Sensitivity study of the charged lepton flavor violating process τ→γμ\tau \to \gamma \mu at STCF

A sensitivity study for the search for the charged lepton flavor violating process $\tau \to \gamma\mu$ at the Super $\tau$-Charm Facility is performed with a fast simulation. With the expected performance of the current detector design and an integrated luminosity of \SI{1}{ab^{-1}} corresponding to one-year of data taking, the sensitivity on the branching fraction (BF) of $\tau \to \gamma\mu$ is estimated to be at the level of \num{e-8}. The sensitivity under different detector performances are also studied. With ideal performance, the BF could be probed to be \num{2.8e-8} at \SI{90}{\percent} confidence level. The sensitivity is expected to scale with the square root of the luminosity, therefore with a total luminosity of \SI{10}{ab^{-1}} corresponding to ten-year of data taking, the sensitivity could reach \num{8.8e-9}, which is about one order of magnitude improvement upon the current best upper limit

Fibrinogen deposition on silicone oil-infused silver-releasing urinary catheters compromises antibiofilm and anti-encrustation properties

[Image: see text] Slippery silicone-oil-infused (SOI) surfaces have recently emerged as a promising alternative to conventional anti-infection coatings for urinary catheters to combat biofilm and encrustation formation. Benefiting from the ultralow low hysteresis and slippery behavior, the liquid-like SOI coatings have been found to effectively reduce bacterial adhesion under both static and flow conditions. However, in real clinical settings, the use of catheters may also trigger local inflammation, leading to release of host-secreted proteins, such as fibrinogen (Fgn) that deposits on the catheter surfaces, creating a niche that can be exploited by uropathogens to cause infections. In this work, we report on the fabrication of a silicone oil-infused silver-releasing catheter which exhibited superior durability and robust antibacterial activity in aqueous conditions, reducing biofilm formation of two key uropathogens Escherichia coli and Proteus mirabilis by ∼99%, when compared with commercial all-silicone catheters after 7 days while remaining noncytotoxic toward L929 mouse fibroblasts. After exposure to Fgn, the oil-infused surfaces induced conformational changes in the protein which accelerated adsorption onto the surfaces. The deposited Fgn blocked the interaction of silver with the bacteria and served as a scaffold, which promoted bacterial colonization, resulting in a compromised antibiofilm activity. Fgn binding also facilitated the migration of Proteus mirabilis over the catheter surfaces and accelerated the deposition and spread of crystalline biofilm. Our findings suggest that the use of silicone oil-infused silver-releasing urinary catheters may not be a feasible strategy to combat infections and associated complications arising from severe inflammation

Deviatoric stress-strain curve construction with strain-softening account via the damage-modified Duncan-Chang, arctangent and informer models: a comparative analysis

Engineering construction in cold regions cannot be separated from permafrost research. This study aimed to determine the mechanical properties and changing laws of artificially frozen clay through triaxial tests. Two models have been established: a physical model based on the tradi-tional phenomenological constitutive theory and a deep learning model based on the data-driven constitutive theory, taking into account the softening phenomenon. The accuracy and applica-bility of the models were verified, followed by a comparative analysis. The results of the analysis are as follows. The Duncan-Chang model can describe the characteristics of the hardening-type deviatoric stress-strain curve, but it cannot describe the characteristics of the softening-type de-viatoric stress-strain curve. The Modified Duncan-Chang (MDC) model fails to accurately de-scribe the characteristics of a smooth deviatoric stress-strain curve. The Strain-Damage Modified Duncan-Chang (SD-MDC) model exhibits a good fit in both the ascending and descending seg-ments of the curve, but it lacks effectiveness in the convergence segment of the S-shaped sof-tening curve. For this reason, this paper has chosen the arctangent function to establish a Strain-Damage Modified arctangent constitutive model (SD-MAM). This model accurately re-flects the stress evolution process of different types of frozen soils. Additionally, the Informer time series prediction algorithm was utilized to develop the Informer permafrost deviatoric stress prediction model which achieved an R2 value above 99%. In comparison to the SD-MAM model, the Informer model demonstrates higher precision, does not rely on assumptions, is cost-effective, and has a wide range of applications. However, it lacks physical meaning, and interpretability, and requires further discussion regarding the reliability of the results. This study offers valuable insights into the development and application of constitutive models for frozen soils

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.

The major histocompatibility complex (MHC) is most closely associated with nasopharyngeal carcinoma (NPC), but the complexity of its genome structure has proven challenging for the discovery of causal MHC loci or genes. We conducted a targeted MHC sequencing in 40 Cantonese NPC patients followed by a two-stage replication in 1065 NPC cases and 2137 controls of Southern Chinese descendent. Quantitative RT-PCR analysis (qRT-PCR) was used to detect gene expression status in 108 NPC and 43 noncancerous nasopharyngeal (NP) samples. Luciferase reporter assay and chromatin immunoprecipitation (ChIP) were used to assess the transcription factor binding site. We discovered that a novel SNP rs117565607_A at TRIM26 displayed the strongest association (OR = 1.909, Pcombined = 2.750 × 10-19 ). We also observed that TRIM26 was significantly downregulated in NPC tissue samples with genotype AA/AT than TT. Immunohistochemistry (IHC) test also found the TRIM26 protein expression in NPC tissue samples with the genotype AA/AT was lower than TT. According to computational prediction, rs117565607 locus was a binding site for the transcription factor Yin Yang 1 (YY1). We observed that the luciferase activity of YY1 which is binding to the A allele of rs117565607 was suppressed. ChIP data showed that YY1 was binding with T not A allele. Significance analysis of microarray suggested that TRIM26 downregulation was related to low immune response in NPC. We have identified a novel gene TRIM26 and a novel SNP rs117565607_A associated with NPC risk by regulating transcriptional process and established a new functional link between TRIM26 downregulation and low immune response in NPC