Prostate cancer and chronic lymphocytic leukemia

The association between prostate cancer and chronic lymphocytic leukemia (CLL) is rare.We report a case of 69 year old man who presented a CLL, classified as Binet stage C, treated with FCR protocol. After six cycles of chemotherapy, itwas in complete remission. Eighteen months after the end of treatment, the patient presented with dysuria and back pain. Digital rectal examination revealed an indurated prostate. The PSA was elevated to 1103 ng/ml. Prostate biopsy with histopathologic study showed poorly differentiated prostate adenocarcinoma (Gleason score: 8). Staging workup revealed bone metastases. Adjuvant radiotherapy and pulpectomy associated with bisphosphonates and analgesics was proposed. The association between CLL and prostate cancer appears too frequent to be accidental.Keywords: Prostate cancer; Chronic lymphocytic leukaemia; TreatmentAfrican Journal of Urology (2013) 19, 35–3

Gender trouble and its impact on fertility intentions

It is often an underlying assumption that the new role of women and in general the trend toward a more egalitarian view of the concept of partnership is a main factor behind the low fertility rates in rich countries The aim of this paper is to test the consequences of gender (in)equity on the desire of women and men to have (further) children by using gender inequity as an important category within population science. In our assumptions we want to test whether an unequal distribution of household chores and childcare duties has a negative effect on the desire to have children. Another assumption examines the potential correlation that the perception of (in)equality of women and men in society or the acceptance of government measures to ensure equal rights might have with the desire to have children. The data are derived from the recent Austrian survey Population Policy Acceptance Survey. The assumptions are tested by means of logistic regression analysis. The results show that it is new men who are likely to express a wish for children, rather than those who live in traditional partnership models

Politik zu Vaterschaft

"Bei der Analyse der Strukturen und Funktionsweisen von Familien bzw. der familienpolitischen Einflussnahme wird der Part der Väter zumeist nachrangig behandelt. In diesem Beitrag wird die Frage aufgeworfen, ob es im Wohlfahrtsstaat Österreich eine Politik gibt, die auf Väter abzielt, und welchen Charakter eine solche besitzt. Es wird von der These ausgegangen, dass politische Regelungen zu Familie im Spannungsfeld von Familie, Arbeitsmarkt und Staat zu betrachten sind und nur so Widersprüche innerhalb der Politik zu Vaterschaft sowie die ambivalente Haltung von Vätern selbst erklärbar sind. In diesem Zusammenhang werden die geschlechtsspezifische Verfasstheit der österreichischen Familienpolitik und ihrer politischen und rechtlichen Maßnahmen sowie die Normativität von Familienleitbildern überprüft. In den Ergebnissen werden die Ambivalenzen der österreichischen Politik zu Vaterschaft aufgezeigt." (Autorenreferat)"Most studies on the influence of family policy on family structures and other family-related issues account only insufficiently for the role of the father within these structures. This contribution will explore, whether the Austrian welfare state pursues policies aimed specifically at fathers and what is the nature of such policies. The article assumes that political regulations of family are to be regarded between the conflicting priorities of family, labor market and the state, and this is the only way that contradictions in the policy on fatherhood and the ambivalent attitudes of fathers themselves can be explained. In this regard the contribution focuses on exploring the gender paradigm of Austrian policies relating to family issues and the implementation of political and legal measures. Furthermore, the norms and conventional ideas about family, which underlie political decision-making processes, will be reviewed. The results demonstrate that Austrian policies on fatherhood are ambivalent." (author's abstract

Management of Pediatric Tumor Lysis Syndrome

Introduction: Tumor lysis syndrome (TLS) is a serious complication of malignancies and can result in renal failure or death. Review: In tumors with a high proliferative rate with a relatively large mass and a high sensitivity to cytotoxic agents, the initiation of therapy often results in the rapid release of intracellular anions, cations and the metabolic products of proteins and nucleic acids into the bloodstream. The increased concentrations of uric acid, phosphates, potassium and urea can overwhelm the body’s homeostatic mechanisms to process and excrete these materials and result in the clinical spectrum associated with TLS. Typical clinical sequelae include gastrointestinal disturbances, neuromuscular effects, cardiovascular complications, acute renal failure and death. Tumor lysis syndrome can also compromise the efficacy or administration of curative therapies. Available evidence suggests that the incidence of clinical TLS is approximately 3–7% for acute leukemias and 4–11% for lymphomas. Pediatric cancers are the leading cause of death by disease in children. The most common pediatric cancers include the leukemias, lymphomas, central nervous system tumors and neuroblastoma. Thus, TLS is a major concern to practitioners caring for pediatric oncology patients. Given the complexity of TLS prevention and treatment, a multidisciplinary approach involving the collaboration of medical oncologists/ hematologists and nephrologists has the greatest potential of ensuring optimal patient outcomes. Rehydration is fundamental in the management of TLS in addition to the current standard therapy for hyperuricemia which include rasburicase and allopurinol. Conclusion: The early recognition and treatment of metabolic abnormalities often prevents the severe and life-threatening complications associated with tumor lysis syndrome.Keyswords: Acute Renal Failure; Burkitt’s Lymphoma; Hematologic Malignancies; Hydration; Tumor Lysis Syndrom

Le médicament générique au Maroc: le point de vue du consommateur

Introduction: Le médicament générique est souvent une origine de préjugés négatifs et de méfiance chez les professionnels de santé et les patients. Ceci pourrait être dû à plusieurs facteurs entre autre le manque des connaissances du patient sur ces médicaments. Le but de notre étude était d'évaluer l'information du consommateur sur les médicaments génériques et apprécier leur utilisation de ces médicaments. Méthodes: Il s'agit d'une étude transversale réalisée de Janvier à Mars 2010 auprès de 251 sujets. Un questionnaire comprenant dix questions fermées a été utilisé. Les questions concernaient l'évaluation des connaissances sur les médicaments génériques, les sources d'information, le degré de confiance et d'information des patients sur ces médicaments. Une analyse descriptive simple des différentes variables a été réalisée. Résultats: Dans notre étude, 126 sujets (50,2%) ont répondu connaître les médicaments génériques. Parmi eux, 52,3% les utilisaient et 67,4% estimaient qu'ils étaient insuffisamment informés sur ces médicaments. Les cadres supérieurs et les étudiants ont représenté la catégorie qui utilisait le plus les médicaments génériques (respectivement dans 40,9% et 25,7%) et qui était la mieux informée (respectivement dans 61,9% et 23,81%). Le faible coût a été la principale motivation d'utilisation du médicament générique (93,9%). Les médias ont représenté la première source d'information (59,5%). Après sensibilisation, 88,8% des sujets qui ne connaissaient pas le médicament générique ont été favorable à son utilisation.Conclusion: Une promotion efficace par une politique d'information soutenue auprès des consommateurs et par des mesures incitatrices à la prescription et à la délivrance du générique par les médecins et les pharmaciens, pourront améliorer l'utilisation de ces médicaments dans notre pays.Key words: Médicament générique, consommateur, perception, Maro

Transitional cell carcinoma of the ovary: A rare case and review of literature

<p>Abstract</p> <p>Introduction</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer.</p> <p>Case presentation</p> <p>A 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. Abdominal computed tomography showed a pelvic mass. CA-125 was normal. A staging operation with total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy and pelvic lymph node dissection was performed. After surgery, the pathologic report of the right ovarian tumour was TCC, grade 3, stage IC. The patient underwent 3 cycles of chemotherapy: carboplatin and paclitaxel. She is regularly followed up and has been disease free for 10 months</p> <p>Conclusion</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient outcomes after chemotherapy are better than for other types of ovarian cancers.</p

Remission of hypertension after treatment of giant simple renal cyst: a case report

Renal cysts are common in old patients, and usually remain untreated. Giant renal cysts measuring more than 15 cm in greatest diameter are uncommon and the association with hypertension is very rare. We present a case of a 25-year-old woman with a giant right renal cyst associated with hypertension that was treated by laparoscopic excision, followed by resolution hypertension

Fertility Intentions and Their Realization in Couples : How the Division of Household Chores Matters

Most research on Europe indicates that a gender-balanced division of family work tends to increase childbearing probabilities, but empirical results vary substantially. The present article proposes explanations for this observed discrepancy. It develops prior research further by (1) studying short-term fertility intentions and their realization within the subsequent 4 years, (2) analyzing the role of the spouses’ satisfaction with the division for the effects that the division may have on childbearing, (3) proving a mediation by relationship satisfaction, and (4) considering gender as well as parity as moderators. Using data from two waves of the Generations and Gender Survey, we show that the division of work affects childbearing intentions. We find that the effect (a) depends on the spouses’ satisfaction with the division, (b) is partly moderated by relationship satisfaction, and (c) varies by parity. The division of household labor, however, seems of less importance for the realization of childbearing intentions

Unicentric castleman's disease located in the lower extremity: a case report

<p>Abstract</p> <p>Background</p> <p>Castleman's disease is a rare form of localized lymph node hyperplasia of uncertain etiology. Although the mediastinum is the most common site of involvement, rare cases occurring in lymph node bearing tissue of other localization have been reported, including only a few intramuscular cases. Unicentric and multicentric Castleman's disease are being distinguished, the latter harboring an unfavorable prognosis.</p> <p>Case Presentation</p> <p>Here, we present a case of unicentric Castleman's disease in a 37-year-old woman without associated neoplastic, autoimmune or infectious diseases. The lesion was located in the femoral region of the right lower extremity and surgically resected after radiographic workup and excisional biopsy examinations. The tumor comprised lymphoid tissue with numerous germinal centers with central fibrosis, onion-skinning and rich interfollicular vascularization. CD23-positive follicular dendritic cells were detected in the germinal centers and numerous CD138-positive plasma cells in interfollicular areas. The diagnosis of mixed cellularity type Castleman's disease was established and the patient recovered well.</p> <p>Conclusions</p> <p>In conclusion, the differential diagnosis of Castleman's disease should be considered when evaluating a sharply demarcated, hypervascularized lymphatic tumor located in the extremities. However, the developmental etiology of Castleman's disease remains to be further examined.</p