Perturbations of Dark Solitons

A method for approximating dark soliton solutions of the nonlinear Schrodinger equation under the influence of perturbations is presented. The problem is broken into an inner region, where core of the soliton resides, and an outer region, which evolves independently of the soliton. It is shown that a shelf develops around the soliton which propagates with speed determined by the background intensity. Integral relations obtained from the conservation laws of the nonlinear Schrodinger equation are used to approximate the shape of the shelf. The analysis is developed for both constant and slowly evolving backgrounds. A number of problems are investigated including linear and nonlinear damping type perturbations

Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method

Direct infusion nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry (DI nESI FT-ICR MS)offers high mass accuracy and resolution for analyzing complex metabolite mixtures. High dynamic range across a wide mass range, however, can only be achieved at the expense of mass accuracy, since the large numbers of ions entering the ICR detector induce adverse spacecharge effects. Here we report an optimized strategy for wide-scan DI nESI FT-ICR MS that increases dynamic range but maintains high mass accuracy. It comprises the collection if multiple adjacent selected ion monitoring (SIM) windows that are stitched together using novel algorithms. The final SIM-stitching method, derived from several optimization experiments, comprises 21 adjoining SIM windows each of width m/z 30 (from m/z 70 to 500; adjacent windows overlap by m/z 10) with an automated gain control (AGC) target of 1 105 charges. SIMstitching and wide-scan range (WSR; Thermo Electron)were compared using a defined standard to assess mass accuracy and a liver extract to assess peak count and dynamic range. SIM-stitching decreased the maximum mass error by 1.3- and 4.3-fold, and increased the peak count by 5.3- and 1.8-fold, versus WSR (AGC targets of 1 x 105 and 5 x 105, respectively). SIM-stitching achieved an rms mass error of 0.18 ppm and detected over 3000 peaks in liver extract. This novel approach increases metabolome coverage, has very high mass accuracy, and at 5.5 min/sample is conducive for high- throughput metabolomics

From far-field to near-field micro- and nanoparticle optical trapping

Optical tweezers is a very well-established technique that has developed into a standard tool for trapping and manipulating micron and submicron particles with great success in the last decades. Although the nature of light enforces restrictions on the minimum particle size that can be efficiently trapped due to Abbe's diffraction limit, scientists have managed to overcome this problem by engineering new devices that exploit near-field effects. Nowadays, metallic nanostructures can be fabricated which, under laser illumination, produce a secondary plasmonic field that does not suffer from the diffraction limit. This advance offers a great improvement in nanoparticle trapping, as it relaxes the trapping requirements compared to conventional optical tweezers. In this work, we review the fundamentals of conventional optical tweezers, the so-called plasmonic tweezers, and related phenomena. Starting from the conception of the idea by Arthur Ashkin until recent improvements and applications, we present some of the challenges faced by these techniques as well as their future perspectives. Emphasis in this review is on the successive improvements of the techniques and the innovative aspects that have been devised to overcome some of the main challenges.Comment: 15 pages, 10 figure

Bridging Dimensions: General Embedding Algorithm and Field-Theory Reconstruction in 5D Braneworld Models

We develop a general algorithm that enables the consistent embedding of any four-dimensional static and spherically symmetric geometry into any five-dimensional single-brane braneworld model, characterized by an injective and nonsingular warp factor. Furthermore, we supplement the algorithm by introducing a method that allows one to, in principle, reconstruct 5D field theories that support the aforementioned geometries. This approach is based on a conformal transformation of the metric with the conformal factor being identified with the warp factor of the bulk geometry. The reconstructed theories depend solely on the induced brane geometry, since the warp factor is model-independently represented by a scalar field in the Lagrangian density. As a first application of our reconstruction method, we present for the first time a complete theory that supports the five-dimensional brane-localized extension of the Schwarzschild black hole, for any warp factor. The same method is subsequently utilized to illustrate the process of coherently embedding a de Sitter brane in braneworld models.Comment: 5 pages, 1 figur

Enabling self-induced back-action trapping of gold nanoparticles in metamaterial plasmonic tweezers

The pursuit for efficient nanoparticle trapping with low powers has led to optical tweezers technology moving from the conventional free-space configuration to advanced plasmonic tweezers systems. However, trapping nanoparticles smaller than 10 nm still remains a challenge even for plasmonic tweezers. Proper nanocavity design and excitation has given rise to the self-induced back-action (SIBA) effect offering enhanced trapping stiffness with decreased laser power. In this work, we investigate the SIBA effect in metamaterial tweezers and its synergy with the exhibited Fano resonance. We demonstrate stable trapping of 20 nm gold particles for on-resonant and off-resonant conditions with experimental trap stiffnesses as high as 4.18 fN/(nm*mW/$\mu$m$^2$ and very low excitation intensity of about 1 mW/$\mu$m$^2$. Simulations reveal the existence of two different groups of hotspots per unit cell of the metamaterial array. The two hotspots exhibit tunable trap stiffnesses and this is a unique feature of these systems. It can allow for sorting of particles and biological molecules based on their size, shape, and refractive index.Comment: 27 pages, 10 figure

Fiber Optic Projection-Imaging System for Shape Measurement in Confined Space

A fiber-based projection-imaging system is proposed for shape measurement in confined space. Owing to the flexibility of imaging fibers, the system can be used in special scenarios that are difficult for conventional experimental setups. Three experiments: open space, closed space, and underwater are designed to demonstrate the strength and weakness of the system. It is shown that when proper alignment is possible, relatively high accuracy can be achieved; the error is less than 2% of the overall height of a specimen. In situations where alignment is difficult, significantly increased error is observed. The error is in the form of gross-scale geometrical distortion; for example, flat surface is reconstructed with curvature. In addition, the imaging fibers may introduce fine-scale noise into phase measurement, which has to be suppressed by smoothing filters. Based on results and analysis, it is found that although a fiber-based system has its unique strength, existing calibration and processing methods for fringe patterns have to be modified to overcome its drawbacks so as to accommodate wider applications

Bimodal pumice populations in the 13.5 Ma Harsány ignimbrite, Bükkalja Volcanic Field, Northern Hungary: Syn-eruptive mingling of distinct rhyolitic magma batches?

Abstract The 13.5 Ma Harsány ignimbrite, in the eastern part of the Bükkalja volcanic field, eastern-central Europe, provides a rare example of mingled rhyolite. It consists of two distinct pumice populations (‘A’- and ‘B’-type) that can be recognized only by detailed geochemical work. The pumice and the host ignimbrite have a similar mineral assemblage involving quartz, plagioclase, biotite and sporadic Kfeldspar. Zircon, allanite, apatite and ilmenite occur as accessory minerals. The distinct pumice types are recognized by their different trace element compositions and the different CaO contents of their groundmass glasses. Plagioclase has an overlapping composition; however, biotite shows bimodal composition. Based on trace element and major element modeling, a derivation of ‘A’-type rhyolite magma from the ‘B’-type magma by fractional crystallization is excluded. Thus, the two pumice types represent two isolated rhyolite magma batches, possibly residing in the same crystal mush. Coeval remobilization of the felsic magmas might be initiated by intrusion of hot basaltic magma into the silicic magma reservoir The rapid ascent of the foaming rhyolite magmas enabled only a short-lived interaction and thus, a syn-eruptive mingling between the two magma batches

Modern Medical Ethics and the Legacy of Hippocrates

The most enduring guideline for medical ethics in the history of medicine is the Hippocratic Oath. Four of the six core values currently recognized in medical ethics (beneficence, non-maleficence, justice, and confidentiality), are in accordance with ideas codified in the Hippocratic Oath or in the Hippocrates work, in general. With the passing of the years, however, new ethics created by the society added new values, such as autonomy and respect, to values proposed by Hippocrates. On the other hand, certain social ethics, predominating in various countries, are in marked contrast to Hippocratic principles. The most significant of them are the issues of aid in suicide and of abortion. Regardless the rules of conduct prevailing in a given society, the primary task of a physician is to provide competent medical care, with compassion and respect for human dignity and rights, a principle in accordance with the Hippocratic motto “επ’ ωφελείη καμνόντων” ("for the benefit of patients")

Hippocrates and the essence of evidence based medicine

oai:ojs.pkp.sfu.ca:article/

The interactions between municipal socioeconomic status and age on hip fracture risk

The final publication is available at Springer via http://dx.doi.org/10.1007/s00198-014-2869-0SUMMARY: Age modifies the effect of area-level socioeconomic status (SES) in the risk of fragility hip fractures (HF). For older individuals, the risk of HF increases as SES increases. For younger individuals, risk of HF increases as SES decreases. Our study may help decision-makers to better direct the implementation of political decisions. INTRODUCTION: The effect of socioeconomic status (SES) on hip fracture (HF) incidence remains unclear. The objective of this study is to evaluate the association between HF incidence and municipality-level SES as well as interactions between age and SES. METHODS: From the Portuguese Hospital Discharge Database, we selected hospitalizations (2000-2010) of patients aged 50+, with HF diagnosis (codes 820.x, ICD9-CM), caused by traumas of low/moderate energy, excluding bone cancer cases and readmissions for aftercare. Municipalities were classified according to SES (deprived to affluent) using 2001 Census data. A spatial Bayesian hierarchical regression model (controlling for data heterogeneity and spatial autocorrelation), using the Poisson distribution, was used to quantify the relative risk (RR) of HF, 95% credible interval (95%CrI), and analyze the interaction between age and SES after adjusting for rural conditions. RESULTS: There were 96,905 HF, 77.3% of which were on women who, on average, were older than men (mean age 81.2±8.5 vs 78.2±10.1 years) at admission (p<0.001). In women, there was a lower risk associated with better SES: RR=0.83 (95%CrI 0.65-1.00) for affluent versus deprived. There was an inverse association between SES and HF incidence rate in the youngest and a direct association in the oldest, for both sexes, but significant only between deprived and affluent in older ages (≥75 years). CONCLUSIONS: Interaction between SES and age may be due to inequalities in lifestyles, access to health systems, and preventive actions. These results may help decision-makers to better understand the epidemiology of hip fractures and to better direct the available funding.Programa Operacional Factores de Competitividade (COMPETE)Fundação para a Ciência e a Tecnologia (FCT