9 research outputs found
Need to move and maintain a good posture in elderly on surgery: quasi-experimental study
Objective: To identify in elderly people on surgery the need to move and maintain desirable postures; to evaluate the outcome of interventions for the need in a study group. Method: This is a quantitative and quasi-experimental study, conducted with 30 elderly in the postoperative in hospital in Rio de Janeiro. It was used for data collection the protocol for evaluation of basic needs second Virginia Henderson and for the experimental group was used the healthcare. Results: The main needs identified were painful to jogging, decreased joint flexibility, bed restriction, balance disorders, decreased strength and muscular endurance. From the 40 identified needs in the experimental group could be reduced 8 and in the control group from 35 were reduced to 3, obtained Oddis Ratio (0R) of 2,66. Conclusion: There was significant improvement in the experimental group and the reduction of the identified problems when compared to the control group
Comparação entre o aspirado de medula óssea concentrado e o corticóide na tendinopatia glútea
INTRODUCTION Adult gluteal tendinopathy is part of a group of pathologies of Greater Trochanteric Pain Syndrome (GTPS). This disorder is characterized by pain, functional limitation and loss of local strength. The diagnosis is made from clinical examination associated with complementary exams (Ultrasound or Magnetic Resonance). OBJECTIVE Comparative study between standard treatment and bone marrow aspirate concentrate (BMAC) for the treatment of gluteal tendinopathies. The randomized clinical trial selected patients diagnosed with gluteal tendinopathy at a university hospital and divided them into two groups: (G1) bone marrow aspirate concentrate and (G2) Corticosteroids injection. RESULTS 48 patients were selected, of which 40 were monitored for 06 months, with an improvement in scores in both groups. Patients who were submitted to the BMAC treatment had a statistically significant improvement in VAS scores and Lequesne scores compared to standard treatment. There was an improvement in the assessment of the quality of life in both groups with no statistically significant difference. CONCLUSION BMAC arises as an alternative to the standard treatment of gluteal tendinopathy, proving to be a safe technique and with promising results when combined with multidisciplinary team behavioral therapy.INTRODUÇÃO A tendinopatia glútea adulta faz parte de um grupo de patologias da SÃndrome Dolorosa Trocantérica (SDT). Esse distúrbio é caracterizado por dor, limitação funcional e perda de força local. O diagnóstico é feito a partir de exames clÃnicos associados a exames complementares (ultrassonografia ou ressonância magnética). OBJETIVO Estudo comparativo entre tratamento com corticóide e aspirado de medula óssea concentrado (BMAC) para o tratamento de tendinopatias glúteas. MATERIAL E MÉTODOS O ensaio clÃnico randomizado selecionou pacientes diagnosticados com tendinopatia glútea e os dividiu em dois grupos: (G1) aspirado de medula óssea concentrada e (G2) injeção de corticosteróide . RESULTADOS Foram selecionados 48 pacientes, dos quais 40 foram monitorados por 06 meses, com melhora nos escores nos dois grupos. Os pacientes que foram submetidos ao tratamento com BMAC tiveram uma melhora estatisticamente significativa nos escores de EVA e nos escores de Lequesne em comparação ao tratamento padrão. Houve uma melhora na avaliação da a qualidade de vida em ambos os grupos, sem diferença estatisticamente significativa. CONCLUSÃO O aspirado de medula óssea concentrada surge como uma alternativa ao tratamento padrão da tendinopatia glútea, provando ser uma técnica segura e com resultados promissores quando combinada à terapia comportamental de equipe multidisciplinar.
Ensaio ClÃnico Randomizado
Use of autologous bone marrow stem cell implantation for osteonecrosis of the knee in sickle cell disease: a preliminary report
Abstract Background The purpose of our study was to evaluate safety, feasibility and clinical results of bone marrow mononuclear cell (BMC) implantation for early-stage osteonecrosis of the knee (OK) secondary to sickle cell disease. Methods Thirty-three SCD patients (45 knees) with OK treated with BMC implantation in the osteonecrotic lesion were clinically and functionally evaluated through the American Knee Society Clinical Score (KSS), Knee Functional Score (KFS) and Numeric Rating Scale (NRS) pain score. MRI and radiographic examinations of the knee were assessed during a period of five years after intervention. Results No complications or serious adverse event were associated with BMC implantation. From preoperative assessment to the latest follow-up, there was a significant (p < 0.001) improvement of clinical KSS (64.3 ± 9.7, range: 45–80 and 2.2 ± 4.1, range: 84–100, respectively), KFS (44.5 ± 8.0, range: 30–55 and 91.6 ± 5.8, range: 80–100, respectively) and reduction of NRS pain score (6.7 ± 1.2, range: 4–9 and 3.4 ± 1.0, range: 2–5, respectively). In total, 87% of patients (29/33) consistently experienced improvements in joint function and activity level as compared to preoperative score. No patient had additional surgery following BMC implantation. Radiographic assessment showed joint preservation and no progression to subchondral collapse at most recent follow-up. Conclusions The technique of BMC implantation is a promising, relatively simple and safe procedure for OK in SCD patients. Larger and long-term controlled trials are needed to support its clinical effectiveness. Trial registration ClinicalTrials.gov NCT02448121. Retrospectively registered 19 May 2015
Need to move and maintain a good posture in elderly on surgery: quasi-experimental study
Objetivos: Identificar problemas em idosos cirúrgicos na necessidade de Movimentar-se e Manter uma Boa Postura; Avaliar o desfecho das intervenções para a necessidade nos grupos envolvidos no estudo. Métodos: Trata-se de uma pesquisa quantitativa, quase experimental, aplicada a 30 idosos em pós-operatório. Ao grupo experimento foram aplicadas intervenções baseadas na NIC. Resultados: Dentre os principais problemas identificados estiveram presentes as dores ao movimentar, diminuição da flexibilidade das articulações, restrição ao leito, déficit de equilÃbrio, diminuição da força e da resistência muscular. E ao comparar os resultados dos grupos, obteve-se Oddis Ratio 0R=2,66, ou seja, significativamente aponta fator de proteção ao grupo experimento. Conclusão: Houve melhora significativa no grupo experimento na redução dos problemas identificados quando comparado ao grupo controle. Descritores: Idoso, mobilidade, cuidado de enfermagem, enfermagem cirúrgica perioperatória
Hydro alcoholic extract of pequi peel (Caryocar brasiliense) in rats submitted to the application of doxorubicin
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Previous issue date: 2013-01O objetivo deste estudo foi avaliar o efeito
antioxidante do extrato hidroalcoolico da casca do pequi
(EHCP) em ratos após a administração de doxorrubicina
(DOX). Foram utilizados ratos da raça Wistar, distribuÃdos em
quatro grupos, sendo que os animais do G1 (n=6) receberam
água e solução salina (grupo controle), G2 (n=7) EHCP e
solução salina, G3 (n=7) água e DOX e G4 (n=6) EHCP e
DOX. O EHCP foi administrado por gavagem durante 10 dias
aos ratos dos grupos G2 e G4 e água aos dos G1 e G3. DOX na
dose de 10mg kg-1 e solução salina 0,9% foram administradas
por via intravenosa no dia sete após o inÃcio do experimento
aos animais de G3 e G4 e aos de G1 e G2, respectivamente.
Foram avaliados peso e taxa de mortalidade. Dez dias após o
inÃcio do experimento, foi avaliada a concentração sérica de
creatina quinase MB (CK-MB), troponina e mioglobina, e os
ratos foram submetidos à eutanásia e à avaliação
anatomopatológica. Não houve diferença entre os tratamentos
quanto ao peso dos animais (P 0,05). Com relação à taxa de
mortalidade, houve aumento no grupo 2 (P<0,05). Os
resultados do teste qualitativo para a detecção de CK-MB,
troponina I e mioglobina nos quatro grupos foram negativos
e não foram observadas alterações macroscópicas nos órgãos
dos ratos dos diferentes grupos. Constatou-se necrose tubular
aguda multifocal de intensidade moderada a acentuada nas
regiões cortical e medular nos rins de todos os ratos avaliados.
A DOX em dose única de 10mg kg-1 e via intravenosa não
promove alterações cardÃacas em ratos e o EHCP nas condições
avaliadas aumenta o Ãndice de mortalidade em ratos, o que
pode estar relacionado a substâncias tóxicas presentes na casca
desse fruto.The objective of this study was to evaluate the
antioxidant effect of the hydroalcoholic extract of pequi peel
(HEPP) in rats after administration of doxorubicin (DOX).
Were used 26 Wistar rats divided into four groups, which G1
(n=6) received water and saline solution (control group), G2
(n=7) HEPP and saline solution, G3 (n=7) water and DOX,
and G4 (n=6) HEPP and DOX. The HEPP was administered
by gavage for 10 days to G2 and G4 and water to G1 and G3.
DOX and saline solution were administered intravenously on
day seven after the start of the experiment, with the DOX (10mg
kg-1) applied in G3 and G4, and saline solution 0.9% in G1
and G2. Were evaluated weight and mortality rate. Ten days
after the start of the experiment were evaluated creatina kinase
MB (CK-MB), troponin and myoglobin, and the rats were
euthanized and evaluated morphologically. There was no
difference between treatments in weight of animals (P>0.05).
About the mortality rate an increase in group 2 was showed
(P<0.05). The results of the qualitative test for the detection of
CK-MB, troponin I and myoglobin in the four groups were
negative and there were no macroscopic changes in different
rat’s organs of different groups. Multifocal and moderate to
severe acute tubular necrosis in cortical and medullary regions
of the kidneys was observed in all rats studied. DOX intravenous
and in a one dose of 10mg kg-1 don’t induce cardiac changes
in rats and the HEPP in conditions here evaluated increase the
rate of mortality of rats, which may be related to toxic substances
in the peel of this fruit