Teoría de la educación : educación y cultura en la sociedad de la información

Monográfico con el título: 'Educación matemática y tecnologías de la información'. Resumen basado en el de la publicaciónLa difusión de Internet, junto con la evolución que ha experimentado el software estadístico y matemático, ofrecen nuevas formas de enseñar, aprender y aplicar conceptos y técnicas cuantitativas en ámbitos como el informático y el de las telecomunicaciones. En este contexto se presenta el proyecto e-Math del Internet Interdisciplinary Institute (IN3), en el que participan profesores de la Universitat Oberta de Catalunya (UOC) y otras universidades de ámbito estatal. Este proyecto tiene por finalidad fomentar y difundir la utilización e integración de las herramientas tecnológicas actuales en los currículos de asignaturas cuantitativas aplicadas. Al mismo tiempo se muestran también experiencias que, siguiendo las líneas metodológicas propuestas en e-Math, se han llevado a cabo en la UOC; en ellas se ha apostado por un uso intensivo de los recursos que Internet ofrece y también por la utilización de software matemático y estadístico como parte integral de los currículos formativos.Castilla y LeónES

Uso e integración de las TIC en asignaturas cuantitativas aplicadas: la experiencia de los estudios de informática y multimedia de la UOC

La difusión de Internet, junto con la evolución que ha experimentado el software estadístico y matemático, nos ofrecen nuevas formas de enseñar, aprender y aplicar conceptos y técnicas cuantitativas en ámbitos como el informático y el de las telecomunicaciones.En este artículo presentamos el proyecto e-Math del Internet Interdisciplinary Institute (IN3), en el cual participan profesores de la Universitat Oberta de Catalunya (UOC) y otras universidades de ámbito estatal. Este proyecto tiene por finalidad fomentar y difundir la utilización e integración de las herramientas tecnológicas actuales en los currículos de asignaturas cuantitativas aplicadas.En el artículo se muestran también experiencias que, siguiendo las líneas metodológicas propuestas en e-Math, se han llevado a cabo en la UOC; en ellas se ha apostado por un uso intensivo de los recursos que Internet ofrece y también por la utilización de software matemático y estadístico como parte integral de los currículos formativos.Internet diffusion, together with the evolution that has experienced the statistical and mathematical software, offer us new ways of teaching, learning and applying concepts and quantitative technologies in areas as computer sciences and telecommunications.In this paper we present the e-Math project, supported by the Internet Interdisciplinary Institute (IN3), in which professors from the Open University of Catalonia (UOC) and other Spanish universities have collaborated. The main target of this project is to foment and spread the utilization and integration of software tools in the curricula of quantitative applied subjects.Some experiences are also presented. They illustrate the methodological lines proposed in the e-Math project, which have derived in an intensive use of Internet resources and also in the utilization of mathematical and statistical software as an integral part of the formative curricula

Application of liquid biopsies in metastatic gastrointestinal cancer to identify candidate therapeutic targets

Producción CientíficaBackground:Next-generation sequencing (NGS) of cell-free tumor DNA (ctDNA) hasgreat potential for liquid biopsy in cancer diagnostics and to identify patients withactionable genomic alteration. This study, a prospective longitudinal study, focused ina cohort of metastatic cancer patients without standard effective active antineoplasticmedical treatment options to establish the rate of patients with actionable genomicalteration and the rate of patients accessing medical treatment. The final objective wasto determine the clinical performance based on non-invasive tumor sequencing.Methods:We collected plasma of 10 metastatic gastrointestinal patients with knownstatus of the RAS genes and microsatellites instability in tumor tissue. CtDNA wasextracted from plasma and genomic alterations were analyzed by Guardant 360(Guardant Health, Biosequence, OncoDNA), a next generation sequencing panel. Thispanel consists of 73 cancer related genes and is able to identify different types ofgenomic alterations. Informed consent was obtained from all patients.Results:We were able to identify 78 somatic mutations in total resulting in a mediannumber of eight somatic mutations per patient. The most common altered genes arewell known tumor suppressor and oncogenes like TP53, APC, KRAS, MYC andEGFR.At least one actionable alteration in plasma cfDNA were detected in eight from the 10patients (80%) but the proportion of patients for which a genomic identified recom-mended therapy was available to effectively initiate the treatment were only 37,5%(3/8). In these patients, the identification of alterations like c-MET amplification,FGFR1 amplification or PIK3CA c.1633G>A (p.E545K) mutation, involved inclinically actionable pathways, allowed the selection of a specific therapy. For the rest ofcases the main causes of non-access to medical treatment associated with a specificmutation were, among others, the advanced pre-treated patient and clinical triallogistical access difficulties.Conclusions:Our findings confirm the percentage of cases with potentially druggableaberrations is similar to other studies using this strategy and emphasizes their clinicalvalue to identify candidate therapeutic target

Application of liquid biopsies in metastatic gastrointestinal cancer to identify candidate therapeutic targets

[Background]: Next-generation sequencing (NGS) of cell-free tumor DNA (ctDNA) has great potential for liquid biopsy in cancer diagnostics and to identify patients with actionable genomic alteration. This study, a prospective longitudinal study, focused in a cohort of metastatic cancer patients without standard effective active antineoplastic medical treatment options to establish the rate of patients with actionable genomic alteration and the rate of patients accessing medical treatment. The final objective was to determine the clinical performance based on non-invasive tumor sequencing.[Methods]: We collected plasma of 10 metastatic gastrointestinal patients with known status of the RAS genes and microsatellites instability in tumor tissue. CtDNA was extracted from plasma and genomic alterations were analyzed by Guardant 360 (Guardant Health, Biosequence, OncoDNA), a next generation sequencing panel. This panel consists of 73 cancer related genes and is able to identify different types of genomic alterations. Informed consent was obtained from all patients.[Results]: We were able to identify 78 somatic mutations in total resulting in a median number of eight somatic mutations per patient. The most common altered genes are well known tumor suppressor and oncogenes like TP53, APC, KRAS, MYC andEGFR. At least one actionable alteration in plasma cfDNA were detected in eight from the 10 patients (80%) but the proportion of patients for which a genomic identified recommended therapy was available to effectively initiate the treatment were only 37,5% (3/8). In these patients, the identification of alterations like c-MET amplification, FGFR1 amplification or PIK3CA c.1633G>A (p.E545K) mutation, involved in clinically actionable pathways, allowed the selection of a specific therapy. For the rest of cases the main causes of non-access to medical treatment associated with a specific mutation were, among others, the advanced pre-treated patient and clinical trial logistical access difficulties.[Conclusions]: Our findings confirm the percentage of cases with potentially druggable aberrations is similar to other studies using this strategy and emphasizes their clinical value to identify candidate therapeutic targets