the course of the project, the team faced many setbacks that needed to be overcome. Due to constraints with time we were unable to test as many components as we had wanted to. In future works we would want to work better with integrating the two prototypes together and testing to see if our specifications were met. We were able to however stay well below our budget when ordering our components. If we were given more time we are confident that we would be able to complete the project and make a production ready device

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Multiple sclerosis is a complex neurological disease, with 3c20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that much of the remaining heritability is also due to additive effects of common variants rather than epistasis between these variants or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that up to 5% of this heritability is explained by low-frequency variation in gene coding sequence. We identify four novel genes driving MS risk independently of common-variant signals, highlighting key pathogenic roles for regulatory T cell homeostasis and regulation, IFN\u3b3 biology, and NF\u3baB signaling. As low-frequency variants do not show substantial linkage disequilibrium with other variants, and as coding variants are more interpretable and experimentally tractable than non-coding variation, our discoveries constitute a rich resource for dissecting the pathobiology of MS. In a large multi-cohort study, unexplained heritability for multiple sclerosis is detected in low-frequency coding variants that are missed by GWAS analyses, further underscoring the role of immune genes in MS pathology

Programmsystem PAS-Stahlbeton, Benutzerhandbuch. T. 2 Benutzeranleitung

SIGLEDEGerman

Programmsystem PAS - Stahlbeton. Benutzerhandbuch. T. 3 Beispiele

SIGLEDEGerman