Supernova Explosions in the Early Universe: Evolution of Radiative Remnants and the Halo Destruction Efficiency

We study the evolution of supernova (SN) remnants of the first stars, taking proper account of the radiative feedback of the progenitor stars on the surroundings. We carry out a series of one-dimensional hydrodynamic simulations with radiative cooling, starting from initial configurations that are drawn from the results of our earlier radiation hydrodynamic simulations of the first HII regions. In low-mass (< 10^6 M_sun) halos, the stellar radiation significantly reduces the ambient gas density prior to the SN explosion. The blastwave quickly propagates over the halo's virial radius, leading to complete evacuation of the gas even with the input energy of 10^50 erg. We find that a large fraction of the remnant's thermal energy is lost in 0.1-10 Myr by line cooling, whereas, for larger explosion energies, the remnant expands even more rapidly with decreasing interior density, and cools predominantly via inverse Compton process. In higher mass halos, the gas density near the explosion site remains high and the SN shock is heavily confined; the thermal energy of the remnant is quickly radiated away by free-free emission, even if the total input energy exceeds the binding energy of halos by two orders of magnitude. We show that the efficiency of halo destruction is determined not only by the explosion energy but also by the gas density profile, and thus controlled by radiative feedback prior to the explosion. Several implications of our results for the formation of first quasars and second-generation stars in the universe are also discussed.Comment: 13 pages, 11 embedded figures. Accepted for publication in Ap

Systematic Errors in the Hubble Constant Measurement from the Sunyaev-Zel'dovich effect

The Hubble constant estimated from the combined analysis of the Sunyaev-Zel'dovich effect and X-ray observations of galaxy clusters is systematically lower than those from other methods by 10-15 percent. We examine the origin of the systematic underestimate using an analytic model of the intracluster medium (ICM), and compare the prediction with idealistic triaxial models and with clusters extracted from cosmological hydrodynamical simulations. We identify three important sources for the systematic errors; density and temperature inhomogeneities in the ICM, departures from isothermality, and asphericity. In particular, the combination of the first two leads to the systematic underestimate of the ICM spectroscopic temperature relative to its emission-weighed one. We find that these three systematics well reproduce both the observed bias and the intrinsic dispersions of the Hubble constant estimated from the Sunyaev-Zel'dovich effect.Comment: 26 pages, 7 figures, accepted for publication in ApJ, Minor change

Variations of the cephalic vein anterior to the clavicle in humans

Background: Clinicians should understand that jugulocephalic vein (JCV) variants may be occasionally found. This study aims to classify JCV variants and obtain their frequency.   Materials and methods: We investigated anatomical variants of the cephalic vein in 55 human cadavers during a gross anatomy course at our medical school.   Results: The percentage of JCVs that pass through the anterior part of the clavicle and anastomose to the jugular vein as per previous studies and our study was 2–5%. Five cases with anastomosis between the cephalic and external jugular veins that pass through the anterior part of the clavicle were found. The courses were classified into 1A, 1B, 2A, and 2B. Type 1 extends beyond the clavicle and anastomoses with the external jugular vein. Type 2 follows the same course as type 1, but anastomoses with the subclavian vein. Subtype A does not have a branch that anastomoses with the axillary vein, whereas subtype B does. We encountered two cases of type 1A and three of type 1B.   Conclusions: Four anatomical variants of the cephalic vein around the clavicle were identified. Clinicians’ knowledge of these variants is expected to decrease possible complications if venous access via the cephalic vein is needed

Submillimeter detection of the Sunyaev -- Zel'dovich effect toward the most luminous X-ray cluster at z=0.45

We report on the detection of the Sunyaev -- Zel'dovich (SZ) signals toward the most luminous X-ray cluster RXJ1347-1145 at Nobeyama Radio Observatory (21 and 43 GHz) and at James Clerk Maxwell Telescope (350 GHz). In particular the latter is the first successful detection of the SZ temperature increment in the submillimeter band which resolved the profile of a cluster of galaxies. Both the observed spectral dependence and the radial profile of the SZ signals are fully consistent with those expected from the X-ray observation of the cluster. The combined analysis of 21GHz and 350GHz data reproduces the temperature and core-radius of the cluster determined with the ROSAT and ASCA satellites when we adopt the slope of the density profile from the X-ray observations. Therefore our present data provide the strongest and most convincing case for the detection of the submillimeter SZ signal from the cluster, as well as in the Rayleigh -- Jeans regime. We also discuss briefly the cosmological implications of the present results.Comment: 11 pages, The Astrophysical Journal (Letters), in pres

Formation of Sub-galactic Clouds under UV Background Radiation

The effects of the UV background radiation on the formation of sub-galactic clouds are studied by means of one-dimensional hydrodynamical simulations. The radiative transfer of the ionizing photons due to the absorption by HI, HeI and HeII, neglecting the emission, is explicitly taken into account. We find that the complete suppression of collapse occurs for the clouds with circular velocities typically in the range V_c \sim 15-40 km/s and the 50% reduction in the cooled gas mass with V_c \sim 20-55 km/s. These values depend most sensitively on the collapse epoch of the cloud, the shape of the UV spectrum, and the evolution of the UV intensity. Compared to the optically thin case, previously investigated by Thoul & Weinberg (1996), the absorption of the external UV photon by the intervening medium systematically lowers the above threshold values by \Delta V_c \sim 5 km/s. Whether the gas can contract or keeps expanding is roughly determined by the balance between the gravitational force and the thermal pressure gradient when it is maximally exposed to the external UV flux. Based on our simulation results, we discuss a number of implications on galaxy formation, cosmic star formation history, and the observations of quasar absorption lines. In Appendix, we derive analytical formulae for the photoionization coefficients and heating rates, which incorporate the frequency/direction-dependent transfer of external photons.Comment: 38 pages, 16 figures, accepted for publication in Ap

Common and separate origins of the left and right inferior phrenic artery with a review of the literature

In a 94-year-old male cadaver, upon which routine dissection was being conducted, a rare variation was found in the gastrophrenic trunk (GPT), the common trunk of the left gastric artery (LGA), right inferior phrenic artery (RIPA), and left inferior phrenic artery (LIPA); the GPT arises from the abdominal aorta. A hepatosplenic trunk accompanied the variation. In this variation, the RIPA first branched from the GPT and then to the LIPA and LGA. Variations in the common trunk of the LIPA and RIPA in the GPT are common, but to our knowledge, a variation (separate inferior phrenic artery in the GPT) similar to our findings has not been previously reported. We discuss the incidence and developmental and clinical significance of this variation with a detailed review of the literature. Knowledge of such a case has important clinical significance for invasive and non-invasive arterial procedures. Therefore, different variations concerning the LGA and inferior phrenic artery should be considered during surgical and non-surgical evaluations

Liquid Water Cloud Measurements Using the Raman Lidar Technique: Current Understanding and Future Research Needs

This paper describes recent work in the Raman lidar liquid water cloud measurement technique. The range-resolved spectral measurements at the National Aeronautics and Space Administration Goddard Space Flight Center indicate that the Raman backscattering spectra measured in and below low clouds agree well with theoretical spectra for vapor and liquid water. The calibration coefficients of the liquid water measurement for the Raman lidar at the Atmospheric Radiation Measurement Program Southern Great Plains site of the U.S. Department of Energy were determined by comparison with the liquid water path (LWP) obtained with Atmospheric Emitted Radiance Interferometer (AERI) and the liquid water content (LWC) obtained with the millimeter wavelength cloud radar and water vapor radiometer (MMCR-WVR) together. These comparisons were used to estimate the Raman liquid water cross-sectional value. The results indicate a bias consistent with an effective liquid water Raman cross-sectional value that is 28%-46% lower than published, which may be explained by the fact that the difference in the detectors' sensitivity has not been accounted for. The LWP of a thin altostratus cloud showed good qualitative agreement between lidar retrievals and AERI. However, the overall ensemble of comparisons of LWP showed considerable scatter, possibly because of the different fields of view of the instruments, the 350-m distance between the instruments, and the horizontal inhomogeneity of the clouds. The LWC profiles for a thick stratus cloud showed agreement between lidar retrievals andMMCR-WVR between the cloud base and 150m above that where the optical depth was less than 3. Areas requiring further research in this technique are discussed

A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation

Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in the cytoplasm during S phase in a variety of cancer cells. This is mediated by phosphorylation at Thr286 through the activity of the Ras/Raf/MEK/ERK cascade and the F-box protein FBXW8, which is an E3 ligase. The majority of FBXW8 is expressed in the cytoplasm during G1 and S phase. In contrast, cyclin D1 accumulates in the nucleus during G1 phase and exits into the cytoplasm in S phase. Increased cyclin D1 degradation is linked to association with FBXW8 in the cytoplasm, and enhanced phosphorylation of cyclin D1 through sustained ERK1/2 signaling. Depletion of FBXW8 caused a significant accumulation of cyclin D1, as well as sequestration of CDK1 in the cytoplasm. This resulted in a severe reduction of cell proliferation. These effects could be rescued by constitutive nuclear expression of cyclin D1-T286A. Thus, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1. It may present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT activation confers a poor prognosis. However, the functional significance of deregulated WNT signalling in gastric homoeostasis and cancer is still unclear. In this study we have addressed this by investigating the immediate effects of WNT signalling activation within the stomach epithelium. We have specifically activated the WNT signalling pathway within the mouse adult gastric epithelium via deletion of either glycogen synthase kinase 3 (GSK3) or APC or via expression of a constitutively active β-catenin protein. WNT pathway deregulation dramatically affects stomach homoeostasis at very short latencies. In the corpus, there is rapid loss of parietal cells with fundic gland polyp (FGP) formation and adenomatous change, which are similar to those observed in familial adenomatous polyposis. In the antrum, adenomas occur from 4 days post-WNT activation. Taken together, these data show a pivotal role for WNT signalling in gastric homoeostasis, FGP formation and adenomagenesis. Loss of the parietal cell population and corresponding FGP formation, an early event in gastric carcinogenesis, as well as antral adenoma formation are immediate effects of nuclear β-catenin translocation and WNT target gene expression. Furthermore, our inducible murine model will permit a better understanding of the molecular changes required to drive tumourigenesis in the stomach