Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex

The SMC protein complexes play important roles in chromosome dynamics. The function of the SMC5-6 complex remains unclear, though it is involved in resolution of different DNA structures by recombination. We have now identified and characterized the four non-SMC components of the human complex and in particular demonstrated that the MAGEG1 protein is part of this complex. MAGE proteins play important but as yet undefined roles in carcinogenesis, apoptosis, and brain development. We show that, with the exception of the SUMO ligase hMMS21/hNSE2, depletion of any of the components results in degradation of all the other components. Depletion also confers sensitivity to methyl methanesulfonate. Several of the components are modified by sumoylation and ubiquitination

Simple random-interval generation reveals the irresistibly periodic structure of perceived time

Whole-integer ratios in musical rhythm are culturally universal. The reliable periodicity of rhythm inspired us to determine whether time perception, which is foundational to and inherently less structured than rhythm, is subject to similar biases. We created a random-interval generation task that exploits the nonrandom tendencies in perception and action in order to uncover the structural biases underlying temporal duration perception. Participants listened to and watched an audiovisual suprasecond temporal cue and were asked to subdivide it as randomly as possible in a prescribed number of responses. The results showed that the subdivision probability distributions were distinctly nonrandom, and closely resembled multimodal distributions with a number of equally spaced, symmetrical peaks equal to the number of subdivisions required. These patterns were thus highly periodic and isochronous, despite explicit instructions to act as randomly as possible. We interpreted this bias as an organizing heuristic that divides perceived time into smaller, equal-duration chunks in order to facilitate representation

When Walls are No Longer Barriers: Perception of Wall Height in Parkour

Through training, skilled parkour athletes (traceurs) overcome everyday obstacles, such as walls, that are typically insurmountable. Traceurs and untrained novices estimated the height of walls and reported their anticipated ability to climb the wall. The traceurs perceived the walls as shorter than did novices. This result suggests that perception is scaled by the perceiver’s anticipated ability to act, and is consistent with the action-specific account of perception

Action-Specific Effects Underwater

Action-specific effects on perception are apparent in terrestrial environments. For example, targets that require more effort to walk, jump, or throw to look farther away than when the targets require less effort. Here, we examined whether action-specific effects would generalize to an underwater environment. Instead, perception might be geometrically precise, rather than action-specific, in an environment that is novel from an evolutionary perspective. We manipulated ease to swim by giving participants swimming flippers or taking them away. Those who estimated distance while wearing the flippers judged underwater targets to be closer than did participants who had taken them off. In addition, participants with better swimming ability judged the targets to be closer than did those with worse swimming ability. These results suggest perceived distance underwater is a function of the perceiver’s ability to swim to the targets

Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia

Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the hypothesis that selective dopamine receptor activation induces emergence from isoflurane anesthesia. Methods: In adult rats, we tested the effects of chloro-APB (D1 agonist) and quinpirole (D2 agonist) on time to emergence from isoflurane general anesthesia. We then performed a dose–response study to test for chloro-APB–induced restoration of righting during continuous isoflurane anesthesia. SCH-23390 (D1 antagonist) was used to confirm that the effects induced by chloro-APB are specifically mediated by D1 receptors. In a separate group of animals, spectral analysis was performed on surface electroencephalogram recordings to assess neurophysiologic changes induced by chloro-APB and quinpirole during isoflurane general anesthesia. Results: Chloro-APB decreased median time to emergence from 330 to 50 s. The median difference in time to emergence between the saline control group (n = 6) and the chloro-APB group (n = 6) was 222 s (95% CI: 77–534 s, Mann–Whitney test). This difference was statistically significant (P = 0.0082). During continuous isoflurane anesthesia, chloro-APB dose-dependently restored righting (n = 6) and decreased electroencephalogram δ power (n = 4). These effects were inhibited by pretreatment with SCH-23390. Quinpirole did not restore righting (n = 6) and had no significant effect on the electroencephalogram (n = 4) during continuous isoflurane anesthesia. Conclusions: Activation of D1 receptors by chloro-APB decreases time to emergence from isoflurane anesthesia and produces behavioral and neurophysiologic evidence of arousal during continuous isoflurane anesthesia. These findings suggest that selective activation of a D1 receptor–mediated arousal mechanism is sufficient to induce emergence from isoflurane general anesthesia.National Institutes of Health (U.S.) (Grant DP1-OD003646)National Institutes of Health (U.S.) (Grant K08-GM094394)Massachusetts General Hospital. Dept. of Anesthesia and Critical Car

A comparison of sex offenders and other types of offenders referred to intellectual disability forensic services

This study compared 131 sex offenders with ID and 346 other types of offenders with ID using case file records. All the females in the study were non sexual offenders. Significantly more sexual offenders were referred from court and criminal justice services while significantly fewer were referred from secondary healthcare. A higher percentage of sex offenders had some form of legal status at time of referral. Greater proportions of non sexual offenders were referred for aggression, damage to property, substance abuse and fire setting while only the sex offenders had an index sex offence. For previous offending, the non sexual offenders had higher rates of aggression, cruelty and neglect of children, property damage and substance abuse while the sexual offenders had higher rates of previous sexual offending. For psychiatric disturbance and adversity in childhood, only ADHD showed a significant difference between groups with the non sexual offenders recording higher rates