Wanprestasi Dalam Perjanjian Makan Hasil Dusun

There is a shape of agreement to enjoy the results of the community in Kehly Village, Damer Island District, Southwest Maluku Regency, which is commonly known as "eating hamlets" or in the regional language "Rsakar" or "Rsakaro Likut/Ela", where the essence of the agreement is the same as the production sharing agreement. The distribution of the results of the agreement is influenced by factors such as soil fertility, soil availability, provision of seeds, types of crops, and so on. If the land to be managed will be made into a hamlet, and the crops provided by the landowner (the grantor of inheritance), then the proceeds are divided based on the number of heirs entitled to receive the inheritance.  This kind of agreement is called "Elab Nuru". This research used normative legal research.  The results showed that the agreement written or oral is a valid agreement because it meets the elements of the agreement listed in article 1320 of the Civil Code. Therefore, the parties who make the agreement either orally or in writing are obliged to carry out the obligations according to the agreement, as stipulated in article 1234 of the Civil Code which states that "every engagement aims to give something, do something, or not do something." If one of the parties does not fulfill its obligations, then that party has defaulted

Vaksin Covid-19 Sebagai Karya Paten Dalam TRIPs Agreement

The Covid-19 pandemic is a Public Health Emergency, a challenge for developing and underdeveloped countries to get a Covid-19 vaccine. Patent protection that is accommodated in the TRIPS Agreement is considered burdensome for vaccine accessibility, because it has a direct impact on increasing vaccine prices, making it difficult for some countries with low per capita incomes and lagging industries to reach them. The purpose of this paper is to determine the arrangement of patent rights based on the TRIPS Agreement. The research method used in this paper is normative juridical, namely by examining library data or materials in the form of primary legal materials and secondary legal materials. Then it will be described descriptively and given a conclusion. The strict patent system and the exclusive rights of patent holders contained in the TRIPS Agreement are barriers to reaching pharmaceutical inventions. Therefore, every country needs a National Emergency Plan that can accommodate health services such as vaccines. This can be implemented using a Compulsory License or Government Use (Patent Implementation by the Government) instrument

Perlindungan Hukum Bagi Konsumen Kosmetik Atas Produk Parfum Isi Ulang

ABSTRACT: Currently, there are many business actors who get more profit by producing refill perfume containing hazardous substances that do not meet the requirements for circulation, so that Law No. 8 of 1999 was issued to provide legal protection for consumers. The purpose of this research was conducted to find out how the form of legal protection for cosmetic consumers for the distribution of perfume products containing dangerous substances and what form of legal protection for cosmetic perfume consumers who experience losses. The research method used is normative legal research method. The problem approach used is the statutory approach, the conceptual approach. The legal materials used are primary legal materials and secondary legal materials. Procedures and Collection of Legal Materials using the method of inventorying laws and regulations and Processing and Analysis of legal materials is carried out using qualitative analysis techniques to answer problems. Based on the results of the study it can be concluded: Forms of Legal Protection for Consumers of Cosmetics for the Circulation of Refillable Perfumes are divided into 2, namely, Forms of Preventive Legal Protection as a preventive measure for a person/group who wants to carry out activities or actions that are negative and Forms of Repressive Legal Protection are efforts settlement of the occurrence of violations with the aim of resolving disputes. Consumers who are disadvantaged as a result of using dangerous refill perfumes based on Law Number 8 of 1999 concerning Consumer Protection, there are two forms of legal remedies, namely through out-of-court dispute resolution which is carried out by the Consumer Dispute Settlement Agency and legal remedies through dispute resolution in court carried out with reference to to the provisions of the general court in force

Telemedicine implementation across academic medical centers: How can we improve virtual diabetes care?

For patients with diabetes mellitus requiring specialty care, access to routine careis essential for maintaining a high quality of life and avoiding adverse health outcomes. Telemedicine improves access to diabetes specialists and was rapidly adopted during the COVID-19 pandemi

Investigation of Silicon Nanoparticle-Polystyrene Hybrids

Current LED lights are created with quantum dots made of metals like selenium, tellurium, and cadmium which can be toxic. Silicon is used as a non-toxic substance and is the second most abundant element in the earth's crust. When silicon is prepared at a nanometer size, unique luminesce optical properties emerge that can be tuned using sized surface chemistry. Therefore, silicon nanoparticles can be used as an alternative emitter for LED lights. To produce hydride-terminated silicon nanoparticles we must synthesize the particles. Hydrogen silsesquioxane (HSQ) is processed at 1100 °C for one hour causing Si to cluster and form a SiO2 matrix, also known as the composite. The composite is then manually crushed in ethanol. The solution is further ground using glass beads, then filtered to get the composite powder. The final step is the HF etching. The hydride-terminated particles are then functionalized using three different methods to synthesize silicon nanoparticle-polystyrene hybrids, which determine the magnitude of luminosity and the quality of the hybrids. We spin coat each method and results were analyzed. Method 1 uses heat to functionalize hydride-terminated silicon nanoparticles with styrene. This process also causes styrene to attach to styrene to form a polystyrene chain. Method 1 gave a homogeneous mixture which yielded a consistent, bright and homogenous film. In method 2, dodecyl-terminated silicon nanoparticles are mixed with premade polystyrene. While this method gave better control of the amount of silicon nanoparticles inside the polymer hybrid, a homogeneous mixture was not created due to the different structures of polystyrene and dodecyl chains. Method 3 has dodecyl-terminated silicon with in-situ styrene polymerization. It generated a homogeneous mixture. The in-situ polymerization stabilizes the particles, allowing for brighter luminescence. Because of the stability and lower molecular weight, the mixture was easier to dissolve. We concluded that the different methods resulted in different polymer molecular weights and this created distinct properties between the polymer hybrids when spin-coating.   &nbsp

1H-NMR metabolite profiles of different strains of Plasmodium falciparum

Although efforts to understand the basis for inter-strain phenotypic variation in the most virulent malaria species, Plasmodium falciparum, have benefited from advances in genomic technologies, there have to date been few metabolomic studies of this parasite. Using 1H-NMR spectroscopy, we have compared the metabolite profiles of red blood cells infected with different P. falciparum strains. These included both chloroquine-sensitive and chloroquine-resistant strains, as well as transfectant lines engineered to express different isoforms of the chloroquine-resistance-conferring pfcrt (P. falciparum chloroquine resistance transporter). Our analyses revealed strain-specific differences in a range of metabolites. There was marked variation in the levels of the membrane precursors choline and phosphocholine, with some strains having >30-fold higher choline levels and >5-fold higher phosphocholine levels than others. Chloroquineresistant strains showed elevated levels of a number of amino acids relative to chloroquine-sensitive strains, including an approximately 2-fold increase in aspartate levels. The elevation in amino acid levels was attributable to mutations in pfcrt. Pfcrt-linked differences in amino acid abundance were confirmed using alternate extraction and detection (HPLC) methods. Mutations acquired to withstand chloroquine exposure therefore give rise to significant biochemical alterations in the parasite

Fully Proprioceptive Slip-Velocity-Aware State Estimation for Mobile Robots via Invariant Kalman Filtering and Disturbance Observer

This paper develops a novel slip estimator using the invariant observer design theory and Disturbance Observer (DOB). The proposed state estimator for mobile robots is fully proprioceptive and combines data from an inertial measurement unit and body velocity within a Right Invariant Extended Kalman Filter (RI-EKF). By embedding the slip velocity into $\mathrm{SE}_3(3)$ Lie group, the developed DOB-based RI-EKF provides real-time accurate velocity and slip velocity estimates on different terrains. Experimental results using a Husky wheeled robot confirm the mathematical derivations and show better performance than a standard RI-EKF baseline. Open source software is available for download and reproducing the presented results.Comment: github repository at https://github.com/UMich-CURLY/slip_detection_DOB. arXiv admin note: text overlap with arXiv:1805.10410 by other author

A Flexible and Efficient Approach to Missing Transverse Momentum Reconstruction

The article processing charge was funded by the Open Access Publication Fund of Humboldt-Universität zu Berlin.Missing transverse momentum is a crucial observable for physics at hadron colliders, being the only constraint on the kinematics of “invisible” objects such as neutrinos and hypothetical dark matter particles. Computing missing transverse momentum at the highest possible precision, particularly in experiments at the energy frontier, can be a challenging procedure due to ambiguities in the distribution of energy and momentum between many reconstructed particle candidates. This paper describes a novel solution for efficiently encoding information required for the computation of missing transverse momentum given arbitrary selection criteria for the constituent reconstructed objects. Pileup suppression using information from both the calorimeter and the inner detector is an integral component of the reconstruction procedure. Energy calibration and systematic variations are naturally supported. Following this strategy, the ATLAS Collaboration has been able to optimise the use of missing transverse momentum in diverse analyses throughout Runs 2 and 3 of the Large Hadron Collider and for future analyses.Peer Reviewe

Triple Bioluminescence Imaging for In Vivo Monitoring of Cellular Processes

Bioluminescence imaging (BLI) has shown to be crucial for monitoring in vivo biological processes. So far, only dual bioluminescence imaging using firefly (Fluc) and Renilla or Gaussia (Gluc) luciferase has been achieved due to the lack of availability of other efficiently expressed luciferases using different substrates. Here, we characterized a codon-optimized luciferase from Vargula hilgendorfii (Vluc) as a reporter for mammalian gene expression. We showed that Vluc can be multiplexed with Gluc and Fluc for sequential imaging of three distinct cellular phenomena in the same biological system using vargulin, coelenterazine, and D-luciferin substrates, respectively. We applied this triple imaging system to monitor the effect of soluble tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) delivered using an adeno-associated viral vector (AAV) on brain tumors in mice. Vluc imaging showed efficient sTRAIL gene delivery to the brain, while Fluc imaging revealed a robust antiglioma therapy. Further, nuclear factor-κB (NF-κB) activation in response to sTRAIL binding to glioma cells death receptors was monitored by Gluc imaging. This work is the first demonstration of trimodal in vivo bioluminescence imaging and will have a broad applicability in many different fields including immunology, oncology, virology, and neuroscience

An evaluation of the genus Amphidinium (Dinophyceae) combining evidence from morphology, phylogenetics, and toxin production, with the introduction of six novel species

The genus Amphidinium is an important group of athecated dinoflagellates because of its high abundance in marine habitats, its member’s ability to live in a variety of environmental conditions and ability to produce toxins. Furthermore, the genus is of particular interest in the biotechnology field for its potential in the pharmaceutical arena. Taxonomically the there is a history of complication and confusion over the proper identities and placements of Amphidinium species due to high genetic variability coupled with high morphological conservation. Thirteen years has passed since the most recent review of the group, and while many issues were resolved, some remain. The present study used microscopy, phylogenetics of the 28S region of rDNA, secondary structure of the ITS2 region of rDNA, compensatory base change data, and cytotoxicity data from Amphidinium strains collected world-wide to elucidate remaining confusion. This holistic approach using multiple lines of evidence resulted in a more comprehensive understanding of the morphological, ecological, and genetic characteristics that are attributed to organisms belonging to Amphidinium, including six novel species: A. fijiensis, A. magnum, A. paucianulatum, A. pseudomassartii, A. theodori, and A. tomasii