Ultraviolet Three Axis Attitude Sensor

It is becoming increasingly obvious that satellite bus technologies, which have been developed for traditional larger satellite platforms, are not always suitable for use with smallsats. This is due to the intrinsic limitations in size, weight, available power, and cost associated with the latter. The problem is particularly obvious for attitude reference sensors of both the earth and star viewing type. In response to the lack of suitable sensors for this purpose, Honeywell is developing a system that determines three axis attitude through ultraviolet imaging of the earth\u27s limb and adjacent stars. A non-conventional wide angle optics assembly and intensified CCD array are utilized for this purpose. Because of the intrinsic stability of the features being observed and the large number of pixels on which the scene is imaged, it should be possible to obtain accuracies on the order of .05 degrees with a very small and lightweight sensor configuration

Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity.

Inflammation attenuates gap junction (GJ) communication in cultured astrocytes. Here we used a well-characterized model of experimental brain abscess as a tool to query effects of the CNS inflammatory milieu on astrocyte GJ communication and electrophysiological properties. Whole-cell patch-clamp recordings were performed on green fluorescent protein (GFP)-positive astrocytes in acute brain slices from glial fibrillary acidic protein-GFP mice at 3 or 7 d after Staphylococcus aureus infection in the striatum. Astrocyte GJ communication was significantly attenuated in regions immediately surrounding the abscess margins and progressively increased to levels typical of uninfected brain with increasing distance from the abscess proper. Conversely, astrocytes bordering the abscess demonstrated hemichannel activity as evident by enhanced ethidium bromide (EtBr) uptake that could be blocked by several pharmacological inhibitors, including the connexin 43 (Cx43) mimetic peptide Gap26, carbenoxolone, the pannexin1 (Panx1) mimetic peptide (10)Panx1, and probenecid. However, hemichannel opening was transient with astrocytic EtBr uptake observed near the abscess at day 3 but not day 7 after infection. The region-dependent pattern of hemichannel activity at day 3 directly correlated with increases in Cx43, Cx30, Panx1, and glutamate transporter expression (glial L-glutamate transporter and L-glutamate/L-aspartate transporter) along the abscess margins. Changes in astrocyte resting membrane potential and input conductance correlated with the observed changes in GJ communication and hemichannel activity. Collectively, these findings indicate that astrocyte coupling and electrical properties are most dramatically affected near the primary inflammatory site and reveal an opposing relationship between the open states of GJ channels versus hemichannels during acute infection. This relationship may extend to other CNS diseases typified with an inflammatory component

Study protocol for the Anesthesiology Control Tower—Feedback Alerts to Supplement Treatments (ACTFAST-3) trial: A pilot randomized controlled trial in intraoperative telemedicine [version 1; referees: 2 approved]

Background: Each year, over 300 million people undergo surgical procedures worldwide. Despite efforts to improve outcomes, postoperative morbidity and mortality are common. Many patients experience complications as a result of either medical error or failure to adhere to established clinical practice guidelines. This protocol describes a clinical trial comparing a telemedicine-based decision support system, the Anesthesiology Control Tower (ACT), with enhanced standard intraoperative care. Methods: This study is a pragmatic, comparative effectiveness trial that will randomize approximately 12,000 adult surgical patients on an operating room (OR) level to a control or to an intervention group. All OR clinicians will have access to decision support software within the OR as a part of enhanced standard intraoperative care. The ACT will monitor patients in both groups and will provide additional support to the clinicians assigned to intervention ORs. Primary outcomes include blood glucose management and temperature management. Secondary outcomes will include surrogate, clinical, and economic outcomes, such as incidence of intraoperative hypotension, postoperative respiratory compromise, acute kidney injury, delirium, and volatile anesthetic utilization. Ethics and dissemination: The ACTFAST-3 study has been approved by the Human Resource Protection Office (HRPO) at Washington University in St. Louis and is registered at clinicaltrials.gov (NCT02830126). Recruitment for this protocol began in April 2017 and will end in December 2018. Dissemination of the findings of this study will occur via presentations at academic conferences, journal publications, and educational materials

Stress e coping académico: Contributos para a adaptação da escala MMC

Este estudo enquadra-se na investigação do coping perante dificuldades associadas ao quotidiano escolar. Utilizando entrevistas a 30 alunos, o estudo (1) identificou as principais situações geradoras de stress, reconhecendo a importância relativa do stress académico na vida dos alunos, e (2) analisou a validade cultural para o contexto português das situações stressantes usadas na escala Multidimensional Measure of Coping (MMC), avaliando as perceções dos alunos quanto ao nível de stress induzido e controlo percebido relativamente a essas situações. Os resultados confirmaram a importância da escola enquanto fonte significativa de stress, e a adequação da MMC ao contexto português

Auszug aus der Richtlinie des Akademischen Senats für die Vergabe der Bruno Snell-Plakette für beispielhaftes Wirken in Wissenschaft und Gesellschaft vom 12. Juni 1997

Dieser Band vereint Reden, die anlässlich der Verleihung der Bruno Snell-Plakette an den Historiker Prof. Fritz Stern gehalten wurden.This volume brings together speeches made on the occasion of the presentation of the Bruno Snell plaque to the historian Prof. Fritz Stern

Dating of Archaeological Gold by Means of Solid State Electrochemistry

This is the peer reviewed version of the following article: Doménech Carbó, Antonio, Scholz, Fritz , Domenech Carbo, Mª Teresa, Piquero-Cilla, Juan , Montoya, Noemí, Pasies -Oviedo, Trinidad, Gozalbes, Manuel , Melchor Montserrat, José Manuel , Oliver, Arturo . (2018). Dating of Archaeological Gold by Means of Solid State Electrochemistry.ChemElectroChem, 5, 15, 2113-2117. DOI: 10.1002/celc.201800435 , which has been published in final form at http://doi.org/10.1002/celc.201800435. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving[EN] In archaeology and history of art, age determination is a fundamental analytical problem. While several techniques for age determination of various materials, like radiocarbon dating, are established, these methods cannot be applied for metals, for which new techniques have to be developed. For the first time a dating method for archaeological gold objects is described which is based on a corrosion clock and electrochemical measurements, using the voltammetry of immobilized particles. Samples are prepared by one touch' with a graphite pencil, only transferring a few nanograms of the archaeological gold. The method has been calibrated with the help of a series of well-documented gold specimen from different prehistory museums covering the last 2600years. Our results prove that this corrosion clock is going on a constant pace, practically independent of the environment, making it most attractive for applications in archaeometry.Projects CTQ2014-53736-C3-1-P and CTQ2014-53736-C3-2-P, which are supported with Ministerio de Economia, Industria y Competitividad (MINECO) and Fondo Europeo de Desarrollo Regional (ERDF) funds, as well as project CTQ2017-85317-C2-1-P supported with funds from, MINECO, ERDF and Agencia Estatal de Investigacion (AEI) are gratefully acknowledged. The authors also wish to thank Dr. Jose Luis Moya Lopez, Mrs. Alicia Nuez Inbernon and Mr. Manuel Planes Insausti (Microscopy Service of the Universitat Politecnica de Valencia) and M. Teresa Minguez and Clara Yebenes (Seccion de Microscopia del SCSIE, Universitat deValencia) for technical support.Doménech Carbó, A.; Scholz, F.; Domenech Carbo, MT.; Piquero-Cilla, J.; Montoya, N.; Pasies -Oviedo, T.; Gozalbes, M.... (2018). Dating of Archaeological Gold by Means of Solid State Electrochemistry. ChemElectroChem. 5(15):2113-2117. https://doi.org/10.1002/celc.201800435S2113211751