5-Chloro­spiro­[indoline-3,7′-6H,7H,8H-pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione

The asymmetric unit of the title compound, C26H12ClNO6, consists of two independent mol­ecules. The central pyran rings and both the 1-benzopyran ring systems are nearly planar in both mol­ecules [r.m.s. deviations of pyan rings = 0.0264 (1) and 0.0326 (1) Å for molecules A and B, respectively; r.m.s. deviations of benzopyran rings = 0.0439 (1) and 0.0105 (1) for molecule A, 0.0146 (1) and 0.0262 (1) Å for molecule B]. In the crystal, the molecules are linked by C—H⋯O, N—H⋯O and C—H⋯π inter­actions

Annular substructures in the transition disks around LkCa 15 and J1610

We present high resolution millimeter continuum ALMA observations of the disks around the T Tauri stars LkCa 15 and J1610. These disks host dust-depleted inner regions, possibly carved by massive planets, and are of prime interest to study the imprints of planet-disk interactions. While at moderate angular resolution they appear as a broad ring surrounding a cavity, the continuum emission resolves into multiple rings at a resolution of ~60$\times$40 mas (~7.5 au for LkCa 15, ~6 au for J1610) and ~$7\,\mu$Jy beam$^{-1}$ rms at 1.3 mm. In addition to a broad extended component, LkCa 15 and J1610 host 3 and 2 narrow rings, respectively, with two bright rings in LkCa 15 being radially resolved. The rings look marginally optically thick, with peak optical depths of ~0.5 (neglecting scattering), in agreement with high angular resolution observations of full disks. We perform hydrodynamical simulations with an embedded, sub-Jovian-mass planet and show that the observed multi-ringed substructure can be qualitatively explained as the outcome of the planet-disk interaction. We note however that the choice of the disk cooling timescale alone can significantly impact the resulting gas and dust distributions around the planet, leading to different numbers of rings and gaps and different spacings between them. We propose that the massive outer disk regions of transition disks are favorable places for planetesimals and possibly second generation planet formation of objects with a lower mass than the planets carving the inner cavity (typically few $M_{\rm Jup}$), and that the annular substructures observed in LkCa 15 and J1610 may be indicative of planetary core formation within dust-rich pressure traps. Current observations are compatible with other mechanisms being at the origin of the observed substructures, in particular with narrow rings generated at the edge of the CO and N$_2$ snowlines.Comment: 17 pages, accepted for publication in Astronomy & Astrophysic

Emission-Line Galaxy Surveys as Probes of the Spatial Distribution of Dwarf Galaxies. I. The University of Michigan Survey

Objective-prism surveys which select galaxies on the basis of line-emission are extremely effective at detecting low-luminosity galaxies and constitute some of the deepest available samples of dwarfs. In this study, we confirm that emission-line galaxies (ELGs) in the University of Michigan (UM) objective-prism survey (MacAlpine et al. 1977-1981) are reliable tracers of large-scale structure, and utilize the depth of the samples to examine the spatial distribution of low-luminosity (M$_{B} >$ -18.0) dwarfs relative to higher luminosity giant galaxies (M$_{B} \leq$ -18.0) in the Updated Zwicky Catalogue (Falco et al. 1999). New spectroscopic data are presented for 26 UM survey objects. We analyze the relative clustering properties of the overall starbursting ELG and normal galaxy populations, using nearest neighbor and correlation function statistics. This allows us to determine whether the activity in ELGs is primarily caused by gravitational interactions. We conclude that galaxy-galaxy encounters are not the sole cause of activity in ELGs since ELGs tend to be more isolated and are more often found in the voids when compared to their normal galaxy counterparts. Furthermore, statistical analyses performed on low-luminosity dwarf ELGs show that the dwarfs are less clustered when compared to their non-active giant neighbors. The UM dwarf samples have greater percentages of nearest neighbor separations at large values and lower correlation function amplitudes relative to the UZC giant galaxy samples. These results are consistent with the expectations of galaxy biasing.Comment: 17 pages, 4 tables, 10 figures. Accepted for publication in the Ap

Boron Nitride Monolayer: A Strain-Tunable Nanosensor

The influence of triaxial in-plane strain on the electronic properties of a hexagonal boron-nitride sheet is investigated using density functional theory. Different from graphene, the triaxial strain localizes the molecular orbitals of the boron-nitride flake in its center depending on the direction of the applied strain. The proposed technique for localizing the molecular orbitals that are close to the Fermi level in the center of boron nitride flakes can be used to actualize engineered nanosensors, for instance, to selectively detect gas molecules. We show that the central part of the strained flake adsorbs polar molecules more strongly as compared with an unstrained sheet.Comment: 20 pages, 9 figure

Dietary Soy Galactooligosaccharides Affect the Performance, Intestinal Function, and Gut Microbiota Composition of Growing Chicks

The objective of this experiment was to investigate the effects of the dietary soy galactooligosaccharides (GOS), raffinose and stachyose, on performance, gastrointestinal health, and systemic stress in young broilers. Birds were fed a GOS-devoid diet based on soy protein isolate (SPI) or the SPI diet with 0.9, 1.8, 2.7, or 3.6% added stachyose and raffinose in a ratio of 4:1 at the expense of corn starch. These 5 treatments were administered to 10 replicate cages of 8 birds. Performance was measured weekly and excreta moisture, N retention, apparent metabolizeable energy, and complete blood cell counts were determined at 14 and 21 d. At 21 d, 2 birds per cage were orally gavaged with fluorescein isothiocyanate-dextran (FITC-d) and serum samples were analyzed for FITC-d as a marker of gut leakage. Additionally, intestinal morphology, crop presumptive lactic acid bacteria (LAB) counts, crop and cecal pH, and cecal microbiota via16S rRNA microbial sequencing were evaluated at 21 d. From 0 to 21 d, feed intake increased linearly (P \u3c 0.01) as dietary GOS increased, whereas BWG increased (P \u3c 0.05) quadratically. Feed conversion ratio increased (P \u3c 0.01) linearly as GOS increased. There were linear increases (P \u3c 0.05) in excreta moisture as dietary GOS increased at 14 and 21 d, as well as dose-dependent responses (P \u3c 0.05) in N retention, AME, and AMEn. There was a quadratic increase (P \u3c 0.05) in crop LAB recovery and a linear decrease (P \u3c 0.01) in ceca pH as GOS increased. At 14 d, a linear increase (P \u3c 0.05) in blood heterophil to lymphocyte ratio was observed as dietary GOS increased. Serum concentrations of FITC-d increased quadratically (P \u3c 0.01) to dietary GOS. Increasing levels of GOS influenced alpha and beta diversities and composition of gut microbiota, including the abundance of Ruminococcus and Bifidobacterium. Results from this trial indicate that soy-derived GOS exert dose-dependent effects on nutrient utilization and intestinal health in young broilers

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci

A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event models. A multivariate form of the reduction principle is found: reduction results at individual loci combine topologically to produce a surface of mutation rate alterations that are neutral for a new modifier allele. New mutation rates survive if and only if they fall below this surface - a generalization of the hyperplane found by Zhivotovsky et al. (1994) for a multilocus recombination modifier. Increases in mutation rates at some loci may evolve if compensated for by decreases at other loci. The strength of selection on the modifier scales in proportion to the number of germline cell divisions, and increases with the number of loci affected. Loci that do not make a difference to marginal fitnesses at equilibrium are not subject to the reduction principle, and under fine tuning of mutation rates would be expected to have higher mutation rates than loci in mutation-selection balance. Other results include the nonexistence of 'viability analogous, Hardy-Weinberg' modifier polymorphisms under multiplicative mutation, and the sufficiency of average transmission rates to encapsulate the effect of modifier polymorphisms on the transmission of loci under selection. A conjecture is offered regarding situations, like recombination in the presence of mutation, that exhibit departures from the reduction principle. Constraints for tractability are: tight linkage of all loci, initial fixation at the modifier locus, and mutation distributions comprising transition probabilities of reversible Markov chains.Comment: v3: Final corrections. v2: Revised title, reworked and expanded introductory and discussion sections, added corollaries, new results on modifier polymorphisms, minor corrections. 49 pages, 64 reference

Serum kynurenic acid is reduced in affective psychosis

A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites. Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative Nmethyl- D-aspartate (NMDA) receptor agonist. In contrast, schizophrenia and psychosis are hypothesized to arise from increased metabolism of the NMDA receptor antagonist, kynurenic acid (KynA), leading to hypofunction of GABAergic interneurons, the disinhibition of pyramidal neurons and striatal hyperdopaminergia. Here we present results that challenge the model of excess KynA production in affective psychosis. After rigorous control of potential confounders and multiple testing we find significant reductions in serum KynA and/or KynA/QA in acutely ill inpatients with major depressive disorder (N = 35), bipolar disorder (N = 53) and schizoaffective disorder (N = 40) versus healthy controls (N = 92). No significant difference was found between acutely ill inpatients with schizophrenia (n = 21) and healthy controls. Further, a post hoc comparison of patients divided into the categories of non-psychotic affective disorder, affective psychosis and psychotic disorder (non-affective) showed that the greatest decrease in KynA was in the affective psychosis group relative to the other diagnostic groups. Our results are consistent with reports of elevations in proinflammatory cytokines in psychosis, and preclinical work showing that inflammation upregulates the enzyme, kynurenine mono-oxygenase (KMO), which converts kynurenine into 3-hydroxykynurenine and quinolinic acid

Protoplanetary disks in Kₛ-band total intensity and polarized light

Context. The diverse morphology among protoplanetary disks may result from planet-disk interactions, suggesting the presence of planets undergoing formation. The characterization of disks can provide information on the formation environments of planets. To date, most imaging campaigns have probed the polarized light from disks, which is only a fraction of the total scattered light and not very sensitive to planetary emission. / Aims. We aim to observe and characterize protoplanetary disk systems in the near-infrared in both polarized and total intensity light to carry out an unprecedented study of the dust scattering properties of disks, as well as of any possible planetary companions. / Methods. Using the star-hopping mode of the SPHERE instrument at the Very Large Telescope, we observed 29 young stars hosting protoplanetary disks and their reference stars in the Ks-band polarized light. We extracted disk signals in total intensity by removing stellar light using the corresponding reference star observations, by adopting the data imputation concept with sequential non-negative matrix factorization (DI-sNMF). For well-recovered disks in both polarized and total intensity light, we parameterized the polarization fraction phase functions using a scaled beta distribution. We investigated the empirical DI-sNMF detectability of disks using logistic regression. For systems with SPHERE data in the Y, J, and H bands, we have summarized their polarized color at an approximately 90° scattering angle. / Results. We obtained high-quality disk images in total intensity for 15 systems and in polarized light for 23 systems. The total intensity detectability of disks primarily depends on the host star brightness, which determines adaptive-optics control ring imagery and thus stellar signals capture using DI-sNMF. The peak of polarization fraction tentatively correlates with the peak scattering angle, which could be reproduced using certain composition for compact dust, yet more detailed modeling studies are needed. Most of the disks are blue in polarized J – Ks color and the fact that they are relatively redder as stellar luminosity increases indicates larger scatterers. / Conclusions. High-quality disk imagery in both total intensity and polarized light allows for disk characterizations in the polarization fraction. Combining these techniques reduces the confusion between the disk and planetary signals