Kaempferol treatment ameliorates memory impairments in STZ-induced neurodegeneration by acting on reelin signaling

Many treatment initiatives, like herbal products and their active ingredients, aim to alleviate neurodegeneration to increase cognitive functions. Kaempferol may be a candidate molecule for treating neurodegeneration because of its antioxidant effects. In the present study, we examined the molecular changes associated with kaempferol’s memory-enhancing effects on streptozotocin (STZ)-induced neurodegeneration. After intracerebroventricular STZ injection in Long-Evans male rats, intraperitoneal kaempferol was administered for 12 days. The Morris water maze (MWM) was used to measure learning and memory performance in the rats, and proteins related to memory formation were investigated in the hippocampi with western blotting. Kaempferol improved learning performance and memory decline in STZ-treated rats. At the molecular level, STZ-induced neurodegeneration resulted in a decrease in the expression of GAD67, reelin, and phosphorylated-NMDAR. However, kaempferol treatment ameliorated these changes by enhancing their levels similar to the controls. While neither STZ injection nor kaempferol treatment produced any significant change in phosphorylated-CAMKII levels, they increased the expression of klotho and prealbumin. These results show that kaempferol has positive effects on memory loss, affecting synaptic plasticity by ameliorating both the levels and activity of memory-relevant molecules through reelin signaling. In summary, this study provides a guide to future studies by examining in detail the healing effect of kaempferol as a candidate molecule in the treatment of neurodegeneration, such as that observed in Alzheimer’s disease

LIMPRINT study - the Turkish experience

Background: Lymphedema and chronic oedema is a major healthcare problem in both developed and non-developed countries The LIMPRINT study is an international health service based study to determine the prevalence and functional impact in adult populations of member countries of the International Lymphoedema Framework (ILF). Methods: 1051 patients from 8 centers in Turkey were recruited using the LIMPRINT study protocol. Data were collected using the core and module tools which assess the demographic and clinical properties as well as disability and QoL. Results: Most of the Turkish patients were recruited from specialist lymphedema services and were found to be female, housewives and having secondary lymphedema due to cancer treatment. The duration of lymphedema was commonly less than 5 years and most of them had ISL Grade 2 lymphedema. Cellulitis, infection and wounds were uncommon. The majority of patients did not get any treatment or advice before. Most of the patients had impaired QoL and decreased functionality, but psychological support was neglected. Although most had social health security access to Lymphedema centres nevertheless access seemed difficult due to distance and cost. Conclusion: The study has shown the current status and characteristics of lymphedema patients, treatment conditions, the unmet need for the diagnosis and treatment as well as burden of the disease in both patients and families in Turkey. National health policies are needed for the prevention, diagnosis and treatment in Turkey that utilise this informative data

Effects of apricot kernel meal on performance parameters and intestinal microbiota in broiler diets

Bu çalısmada etlik piliçlerde kayısı çekirdegi küspesi kullanımının performans üzerine etkileri, etin vitamin E içerigi ve bagırsak mikrobiyotası saptanmıstır. 120 adet etlik piliçler birbirine komsu olan tel kafeslerde beslenmislerdir. Deneme 21 gün sürmüstür. Denemede, farklı seviyelerde ( % 0, 5, 10, 20) kayısı çekirdegi küspesi kullanımının etkileri arastırılmıstır. %20 oranında kayısı çekirdegi küspesi verilen grupta canlı agırlık artısı %0 ve %5 oranında kayısı çekirdegi küspesi verilenlerden önemli sekilde daha yüksek bulunmustur. Buna ragmen; %0, 5 ve 10 oranlarında kayısı çekirdegi küspesi ile beslenen grup, %20 oranında kayısı çekirdegi ile beslenenlere göre daha az miktarda yem tüketmislerdir. leum mikrobiyotası muamelelerden önemli ölçüde etkilenmistir. leuma ait içeriklerin laktik asit bakteri sayımları incelendiginde, %10 oranında kayısı çekirdegi küspesi ile beslenen gruplar için diger gruplardan önemli sekilde daha düsük oldugu saptanmıstır. Çalısmada, kayısı çekirdegi küspesi ilavesinin, alfa-tokoferol içerigini arttırdıgı görülmüstür.This study was carried out to determine the effects of apricot kernel meal (AKM) on performance, vitamin E content of meat and intestinal microbiota in broiler chickens. One hundred twenty broiler chickens raised in contiguous wire cages were used. The duration of the experiment was 21 days. In the trial, four diets containing different levels of AKM (0, 5, 10, and 20%) were utilized as the treatments. Birds given the 20% AKM diets from 1 to 21 days had significantly better body weight gain than those given the 0 and 5% AKM diets. However, birds fed the 0, 5 and 10% AKM diets consumed significantly less feed intake than did those fed the 20% AKM diet. Ileum microbiota were significantly affected by dietary treatment. Respective counts of lactic acid bacteria in the ileal contents, for the 10% AKM fed groups were significantly lower than those of the other groups. Supplementation of AKM increased the alpha- tocopherol content in the all examined products

A case of pediatric neuroboreliosis presenting with psychiatric symptoms

Research on the role of inflammation and initiating pathogens in psychiatric diseases has been increasing in recent years. Borrelia burgdorferi infection is transmitted to animals and humans with Ixodes group hard ticks. Borrelia burgdorferi bacteria cause Lyme Disease (LD). There are over 250 peer-reviewed scientific articles addressing the causal relationship between tick-borne diseases and mental disorders. Infection with LD has been associated with various psychiatric conditions. Studies show that many psychiatric disorders are seen in LD, including schizophrenia, bipolar disorder, panic attack, major depression, anorexia nervosa and obsessive compulsive disorder. It is important to identify infectious agents and associated inflammatory and immunological factors in treatment-resistant mental disorders. More research is needed, especially in the child and adolescent population. In these case report the relationship between borrelia burgdorferi infection and psychotic symptoms in a child who presented to the emergency department with restlessness, agitation and psychotic symptoms is discussed. © 2020, Cukurova University, Faculty of Medicine. All rights reserved

EFFECTS OF APRICOT KERNEL MEAL ON PERFORMANCE PARAMETERS AND INTESTINAL MICROBIOTA IN BROILER DIETS

Bu çalışmada etlik piliçlerde kayısı çekirdeği küspesi kullanımının performans üzerine etkileri, etin vitamin E içeriği ve bağırsak mikrobiyotası saptanmıştır. 120 adet etlik piliçler birbirine komşu olan tel kafeslerde beslenmişlerdir. Deneme 21 gün sürmüştür. Denemede, farklı seviyelerde ( % 0, 5, 10, 20) kayısı çekirdeği küspesi kullanımının etkileri araştırılmıştır. %20 oranında kayısı çekirdeği küspesi verilen grupta canlı ağırlık artışı %0 ve %5 oranında kayısı çekirdeği küspesi verilenlerden önemli şekilde daha yüksek bulunmuştur. Buna rağmen; %0, 5 ve 10 oranlarında kayısı çekirdeği küspesi ile beslenen grup, %20 oranında kayısı çekirdeği ile beslenenlere göre daha az miktarda yem tüketmişlerdir. İleum mikrobiyotası muamelelerden önemli ölçüde etkilenmiştir. İleuma ait içeriklerin laktik asit bakteri sayımları incelendiğinde, %10 oranında kayısı çekirdeği küspesi ile beslenen gruplar için diğer gruplardan önemli şekilde daha düşük olduğu saptanmıştır. Çalışmada, kayısı çekirdeği küspesi ilavesinin, alfa-tokoferol içeriğini arttırdığı görülmüştür.This study was carried out to determine the effects of apricot kernel meal (AKM) on performance, vitamin E content of meat and intestinal microbiota in broiler chickens. One hundred twenty broiler chickens raised in contiguous wire cages were used. The duration of the experiment was 21 days. In the trial, four diets containing different levels of AKM (0, 5, 10, and 20%) were utilized as the treatments. Birds given the 20% AKM diets from 1 to 21 days had significantly better body weight gain than those given the 0 and 5% AKM diets. However, birds fed the 0, 5 and 10% AKM diets consumed significantly less feed intake than did those fed the 20% AKM diet. Ileum microbiota were significantly affected by dietary treatment. Respective counts of lactic acid bacteria in the ileal contents, for the 10% AKM fed groups were significantly lower than those of the other groups. Supplementation of AKM increased the alpha- tocopherol content in the all examined products

Tip 1 diabetes mellituslu çocuklarda kaygı ve depresyon sıklığı ve bunların metabolik kontrole etkisi

Objective: Chronic diseases affect the quality of life negatively. Parents’ mental problems and their coping methods, may play a role on the behavior of children and adolescents. The aim of the study is to determine the anxiety and depression status of children and adolescents with type 1 DM, and to investigate their relationship with metabolic control. Methods: Forty-three patients between 6 and 17 years old with type 1 DM were included in this prospective study. Metabolic and clinical data of cases were retrospectively collected. Questionnaire forms were used for demographic data. Individual and family interviews were made by pediatric and adult psychiatrist. State-Trait Anxiety Inventory (STAI), Child Depression Inventory (CDI) and Beck Depression Scale (BDS) were used to determine depression and anxiety rates. Results: Depression was detected in 2.3 %, state anxiety in 23.2 % and trait anxiety in 25.5 % of the children with type 1 DM. Mild depression was detected in 24.4 %, moderate depression was detected in 6.9 % of mothers. There was a state anxiety in 7.3 %, trait anxiety in 11.6 % of the mothers. There was a significant correlation between the depression, STAI scores of mothers and children. It was found that an increase in depression scale point of child, affected trait anxiety score of mother (OR: 1.2, CI: 1.01-1.49), (p=0.02). Conclusion: Mental health condition is usually unnoticed in daily practice while monitoring T1 DM. Validated and efficient strategies are needed to screen and treat anxiety and depression symptoms in children and adolescents with T1 DM. © 2020, Istanbul Universitesi. All rights reserved

Assessing clinicians' views: The development of the Bakirkoy Clinician Stance Questionnaire

Objective: Although there is a wide range of theoretical perspectives and clinical practices, there is no assessment tool that reveals these variations among clinicians. In this study, we presented the development process of a new measure for clinicians that assess their psychological flexibility levels, attitudes towards psychotherapy and inclination to the mechanistic approach. Method: Participants included 167 psychiatrists and psychiatry residents from all over Turkey. They completed 29 items intended to form the basis for the Bakirkoy Clinician's Attitude Questionnaire (BCSQ). Item-total correlation and Cronbach's alpha correlation analyses were performed to determine internal consistency. The Acceptance and Action Questionnaire-II (AAQ-II) and the Mental Illness: Clinicians' Attitude Scale V.4 (MICA v4) were used to assess the convergent and concurrent validity of BCSQ. Results: Principal component analyses with varimax rotation were conducted to ensure construct validity and to explore subdimensions. Finally, a three-dimensional version (Clinical inflexibility, Treatment preference, Mechanistic approach) of the scale with 20 items was created. The BCSQ demonstrated good internal consistency (Cronbach's alpha coefficient was 0.82) and transient stability. Convergent validity analyses showed that BCSQ subscales have significant relationships with higher psychological inflexibility and stigmatization levels. Conclusion: BCSQ proves to be a valuable tool for assessing changes in the level of psychological flexibility of clinicians in clinical practice, their attitudes towards psychotherapy/psychopharmacology and their view of psychopathology

Etlik Piliçlerde Kayısı Küspesinin Performansa ve Bağırsak Mikrobiyotasi Üzerine Etkileri

Yürütülen bu çalışma ile kayısı çekirdeği küspesinin (KÇK) etlik piliç performansı ve bağırsak mikrobiyotası üzerine etkilerinin ortaya konulması amaçlanmıştır. Denemede, tel kafeslerde yetiştirilen yüz yirmi adet etlik piliç kullanılmıştır. Deneme 21 gün sürmüştür. Çalışmada, farklı düzeylerde KÇK (kontrol, %5, %10 ve %20) içeren dört muamele bulunmaktadır. Kayısı çekirdeği küspesini %0 ve 5 tüketenlere göre, %20 tüketen gruplarda daha iyi canlı ağırlık artışı görülmüştür. Bununla birlikte, %0, 5 ve 10 KÇK içeren rasyonlarla beslenen hayvanlar, %20 KÇK tüketen gruplara göre daha az yem tüketmiştir. İleum mikrobiyotası da muamelelerden önemli derecede etkilenmiştir. %10 KÇK içeren rasyonu tüketen grupların ileal içerikteki laktik asit bakteri sayıları, diğer gruplara göre önemli derecede daha düşük bulunmuştur. Bununla birlikte, maya ve koliform sayıları %10 KÇK tüketen gruplarda en yüksek saptanmıştır.Söz konusu yan ürün kanatlı beslemede alternatif bir protein kaynağı olarak kullanılabilir. Bununla birlikte KÇK nın kanatlı rasyonlarında kullanılmasıyla ilgili daha fazla çalışmaya gereksinim vardır.This study was carried out to determine the effects of apricot kernel meal (AKM) on performance and intestinal microbiota in broiler chickens. One hundred twenty broiler chickens raised in contiguous wire cages were used. The duration of the experiment was 21 days. In the trial, four diets containing different levels of AKM (control, 5, 10, and 20%) were utilized as the treatments. Birds given the 20% AKM diets from 1 to 21 days had significantly better body weight gain than those given the 0 and 5% AKM diets. However, birds fed the 0, 5 and 10% AKM diets consumed significantly less feed intake than did those fed the 20% AKM diet. Also, ileum microbiota was significantly affected by dietary treatment. Respective counts of lactic acid bacteria in the ileal contents, for the 10% AKM fed groups were found significantly lower than those of the other groups. Although, yeast and coliform counts were determined the highest in the 10% AKM fed groups. This by-product might be an alternative protein source in poultry nutrition. Further works are required to test their suitability in poultry diets

The relationship between coping styles, depressive symptom levels and caregiver burden in caregivers of children with disability

Engelli çocukların ailelerinin bakım verme durumuna uyumda güçlük yaşayabildikleri ve bakım yükü olarak adlandırılan bu durumun başa çıkma tutumları ile ilişkili olabileceği bildirilmiştir. Çalışmamızda engelli çocukların bakımverenlerinde başa çıkma tutumlarının bakım yükü ve depresyon düzeyleriyle ilişkisinin araştırılması amaçlanmıştır. Araştırmaya 1 Mart 2018 – 1 Mayıs 2018 tarihleri arasında özel bir bakım merkezinde ayaktan takipleri devam etmekte olan engelli çocukların bakımverenlerinden oluşan 84 birey dahil edilmiştir. Katılımcılara sosyo-demografik veri formu, Zarit Bakım Yük Ölçeği (ZBYÖ), Beck Depresyon Ölçeği (BDÖ), Fonksiyonel Olmayan Tutumlar Ölçeği (FOTÖ-A), Ruminatif Düşünme Biçimi Ölçeği (RDBÖ) ve Başa Çıkma Tutumlarını Değerlendirme Ölçeği (COPE) uygulanmıştır. Verilerin analizinde Pearson korelasyon analizi ve aşamalı çoklu doğrusal regresyon analizi kullanılmıştır. Pearson Korelasyon Analizi uygulanarak saptanan sonuçlara göre RDBÖ ile BDÖ (r=0,290), FOTÖ (r=0,242) ve COPE alt ölçek puanları arasında istatistiksel olarak anlamlı düzeyde pozitif yönlü düşük korelasyon saptanırken; ZBYÖ ile BDÖ (r=0,338) ve FOTÖ (r=0,235) ölçek puanları arasında yine istatistiksel olarak anlamlı düzeyde pozitif yönlü düşük korelasyon bulunmuştur. Yapılan aşamalı çoklu doğrusal regresyon analizi sonucunda ise BDÖ toplam puanı ve eğitim ayının ZBYÖ toplam puanı üzerine pozitif yönde yordayıcı etkisi olduğu, FOTÖ-A, RDBÖ ve COPE alt ölçek toplam puanlarının ise ZBYÖ puanları üzerinde anlamlı yordayıcı etkisi olmadığı görülmüştür. Bakım yükü şiddetinin genel ruminatif düşünme biçimi ile işlevsel olmayan tutumlar ve ara inançlar tarafından yordanmadığını gösteren bulgularımız dikkate alındığında; bakım yükü üzerinde bilişsel süreçlerden ziyade davranışsal başa çıkma yöntemlerinin etkili olduğu ileri sürülebilir. Bakım veren bireylerde kaçınma davranışlarını hedef alan müdahalelerin kullanılması yaşam kalitesini arttırmada etkili olabilir.Parents of children with disabilities may have difficulty in adapting to the caregiving situation and this situation, called caregiver burden, has been reported to be related to coping styles. In our study, it was aimed to investigate the relationship between caregiver burden, depression levels and coping styles in caregivers of children with disability. 84 caregivers of children with disability who applied to special care center were included into the study between 1 March 2018 and 1 May 2018. Sociodemographic data form, Zarit Caregiver Burden Interview (ZBI), Beck Depression Inventory (BDI), Dysfunctional Attitudes Scale (DAS-A), Ruminative Thought Style Questionnaire (RTSQ) and COPE Inventory were applied to the participants. Pearson correlation analysis and multiple linear regression analysis were used to analyze the data. According to Pearson Correlation Analysis, while a statistically significant positive correlation was found between RTSQ and BDI (r=0.290), DAS-A (r=0.242) and COPE subscale scores; there was also a statistically significant low positive correlation between ZBI and BDI (r=0.338) and DAS-A (r=0.235). As a result of the multiple linear regression analysis, the BDI total score and the training duration had a positive predictive effect on the total score of ZBI while the total score of the DAS-A, RTSQ, and COPE subscales did not have a significant predictive effect on ZBI. Considering our findings shows that the caregiver burden levels are not predicted by general ruminative thinking and dysfunctional attitudes and intermediate beliefs; it can be said that behavioral coping methods are more effective than cognitive processes on caregiver burden. Interventions targeting avoidance behaviors in may be more effective in improving the quality of life in caregivers