Buckling without bending: a new paradigm in morphogenesis

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the oscillations are in-phase. The former cannot be explained by elastic bilayer instability, and contradict the notion that there is a universal mechanism by which brains, intestines, teeth, and other organs develop surface wrinkles and folds. Inspired by the microstructure of the embryonic cerebellum, we develop a new model of 2d morphogenesis in which system-spanning elastic fibers endow the organ with a preferred radius, while a separate fiber network resides in the otherwise fluid-like film at the outer edge of the organ and resists thickness gradients thereof. The tendency of the film to uniformly thicken or thin is described via a "growth potential". Several features of cerebellum, +blebbistatin organoid, and retinal fovea morphogenesis, including out-of-phase behavior and a film thickness amplitude that is comparable to the radius amplitude, are readily explained by our simple analytical model, as may be an observed scale-invariance in the number of folds in the cerebellum. We also study a nonlinear variant of the model, propose further biological and bio-inspired applications, and address how our model is and is not unique to the developing nervous system.Comment: version accepted by Physical Review

Pengaruh Pengurangan Diameter Valvestem Dan Penambahan Radius Valveneck Terhadap Performa Motor Bakar Honda Supra Fit 100 CC

Salah satu untuk meningkatkan performa dari sepeda motor adalah dengan melakukan penggantian katup standard ke katup racing. Katup racing ini bertujuan untuk memperlancar aliran udara yang masuk ke ruang bakar. Katup racing, biasanya, cara memodifikasinya adalah dengan melakukan pengurangan diameter pada batang katup. Pemilihan diameter katup pada penelitian ini adalah pengurangan sebesar 0,7 mm, 0,9 mm, dan 1,1 mm, dan membandingkan ketiga diameter dengan katup ukuran standard. Metode pengujian yang dilakukan pada penelitian ini adalah dengan melakukan simulasi aliran dengan menggunakan program komputer ANSYS. Serta dengan melakukan uji dynotest untuk mengetahui peningkatan daya dan torsi, sebelum dan sesudah dilakukan penggantian pada masing-masing variasi pada katup. Hasil yang didapatkan setelah melakukan simulasi adalah katup dengan diameter batang yang diperkecil menghasilkan pressure drop yang lebih kecil dan velocity yang besar. Hasil tersebut dicapai oleh katup dengan pengurangan sebesar 0,9 mm. Untuk hasil dynotest, daya tertinggi dicapai oleh katup dengan pengurangan sebesar 1,1 mm. yaitu 6,8 HP, mengalami pengingkatan sebesar 17,24%. Sedangkan torsi maksimum dicapai oleh katup dengan pengurangan 0,9 mm, yaitu 7,39 N.m, meningkat sebesar 14,75% dari katup standard

Unified cyclic stress-strain model for normal and high strength concrete confined with FRP

Fiber reinforced polymer (FRP) has become increasingly popular as a confining material for concrete, both in the strengthening of existing columns where FRP wraps with fibers oriented completely or predominantly in the hoop direction are typically used, and in new construction where filament-wound FRP tubes with fibers oriented at desired angles to the longitudinal axis are typically used. For both types of applications, the stress-strain behavior of FRP-confined concrete under cyclic axial compression needs to be properly understood and modeled for the accurate simulation of such columns under seismic loading. This paper presents an improved cyclic stress-strain model for FRP-confined concrete on the basis of a critical assessment of an earlier model proposed by Lam and Teng in 2009 by making use of a database containing new test results of both concrete-filled FRP tubes (CFFTs) and concrete cylinders confined with an FRP wrap. The assessment reveals several deficiencies of Lam and Teng\u27s model due to the limited test results available to them. The proposed model corrects these deficiencies and is shown to provide reasonably accurate predictions for both concrete in CFFTs and concrete confined with an FRP wrap and for both normal strength concrete (NSC) and high strength concrete (HSC)

A Storm in a "T" Cup

We revisit the process of transversification and agglomeration of particle momenta that are often performed in analyses at hadron colliders, and show that many of the existing mass-measurement variables proposed for hadron colliders are far more closely related to each other than is widely appreciated, and indeed can all be viewed as a common mass bound specialized for a variety of purposes.Comment: 3 pages, 2 figures, presented by K.C. Kong at the 19th Particles and Nuclei International Conference, PANIC 2011, MIT, Cambridge, MA (July 24-29, 2011

BUSINESS PROCESS REDESIGN AND INFORMATION ARCHITECTURE: ESTABLISHING THE MISSING LINKS

Business Process Redesign (BPR) and Information Architecture (IA) have been recognized as high organizational priority agenda items in the 1990s. This paper provides tile premise for integrating these two critical issues. A model depicting the relationship between IA and BPR is presented. IA design and BPR share a common focus on business processes and, when properly conducted, IA design should produce a stable information architecture capable of supporting existing as well as improved business processes. Furthermore, selected IA methods and techniques are recommended for possible application in BPR. Future research is suggested concerning the need to validate this BPR and IA relationship and test the appropriateness of applying IA methodologies to BPR

Skill, or style? Classification of fetal sonography eye-tracking data

We present a method for classifying human skill at fetal ultrasound scanning from eye-tracking and pupillary data of sonographers. Human skill characterization for this clinical task typically creates groupings of clinician skills such as expert and beginner based on the number of years of professional experience; experts typically have more than 10 years and beginners between 0-5 years. In some cases, they also include trainees who are not yet fully-qualified professionals. Prior work has considered eye movements that necessitates separating eye-tracking data into eye movements, such as fixations and saccades. Our method does not use prior assumptions about the relationship between years of experience and does not require the separation of eye-tracking data. Our best performing skill classification model achieves an F1 score of 98% and 70% for expert and trainee classes respectively. We also show that years of experience as a direct measure of skill, is significantly correlated to the expertise of a sonographer