Self-consistent Gravitational Lens Reconstruction

We present a new method for directly determining accurate, self-consistent cluster lens mass and shear maps in the strong lensing regime from the magnification bias of background galaxies. The method relies upon pixellisation of the surface mass density distribution which allows us to write down a simple, solvable set of equations. We also show how pixellisation can be applied to methods of mass determination from measurements of shear and present a simplified method of application. The method is demonstrated with cluster models and applied to magnification data from the lensing cluster Abell 1689.Comment: 5 pages, 4 figures. References added to introduction. Accepted by MNRA

Nonlinear Cosmological Power Spectra in Real and Redshift--Space

We present an expression for the nonlinear evolution of the cosmological power spectrum based on following Lagrangian trajectories. This is simplified using the Zel'dovich approximation to trace particle displacements, assuming Gaussian initial conditions. The model is found to exhibit the transfer of power from large to small scales expected in self- gravitating fields. We have extended this analysis into redshift-space and found a solution for the nonlinear, anisotropic redshift-space power spectrum in the limit of plane--parallel redshift distortions. The quadrupole-to- monopole ratio is calculated for the case of power-law initial spectra. We find that the shape of this ratio depends on the shape of the initial spectrum, but when scaled to linear theory depends only weakly on the redshift-space distortion parameter, $\beta$. The point of zero-crossing of the quadrupole, $k_0$, is found to obey a scaling relation. This model is found to be in agreement with $N$-body simulations on scales down to the zero-crossing of the quadrupole, although the wavenumber at zero-crossing is underestimated. These results are applied to the quadrupole--monopole ratio found in the merged QDOT+1.2 Jy IRAS redshift survey. We have estimated that the distortion parameter is constrained to be $\beta>0.5$ at the $95 \%$ level. The local primordial spectral slope is not well constrained, but analysis suggests $n \approx -2$ in the translinear regime. The zero-crossing scale of the quadrupole is $k_0=0.5 \pm 0.1 h/Mpc$ and from this we infer the amplitude of clustering is $\sigma_8=0.7 \pm 0.05$. We suggest that the success of this model is due to nonlinear redshift--space effects arising from infall onto caustics and is not dominated by virialised cluster cores.Comment: 13 pages, uufiles, Latex with 6 postscript figures, submitted to MNRA

Topical prostaglandin analogues and conjunctival inflammation in uveitic glaucoma.

A pilot study to determine whether topical prostaglandin analogues alter the expression of conjunctival inflammatory markers in patients with uveitic glaucoma.Prospective, single-masked case series of 20 patients with uveitis and secondary raised intraocular pressure. Participants were divided into four groups of five patients dependent on their use of topical medication: (1) prostaglandin analogues only, (2) corticosteroids only, (3) both prostaglandin analogues and corticosteroids, (4) no topical medication. Conjunctival cells were harvested by impression cytology and were examined for inflammatory markers (CD3, CD54, HLA-DR, CCR4, CCR5) by flow cytometry. A tear fluid sample was also examined for inflammatory cytokines (IL-12p70, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IFN-gamma, IL-1beta, IFN-alpha, IFN-beta) by multiplex bead arrays.All groups demonstrated increased markers of conjunctival inflammation. There was no significant difference in levels of any inflammatory markers between the four groups, suggesting that the use of topical prostaglandin analogues does not increase conjunctival levels of inflammation beyond those already seen in uveitis.The use of topical prostaglandins does not appear to induce conjunctival inflammation over that which is already present in patients with uveitic glaucoma. This supports the use of topical prostaglandin analogues in patients with uveitic glaucoma, indicating that their use is unlikely to adversely affect subsequent glaucoma filtration surgery through the induction of chronic conjunctival inflammation

Inferring HIV escape rates from multi-locus genotype data

Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells. Virus variants whose protein fragments are not efficiently presented on infected cells or whose fragments are presented but not recognized by CTLs therefore have a competitive advantage and spread rapidly through the population. We present a method that allows a more robust estimation of these escape rates from serially sampled sequence data. The proposed method accounts for competition between multiple escapes by explicitly modeling the accumulation of escape mutations and the stochastic effects of rare multiple mutants. Applying our method to serially sampled HIV sequence data, we estimate rates of HIV escape that are substantially larger than those previously reported. The method can be extended to complex escapes that require compensatory mutations. We expect our method to be applicable in other contexts such as cancer evolution where time series data is also available

Proton beam radiotherapy in the management of uveal melanoma: clinical experience in Scotland

<p>Aim: To evaluate proton-beam radiotherapy (PBRT) in the management of uveal melanoma in Scotland.</p> <p>Methods: A retrospective review was undertaken on all patients receiving PBRT for uveal melanoma (1994–2005). Data obtained included: gender, past ocular/medical history, age, presenting complaint(s), diagnosis, laterality, tumor location/ultrasound characteristics, visual acuity (VA) and intraocular pressure. At post-treatment reviews (3, 6, 12, and 24 months), the following data was obtained: VA, intraocular pressure, tumor appearance and ultrasound characteristics. Mean follow up was 38.8 months.</p> <p>Results: Seventy-six patients were included. Mean age was 64 years; male to female ratio was 1.1:1. Ninety-seven percent demonstrated initial treatment response; 87% had successful control of tumor growth. Mean pre-treatment tumor height was 6.2 mm v.s. 4.8 mm post-irradiation (p < 0.001). Pre-irradiation VA was <3/60 in 18.5% compared with 74% post-irradiation (p < 0.0001). There was a statistically significant association between adverse events (enucleation, metastasis) and greater maximal basal tumor diameter. Eighteen eyes were enucleated. The median survival time was estimated to be 54 months.</p> <p>Conclusion: In our experience, PBRT is a precise, reliable and effective treatment in the management of large, and previously treated uveal melanomas. It prevents enucleation in the majority at short term follow-up.</p&gt

The diffuse neutrino flux from the inner Galaxy: constraints from very high energy gamma-ray observations

Recently, the MILAGRO collaboration reported on the detection of a diffuse multi-TeV emission from a region of the Galactic disk close to the inner Galaxy. The emission is in excess of what is predicted by conventional models for cosmic ray propagation, which are tuned to reproduce the spectrum of cosmic rays observed locally. By assuming that the excess detected by MILAGRO is of hadronic origin and that it is representative for the whole inner Galactic region, we estimate the expected diffuse flux of neutrinos from a region of the Galactic disk with coordinates $-40^{\circ} < l < 40^{\circ}$. Our estimate has to be considered as the maximal expected neutrino flux compatible with all the available gamma ray data, since any leptonic contribution to the observed gamma-ray emission would lower the neutrino flux. The diffuse flux of neutrinos, if close to the maximum allowed level, may be detected by a km$^3$--scale detector located in the northern hemisphere. A detection would unambiguously reveal the hadronic origin of the diffuse gamma-ray emission.Comment: submitted to Astroparticle Physic