Prevalencia y severidad de lactantes sibilantes en la ciudad de Córdoba

Las sibilancias constituyen un síntoma respiratorio muy frecuente en los lactantes. La prevalencia de sibilancias en lactantes, realizadas en países desarrollados tienen tasas de prevalencia que varían entre el 20% y el 30 %. El objetivo fue conocer prevalencia y severidad de sibilancias en los lactantes en la ciudad de Córdoba, conocer los factores de riesgo y de protección. Se utilizó un cuestionario escrito estandarizado (WQ-P1-EISL) en lactantes entre 12 y 18 meses de edad que residían en la ciudad de Córdoba. La prevalencia de lactantes sibilantes fue del 39,7%. En el presente estudio la prevalencia de sibilancias fue más baja de la esperada en relación a la media de Latioamérica. Lo mismo observamos con la severidad. Es dable destacar que los problemas respiratorios persistentes en los niños debidos al bajo nivel socioeconómico son un factor de riesgo para sibilancias, neumonía y podría ser un factor determinante para la prevalencia y severidad de SR en lactantes.Fil: Teijeiro, Álvaro. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentin

Prevalencia y severidad de lactantes sibilantes en la ciudad de Córdoba

Las sibilancias constituyen un síntoma respiratorio muy frecuente en los lactantes. La prevalencia de sibilancias en lactantes, realizadas en países desarrollados tienen tasas de prevalencia que varían entre el 20% y el 30 %. El objetivo fue conocer prevalencia y severidad de sibilancias en los lactantes en la ciudad de Córdoba, conocer los factores de riesgo y de protección. Se utilizó un cuestionario escrito estandarizado (WQ-P1-EISL) en lactantes entre 12 y 18 meses de edad que residían en la ciudad de Córdoba. La prevalencia de lactantes sibilantes fue del 39,7%. En el presente estudio la prevalencia de sibilancias fue más baja de la esperada en relación a la media de Latioamérica. Lo mismo observamos con la severidad. Es dable destacar que los problemas respiratorios persistentes en los niños debidos al bajo nivel socioeconómico son un factor de riesgo para sibilancias, neumonía y podría ser un factor determinante para la prevalencia y severidad de SR en lactantes.Fil: Teijeiro, Álvaro. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentin

La carta de Jerusalén: un nuevo paradigma en el cuidado de los niños y adolescentes alérgicos en las escuelas de Latinoamérica

De acuerdo con la Organización Mundial de la Salud, las enfermedades alérgicas ocupan el sexto lugar entre las enfermedades infantiles y representan un tercio de las enfermedades crónicas en los niños. En 1 de cada 5 niños, la enfermedad alérgica se manifiesta en la edad escolar

Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw

Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC

Evaluation of Macular Retinal Ganglion Cell-Inner Plexiform Layer Thickness after Vitrectomy with Internal Limiting Membrane Peeling for Idiopathic Macular Holes

Purpose. To evaluate macular retinal ganglion cell-inner plexiform layer (GCIPL) thickness changes after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole repair using a high-resolution spectral-domain optical coherence tomography (SD-OCT). Methods. 32 eyes from 32 patients with idiopathic macular holes who underwent vitrectomy with internal limiting membrane peeling between January 2011 and July 2012 were retrospectively analyzed. GCIPL thickness was measured before surgery, and at one month and at six months after surgery. Values obtained from automated and semimanual SD-OCT segmentation analysis were compared (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA). Results. No significant differences were found between average GCIPL thickness values between preoperative and postoperative analysis. However, statistical significant differences were found in GCIPL thickness at the temporal macular quadrants at six months after surgery. Quality measurement analysis performed by automated segmentation revealed a significant number of segmentation errors. Semimanual segmentation slightly improved the quality of the results. Conclusion. SD-OCT analysis of GCIPL thickness found a significant reduction at the temporal macular quadrants at 6 months after Brilliant Blue G-assisted internal limiting membrane peeling for idiopathic macular hole

Emerging Role of Decoy Receptor-2 as a Cancer Risk Predictor in Oral Potentially Malignant Disorders

The aim of this study was to evaluate the expression of the senescence markers, Decoy Receptor 2 (DcR2) and Differentiated Embryo-Chondrocyte expressed gen 1 (DEC1), in oral potentially malignant disorders (OPMDs) to ascertain their possible association with oral cancer risk. The immunohistochemical analysis of DcR2 and DEC1 expression (along with p16 and Ki67 expression) was carried out in 60 patients with clinically diagnosed oral leukoplakia. Fifteen cases (25%) subsequently developed an invasive carcinoma. Correlations between protein marker expression, histological grade and oral cancer risk were assessed. DcR2, DEC1 and Ki67 protein expressions were found to correlate significantly with increased oral cancer risk, and also with an increased grade of dysplasia. Multivariate analysis demonstrated that DcR2 and Ki67 expression are independent predictors of oral cancer development. Our results evidence for the first time the potential of DcR2 as an early biomarker to assess oral cancer risk in patients with oral leukoplakia (HR = 59.7, p = 0.015), showing a superior predictive value to histology (HR = 4.225, p = 0.08). These findings reveal that the increased expression of DcR2 and DEC1 occurred frequently in OPMDs. In addition, DcR2 expression emerges as a powerful biomarker for oral cancer risk assessment in patients with oral leukoplakia

The Jerusalem Chapter: A new paradigm in the care of allergic children and adolescents in Latin-American schools

No abstract

Neuroblastoma in Spain : Linking the national clinical database and epidemiological registries - A study by the Joint Action on Rare Cancers

Altres ajuts: Ministerio de Sanidad; Universitat de València; Sociedad Española de Oncología Pediátrica; Fundación de Oncología Infantil Enriqueta Villavecchia.Purpose: Linkage between clinical databases and population-based cancer registries may serve to evaluate European Reference Networks' (ERNs) activity, by monitoring the proportion of patients benefiting from these and their impact on survival at a population level. To test this, a study targeting neuroblastoma (Nb) was conducted in Spain by the European Joint Action on Rare Cancers. Material and methods: Subjects: Nb cases, incident 1999-2017, aged < 15 years. Linkage included: Spanish Neuroblastoma Clinical Database (NbCDB) (1217 cases); Spanish Registry of Childhood Tumours (RETI) (1514 cases); and 10 regional population-based registries (RPBCRs) which cover 33% of the childhood population (332 cases). Linkage was semiautomatic. We estimated completeness, incidence, contribution, deficit, and 5-year survival in the databases and specific subsets. Results: National completeness estimates for RETI and NbCDB were 91% and 72% respectively, using the Spanish RPBCRs on International Incidence of Childhood Cancer (https://iicc.iarc.fr/) as reference. RPBCRs' specific contribution was 1.6%. Linkage required manual crossover in 54% of the semiautomatic matches. Five-year survival was 74% (0-14 years) and 90% (0-18 months). Conclusions: All three databases were incomplete as regards Spain as a whole and should therefore be combined to achieve full childhood cancer registration. A unique personal patient identifier could facilitate such linkage. Most children have access to Nb clinical trials. Consolidated interconnections between the national registry and clinical registries (including ERNs and paediatric oncology clinical groups) should be established to evaluate outcomes