Effect of care standard consciousness on cognitive stress levels of home caretakers

Orientador: Pedro Jose Steiner NetoMonografia(Especialização) - Universidade Federal do Paraná,Setor de Ciências Sociais Aplicadas, Curso de Especialização em Gestão EmpresarialResumo: Este trabalho tem o objetivo de apresentar e avaliar a comunicação empresarial interna da agência Bacacheri, um ponto de venda (PV) da empresa Caixa Econômica Federal (CEF). O trabalho foi divido em 3 principais partes: na primeira parte foi realizada uma recapitulação teórica do conceito de comunicação empresarial e a sua utilização como ferramenta de gestão e motivação; seguida da apresentação da Caixa Econômica, em especial da agência Bacacheri e seus instrumentos de comunicação interna utilizados; e finalizando com a apresentação de algumas considerações dos funcionários da agência acerca do tema

Knowledge of Criteria for Brain Death and Attitudes towards Organ Donation and Transplantation of Nursing Professionals in Tottori Prefecture, Japan

The nursing professional population in Tottori Prefecture, Japan, was studied for their knowledge of criteria towards brain death and their attitudes towards organ donation and organ transplantation. An attempt was also made to clarify factors involved in issues concerning organ donation and organ transplantation. We distributed 2200 questionnaires to 9 hospitals, and obtained 1879 responses, of which 1683 were valid. The rate of nursing professionals holding donor cards to all respondents was 384/1683 (22.8%). The length of nursing service showed no difference in improvement of awareness of brain death. Longer length of service tended to produce a negative attitude in nurses towards donating their own organs in both brain death and cardiac death. Subjects who were willing to donate organs to others in cardiac death were also willing to do so in brain death. We provided some general suggestions for improving education about organ transplantation in Japan, such as commencing provisions for education regarding organ donation and organ transplantation in junior high school due to ethical issues. To more clearly identify the barriers against the improvement of the situation surrounding organ transplantation, research needs to be cumulated for nursing professionals

pH-Sensitive Amphiphilic Diblock Polyphosphoesters with Lactate Units: Synthesis and Application as Drug Carriers

pH-sensitive amphiphilic diblock polyphosphoesters containing lactic acid units were synthesized by multistep one-pot polycondensation reactions. They comprise acid-labile P(O)-O-C and C(O)-O-C bonds, the cleavage of which depends on the pH of the medium. The structure of these copolymers was characterized by 1H, 13C {H}, 31P NMR, and size exclusion chromatography (SEC). The newly synthesized polymers self-assembled into the micellar structure in an aqueous solution. The effects of the molecular weight of the copolymer and the length of the hydrophobic chain on micelle formation and stabilityand micelle size were studied via dynamic light scattering (DLS). Drug loading and encapsulation efficiency tests using doxorubicin revealed that hydrophobic drugs can be delivered by copolymers. It was established that the molecular weight of the copolymer, length of the hydrophobic chain and content of lactate units affects the size of the micelles, drug loading, and efficiency of encapsulation. A copolymer with 10.7% lactate content has drug loading (3.2 ± 0.3) and efficiency of encapsulation (57.4 ± 3.2), compared to the same copolymer with 41.8% lactate content (1.63%) and (45.8%), respectively. It was demonstrated that the poly[alkylpoly(ethylene glycol) phosphate-b-alkylpoly(ethylene glycol)lactate phosphate] DOX system has a pH-sensitive response capability in the result in which DOX was selectively accumulated into the tumor, where pH is acidic. The results obtained indicate that amphiphilic diblock polyphosphoesters have potential as drug carriers

Thermoresponsive Polyphosphoester via Polycondensation Reactions: Synthesis, Characterization, and Self-Assembly

Using a novel strategy, amphiphilic polyphosphoesters based on poly(oxyethylene H-phosphonate)s (POEHP) with different poly(ethylene glycol) segment lengths and aliphatic alcohols with various alkyl chain lengths were synthesized using polycondensation reactions. They were characterized by 1H NMR, 13C {H} NMR 31P NMR, IR, and size exclusion chromatography (SEC). The effects of the polymer structure on micelle formation and stability, micelle size, and critical micelle temperature were studied via dynamic light scattering (DLS). The hydrophilic/hydrophobic balance of these polymers can be controlled by changing the chain lengths of hydrophilic PEG and hydrophobic alcohols. A solubilizing test, using Sudan III, revealed that hydrophobic substances can be incorporated inside the hydrophobic core of polymer associates. Loading capacity depends on the length of alkyl side chains. The results obtained indicate that these structurally flexible polymers have the potential as drug carriers