Organizational, regulatory and legal aspects оf european integration of higher medical education in Ukraine: a critical review

The aim: The main purpose of this research is to conduct the theoretical and applied study of the legal profile enforcement for state attestation of medical graduates, the relevant legislative system, and its effectiveness; to identify the issues of special legislative requirements, as well as the search for ways to resolve it. Materials and methods: Basic methods: analysis, synthesis and comparison. Object of research: system of state certification of graduates of medical sciences. Investigation of this topic in the paper is carried out in the following logical sequence: firstly, the basic principles of the state integrated qualification exam were determined and analyzed; then the legal enforcement for integrated state qualification exam of master’s degree in discipline “22 Health Care” was considered. Also, a critical review of Ukrainian normative base for holding the state attestation of medical graduates was conducted. Conclusions: In view of foregoing, we can make a conclusion that in the modern globalization world, competition of national educational services should be ensured by a range of different activities: legal, organizational, financial, etc. The legal direction, domestic rules should correspond to similar, uniform rules and practices of the most effective state (regional, international) systems

Classification of regional ionospheric disturbance based on machine learning techniques

In this study, Total Electron Content (TEC) estimated from GPS receivers is used to model the regional and local variability that differs from global activity along with solar and geomagnetic indices. For the automated classification of regional disturbances, a classification technique based on a robust machine learning technique that have found wide spread use, Support Vector Machine (SVM) is proposed. Performance of developed classification technique is demonstrated for midlatitude ionosphere over Anatolia using TEC estimates generated from GPS data provided by Turkish National Permanent GPS Network (TNPGN-Active) for solar maximum year of 2011. As a result of implementing developed classification technique to Global Ionospheric Map (GIM) TEC data, which is provided by the NASA Jet Propulsion Laboratory (JPL), it is shown that SVM can be a suitable learning method to detect anomalies in TEC variations

Avaliação de basidiomicetos do gênero Ganoderma quanto ao potencial de síntese de enzimas lignocelulolíticas.

Seção: Derivados Energéticos de Alto Valor Agregado

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in vivo tumours. Above the 3-8% oxygen concentration typical of most tissues, we find that cancer cells depend on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1. Mammary or subcutaneous tumours grow despite suppression of NFS1, whereas metastatic or primary lung tumours do not. Consistent with a role in surviving the high oxygen environment of incipient lung tumours, NFS1 lies in a region of genomic amplification present in lung adenocarcinoma and is most highly expressed in well-differentiated adenocarcinomas. NFS1 activity is particularly important for maintaining the iron-sulfur co-factors present in multiple cell-essential proteins upon exposure to oxygen compared to other forms of oxidative damage. Furthermore, insufficient iron-sulfur cluster maintenance robustly activates the iron-starvation response and, in combination with inhibition of glutathione biosynthesis, triggers ferroptosis, a non-apoptotic form of cell death. Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis in vitro and slow tumour growth. Therefore, lung adenocarcinomas select for expression of a pathway that confers resistance to high oxygen tension and protects cells from undergoing ferroptosis in response to oxidative damage

Uso de substrato alternativo na produção de celulose bacteriana.

SIAN. 17 e 18 de junho de 2019. Pôster. R021