Statistical classification techniques for engineering and climatic data samples

Fisher's sample linear discriminant function is modified through an appropriate alteration of the common sample variance-covariance matrix. The alteration consists of adding nonnegative values to the eigenvalues of the sample variance covariance matrix. The desired results of this modification is to increase the number of correct classifications by the new linear discriminant function over Fisher's function. This study is limited to the two-group discriminant problem

Calculation of Eddy Current Fields for Coils of Arbitrary Shape

In the design of an eddy current inspection device, it is useful to have available a means of visualizing the eddy current distribution produced in the material to be tested. This is evidenced by the widespread use of the early models of Dodd and Deeds [1], who provided analytic solutions for the field in a number of axisymmetric probe geometries. The analytic approach was later extended [2–4] to include a more general class of coils, and was applied to the case of a circular, air-core horizontal coil [4]

Simulation study for investment decisions on the EcoBoost camshaft machining line

Design/redesign of manufacturing systems is a complex, risky, and expensive task. Ford Motor Company’s Valencia Engine Plant faces this challenge as it plans to upgrade its machining and assembly lines to introduce the new EcoBoost engines. The research project described in this paper aimed to support the transition process particularly at the camshaft machining line by using simulation modelling techniques. A series of experiments was carried out using the simulation model developed, and recommendations were proposed based on the results of these experiments to support the decision as to where to invest on the line. The outcomes from the research project indicated that investment is required in terms of increasing the capacity of two bottleneck operations through retooling and improving the conveyor routing logic in one key area. Keywords: simulation modelling, closed-loop network, automotive production system

Perturbed Spherically Symmetric Dust Solution of the Field Equations in Observational Coordinates with Cosmological Data Functions

Using the framework for solving the spherically symmetric field equations in observational coordinates given in Araujo and Stoeger (1999), their formulation and solution in the perturbed FLRW sperically symmetric case with observational data representing galaxy redshifts, number counts and observer area distances, both as functions of redshift on our past light cone, are presented. The importance of the central conditions, those which must hold on our world line C, is emphasized. In detailing the solution for these perturbations, we discuss the gauge problem and its resolution in this context, as well as how errors and gaps in the data are propagated together with the genuine perturbations. This will provide guidance for solving, and interpreting the solutions of the more complicated general perturbation problem with observational data on our past light cone.Comment: Latex 23 pages, no figures, submitted to Astrophysical Journa

Perturbation expansions for a class of singular potentials

Harrell's modified perturbation theory [Ann. Phys. 105, 379-406 (1977)] is applied and extended to obtain non-power perturbation expansions for a class of singular Hamiltonians H = -D^2 + x^2 + A/x^2 + lambda/x^alpha, (A\geq 0, alpha > 2), known as generalized spiked harmonic oscillators. The perturbation expansions developed here are valid for small values of the coupling lambda > 0, and they extend the results which Harrell obtained for the spiked harmonic oscillator A = 0. Formulas for the the excited-states are also developed.Comment: 23 page

Imaging characteristics and treatment of a penetrating brain injury caused by an oropharyngeal foreign body in a dog

A 4-year-old Border collie was presented with one episode of collapse, altered mentation, and a suspected pharyngeal stick injury. Magnetic resonance imaging (MRI) and computed tomography showed a linear foreign body penetrating the right oropharynx, through the foramen ovale and the brain parenchyma. The foreign body was surgically removed and medical treatment initiated. Complete resolution of clinical signs was noted at recheck 8 weeks later. Repeat MRI showed chronic secondary changes in the brain parenchyma. To the authors' knowledge, this is the first report of the advanced imaging findings and successful treatment of a penetrating oropharyngeal intracranial foreign body in a dog

Efficacy of Stochastic Vestibular Stimulation to Improve Locomotor Performance in a Discordant Sensory Environment

Astronauts exposed to microgravity face sensorimotor challenges incurred when readapting to a gravitational environment. Sensorimotor Adaptability (SA) training has been proposed as a countermeasure to improve locomotor performance during re-adaptation, and it is suggested that the benefits of SA training may be further enhanced by improving detection of weak sensory signals via mechanisms such as stochastic resonance when a non-zero level of stochastic white noise based electrical stimulation is applied to the vestibular system (stochastic vestibular stimulation, SVS). The purpose of this study was to test the efficacy of using SVS to improve short-term adaptation in a sensory discordant environment during performance of a locomotor task

Polarisation vision: overcoming challenges of working with a property of light we barely see.

In recent years, the study of polarisation vision in animals has seen numerous breakthroughs, not just in terms of what is known about the function of this sensory ability, but also in the experimental methods by which polarisation can be controlled, presented and measured. Once thought to be limited to only a few animal species, polarisation sensitivity is now known to be widespread across many taxonomic groups, and advances in experimental techniques are, in part, responsible for these discoveries. Nevertheless, its study remains challenging, perhaps because of our own poor sensitivity to the polarisation of light, but equally as a result of the slow spread of new practices and methodological innovations within the field. In this review, we introduce the most important steps in designing and calibrating polarised stimuli, within the broader context of areas of current research and the applications of new techniques to key questions. Our aim is to provide a constructive guide to help researchers, particularly those with no background in the physics of polarisation, to design robust experiments that are free from confounding factors

Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica

Heterotrimeric G-protein signaling pathways are vital components of physiology, and many are amenable to pharmacologic manipulation. Here, we identify functional heterotrimeric G-protein subunits in Entamoeba histolytica, the causative agent of amoebic colitis. The E. histolytica Gα subunit EhGα1 exhibits conventional nucleotide cycling properties and is seen to interact with EhGβγ dimers and a candidate effector, EhRGS-RhoGEF, in typical, nucleotide-state-selective fashions. In contrast, a crystal structure of EhGα1 highlights unique features and classification outside of conventional mammalian Gα subfamilies. E. histolytica trophozoites overexpressing wildtype EhGα1 in an inducible manner exhibit an enhanced ability to kill host cells that may be wholly or partially due to enhanced host cell attachment. EhGα1-overexpressing trophozoites also display enhanced transmigration across a Matrigel barrier, an effect that may result from altered baseline migration. Inducible expression of a dominant negative EhGα1 variant engenders the converse phenotypes. Transcriptomic studies reveal that modulation of pathogenesis-related trophozoite behaviors by perturbed heterotrimeric G-protein expression includes transcriptional regulation of virulence factors and altered trafficking of cysteine proteases. Collectively, our studies suggest that E. histolytica possesses a divergent heterotrimeric G-protein signaling axis that modulates key aspects of cellular processes related to the pathogenesis of this infectious organism