42 research outputs found
The limb darkening of alpha Cen B: Matching 3D hydrodynamical models with interferometric measurements
Get PDFFor the nearby dwarf star alpha Cen B (K1 V), we present limb darkening
predictions from a 3D hydro-dynamical radiative transfer model of its
atmosphere. We first compare the results of this model to a standard Kurucz's
atmosphere. Then we use both predictions to fit the new interferometric
visibility measurements of alpha Cen B obtained with the VINCI instrument of
the VLT Interferometer. Part of these new visibility measurements were obtained
in the second lobe of the visibility function, that is sensitive to stellar
limb darkening. The best agreement is found for the 3D atmosphere limb
darkening model and a limb darkened angular diameter of theta\_3D =
6.000+-0.021 mas, corresponding to a linear radius of 0.863+-0:003Ro (assuming
pi = 747.1+-1.2 mas). Ournew linear radius is in good agreement with the
asteroseismic value predicted by Thevenin et al. (2002). In view of future
observations of this star with the VLTI/AMBER instrument, we also present limb
darkening predictions in the J, H and K bands.Comment: Accepted for publication in Astronomy & Astrophysic
Targeted acidosis mediated delivery of antigenic MHC-binding peptides
Get PDFCytotoxic T lymphocytes are the primary effector immune cells responsible for protection against cancer, as they target peptide neoantigens presented through the major histocompatibility complex (MHC) on cancer cells, leading to cell death. Targeting peptide-MHC (pMHC) complex offers a promising strategy for immunotherapy due to their specificity and effectiveness against cancer. In this work, we exploit the acidic tumor micro-environment to selectively deliver antigenic peptides to cancer using pH(low) insertion peptides (pHLIP). We demonstrated the delivery of MHC binding peptides directly to the cytoplasm of melanoma cells resulted in the presentation of antigenic peptides on MHC, and activation of T cells. This work highlights the potential of pHLIP as a vehicle for the targeted delivery of antigenic peptides and its presentation via MHC-bound complexes on cancer cell surface for activation of T cells with implications for enhancing anti-cancer immunotherapy
