Poverty reduction through irrigation and smallholder markets (PRISM)

Manual pumpsDrip irrigationWater storage

New Development in National Leprosy Control Programme and the Issue of Integration

BACKGROUNDThe history of leprosy in Ethiopia before the 20th Century is not well-documented other than the traditional assistance given for many centuries by the Ethiopian Orthodox church, in the name of Gebre-Kirstos, patron Saint of leprosy patients. The assistance was given to those patients who lived around its churches and monasteries. Today, alms seekers and deformed leprosy patients still crowd around churches on church feast days begging for alms from the church and the faithful. Dr. Feron from France was the first to attempt to provide "modern " leprosy care at the beginning of this Century .He had obtained permission to care for leprosy patients outside Harar town. The project was known as St. Antoine's and still exists today as a typical old leprosy village just outside the city. Specialized hospital care began in 1930 when the Sudan Interior Mission (SIM)2 built a leprosarium in the suburb of Addis Ababa to care for the growing number of patients in the city. The foundation stone of the former Princess Zenebe Work Memorial Hospital, now called Addis Ababa Leprosy Hospital was laid in November 1932

Time-cost Trade-off Analysis for Highway Construction projects

The Construction industry, which can be in the form of residential building, commercial, public and utility buildings, or civil engineering building, has a huge influence on any nation\u27s economy. Its influence can be either manifested in its contribution to the economy or the service it provides to the community. In order to build any infrastructure project with a balanced cost, time, and quality, project managers search for alternatives that can satisfy these contradicting attributes. The traditional time-cost trade-off was enhanced with the three-dimensional time-cost- quality optimization in the last two decades. The optimization is aimed to minimize the time and cost as much as possible while increasing the quality of the infrastructure to be built. The issue of financing in developing countries has been a bottle neck of success in constructing infrastructure like highway. Many researchers have concluded in their studies the causes of time and cost overrun in high-way construction were, contractors\u27 financial problems, Inflation, progress payments delay by owner, political issues, variations, lack of managemental skills, cost fluctuation of materials during construction, environmental issues, Shortage in equipment, Inadequate contractor experience etc. The number of studies in the literature that deals with financial optimization and cash-flow analysis to address the problem of financing and inflation are getting more attention. The cash-flow analysis and maximum overdraft to be paid give a good indication to the main participants about the trends toward cost and time overrun. They can also help in making a proper decision right at the beginning. The purpose of this study is to deal with the optimization of time and profit of highway constructions taking in to consideration the amount of available credit and future value of the cost of each activity and cash-flow analysis in a comprehensive model. This type of analysis gives the contractor how its profit will be influenced with his allowable credits and the time associated with it. Besides, the model also generates a line of balance scheduling for the project as highways are among the repetitive projects. The cash-flow analysis gives extra information on the overdraft so that it can be optimized to find good combination of execution of the activities which will minimize the overdraft, interest paid to banks and most importantly maximize the profit to be gained by the project using GA approach. This type of analysis also gives alternatives for contractors how much profit would they like to gain by providing different amount of credits. At first the profit and time are optimized individually to get the maximum profit and minimum time for completing the project. Then the multi-objective optimization using goal programing takes place which tries to minimize the deviation from the optimum individual values by assigning importance weight to the individual objectives to find the near optimal solution. The model is tested for different allowable credits and its sensitivity analysis outcomes are plotted to see the relationship between the allowable credits and the profit. To validate the efficiency of the developed model, it is applied to a project from the literature that addresses scheduling and cost optimization of repetitive projects. It is found that the outcome of the model that maximizes the profit and minimizing the time outlooks the results of the literature with 4.65% and 0.38% improvement in duration and cost of the project respectively

A Comparative Approach to Racial Stereotyping in South Africa and the United States and How It Has Obliterated the Black Image

There has been a long fight to dehumanize the black body and hinder the black mind through the power to enact individual, institutional, and cultural racism. Medical experiments of the past have occurred as a result of the belief that blacks are intellectually inferior, and, in a sense, a different species. There also has been an implementation of birth control strategies in the United States of America in order to exterminate this supposed “diseugenic”, or un-divine, race. Similarly, South Africa has had abortion laws with the goal being to increase white birth rates, and it not only did that, but black women also bore the consequences of illegal and unsafe abortions due to the high cost. Furthermore, individual racism, or scientific racism, has a long history, and has seeped into the modern day bias of health assessment, and gave birth to iatrophobia- an abnormal or irrational fear of going to the doctors- amongst blacks all around the world. From the exclusion of the black women’s voice due to “white” feminism in both America and South Africa, to the detrimental effects of gentrification on blacks, these two share many of the same issues in regards to filtering out the black image. Finally, cultural racism in both America and South Africa has, with stereotypes in art and media, successfully filtered the black image, and has done so with the help of the black community. However, if we acknowledge this goal of filtering the black image, then the United States of America and South Africa will be able to wholly progress as a society

The Impact of Organizational Culture on Corporate Performance

Lack of effective organizational culture and poor cultural integration in the corporate group affect organizational performance and decrease shareholders return. The purpose of this exploratory case study was to explore successful strategies that one corporate group used to establish an effective organizational culture to improve performance. The Denison organizational culture model served as the conceptual framework for the study. A purposive sample of 20 senior managers from a corporate group in Ethiopia participated in semistructured face-to-face interviews. The selected participant met the criteria of a minimum 5 years of experience with successful strategies in establishing an effective organizational culture in the corporate group. The interview data were transcribed, categorized, and coded; they were subsequently member checked and triangulated to increase the trustworthiness of interpretations. The findings included a well-defined mission that attributed to developing shared understanding between employees and managers, and employee-focused leadership that contributed to motivating employees. Core corporate value findings included the well-being of the society through self-regulated corporate social responsibility. The findings identified in this study could have potential for economic growth in the local economy and may contribute to social change with strategies business managers may use to sustain their business and improve the life standards of employees and the local community

双方向長・短期記憶ニューラルネットワークを用いたティグリーニャ語の形態素分割と英語ティグリーニャ語機械翻訳への影響

国立大学法人長岡技術科学大

Policy Gaps Which Contribute to The Low Quality of Education in Ethiopia

This research aims to bring a better understanding on the challenges of the current education policy in Ethiopia. The current education policy in Ethiopia has been developed to bring a desirable quality education, yet education quality in Ethiopia is getting worse. Here one can assume that there are several factors contributing to the education policy gaps which quensiquently end up in low education quality in Ethiopia. This thesis attempted to see the problem of low quality education in Ethiopia in the light of the concept of institutional monocropping. The concept of institutional monocropping is all about imposing the bluorint of international donors with out considering the local situation and context. Accordingly, this thesis has tried to answer the following question. “How does the institutional mono cropping affect the current education policy which consequently contributes to the low quality of education in Ethiopia?” Finding of this thesis shows that internationalazation of education policy particularly through the push to meet the MDG affects quality education. Since the MDGs provides uniform policy to all developing countries, it is likely to overlook the local need. For insatance, the movement given to all developing countries to achive UPE out of 100% is focused on quantity while the local need of the desirable educaton quality is overlooked. Moreover, finding of this thesis noted that, institutional monocropping is affecting the current education policy in Ethiopia by taking much its attention to wards the supply side, which advocates having more teachers, schools and school materials, while neglecting the demand side which involves the real need of students, parents and the community. That is, however the demand side has mentioned in the policy, it remaind as a paper value since it doesn’t get enough attention. Hence result of the study show that there is a big policy gap between the demand and supply side. Particularly the demand side shuld come to the fore in order to bring the desirable quality education in Ethiopia

Factors influencing maternal health care services utilization by women in Awash Fentale woreda, Ethiopia

PURPOSE: The main aim of this study was to systematically assess the factors that influence maternal health care services utilization by women in Awash Fentale woreda (district), Ethiopia. DESIGN: A quantitative, descriptive, and cross-sectional design was selected as the methodology for this study. METHOD: Data were collected using a structured questionnaire administered to 422 women aged 15 to 49 years through a stratified sampling technique. Data was entered, analyzed and interpreted using SPSS computer program. Binary logistic regression model was used to identify the factors that influence maternal health care services utilization. RESULTS: The findings of this research indicated that not attending school, not watching television, and not owning a Bajaj (three-tire motorbike) significantly influenced low utilization of antenatal care (ANC) visits, while exposure to media, including reading newspapers, was positively associated with the adequacy of ANC visits. Similarly, factors such as not attending school and not watching television at all influenced delivery care (DC) services utilization negatively, while husbands’ low income and not watching television at all were negatively associated with postnatal care (PNC) service utilization. This research study found that 80 (19%) of the respondents preferred to give birth at home and the remaining 342 (81%) preferred a health facility for their delivery services. In addition, 43% of the respondents were not satisfied with the care and attention given by the health care provider and approximately 52% of the respondents were not satisfied with the cleanliness of the health facilities. It was also illustrated in this study that family members’ influence was one of the major barriers identified for DC services utilization. Conclusion: Policy making, planning, and implementation should focus on factors that influence maternal health care services utilization and barriers to DC services. In order to increase the utilization of maternal health care services by women with low levels of educational status, husbands ’low income or wealth quintile, and low media exposure, strategies were developed by the researcher.Health StudiesD. Litt. et Phil. (Health Studies

AI and extremism in social networks

Studien utforsker hvordan midler som kunstig intelligens, AI- drevne chatbots, kan være kilder man kan regne med som moralske aktører på digitale plattformer og som kan være identifiserbare opprørsmodeller til bekjempelse av ekstremistiske og voldsforherligende ytringer på sosiale medieplattformer. Fremveksten av digital nettverkskommunikasjon har lettet prosessen med sosiale bevegelser, noe fenomenet «Den arabiske våren» tydelig demonstrerer. Sosiale medier har vært et verdifullt verktøy når det gjelder å utvikle kollektive identiteter med en felles ideologi for å fremme et bestemt mål eller en sak og gi alternative plattformer for undertrykte samfunn. Imidlertid forblir virkningen og konsekvensene av sosiale medier i samfunn der maktbalansen forrykkes gjennom fundamentale endringer et bekymringsfullt fenomen. Radikaliserte individer og grupper har også hevdet sin tilstedeværelse på sosiale medieplattformer gjennom å fremme fordommer, hat og vold. Ekstremistiske grupper bruker ulike taktikker for å utøve makten sin på disse plattformene. Bekjempelsen av voldelig ekstremisme på sosiale medieplattformer blir som regel ikke koordinert av aktuelle aktører som regjeringer, sosiale medieselskaper, FN eller andre private organisasjoner. I tillegg har fremdeles ikke forsøk på å konstituere AI til bekjempelse av voldelig ekstremisme blitt gjennomført, men lovende resultater har blitt oppnådd gjennom noen initiativer. Prosjektet som en ‘case study’ ser på den nylige reformen i Etiopia som ble gjennomført av Nobels fredsprisvinner 2019 Abiy Ahmed etter at han tiltrådte som statsminister i Etiopia i april 2018. Etter flere tiår med undertrykkelse har den nye maktovertakelsen der det politiske rommet ble åpnet opp og ytringsfrihet ble tillatt, uventet ført til et skred av etniske gruppers polarisering. Nye etno-ekstremister har dukket frem fra alle kriker og kroker av landet og også fra sin tilværelse i diaspora. Studien ser videre på hvilken rolle sosiale medier til tider spiller ved direkte å presse på for å påvirke til og dermed forårsake voldelige handlinger på grasrota.Ved å bruke en kvalitativ forskningsmetode for ustrukturerte intervjuer med etiopiske brukere av sosiale medier, journalister og aktivister, identifiserer studien kjerneaspektene ved konfliktene og foreslår initiativer som kan brukes til å motvirke voldelig etnisk ekstremisme. Ved å bruke relevant litteratur ser prosjektet videre på innarbeidelsen av kunstig intelligens (AI) i «moralske handlinger» på sosiale medier og hvordan den kan utformes slik at den av seg selv kan ta i bruk moralske beslutningsevner i nettverket. I tillegg ser studien på mulighetene videre for bekjempelse av voldelig ekstremisme og skisserer den spesifikke rollen ikke menneskelige aktører som profesjonelle troll og bots på sosiale medier bør spille for å slåss mot radikalisering som kan føre til voldelige handlinger.Mastergradsoppgave i digital kulturMAHF-DIKULDIKULT35

Targeting schistosome cholinesterases for vaccine and drug development

The nervous system of schistosomes has been successfully targeted by anthelmintic drugs but the use of many of these has discontinued because of toxic side effects and so there is a need to better understand key neuronal processes at a molecular level to develop safer and more effective intervention strategies that target this vital system. Cholinesterases - acetylcholinesterases (AChE)s and butyrylcholinesterases (BChE)s - are key enzymes that play a pivotal role in the nervous system of schistosomes by regulating neurotransmission through acetylcholine hydrolysis and, accordingly, are an example of such an intervention target. The first results chapter (chapter two) of this thesis investigated the anti-schistosome efficacy of polypyridylruthenium (II) complexes and showed they were active against all intra-mammalian stages of S. mansoni. Two compounds, Rubb₁₂-tri and Rubb₇-tnl, which were among the most potent in their ability to kill schistosomula and adult worms and inhibit egg hatching in vitro, were assessed for their efficacy in a mouse model of schistosomiasis using 5 consecutive daily i.v. doses of 2 mg/kg (Rubb₁₂-tri) and 10 mg/kg (Rubb₇-tnl). Mice treated with Rubb₁₂-tri showed an average 42% reduction (P = 0.009), over two independent trials, in adult worm burden. Liver egg burdens were not significantly decreased in either drug-treated group but ova from both of these groups showed significant decreases in hatching ability (Rubb₁₂-tri - 68%, Rubb₇-tnl - 56%) and were significantly morphologically altered (Rubb₁₂-tri - 62% abnormal, Rubb₇-tnl - 35% abnormal). I hypothesize that the drugs exerted their activity, at least partially, through inhibition of both neuronal and tegumental acetylcholinesterases (AChEs), as worms treated in vitro showed significant decreases in activity of these enzymes. Further, treated parasites exhibited a significantly decreased ability to uptake glucose, significantly depleted glycogen stores and withered tubercules (a site of glycogen storage), implying drug-mediated interference in this nutrient acquisition pathway. Chapter three of this thesis provided the first comprehensive molecular characterization of three S. mansoni cholinesterases (SmChEs), designated as SmAChE1, SmBChE1 and SmAChE3, which were identified from the interrogation of the now wholly annotated S. mansoni genome. Anti-SmChE antibodies localized the proteins to the tegument and neuromusculature of adults and schistosomula and developmental expression profiling differed among the molecules, suggestive of functions extending beyond traditional cholinergic signaling for each of them. I also reported the presence of ChE activity in parasite ES products for the first time and proteomically identified the molecules responsible (SmAChE1 and SmBChE1). Functional recombinant versions of the three SmChEs were produced in Pichia pastoris and enzyme nomenclature (AChE or BChE) was verified based on substrate preference. Lastly, in the first characterization study of a BChE from helminths, evidence is provided that SmBChE1 may act as a bio-scavenger of AChE inhibitors as the addition of recombinant SmBChE1 to parasite cultures mitigated the effect of the anti-schistosomal AChE inhibitor dichlorvos whereas SmBChE1-silenced parasites displayed increased sensitivity to dichlorvos. SmChEs were further characterized by RNAi-based experiments in chapter four of this thesis. RNAi-mediated silencing of individual SmChEs, or simultaneous silencing of all three SmChEs, significantly suppressed transcript and protein expression levels and AChE activity in parasites. In a dissection of the hypothesis that tegumental AChE mediates exogenous glucose scavenging by the parasite, I showed that RNAi-mediated knockdown of SmAChE1 and SmAChE3, but not SmBChE1, significantly reduced glucose uptake by schistosomes. Parasite survivability in vitro and in vivo was significantly impaired with the silencing of SmChEs, either individually or in combination, attesting to the essentiality of these molecules. Chapter five of this thesis explored the vaccine potential of SmChEs. When treated in vitro with anti-SmChE IgG, parasites displayed significantly decreased ChE activity, which eventually resulted in death. Vaccination with individual SmChEs, or a combination of all three SmChEs, significantly reduced worm burdens (28% - 38%, averaged across two independent trials) compared to controls. Liver egg burdens were significantly decreased for all mice across both trials (13% - 46%) except those vaccinated with SmAChE1 in trial 1. Egg viability, as determined by egg hatching from liver homogenates, was significantly reduced in the groups vaccinated with the SmChE cocktail (40%) and SmAChE3 (46%). Surviving worms from each vaccinated group were significantly stunted and depleted of glycogen stores, compared to controls. In conclusion, this thesis has identified the burgeoning potential of a new class of antischistosome drugs that, at least in part, target the nervous system of the parasite and provided a comprehensive characterization of a family of ChEs from S. mansoni, giving compelling evidence for the essentiality of the proteins and their utility as intervention targets against schistosomiasis