Particle acceleration in sub-cycle optical cells

A single laser pulse with spot size smaller than half its wavelength ($w_0 < \lambda/2$) can provide a net energy gain to ultra-relativistic particles. In this paper, we discuss the properties of an optical cell consisting of $N$ sub-cycle pulses that propagate in the direction perpendicular to the electron motion. We show that the energy gain produced by the cell is proportional to $N$ and it is sizable even for $\mathcal{O}(1\mathrm{~TW})$ pulses.Comment: 13 pages, 7 figures. Version to appear in PRSTA

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Post-traumatic stress disorder and comorbid depression in a West African population

Despite the established relationship between Post-Traumatic Stress Disorder (PTSD) and depression in Western cultures, research concerning the prevalence rates and relationship between the comorbid disorders in Non-Western communities remains sparse. The present study explored the relationship between PTSD and comorbid depression in citizens currently living in Ghana, West Africa. Ghanaian Nationals (n=140) completed the PTSD and demographic sections of the Structured Clinical Interview for the DSM-IV (SCID-I), as well as the Center for Epidemiological Studies Depression Scale (CES-D). Both measures were administered through interview format. Results revealed a lower prevalence rate of PTSD than expected. Further analysis demonstrated that meeting the diagnostic criteria for PTSD increased the chance of meeting the diagnostic criteria for depression, as well as increased depression scores. To confirm that the prevalence rates found in this study were reflective of actual cases of depression (not measurement error) a scale reliability analysis was conducted on the CES-D. The results of this analysis confirmed internal consistency. Results suggest that although the prevalence rate of PTSD was low, a relationship is present between the disorders in a non-Western sample. The reliability of the measures means that PTSD and depression were assessed for, but what is not certain is whether the actual construct of the disorders could occur differently in a non-Western sample, causing a different presentation of symptoms. Future research is needed to examine the Western construct of PTSD and depression to determine if there is a different presentation of symptoms not accounted for by Western measures.Department of Psychological ScienceThesis (M.A.

Pacemaker Prevention Therapy in Drug–refractory Paroxysmal Atrial Fibrillation: Reliability of Diagnostics and Effectiveness of Prevention Pacing Therapy in Vitatron™ Selection® device

Introduction. Atrial fibrillation (AF), the most common and rising disorder of cardiac rhythm, is quite difficult to control and/or to treat. Non pharmacological therapies for AF may involve the use of dedicated pacing algorithms to detect and prevent atrial arrhythmia that could be a trigger for AF onset. Selection 900E/AF2.0 Vitatron DDDRP pacemaker (1) keeps an atrial arrhythmia diary thus providing detailed onset reports of arrhythmias of interest, (2) provides us data about the number of premature atrial contractions (PACs) and (3) plots heart rate in the 5 minutes preceding the detection of an atrial arrhythmia. Moreover, this device applies four dedicated pacing therapies to reduce the incidence of atrial arrhythmia and AF events. Aim of the Study. To analyze the reliability to record atrial arrhythmias and evaluate effectiveness of its AF preventive pacing therapies. Material and Methods. We enrolled 15 patients (9 males and 6 females, mean age of 71±5 years, NYHA class I–II), with a DDDRP pacemaker implanted for a “bradycardia–tachycardia” syndrome, with advanced atrioventricular conduction disturbances. We compared the number and duration of AF episodes’ stored in the device with a contemporaneous 24h Holter monitoring. After that, we switched on the atrial arrhythmias detecting algorithms, starting from an atrial rate over 180 beats per minute for at least 6 ventricular cycles, and ending with at least 10 ventricular cycles in sinus rhythm. Thereafter, in order to evaluate the possible reduction in PACs number and in number and duration of AF episodes, we tailored all the four pacing preventive algorithms. Patients were followed for 24±8 months (from 20 to 32 months). Results. All 59 atrial arrhythmia episodes occurred in the first part of this trial, were correctly recorded by both systems, with a correlation coefficient (r) of 0.96. During the follow–up, we observed a significant reduction not only in PACs number (from 83±12/day to 2.3±0.8/day) but also in AF episodes (from 46±7/day to 0.12±0.03/day) and AF burden (from 93%±6% to 0.3%±0.06%). An increase in atrial pacing percentages (from 3%±0.5% to 97%±3%) was also contemporaneously observed. Conclusion. In this pacemaker, detection of atrial arrhythmia episodes is highly reliable, thus making available an appropriate monitoring of heart rhythm, mainly suitable in AF asymptomatic patients. Moreover, the significant reduction of atrial arrhythmia episodes indicates that this might represent a suitable therapeutic option for an effective preventive therapy of AF in paced brady–tachy patients

Large Momenta Fluctuations Of Charm Quarks In The Quark-Gluon Plasma

We show that large fluctuations of D mesons kinetic energy (or momentum) distributions might be a signature of a phase transition to the quark gluon plasma (QGP). In particular, a jump in the variance of the momenta or kinetic energy, as a function of a control parameter (temperature or Fermi energy at finite baryon densities) might be a signature for a first order phase transition to the QGP. This behaviour is completely consistent with the order parameter defined for a system of interacting quarks at zero temperature and finite baryon densities which shows a jump in correspondance to a first order phase transition to the QGP. The $J/\Psi$ shows exactly the same behavior of the order parameter and of the variance of the D mesons. We discuss implications for relativistic heavy ion collisions within the framework of a transport model and possible hints for experimental data.Comment: 4 pages 3 figure