Presence of e-EDCs in surface water and effluents of pollution sources in Sai Gon and Dong Nai river basin

© 2016 This study aimed to assess the presence of estrogenic endocrine disrupting compounds (e-EDCs) including estriol, bisphenol A (BPA), atrazine (ATZ), octylphenol, octylphenol diethoxylate, octylphenol triethoxylate, nonylphenol, Nonylphenol triethoxylate (NPE3), nonylphenol diethoxylate (NPE2) and 17β-estradiol in: (i) Sai Gon and Dong Nai river waters which have been major raw water sources for drinking water supply for Ho Chi Minh City (HCMC) and neighbouring provinces, and (ii) water pollution sources located in their catchment basin. NPE3 and NPE2 were detected in most of the surface water samples. Concentrations of NPE3 were in a range of less than 5.9–235 ng L−1, whereas BPA was detected at significantly high concentrations in the dry season in canals in HCMC. In the upstream of Sai Gon and Dong Nai Rivers, ATZ concentrations were observed at water intake of water treatment plants served for HCMC water supply system. Similarly, high potential risk of NPE2 and NPE3 contamination at Phu Cuong Bridge near Hoa Phu water intake was identified. The significant correlation between NPE2, dissolved organic carbon and total nitrogen was found. Estrogenic equivalent or estrogenic activity of Sai Gon and Dong Nai Rivers was lower than those of the previous studies. Compared with other studies, e-EDCs of pollution in Sai Gon river basin were relatively low

The cost-effectiveness of trivalent and quadrivalent influenza vaccination in communities in South Africa, Vietnam and Australia

BACKGROUND: To inform national healthcare authorities whether quadrivalent influenza vaccines (QIVs) provide better value for money than trivalent influenza vaccines (TIVs), we assessed the cost-effectiveness of TIV and QIV in low-and-middle income communities based in South Africa and Vietnam and contrasted these findings with those from a high-income community in Australia. METHODS: Individual based dynamic simulation models were interfaced with a health economic analysis model to estimate the cost-effectiveness of vaccinating 15% of the population with QIV or TIV in each community over the period 2003-2013. Vaccination was prioritized for HIV-infected individuals, before elderly aged 65+ years and young children. Country or region-specific data on influenza-strain circulation, clinical outcomes and costs were obtained from published sources. The societal perspective was used and outcomes were expressed in International$(I$) per quality-adjusted life-year (QALY) gained. RESULTS: When compared with TIV, we found that QIV would provide a greater reduction in influenza-related morbidity in communities in South Africa and Vietnam as compared with Australia. The incremental cost-effectiveness ratio of QIV versus TIV was estimated at I$4183/QALY in South Africa, I$1505/QALY in Vietnam and I$80,966/QALY in Australia. CONCLUSIONS: The cost-effectiveness of QIV varied between communities due to differences in influenza epidemiology, comorbidities, and unit costs. Whether TIV or QIV is the most cost-effective alternative heavily depends on influenza B burden among subpopulations targeted forvaccination in addition to country-specific willingness-to-pay thresholds and budgetary impact

Randomised pharmacokinetic trial of rifabutin with lopinavir/ritonavir-antiretroviral therapy in patients with HIV-associated tuberculosis in Vietnam.

BACKGROUND: Rifampicin and protease inhibitors are difficult to use concomitantly in patients with HIV-associated tuberculosis because of drug-drug interactions. Rifabutin has been proposed as an alternative rifamycin, but there is concern that the current recommended dose is suboptimal. The principal aim of this study was to compare bioavailability of two doses of rifabutin (150 mg three times per week and 150 mg daily) in patients with HIV-associated tuberculosis who initiated lopinavir/ritonavir-based antiretroviral therapy in Vietnam. Concentrations of lopinavir/ritonavir were also measured. METHODS: This was a randomized, open-label, multi-dose, two-arm, cross-over trial, conducted in Vietnamese adults with HIV-associated tuberculosis in Ho Chi Minh City (Clinical trial registry number NCT00651066). Rifabutin pharmacokinetics were evaluated before and after the introduction of lopinavir/ritonavir -based antiretroviral therapy using patient randomization lists. Serial rifabutin and 25-O-desacetyl rifabutin concentrations were measured during a dose interval after 2 weeks of rifabutin 300 mg daily, after 3 weeks of rifabutin 150 mg daily with lopinavir/ritonavir and after 3 weeks of rifabutin 150 mg three times per week with lopinavir/ritonavir. RESULTS: Sixteen and seventeen patients were respectively randomized to the two arms, and pharmacokinetic analysis carried out in 12 and 13 respectively. Rifabutin 150 mg daily with lopinavir/ritonavir was associated with a 32% mean increase in rifabutin average steady state concentration compared with rifabutin 300 mg alone. In contrast, the rifabutin average steady state concentration decreased by 44% when rifabutin was given at 150 mg three times per week with lopinavir/ritonavir. With both dosing regimens, 2 - 5 fold increases of the 25-O-desacetyl- rifabutin metabolite were observed when rifabutin was given with lopinavir/ritonavir compared with rifabutin alone. The different doses of rifabutin had no significant effect on lopinavir/ritonavir plasma concentrations. CONCLUSIONS: Based on these findings, rifabutin 150 mg daily may be preferred when co-administered with lopinavir/ritonavir in patients with HIV-associated tuberculosis. TRIAL REGISTRATION: ClinicalTrials.gov NCT00651066

The influence of human genetic variation on early transcriptional responses and protective immunity following immunization with Rotarix vaccine in infants in Ho Chi Minh City in Vietnam : a study protocol for an open single-arm interventional trial [awaiting peer review]

Background: Rotavirus (RoV) remains the leading cause of acute gastroenteritis in infants and children aged under five years in both high- and low-middle-income countries (LMICs). In LMICs, RoV infections are associated with substantial mortality. Two RoV vaccines (Rotarix and Rotateq) are widely available for use in infants, both of which have been shown to be highly efficacious in Europe and North America. However, for unknown reasons, these RoV vaccines have markedly lower efficacy in LMICs. We hypothesize that poor RoV vaccine efficacy across in certain regions may be associated with genetic heritability or gene expression in the human host. Methods/design: We designed an open-label single-arm interventional trial with the Rotarix RoV vaccine to identify genetic and transcriptomic markers associated with generating a protective immune response against RoV. Overall, 1,000 infants will be recruited prior to Expanded Program on Immunization (EPI) vaccinations at two months of age and vaccinated with oral Rotarix vaccine at two and three months, after which the infants will be followed-up for diarrheal disease until 18 months of age. Blood sampling for genetics, transcriptomics, and immunological analysis will be conducted before each Rotarix vaccination, 2-3 days post-vaccination, and at each follow-up visit (i.e. 6, 12 and 18 months of age). Stool samples will be collected during each diarrheal episode to identify RoV infection. The primary outcome will be Rotarix vaccine failure events (i.e. symptomatic RoV infection despite vaccination), secondary outcomes will be antibody responses and genotypic characterization of the infection virus in Rotarix failure events. Discussion: This study will be the largest and best powered study of its kind to be conducted to date in infants, and will be critical for our understanding of RoV immunity, human genetics in the Vietnam population, and mechanisms determining RoV vaccine-mediated protection. Registration: ClinicalTrials.gov, ID: NCT03587389. Registered on 16 July 2018

Formation of ionospheric irregularities over Southeast Asia during the 2015 St. Patrickˈs Day storm

We investigate the geospace response to the 2015 St. Patrickˈs Day storm leveraging on instruments spread over Southeast Asia (SEA), covering a wide longitudinal sector of the low-latitude ionosphere. A regional characterization of the storm is provided, identifying the peculiarities of ionospheric irregularity formation. The novelties of this work are the characterization in a broad longitudinal range and the methodology relying on the integration of data acquired by Global Navigation Satellite System (GNSS) receivers, magnetometers, ionosondes, and Swarm satellites. This work is a legacy of the project EquatoRial Ionosphere Characterization in Asia (ERICA). ERICA aimed to capture the features of both crests of the equatorial ionospheric anomaly (EIA) and trough (EIT) by means of a dedicated measurement campaign. The campaign lasted from March to October 2015 and was able to observe the ionospheric variability causing effects on radio systems, GNSS in particular. The multiinstrumental and multiparametric observations of the region enabled an in-depth investigation of the response to the largest geomagnetic storm of the current solar cycle in a region scarcely reported in literature. Our work discusses the comparison between northern and southern crests of the EIA in the SEA region. The observations recorded positive and negative ionospheric storms, spread F conditions, scintillation enhancement and inhibition, and total electron content variability. The ancillary information on the local magnetic field highlights the variety of ionospheric perturbations during the different storm phases. The combined use of ionospheric bottomside, topside, and integrated information points out how the storm affects the F layer altitude and the consequent enhancement/suppression of scintillations.Published12211–122331A. Geomagnetismo e Paleomagnetismo2A. Fisica dell'alta atmosfera1IT. Reti di monitoraggio e Osservazioni5IT. Osservazioni satellitariJCR Journalope

The use of reproductive healthcare at commune health stations in a changing health system in Vietnam

Background: With health sector reform in Vietnam moving towards greater pluralism, commune health stations (CHSs) have been subject to growing competition from private health services and increasing numbers of patients bypassing CHSs for higher-level health facilities. This study describes the pattern of reproductive health (RH) and family planning (FP) service utilization among women at CHSs and other health facilities, and explores socio demographic determinants of RH service utilization at the CHS level

Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

Dengue has become one of the most common viral diseases transmitted by infected mosquitoes (with any of the four dengue virus serotypes: DEN-1, -2, -3, or -4). It may present as asymptomatic or illness, ranging from mild to severe disease. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. The pathogenesis of DHF/DSS, however, is not yet completely understood. The immune response, virus virulence, and host genetic background are considered to be risk factors contributing to disease severity. Human leucocyte antigens (HLA) expressed on the cell surface function as antigen presenting molecules and those polymorphism can change individuals' immune response. We investigated the HLA-A, -B (class I), and -DRB1 (class II) polymorphism in Vietnamese children with different severity (DHF/DSS) by a hospital-based case-control study. The study showed persons carrying HLA-A*2402/03/10 are about 2 times more likely to have severe dengue infection than others. On the other hand, HLA-DRB1*0901 persons are less likely to develop DSS with DEN-2 virus infection. These results clearly demonstrated that HLA controlled the susceptibility to severe forms of DV infection

Invasive Non-typhoidal Salmonella Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam.

Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations of iNTS disease in Asia are not well documented. We retrospectively identified >100 cases of iNTS infections in an infectious disease hospital in Southern Vietnam between 2008 and 2013. Clinical records were accessed to evaluate demographic and clinical factors associated with iNTS infection and to identify risk factors associated with death. Multi-locus sequence typing and antimicrobial susceptibility testing was performed on all organisms. Of 102 iNTS patients, 71% were HIV-infected, >90% were adults, 71% were male and 33% reported intravenous drug use. Twenty-six/92 (28%) patients with a known outcome died; HIV infection was significantly associated with death (p = 0.039). S. Enteritidis (Sequence Types (ST)11) (48%, 43/89) and S. Typhimurium (ST19, 34 and 1544) (26%, 23/89) were the most commonly identified serovars; S. Typhimurium was significantly more common in HIV-infected individuals (p = 0.003). Isolates from HIV-infected patients were more likely to exhibit reduced susceptibility against trimethoprim-sulfamethoxazole than HIV-negative patients (p = 0.037). We conclude that iNTS disease is a severe infection in Vietnam with a high mortality rate. As in sub-Saharan Africa, HIV infection was a risk factor for death, with the majority of the burden in this population found in HIV-infected adult men

Correlation and high-resolution timing for Paleo-tethys Permian-Triassic boundary exposures in Vietnam and Slovenia using geochemical, geophysical and biostratigraphic data sets

Two Permian-Triassic boundary (PTB) successions, Lung Cam in Vietnam, and Lukač in Slovenia, have been sampled for high-resolution magnetic susceptibility, stable isotope and elemental chemistry, and biostratigraphic analyses. These successions are located on the eastern (Lung Cam section) and western margins (Lukač section) of the Paleo-Tethys Ocean during PTB time. Lung Cam, lying along the eastern margin of the Paleo-Tethys Ocean provides an excellent proxy for correlation back to the GSSP and out to other Paleo-Tethyan successions. This proxy is tested herein by correlating the Lung Cam section in Vietnam to the Lukač section in Slovenia, which was deposited along the western margin of the Paleo-Tethys Ocean during the PTB interval. It is shown herein that both the Lung Cam and Lukač sections can be correlated and exhibit similar characteristics through the PTB interval. Using time-series analysis of magnetic susceptibility data, high-resolution ages are obtained for both successions, thus allowing relative ages, relative to the PTB age at ~252 Ma, to be assigned. Evaluation of climate variability along the western and eastern margins of the Paleo-Tethys Ocean through the PTB interval, using d18O values indicates generally cooler climate in the west, below the PTB, changing to generally warmer climates above the boundary. A unique Black Carbon layer (elemental carbon present by agglutinated foraminifers in their test) below the boundary exhibits colder temperatures in the eastern and warmer temperatures in the western Paleo-Tethys Ocean.ReferencesBalsam W., Arimoto R., Ji J., Shen Z, 2007. Aeolian dust in sediment: a re-examination of methods for identification and dispersal assessed by diffuse reflectance spectrophotometry. International Journal of Environment and Health, 1, 374-402.Balsam W.L., Otto-Bliesner B.L., Deaton B.C., 1995. Modern and last glacial maximum eolian sedimentation patterns in the Atlantic Ocean interpreted from sediment iron oxide content. Paleoceanography, 10, 493-507.Berggren W.A., Kent D.V., Aubry M-P., Hardenbol J., 1995. Geochronology, Time Scales and Global Stratigraphic Correlation. SEPM Special Publication #54, Society for Sedimentary Geology, Tulsa, OK, 386p.Berger A., Loutre M.F., Laskar J., 1992. Stability of the astronomical frequencies over the Earth's history for paleoclimate studies. Science, 255, 560-566.Bloemendal J., deMenocal P., 1989. Evidence for a change in the periodicity of tropical climate cycles at 2.4 Myr from whole-core magnetic susceptibility measurements. Nature, 342, 897-900.Chen J., Shen S-j., Li X-h., Xu Y-g., Joachimski M.M., Bowring S.A., Erwin D.H., Yuan D-x., Chen B., Zhang H., Wang Y., Cao C-q, Zheng Q-f., Mu L., 2016. High-resolution SIMS oxygen isotope analysis on conodont apatite from South China and implications for the end-Permian mass extinction. Palaeogeography, Palaeoclimatology, Palaeoecology, 448, 26-38.Da Silva A-C., Boulvain F., 2002. Sedimentology, magnetic susceptibility and isotopes of a Middle Frasnian carbonate platform: Tailfer Section, Belgium. Facies, 46, 89-102.Da Silva A.-C., Boulvain F., 2005. Upper Devonian carbonate platform correlations and sea level variations recorded in magnetic susceptibility. Palaeogeography, Palaeoclimatology, Palaeoecology, 240, 373-388.Dettinger M.D., Ghil M., Strong C.M., Weibel W., Yiou P., 1995. Software expedites singular-spectrum analysis of noisy time series. EOS. Transactions of the American Geophysical Union, 76, 12-21.Dinarès-Turell J., Baceta J.I., Bernaola G., Orue-Etxebarria X., Pujalte V., 2007. Closing the Mid-Palaeocene gap: Toward a complete astronomically tuned Palaeocene Epoch and Selandian and Thanetian GSSPs at Zumaia (Basque Basin, W Pyrenees). Earth Planetary Science Letters, 262, 450-467.Ellwood B.B., García-Alcalde J.L., El Hassani A., Hladil J., Soto F.M., Truyóls-Massoni M., Weddige K., Koptikova L., 2006. Stratigraphy of the Middle Devonian Boundary: Formal Definition of the Susceptibility Magnetostratotype in Germany with comparisons to Sections in the Czech Republic, Morocco and Spain. Tectonophysics, 418, 31-49.Ellwood B.B., Wang W.-H., Tomkin J.H., Ratcliffe K.T., El Hassani A., Wright A.M., 2013. Testing high resolution magnetic susceptibility and gamma gradiation methods in the Cenomanian-Turonian (Upper Cretaceous) GSSP and near-by coeval section. Palaeogeography, Palaeoclimatology, Palaeoecology, 378, 75-90.Ellwood B.B., Wardlaw B.R., Nestell M.K., Nestell G.P., Luu Thi Phuong Lan, 2017. Identifying globally synchronous Permian-Triassic boundary levels in successions in China and Vietnam using Graphic Correlation. Palaeogeography, Palaeoclimatology, Palaeoecology, 485, 561-571.Ghil M., Allen R.M., Dettinger M.D., Ide K., Kondrashov D., Mann M.E., Robertson A., Saunders A., Tian Y., Varadi F., Yiou P., 2002. Advanced spectral methods for climatic time series. Reviews of Geophysics, 40, 3.1-3.41. http://dx.doi.org/10.1029/2000RG000092.Gradstein F.M., Ogg J.G., Smith A.G., 2004. A geologic Time Scale 2004. Cambridge University Press, England, 589p.Hartl P., Tauxe L., Herbert T., 1995. Earliest Oligocene increase in South Atlantic productivity as interpreted from “rock magnetics” at Deep Sea drilling Site 522. Paleoceanography, 10, 311-326.Imbrie J., Hays J.D., Martinson D.G., McIntyre A., Mix A.C., Morley J.J., Pisias N.G., Prell W.L., Shackleton N.J., 1984. The Orbital Theory of Pleistocene Climate: Support from a Revised Chronology of the Marine Delta 18O Record. In Berger A.L., Imbrie J., Hays J., Kukla G., Saltzman B. (Eds.), Milankovitch and Climate, Part I, Kluwer Academic Publishers, 269-305.Mead G.A., Yauxe L., LaBrecque J.L., 1986. Oligocene paleoceanography of the South Atlantic: paleoclimate implications of sediment accumulation rates and magnetic susceptibility. Paleoceanography, 1, 273-284.Salvador A., (Ed.), 1994. International Stratigraphic Guide: The International Union of Geological Sciences and The Geological Society of America, Inc., 2nd Edition, 214p.Scotese C.R., 2001. Atlas of Earth History, Volume 1, Paleogeography, PALEOMAP Project, Arlington, Texas, 52p.Scotese C.R., 2013. Map Folio 49, Permo-Triassic Boundary (251 Ma), PALEOMAP PaleoAtlas for ArcGIS, Triassic and Jurassic Paleogeographic, Paleoclimatic and Plate Tectonic Reconstructions, PALEOMAP Project, Evanston, IL, 3.Shackleton N.J., Crowhurst S.J., Weedon G.P., Laskar J., 1999. Astronomical calibration of Oligocene-Miocene time. Philosophical Transactions of the Royal Society London, A357, 1907-1929.Shaw A.B., 1964. Time in Stratigraphy. New York, Mc Graw Hill, 365p.Shen S.-Z., Crowley J.L., Wang Y., Bowring S.A., Erwin D.H., Henderson C.M., Ramezani J., Zhang H., Shen Y.,Wang X.-D., Wang W., Mu L., Li W.-Z., Tang Y.-G., Liu X.-L., Liu X.-L., Zeng Y., Jiang Y.-F., Jin Y.-G., 2011a. High-precision geochronologic dating constrains probable causes of Earth’s largest mass extinction. Science, 334, 1367-1372. Doi:10.1126/science.1213454.Swartzendruber L.J., 1992. Properties, units and constants in magnetism. Journal of Magnetic Materials, 100, 573-575.Weedon G.P., Jenkyns H.C., Coe A.L., Hesselbo S.P., 1999. Astronomical calibration of the Jurassic time-scale from cyclostratigraphy in British mudrock formations. Philosophical Transactions of the Royal Society London, A357, 1787-1813.Weedon G.P., Shackleton N.J., Pearson P.N., 1997. The Oligocne time scale and cyclostratigraphy on the Ceara Rise, western equatorial Atlantic. In: Schackleton N.J., Curry W.B., Richter C., and Bralower T.J. (Eds.). Proceedings of the Ocean Drilling Program, Scientific Results, 154, 101-114.Whalen M.T., Day J.E., 2008. Magnetic Susceptibility, Biostratigraphy, and Sequence Stratigraphy: Insights into Devonian Carbonate Platform Development and Basin Infilling, Western Alberta. Papers on Phanerozoic Reef Carbonates in Honor of Wolfgang Schlager. SEPM (Society for Sedimentary Geology) Special Publication, 89, 291-314