The ASK Corpus – a Language Learner Corpus of Norwegian as a Second Language

In our paper we present the design and interface of ASK, a language learner corpus of Norwegian as a second language which contains essays collected from language tests on two different proficiency levels as well as personal data from the test takers. In addition, the corpus also contains texts and relevant personal data from native Norwegians as control data. The texts as well as the personal data are marked up in XML according to the TEI Guidelines. In order to be able to classify errors in the texts, we have introduced new attributes to the TEI corr and sic tags. For each error tag, a correct form is also in the text annotation. Finally, we employ an automatic tagger developed for standard Norwegian, the Oslo-Bergen Tagger , together with a facility for manual tag correction. As corpus query system, we are using the Corpus Workbench developed at the University of Stuttgart together with a web search interface developed at Aksis, University of Bergen. The system allows for searching for combinations of words, error types, grammatical annotation and personal data.publishedVersio

Interaction of Cold Streaming Protons with the Reconnection Process

We employ a 2.5D particle-in-cell simulation to study a scenario where the reconnection process captures cold streaming protons. As soon as the tailward streaming protons become involved, they contribute to the overall momentum balance, altering the initially symmetric dynamics. Adding tailward-directed momentum to the reconnection process results in a tailward propagation of the reconnection site. We investigate how the reconnection process reorganizes itself due to the changing momentum conditions on the kinetic scale and how the reconnection rate is affected. We find that adding tailward momentum does not result in a significantly different reconnection rate compared to the case without cold streaming protons, when scaled to the total Alfvén velocity. This implies that the effect of changing inflow conditions due to the motion of the reconnection site appears to be minimal. The dynamics of the particles are, however, significantly different depending on whether they enter on the tailward or Earthward side of the reconnection site. On the Earthward side they are reflected and thermalized, while on the tailward side they are picked up and accelerated. The cold proton density and Ez on the Earthward side are turbulent, while the tailward side has laminar cold proton density striations and an embedded Ez layer. Also, since the initial plasma sheet population is swept up on one side and flushed out on the other, asymmetries in the densities and strength of Hall fields emerge. Our results are important for understanding the development and dynamics of magnetospheric substorms and storms.publishedVersio

Evolution of IMF By Induced Asymmetries: The Role of Tail Reconnection

North-south asymmetries arise in the magnetosphere-ionosphere system when a significant east-west (By) component is present in the interplanetary magnetic field (IMF). During such conditions, a By component with the same sign as the IMF By component is induced in the magnetosphere, and the locations of conjugate magnetic footpoints are displaced between the two hemispheres. It has been suggested that these asymmetries are introduced into the closed magnetosphere by tail reconnection. However, recent studies instead suggest that asymmetric lobe pressure induces the asymmetries, which are then reduced during periods of enhanced tail reconnection. To address this, we use the Lyon-Fedder-Mobarry (LFM) model and initiate a loading-unloading cycle in multiple runs by changing the IMF. Asymmetries are induced during the loading phase and reduced during the unloading phase. The model results thus suggest that asymmetries arise during periods with low tail reconnection and are reduced during periods with enhanced tail reconnection.publishedVersio

Collisionless Magnetic Reconnection in an Asymmetric Oxygen Density Configuration

Combined with the magnetic field, the distribution of charged particles in the inflow region is expected to control the rate of magnetic reconnection. This paper investigates how the reconnection process is altered by a cold, asymmetrically distributed, oxygen population, which is initially located away from the current layer in the inflow regions. A particle-in-cell simulation is used to gain further insight into the dynamics of the system. The time evolution of the reconnection process proceeds rapidly compared to the cyclotron period of O urn:x-wiley:grl:media:grl59941:grl59941-math-0001. Therefore, the oxygen remains, to a good approximation, demagnetized. Thus, Alfvén scaling is not an adequate description of the reconnection rate. A scaling relation for the reconnection rate for an asymmetrically distributed, demagnetized species has been developed. Additionally, we find that an asymmetric density configuration leads to a distinct motion of the reconnection site and generates an asymmetry of the diffusion region and the Hall electric field.publishedVersio

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition

The development and implementation of Immune Checkpoint Inhibitors (ICI) in clinical oncology have significantly improved the survival of a subset of cancer patients with metastatic disease previously considered uniformly lethal. However, the low response rates and the low number of patients with durable clinical responses remain major concerns and underscore the limited understanding of mechanisms regulating anti-tumor immunity and tumor immune resistance. There is an urgent unmet need for novel approaches to enhance the efficacy of ICI in the clinic, and for predictive tools that can accurately predict ICI responders based on the composition of their tumor microenvironment. The receptor tyrosine kinase (RTK) AXL has been associated with poor prognosis in numerous malignancies and the emergence of therapy resistance. AXL is a member of the TYRO3-AXL-MERTK (TAM) kinase family. Upon binding to its ligand GAS6, AXL regulates cell signaling cascades and cellular communication between various components of the tumor microenvironment, including cancer cells, endothelial cells, and immune cells. Converging evidence points to AXL as an attractive molecular target to overcome therapy resistance and immunosuppression, supported by the potential of AXL inhibitors to improve ICI efficacy. Here, we review the current literature on the prominent role of AXL in regulating cancer progression, with particular attention to its effects on anti-tumor immune response and resistance to ICI. We discuss future directions with the aim to understand better the complex role of AXL and TAM receptors in cancer and the potential value of this knowledge and targeted inhibition for the benefit of cancer patients.publishedVersio

Magnetospheric Multiscale Observations of an Expanding Oxygen Wave in Magnetic Reconnection

Heavier plasma species such as oxygen ions can have a large impact on the magnetic reconnection process. It has been hypothesized that the acceleration of demagnetized oxygen ions by the Hall electric field will lead to the formation of an oxygen wave that expands into the exhaust. By comparing data from NASA's Magnetospheric Multiscale mission to a fully kinetic particle-in-cell simulation, we can for the first time provide observational evidence of such an expanding oxygen wave. The wave is characterized by an oxygen jet consisting of cold ions directed toward the neutral sheet associated with a density cavity. This density cavity forms as the O+ are subject to collective acceleration by the Hall electric field leaving behind a region of low-density oxygen ions. Our results are important for the understanding of the role and effect of oxygen ions in magnetic reconnection.publishedVersio

The Micro-Macro Coupling of Mass-Loading in Symmetric Magnetic Reconnection With Cold Ions

We investigate how magnetic reconnection is influenced by an inflow of a dense cold ion population. We compare two 2.5D Particle-In-Cell simulations, one containing the cold population and one without. We find that the cold population influences the reconnection process on both global and kinetic scales, and that the dominant contribution can be explained through mass-loading. We provide an analysis of how these multiscale changes are related through kinetic processes in the ion diffusion region, the so-called micro-macro coupling of mass-loading. The inertia of the cold ion population is found to be the significant link that connects the changes on different scales. The cold and warm populations exhibit counter streaming behavior when and after the ion diffusion region reorganizes itself in response to the arrival of the cold population. This signature of the cold population should be observable by spacecraft observatories such as MMS.publishedVersio

The Role of Resistivity on the Efficiency of Magnetic Reconnection in MHD

Using a resistive MagnetoHydroDynamic (MHD) simulation, we study how the magnitude and shape of diffusion influence magnetic reconnection. Specifically, we investigate how and why the reconnection rate is influenced by variations in the diffusion distribution and magnitude. By running multiple MHD simulations where we vary the localized resistivity, we find that the properties of the diffusion region greatly influence the rate of reconnection. Increasing the magnitude of the imposed resistivity results in a higher reconnection rate, but the rate saturates at approximately 0.2. We show how a redistribution of the current density, leading to a bifurcated current sheet, play a major role in this limitation. In addition, we investigate the impact of different shapes of resistive region. The shape of the diffusion region also plays a major role in how efficient the reconnection energy conversion can operate. The highest reconnection rate, approximately 0.25, is achieved for an optimal opening angle. Our results imply that reconnection has a speed limit that may depend on properties outside the diffusion region.publishedVersio

Electron Behavior Around the Onset of Magnetic Reconnection

We investigate the onset of magnetic reconnection, utilizing a fully kinetic Particle-In-Cell (PIC) simulation. Characteristic features of the electron phase-space distributions immediately before reconnection onset are identified. These include signatures of pressure non-gyrotropy in the velocity distributions, and lemon shaped distributions in the in-plane velocity directions. Further, we explain how these features form through particle energization by the out-of-plane electric field. Identification of these features in the distributions can aid in analysis of data where clear signatures of ongoing reconnection are not yet present.publishedVersio

Asymmetrically Varying Guide Field During Magnetic Reconnection: Particle-In-Cell Simulations

Using fully kinetic particle-in-cell modeling, we investigate how magnetic reconnection responds to a varying guide field in one of the inflow regions. We find that the reconnection rate varies significantly when the orientation of the magnetic field changes between being strictly antiparallel and having a guide field. These variations are fairly consistent with the scaling relation for asymmetric reconnection developed by Cassak and Shay (2007). However, the rate is also found to be nonlinearly modulated by changes in the ion inflow velocity. The spatio-temporal change in the inflow velocity arises as the magnetic forces reconfigure to regions of different magnetic field strengths. The variations in the inflow magnetic field configuration allow for different gradients in the magnetic field, leading to asymmetries in the magnetic tension force. By momentum conservation, this facilitates asymmetries in the inflow velocity, which in turn affects the flux transport into the reconnection site. The outflow is found to be less laminar when the inflow varies, and various signatures of the inflow variations are identified in the outflow.publishedVersio